JP2018536031A5 - - Google Patents
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- Publication number
- JP2018536031A5 JP2018536031A5 JP2018545695A JP2018545695A JP2018536031A5 JP 2018536031 A5 JP2018536031 A5 JP 2018536031A5 JP 2018545695 A JP2018545695 A JP 2018545695A JP 2018545695 A JP2018545695 A JP 2018545695A JP 2018536031 A5 JP2018536031 A5 JP 2018536031A5
- Authority
- JP
- Japan
- Prior art keywords
- alkylene
- alkyl
- asteratoarene
- iodo
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 17
- 125000002947 alkylene group Chemical group 0.000 claims 15
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 10
- -1 diaryliodonium compound Chemical class 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000001424 substituent group Chemical group 0.000 claims 5
- 239000012955 diaryliodonium Substances 0.000 claims 4
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 4
- 230000002194 synthesizing effect Effects 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 239000013598 vector Substances 0.000 claims 3
- 125000000041 C6-C10 aryl group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 150000001450 anions Chemical class 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 229910052789 astatine Inorganic materials 0.000 claims 2
- 238000006243 chemical reaction Methods 0.000 claims 2
- 125000005520 diaryliodonium group Chemical group 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 2
- 238000000746 purification Methods 0.000 claims 2
- 230000002285 radioactive effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000002904 solvent Substances 0.000 claims 2
- 150000001298 alcohols Chemical class 0.000 claims 1
- RYXHOMYVWAEKHL-UHFFFAOYSA-N astatine atom Chemical compound [At] RYXHOMYVWAEKHL-UHFFFAOYSA-N 0.000 claims 1
- 125000004057 biotinyl group Chemical group [H]N1C(=O)N([H])[C@]2([H])[C@@]([H])(SC([H])([H])[C@]12[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 125000000298 cyclopropenyl group Chemical group [H]C1=C([H])C1([H])* 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-M iodide Chemical compound [I-] XMBWDFGMSWQBCA-UHFFFAOYSA-M 0.000 claims 1
- 229910052740 iodine Inorganic materials 0.000 claims 1
- 125000002346 iodo group Chemical group I* 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 125000003518 norbornenyl group Chemical group C12(C=CC(CC1)C2)* 0.000 claims 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 claims 1
- 125000005497 tetraalkylphosphonium group Chemical group 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15306862.2 | 2015-11-24 | ||
| EP15306862 | 2015-11-24 | ||
| PCT/EP2016/078729 WO2017089492A1 (en) | 2015-11-24 | 2016-11-24 | Method for synthesizing iodo- or astatoarenes using diaryliodonium salts |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018536031A JP2018536031A (ja) | 2018-12-06 |
| JP2018536031A5 true JP2018536031A5 (enExample) | 2019-11-07 |
| JP6968809B2 JP6968809B2 (ja) | 2021-11-17 |
Family
ID=54843770
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018545695A Active JP6968809B2 (ja) | 2015-11-24 | 2016-11-24 | ジアリールヨードニウム塩を使用してヨード−又はアスタトアレーンを合成するための方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US10703708B2 (enExample) |
| EP (1) | EP3380447B1 (enExample) |
| JP (1) | JP6968809B2 (enExample) |
| AU (1) | AU2016360886B2 (enExample) |
| WO (1) | WO2017089492A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2018395495B2 (en) | 2017-12-29 | 2024-09-05 | Osaka University | Astatine solution and method for producing same |
| KR20220156001A (ko) * | 2020-02-21 | 2022-11-24 | 국립대학법인 홋가이도 다이가쿠 | 방향족 아스타틴 화합물의 제조 방법 |
| WO2021225147A1 (ja) * | 2020-05-07 | 2021-11-11 | 国立大学法人東京工業大学 | アスタチンの簡便な濃縮法 |
| CN112778089B (zh) * | 2021-01-04 | 2023-09-05 | 万知科技股份有限公司 | 一种4,4,4-三氟-1-丁醇及其同系物的新合成方法 |
| EP4526288A1 (en) * | 2022-05-20 | 2025-03-26 | Institut National de la Santé et de la Recherche Médicale | Method for synthesizing iodo- or astatoaryl compounds using arylsulfonium salts |
| WO2023244963A2 (en) * | 2022-06-16 | 2023-12-21 | The General Hospital Corporation | Bicyclononyne reagents for cell imaging |
| CN119552051A (zh) * | 2024-11-15 | 2025-03-04 | 中国船舶集团有限公司第七一八研究所 | 一种阳离子光引发剂4-异丁基苯基-4'-甲基苯基碘鎓六氟磷酸盐的制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3863010A (en) * | 1973-09-28 | 1975-01-28 | American Cyanamid Co | Compositions of matter and method of use of phenyl and substituted phenyl tetrazines |
| AU5194798A (en) | 1996-10-29 | 1998-05-22 | Guilford Pharmaceuticals Inc. | Process for the preparation of radiopharmaceuticals |
| EP1434772A4 (en) * | 2001-10-12 | 2005-05-04 | Smithkline Beecham Corp | CONNECTIONS AND METHODS |
| GB0320313D0 (en) * | 2003-08-29 | 2003-10-01 | Ic Innovations Ltd | Process |
| GB0407952D0 (en) * | 2004-04-08 | 2004-05-12 | Amersham Plc | Fluoridation method |
| GB0921573D0 (en) * | 2009-12-10 | 2010-01-27 | Ge Healthcare Ltd | Iodine radiolabelling method |
| JP5829625B2 (ja) * | 2010-02-03 | 2015-12-09 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 超原子価放射性アスタチン又はヨウ素化合物及びその調製方法 |
| WO2014066772A1 (en) * | 2012-10-27 | 2014-05-01 | Ground Fluor Pharmaceuticals, Inc. | Processes and reagents for making diaryliodonium salts |
| CA2935856A1 (en) * | 2014-01-03 | 2015-10-01 | Nutech Ventures | Radioiodinated compounds |
| CN112094259B (zh) * | 2014-03-07 | 2023-09-01 | 通用医疗公司 | 碘(iii)-介导的放射性氟化 |
| US20170001957A1 (en) * | 2015-06-12 | 2017-01-05 | Nutech Ventures | Radioiodinated bioconjugation reagents |
-
2016
- 2016-11-24 AU AU2016360886A patent/AU2016360886B2/en active Active
- 2016-11-24 EP EP16801234.2A patent/EP3380447B1/en active Active
- 2016-11-24 WO PCT/EP2016/078729 patent/WO2017089492A1/en not_active Ceased
- 2016-11-24 JP JP2018545695A patent/JP6968809B2/ja active Active
- 2016-11-24 US US15/777,828 patent/US10703708B2/en active Active
-
2020
- 2020-04-09 US US16/844,077 patent/US10858306B2/en active Active
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