JP2018535972A5 - - Google Patents
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- Publication number
- JP2018535972A5 JP2018535972A5 JP2018522651A JP2018522651A JP2018535972A5 JP 2018535972 A5 JP2018535972 A5 JP 2018535972A5 JP 2018522651 A JP2018522651 A JP 2018522651A JP 2018522651 A JP2018522651 A JP 2018522651A JP 2018535972 A5 JP2018535972 A5 JP 2018535972A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- naturally encoded
- encoded amino
- antibody
- molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001413 amino acids Chemical group 0.000 claims 32
- 230000001472 cytotoxic effect Effects 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 229920000642 polymer Polymers 0.000 claims 3
- 230000001588 bifunctional effect Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 229920003169 water-soluble polymer Polymers 0.000 claims 2
- JSXMFBNJRFXRCX-NSHDSACASA-N (2s)-2-amino-3-(4-prop-2-ynoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](N)CC1=CC=C(OCC#C)C=C1 JSXMFBNJRFXRCX-NSHDSACASA-N 0.000 claims 1
- NEMHIKRLROONTL-QMMMGPOBSA-N (2s)-2-azaniumyl-3-(4-azidophenyl)propanoate Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N=[N+]=[N-])C=C1 NEMHIKRLROONTL-QMMMGPOBSA-N 0.000 claims 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N Folic acid Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 125000003929 folic acid group Chemical group 0.000 claims 1
- 125000003827 glycol group Chemical group 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000004481 post-translational protein modification Effects 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021132397A JP7220755B2 (ja) | 2015-11-03 | 2021-08-16 | 新規な抗ｃｄ３抗体およびその使用 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562250451P | 2015-11-03 | 2015-11-03 | |
| US62/250,451 | 2015-11-03 | ||
| US201562267086P | 2015-12-14 | 2015-12-14 | |
| US62/267,086 | 2015-12-14 | ||
| US201662374693P | 2016-08-12 | 2016-08-12 | |
| US62/374,693 | 2016-08-12 | ||
| PCT/US2016/060087 WO2017079272A2 (en) | 2015-11-03 | 2016-11-02 | Anti-cd3-folate conjugates and their uses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021132397A Division JP7220755B2 (ja) | 2015-11-03 | 2021-08-16 | 新規な抗ｃｄ３抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018535972A JP2018535972A (ja) | 2018-12-06 |
| JP2018535972A5 true JP2018535972A5 (enExample) | 2019-12-12 |
| JP6931649B2 JP6931649B2 (ja) | 2021-09-08 |
Family
ID=58662682
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018522651A Active JP6931649B2 (ja) | 2015-11-03 | 2016-11-02 | 新規な抗ｃｄ３抗体およびその使用 |
| JP2021132397A Active JP7220755B2 (ja) | 2015-11-03 | 2021-08-16 | 新規な抗ｃｄ３抗体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021132397A Active JP7220755B2 (ja) | 2015-11-03 | 2021-08-16 | 新規な抗ｃｄ３抗体およびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11851488B2 (enExample) |
| EP (1) | EP3370771A4 (enExample) |
| JP (2) | JP6931649B2 (enExample) |
| KR (1) | KR20180077271A (enExample) |
| CN (1) | CN108348603B (enExample) |
| AU (1) | AU2016349786C1 (enExample) |
| BR (1) | BR112018009004A8 (enExample) |
| CA (1) | CA3002573A1 (enExample) |
| IL (1) | IL258759B2 (enExample) |
| MX (1) | MX2018005232A (enExample) |
| NZ (1) | NZ743049A (enExample) |
| SG (2) | SG11201803211TA (enExample) |
| WO (1) | WO2017079272A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20200184381A1 (en) * | 2017-11-22 | 2020-06-11 | Geltor, Inc. | Methods and systems for engineering collagen |
| MX2021002301A (es) * | 2018-08-28 | 2021-04-28 | Ambrx Inc | Bioconjugados de anticuerpo-foliato anti-cd3 y sus usos. |
| KR102239781B1 (ko) * | 2019-04-08 | 2021-04-13 | 주식회사 녹십자 | Gpnmb 및 cd3에 특이적으로 결합하는 이중특이적 항체 및 이의 용도 |
| US20200392230A1 (en) * | 2019-05-14 | 2020-12-17 | Qlb Biotherapeutics | Bispecific anti-cd3 x cd20 antibodies and uses thereof |
| EP3972998A1 (en) | 2019-05-21 | 2022-03-30 | Novartis AG | Cd19 binding molecules and uses thereof |
| TWI888487B (zh) * | 2020-02-14 | 2025-07-01 | 日商協和麒麟股份有限公司 | 與ｃｄ３結合之雙特異性抗體 |
| TWI827807B (zh) * | 2020-02-26 | 2024-01-01 | 香港商潤俊（中國）有限公司 | 抗cd3抗體葉酸生物共軛物及其用途 |
| WO2021173889A1 (en) | 2020-02-26 | 2021-09-02 | Ambrx, Inc. | Uses of anti-cd3 antibody folate bioconjugates |
| IL300256A (en) | 2020-08-25 | 2023-03-01 | Gilead Sciences Inc | Multispecific Antigen Binding Molecules Targeting HIV and Methods of Use |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US4263428A (en) | 1978-03-24 | 1981-04-21 | The Regents Of The University Of California | Bis-anthracycline nucleic acid function inhibitors and improved method for administering the same |
| IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
| FR2504010B1 (fr) | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| EP0092227B1 (en) | 1982-04-19 | 1988-07-27 | Nissan Motor Co., Ltd. | Method for controlling reduction ratio of continuously variable transmission with acceleration compensation |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US4615885A (en) | 1983-11-01 | 1986-10-07 | Terumo Kabushiki Kaisha | Pharmaceutical composition containing urokinase |
| US4625014A (en) | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
| US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
| US4659839A (en) | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
| CA1336076C (en) | 1985-01-14 | 1995-06-27 | Alan R. Fritzberg | Metal radionuclide labeled proteins for diagnosis and therapy |
| US4680338A (en) | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
| US4699784A (en) | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
| US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| DK0615451T3 (da) | 1992-05-26 | 2006-04-24 | Immunex Corp | Hidtil ukendt cytokin der binder til CD30 |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| EP0904107B1 (en) | 1996-03-18 | 2004-10-20 | Board Of Regents, The University Of Texas System | Immunoglobin-like domains with increased half lives |
| DE69838552T2 (de) | 1997-07-14 | 2008-05-21 | Bolder Biotechnology, Inc., Louisville | Derivate des wachstumshormons und verwandte proteine |
| US6451986B1 (en) | 1998-06-22 | 2002-09-17 | Immunex Corporation | Site specific protein modification |
| JP2002531067A (ja) | 1998-10-30 | 2002-09-24 | ノボザイムス アクティーゼルスカブ | 低下したアレルゲン性を有するグリコシル化タンパク質 |
| KR101138643B1 (ko) | 2002-05-30 | 2012-04-26 | 더 스크립스 리서치 인스티튜트 | 구리 촉매 작용하에서의 아지드와 아세틸렌과의 리게이션 |
| CN103215227B (zh) * | 2003-04-17 | 2015-09-16 | 斯克利普斯研究院 | 扩展真核生物遗传密码 |
| CN102618605B (zh) * | 2003-06-18 | 2015-09-02 | 斯克利普斯研究院 | 非天然活性氨基酸遗传密码增加 |
| GB0716160D0 (en) * | 2007-08-17 | 2007-09-26 | Biotransformations Ltd | Materials and methods for treating cancers which express folate receptors |
| JP2012034668A (ja) | 2010-08-12 | 2012-02-23 | Tohoku Univ | ヒト型化抗ｅｇｆｒ抗体リジン置換可変領域断片及びその利用 |
| CN107903325B (zh) * | 2011-05-16 | 2021-10-29 | 埃泰美德(香港)有限公司 | 多特异性fab融合蛋白及其使用方法 |
| SI2714733T1 (sl) * | 2011-05-21 | 2019-06-28 | Macrogenics, Inc. | CD3-vezavne molekule sposobne vezave na humani ali ne-humani CD3 |
| WO2013092001A1 (en) | 2011-12-19 | 2013-06-27 | Synimmune Gmbh | Bispecific antibody molecule |
| US10968276B2 (en) * | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
| MX2016000272A (es) * | 2013-07-12 | 2016-08-03 | Zymeworks Inc | Construcciones de unión a los antígenos cd19 y cd3 biespecificos. |
| EP2840091A1 (en) * | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof |
| US10669337B2 (en) * | 2014-07-25 | 2020-06-02 | Cytomx Therapeutics, Inc. | Bispecific anti-CD3 antibodies, bispecific activatable anti-CD3 antibodies, and methods of using the same |
| CN108431042A (zh) * | 2015-11-02 | 2018-08-21 | 詹森药业有限公司 | 抗-il1rap抗体，结合il1rap和cd3的双特异性抗原结合分子及其用途 |
| BR112020021279A2 (pt) * | 2018-04-17 | 2021-04-13 | Invenra Inc. | Constructos de anticorpos trispecíficos trivalentes |
| MX2021002301A (es) * | 2018-08-28 | 2021-04-28 | Ambrx Inc | Bioconjugados de anticuerpo-foliato anti-cd3 y sus usos. |
| WO2020168017A1 (en) * | 2019-02-12 | 2020-08-20 | Ambrx, Inc. | Compositions containing, methods and uses of antibody-tlr agonist conjugates |
| KR20210142638A (ko) * | 2019-02-22 | 2021-11-25 | 우한 이지 바이오파마 씨오., 엘티디. | Cd3 항원 결합 단편 및 이의 응용 |
-
2016
- 2016-11-02 US US15/773,167 patent/US11851488B2/en active Active
- 2016-11-02 CN CN201680064414.8A patent/CN108348603B/zh active Active
- 2016-11-02 AU AU2016349786A patent/AU2016349786C1/en active Active
- 2016-11-02 JP JP2018522651A patent/JP6931649B2/ja active Active
- 2016-11-02 BR BR112018009004A patent/BR112018009004A8/pt not_active Application Discontinuation
- 2016-11-02 IL IL258759A patent/IL258759B2/en unknown
- 2016-11-02 CA CA3002573A patent/CA3002573A1/en active Pending
- 2016-11-02 WO PCT/US2016/060087 patent/WO2017079272A2/en not_active Ceased
- 2016-11-02 SG SG11201803211TA patent/SG11201803211TA/en unknown
- 2016-11-02 KR KR1020187015756A patent/KR20180077271A/ko not_active Ceased
- 2016-11-02 NZ NZ743049A patent/NZ743049A/en unknown
- 2016-11-02 SG SG10201913746RA patent/SG10201913746RA/en unknown
- 2016-11-02 EP EP16862859.2A patent/EP3370771A4/en not_active Withdrawn
- 2016-11-02 MX MX2018005232A patent/MX2018005232A/es unknown
-
2021
- 2021-08-16 JP JP2021132397A patent/JP7220755B2/ja active Active
-
2023
- 2023-11-06 US US18/503,113 patent/US20240239889A1/en active Pending
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