JP2018534316A5 - - Google Patents

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Publication number
JP2018534316A5
JP2018534316A5 JP2018525743A JP2018525743A JP2018534316A5 JP 2018534316 A5 JP2018534316 A5 JP 2018534316A5 JP 2018525743 A JP2018525743 A JP 2018525743A JP 2018525743 A JP2018525743 A JP 2018525743A JP 2018534316 A5 JP2018534316 A5 JP 2018534316A5
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JP
Japan
Prior art keywords
compound according
alkyl
substituted
tumors
heterocycloalkyl
Prior art date
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Application number
JP2018525743A
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English (en)
Japanese (ja)
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JP6946290B2 (ja
JP2018534316A (ja
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Priority claimed from GBGB1520499.3A external-priority patent/GB201520499D0/en
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Publication of JP2018534316A publication Critical patent/JP2018534316A/ja
Publication of JP2018534316A5 publication Critical patent/JP2018534316A5/ja
Application granted granted Critical
Publication of JP6946290B2 publication Critical patent/JP6946290B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2018525743A 2015-11-20 2016-11-16 Ｍｎｋ阻害剤としてのピロロピリミジン化合物 Expired - Fee Related JP6946290B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1520499.3 2015-11-20
GBGB1520499.3A GB201520499D0 (en) 2015-11-20 2015-11-20 Compounds
PCT/GB2016/053579 WO2017085483A1 (en) 2015-11-20 2016-11-16 Pyrropyrimidine compounds as mnks inhibitors

Publications (3)

Publication Number Publication Date
JP2018534316A JP2018534316A (ja) 2018-11-22
JP2018534316A5 true JP2018534316A5 (OSRAM) 2019-12-26
JP6946290B2 JP6946290B2 (ja) 2021-10-06

Family

ID=55133105

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018525743A Expired - Fee Related JP6946290B2 (ja) 2015-11-20 2016-11-16 Ｍｎｋ阻害剤としてのピロロピリミジン化合物

Country Status (9)

Country Link
US (1) US10604524B2 (OSRAM)
EP (2) EP3792264B1 (OSRAM)
JP (1) JP6946290B2 (OSRAM)
CN (1) CN108368114B (OSRAM)
AU (1) AU2016355103B2 (OSRAM)
CA (1) CA3003554C (OSRAM)
ES (2) ES2972862T3 (OSRAM)
GB (1) GB201520499D0 (OSRAM)
WO (1) WO2017085483A1 (OSRAM)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI713455B (zh) 2014-06-25 2020-12-21 美商伊凡克特治療公司 ＭｎＫ抑制劑及其相關方法
EP3582776B1 (en) 2017-02-14 2023-11-08 Effector Therapeutics, Inc. Piperidine-substituted mnk inhibitors and methods related thereto
CN109020957B (zh) * 2017-06-12 2023-01-13 南京天印健华医药科技有限公司 作为mnk抑制剂的杂环化合物
KR20210102211A (ko) 2018-10-24 2021-08-19 이펙터 테라퓨틱스, 인크. Mnk 억제제의 결정질 형태
CN110903286B (zh) * 2019-12-16 2021-09-24 沈阳药科大学 4,6-双取代吡啶[3,2-d]嘧啶类化合物及其制备和应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
DK0831829T3 (da) * 1995-06-07 2003-12-15 Pfizer Heterocykliske, ringkondenserede pyrimidinderivater
KR20000057228A (ko) * 1996-11-27 2000-09-15 디. 제이. 우드, 스피겔 알렌 제이 축합된 비사이클릭 피리미딘 유도체
BR9916746A (pt) 1999-06-03 2005-01-11 Abbott Lab Compostos anti-inflamatórios que inibem adesão de célula
US20050187389A1 (en) 2004-01-13 2005-08-25 Ambit Biosciences Corporation Pyrrolopyrimidine derivatives and analogs and their use in the treatment and prevention of diseases
AU2005270068B2 (en) 2004-07-02 2012-04-19 Exelixis, Inc. C-Met modulators and method of use
TW200730527A (en) * 2005-12-02 2007-08-16 Takeda Pharmaceuticals Co Fused heterocyclic compound
CA2651898A1 (en) * 2006-04-07 2007-10-18 Develogen Aktiengesellschaft Thienopyrimidines having mnk1/mnk2 inhibiting activity for pharmaceutical compositions
EP1889847A1 (en) * 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidines for pharmaceutical compositions
JP2011504474A (ja) * 2007-11-22 2011-02-10 ベーリンガー インゲルハイム インテルナツィオナール ゲゼルシャフト ミット ベシュレンクテル ハフツング アルツハイマー氏病を治療するためのＭｎｋインヒビターの使用
JP5626748B2 (ja) * 2008-07-02 2014-11-19 キッコーマン株式会社 ペプチド含有調味料
MX2012009735A (es) * 2010-02-26 2012-09-12 Boehringer Ingelheim Int 4-[cicloalquiloxi (hetero) arilamino] tieno [2,3-d] pirimidinas que tienen actividad inhibitoria de mnk1/mnk2 para composiciones farmaceuticas.
WO2011104340A1 (en) 2010-02-26 2011-09-01 Boehringer Ingelheim International Gmbh Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions
EP2951175B1 (en) 2013-02-01 2017-10-04 Bayer Pharma Aktiengesellschaft Substituted pyrazolopyrimidinylamino-indazoles
CN105308054B (zh) 2013-03-06 2017-11-21 拜耳制药股份公司 取代的噻唑并嘧啶
CN104744446B (zh) * 2013-12-30 2019-06-25 广东东阳光药业有限公司 杂芳化合物及其在药物中的应用

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