JP6968809B2 - ジアリールヨードニウム塩を使用してヨード−又はアスタトアレーンを合成するための方法 - Google Patents

ジアリールヨードニウム塩を使用してヨード−又はアスタトアレーンを合成するための方法 Download PDF

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JP6968809B2
JP6968809B2 JP2018545695A JP2018545695A JP6968809B2 JP 6968809 B2 JP6968809 B2 JP 6968809B2 JP 2018545695 A JP2018545695 A JP 2018545695A JP 2018545695 A JP2018545695 A JP 2018545695A JP 6968809 B2 JP6968809 B2 JP 6968809B2
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alkylene
alkyl
formula
astatine
optionally substituted
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JP2018536031A5 (enExample
JP2018536031A (ja
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ゲラール，フランソワ
ジェスタン，ジャン−フランソワ
ブレキビエル，マーティン・ダブリュ
イ，ヨン−ソク
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Centre National de la Recherche Scientifique CNRS
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/06—Preparation of nitro compounds
    • C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/008—Peptides; Proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/361—Preparation of halogenated hydrocarbons by reactions involving a decrease in the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/02—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C247/08—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated
    • C07C247/10—Compounds containing azido groups with azido groups bound to acyclic carbon atoms of a carbon skeleton being unsaturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C247/00—Compounds containing azido groups
    • C07C247/16—Compounds containing azido groups with azido groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00—Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/24—Halogenated aromatic hydrocarbons with unsaturated side chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/09—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis
    • C07C29/10—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by hydrolysis of ethers, including cyclic ethers, e.g. oxiranes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/58—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by elimination of halogen, e.g. by hydrogenolysis, splitting-off
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/62—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/20—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring
    • C07C43/225—Ethers having an ether-oxygen atom bound to a carbon atom of a six-membered aromatic ring containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/307—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
JP2018545695A 2015-11-24 2016-11-24 ジアリールヨードニウム塩を使用してヨード−又はアスタトアレーンを合成するための方法 Active JP6968809B2 (ja)

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EP15306862.2 2015-11-24
EP15306862 2015-11-24
PCT/EP2016/078729 WO2017089492A1 (en) 2015-11-24 2016-11-24 Method for synthesizing iodo- or astatoarenes using diaryliodonium salts

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JP2018536031A JP2018536031A (ja) 2018-12-06
JP2018536031A5 JP2018536031A5 (enExample) 2019-11-07
JP6968809B2 true JP6968809B2 (ja) 2021-11-17

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US (2) US10703708B2 (enExample)
EP (1) EP3380447B1 (enExample)
JP (1) JP6968809B2 (enExample)
AU (1) AU2016360886B2 (enExample)
WO (1) WO2017089492A1 (enExample)

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AU2018395495B2 (en) 2017-12-29 2024-09-05 Osaka University Astatine solution and method for producing same
KR20220156001A (ko) * 2020-02-21 2022-11-24 국립대학법인 홋가이도 다이가쿠 방향족 아스타틴 화합물의 제조 방법
WO2021225147A1 (ja) * 2020-05-07 2021-11-11 国立大学法人東京工業大学 アスタチンの簡便な濃縮法
CN112778089B (zh) * 2021-01-04 2023-09-05 万知科技股份有限公司 一种4,4,4-三氟-1-丁醇及其同系物的新合成方法
EP4526288A1 (en) * 2022-05-20 2025-03-26 Institut National de la Santé et de la Recherche Médicale Method for synthesizing iodo- or astatoaryl compounds using arylsulfonium salts
WO2023244963A2 (en) * 2022-06-16 2023-12-21 The General Hospital Corporation Bicyclononyne reagents for cell imaging
CN119552051A (zh) * 2024-11-15 2025-03-04 中国船舶集团有限公司第七一八研究所 一种阳离子光引发剂4-异丁基苯基-4'-甲基苯基碘鎓六氟磷酸盐的制备方法

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US3863010A (en) * 1973-09-28 1975-01-28 American Cyanamid Co Compositions of matter and method of use of phenyl and substituted phenyl tetrazines
AU5194798A (en) 1996-10-29 1998-05-22 Guilford Pharmaceuticals Inc. Process for the preparation of radiopharmaceuticals
EP1434772A4 (en) * 2001-10-12 2005-05-04 Smithkline Beecham Corp CONNECTIONS AND METHODS
GB0320313D0 (en) * 2003-08-29 2003-10-01 Ic Innovations Ltd Process
GB0407952D0 (en) * 2004-04-08 2004-05-12 Amersham Plc Fluoridation method
GB0921573D0 (en) * 2009-12-10 2010-01-27 Ge Healthcare Ltd Iodine radiolabelling method
JP5829625B2 (ja) * 2010-02-03 2015-12-09 アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル 超原子価放射性アスタチン又はヨウ素化合物及びその調製方法
WO2014066772A1 (en) * 2012-10-27 2014-05-01 Ground Fluor Pharmaceuticals, Inc. Processes and reagents for making diaryliodonium salts
CA2935856A1 (en) * 2014-01-03 2015-10-01 Nutech Ventures Radioiodinated compounds
CN112094259B (zh) * 2014-03-07 2023-09-01 通用医疗公司 碘(iii)-介导的放射性氟化
US20170001957A1 (en) * 2015-06-12 2017-01-05 Nutech Ventures Radioiodinated bioconjugation reagents

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AU2016360886B2 (en) 2021-04-15
EP3380447A1 (en) 2018-10-03
JP2018536031A (ja) 2018-12-06
AU2016360886A1 (en) 2018-06-07
EP3380447C0 (en) 2025-09-03
US20190023646A1 (en) 2019-01-24
US10858306B2 (en) 2020-12-08
WO2017089492A1 (en) 2017-06-01
EP3380447B1 (en) 2025-09-03
US10703708B2 (en) 2020-07-07
US20200239404A1 (en) 2020-07-30

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