JP2018535666A - ナチュラルキラー細胞およびilc3細胞ならびにそれらの使用 - Google Patents

ナチュラルキラー細胞およびilc3細胞ならびにそれらの使用 Download PDF

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JP2018535666A
JP2018535666A JP2018519316A JP2018519316A JP2018535666A JP 2018535666 A JP2018535666 A JP 2018535666A JP 2018519316 A JP2018519316 A JP 2018519316A JP 2018519316 A JP2018519316 A JP 2018519316A JP 2018535666 A JP2018535666 A JP 2018535666A
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cells
medium
population
concentration
cell
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チャン,シャオクイ
ジュレティック,イヴァナ
カン,リン
ヴォスキナリアン−バーセ,ヴァネッサ
スタウト,ババニ
ジェイ. ハリリ,ロバート
ジェイ. ハリリ,ロバート
ホフガートナー,ウォルフガング
エディンガー,ジェームズ
ロウ,エリック
ヤンコビッチ,ウラジーミル
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セルラリティ インコーポレイテッド
セルラリティ インコーポレイテッド
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Priority to JP2021171231A priority Critical patent/JP2022023148A/ja
Priority to JP2023145605A priority patent/JP2023171766A/ja
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JP2018519316A 2015-10-15 2016-10-14 ナチュラルキラー細胞およびilc3細胞ならびにそれらの使用 Pending JP2018535666A (ja)

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Application Number Priority Date Filing Date Title
JP2021171231A JP2022023148A (ja) 2015-10-15 2021-10-19 ナチュラルキラー細胞およびilc3細胞ならびにそれらの使用
JP2023145605A JP2023171766A (ja) 2015-10-15 2023-09-07 ナチュラルキラー細胞およびilc3細胞ならびにそれらの使用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201562242246P 2015-10-15 2015-10-15
US62/242,246 2015-10-15
US201562272984P 2015-12-30 2015-12-30
US62/272,984 2015-12-30
US201662403571P 2016-10-03 2016-10-03
US62/403,571 2016-10-03
PCT/US2016/056988 WO2017066530A1 (en) 2015-10-15 2016-10-14 Natural killer cells and ilc3 cells and uses thereof

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JP2018519316A Pending JP2018535666A (ja) 2015-10-15 2016-10-14 ナチュラルキラー細胞およびilc3細胞ならびにそれらの使用
JP2021171231A Pending JP2022023148A (ja) 2015-10-15 2021-10-19 ナチュラルキラー細胞およびilc3細胞ならびにそれらの使用
JP2023145605A Pending JP2023171766A (ja) 2015-10-15 2023-09-07 ナチュラルキラー細胞およびilc3細胞ならびにそれらの使用

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JP2023145605A Pending JP2023171766A (ja) 2015-10-15 2023-09-07 ナチュラルキラー細胞およびilc3細胞ならびにそれらの使用

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US (2) US20180346877A1 (https=)
EP (1) EP3362075B1 (https=)
JP (3) JP2018535666A (https=)
KR (1) KR20180059555A (https=)
CN (1) CN109310710A (https=)
AU (1) AU2016340005B2 (https=)
BR (1) BR112018007538A2 (https=)
CA (1) CA3002066A1 (https=)
CO (1) CO2018004937A2 (https=)
EA (1) EA201890960A1 (https=)
IL (1) IL258666B2 (https=)
MX (1) MX2018004600A (https=)
MY (1) MY201637A (https=)
NZ (1) NZ741612A (https=)
SG (2) SG10201912576PA (https=)
TW (1) TW201732037A (https=)
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021136883A (ja) * 2020-03-02 2021-09-16 株式会社ガイアバイオメディシン 高活性nk細胞の処理方法
JP2022542321A (ja) * 2019-07-29 2022-09-30 デヴェラ セラピューティクス インコーポレイテッド 免疫療法のためのnk細胞組成物および調製物ならびにそれらの製造のための方法
WO2023038037A1 (ja) * 2021-09-08 2023-03-16 株式会社ガイアバイオメディシン 細胞の処理方法
WO2025028596A1 (ja) * 2023-08-02 2025-02-06 株式会社ヘリオス ナチュラルキラー細胞の製造方法

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
CA3077325A1 (en) * 2017-09-28 2019-04-04 Celularity Inc. Tumor suppression using human placenta-derived intermediate natural killer (pink) cells in combination with an antibody
US12011460B2 (en) 2018-02-20 2024-06-18 Universite De Montreal Expansion of NK and DC cells in vivo mediating immune response
CN108486054B (zh) * 2018-04-12 2022-04-19 平安爱普德(北京)生物技术有限公司 一种体外扩增i型天然细胞毒性淋巴细胞ilc1/nk的方法
CN113454207A (zh) * 2018-11-30 2021-09-28 细胞结构公司 用新型芳香族化合物扩增自然杀伤细胞和ilc3细胞
WO2020231200A1 (ko) * 2019-05-15 2020-11-19 오정훈 효율적 자연살해세포 배양방법 및 이의 배지첨가 키트
WO2020252464A1 (en) * 2019-06-14 2020-12-17 Celularity Inc. Populations of natural killer cells for treating cancers
AU2020409437A1 (en) * 2019-12-18 2022-07-14 Universite De Montreal Modulators of Cullin 3 adaptor KBTBD4 as anti-cancer compounds
WO2021155312A1 (en) * 2020-01-29 2021-08-05 Celularity Inc. Placental derived natural killer cells for treatment of coronavirus infections
US12195759B2 (en) 2020-02-21 2025-01-14 FullHope Biomedical Co., Ltd. Modified natural killer cells, pharmaceutical composition, manufacturing method thereof, and method of using the same
KR20220048775A (ko) * 2020-10-13 2022-04-20 주식회사 노보셀바이오 Nk 세포를 유효성분으로 포함하는 항바이러스 조성물
CN112285083B (zh) * 2020-10-28 2022-01-07 上海睿钰生物科技有限公司 一种细胞杀伤效力的评价方法
CN112251406B (zh) * 2020-10-30 2023-06-09 曹峰林 一种nk细胞活化阶段的外泌体分选方法
US11591381B2 (en) 2020-11-30 2023-02-28 Crispr Therapeutics Ag Gene-edited natural killer cells
WO2022144632A1 (en) 2020-12-30 2022-07-07 Crispr Therapeutics Ag Compositions and methods for differentiating stem cells into nk cells
CN117511867B (zh) * 2023-10-07 2024-08-06 深圳泽医细胞治疗集团有限公司 一种靶向肺部且高表达nkg2d的nk细胞的培养试剂盒及其应用

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06505388A (ja) * 1991-01-24 1994-06-23 ブリストル−マイアーズ スクイブ カンパニー 混合特異性融合蛋白
JP2012507554A (ja) * 2008-10-30 2012-03-29 アイアールエム・リミテッド・ライアビリティ・カンパニー 造血幹細胞を増加させる化合物
JP2015504902A (ja) * 2012-01-27 2015-02-16 ユニヴェルスィテ・ドゥ・モントリオール ピリミド[4,5−b]インドール誘導体及び造血幹細胞の増殖におけるその使用
WO2015035063A2 (en) * 2013-09-05 2015-03-12 Sanford-Burnham Medical Research Institute MODULATION OF γδT CELLS
JP2015528284A (ja) * 2012-08-15 2015-09-28 ボストン メディカル センター コーポレーション 幹細胞からの赤血球および血小板の生成

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9862928B2 (en) * 2010-12-03 2018-01-09 Regents Of The University Of Minnesota Generation of natural killer cells and lymphoid tissue inducer-like (LTi-like) NK-22 cells
ES2856825T3 (es) * 2011-03-18 2021-09-28 Glycostem Therapeutics B V Generación de células NK y progenitores de células NK
DK2812011T3 (da) * 2012-02-08 2020-02-24 Glycostem Therapeutics B V Differentiering ex vivo af nk-celler fra cd34+ hæmatopoietiske celler
CN114134113A (zh) * 2012-08-13 2022-03-04 人类起源公司 自然杀伤细胞及其用途
EP3057986B1 (en) * 2013-10-17 2017-12-27 National University of Singapore Chimeric receptor that triggers antibody-dependent cell cytotoxicity against multiple tumors
NZ733213A (en) * 2014-12-31 2022-10-28 Celularity Inc Natural killer cells and uses thereof
EP3350316B1 (en) 2015-09-15 2024-05-08 Stichting Radboud universitair medisch centrum IMPROVED METHOD FOR EX VIVO EXPANSION CD34+HSPCs INTO NK CELLS USING AN ARYL HYDROCARBON RECEPTOR ANTAGONIST
CN109843304A (zh) * 2016-05-07 2019-06-04 细胞结构公司 使用自然杀伤细胞治疗急性髓性白血病和多发性骨髓瘤的方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06505388A (ja) * 1991-01-24 1994-06-23 ブリストル−マイアーズ スクイブ カンパニー 混合特異性融合蛋白
JP2012507554A (ja) * 2008-10-30 2012-03-29 アイアールエム・リミテッド・ライアビリティ・カンパニー 造血幹細胞を増加させる化合物
JP2015504902A (ja) * 2012-01-27 2015-02-16 ユニヴェルスィテ・ドゥ・モントリオール ピリミド[4,5−b]インドール誘導体及び造血幹細胞の増殖におけるその使用
JP2015528284A (ja) * 2012-08-15 2015-09-28 ボストン メディカル センター コーポレーション 幹細胞からの赤血球および血小板の生成
WO2015035063A2 (en) * 2013-09-05 2015-03-12 Sanford-Burnham Medical Research Institute MODULATION OF γδT CELLS

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CELL REP., vol. 8, JPN6020038135, 2014, pages 150 - 162, ISSN: 0004529353 *
STEM CELLS AND DEVELOPMENT , vol. Volume 24, Number 24, JPN6020038132, 28 September 2015 (2015-09-28), pages 2886 - 2898, ISSN: 0004529352 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022542321A (ja) * 2019-07-29 2022-09-30 デヴェラ セラピューティクス インコーポレイテッド 免疫療法のためのnk細胞組成物および調製物ならびにそれらの製造のための方法
JP2021136883A (ja) * 2020-03-02 2021-09-16 株式会社ガイアバイオメディシン 高活性nk細胞の処理方法
JP7793284B2 (ja) 2020-03-02 2026-01-05 株式会社ガイアバイオメディシン 高活性nk細胞の処理方法
WO2023038037A1 (ja) * 2021-09-08 2023-03-16 株式会社ガイアバイオメディシン 細胞の処理方法
JPWO2023038037A1 (https=) * 2021-09-08 2023-03-16
WO2025028596A1 (ja) * 2023-08-02 2025-02-06 株式会社ヘリオス ナチュラルキラー細胞の製造方法

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