JP2018533625A5 - - Google Patents
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- JP2018533625A5 JP2018533625A5 JP2018543036A JP2018543036A JP2018533625A5 JP 2018533625 A5 JP2018533625 A5 JP 2018533625A5 JP 2018543036 A JP2018543036 A JP 2018543036A JP 2018543036 A JP2018543036 A JP 2018543036A JP 2018533625 A5 JP2018533625 A5 JP 2018533625A5
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- JP
- Japan
- Prior art keywords
- hspc
- cancer
- seq
- cells
- deletion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021065361A JP7378439B2 (ja) | 2015-11-04 | 2021-04-07 | 造血幹細胞における遺伝子編集のための方法および組成物 |
| JP2023097365A JP2023115069A (ja) | 2015-11-04 | 2023-06-14 | 造血幹細胞における遺伝子編集のための方法および組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562250561P | 2015-11-04 | 2015-11-04 | |
| US62/250,561 | 2015-11-04 | ||
| PCT/US2016/060273 WO2017079400A1 (en) | 2015-11-04 | 2016-11-03 | Methods and compositions for gene editing in hematopoietic stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021065361A Division JP7378439B2 (ja) | 2015-11-04 | 2021-04-07 | 造血幹細胞における遺伝子編集のための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018533625A JP2018533625A (ja) | 2018-11-15 |
| JP2018533625A5 true JP2018533625A5 (OSRAM) | 2019-12-05 |
| JP6866385B2 JP6866385B2 (ja) | 2021-04-28 |
Family
ID=58662736
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018543036A Expired - Fee Related JP6866385B2 (ja) | 2015-11-04 | 2016-11-03 | 造血幹細胞における遺伝子編集のための方法および組成物 |
| JP2021065361A Active JP7378439B2 (ja) | 2015-11-04 | 2021-04-07 | 造血幹細胞における遺伝子編集のための方法および組成物 |
| JP2023097365A Pending JP2023115069A (ja) | 2015-11-04 | 2023-06-14 | 造血幹細胞における遺伝子編集のための方法および組成物 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021065361A Active JP7378439B2 (ja) | 2015-11-04 | 2021-04-07 | 造血幹細胞における遺伝子編集のための方法および組成物 |
| JP2023097365A Pending JP2023115069A (ja) | 2015-11-04 | 2023-06-14 | 造血幹細胞における遺伝子編集のための方法および組成物 |
Country Status (17)
| Country | Link |
|---|---|
| US (3) | US10548922B2 (OSRAM) |
| EP (1) | EP3370741B1 (OSRAM) |
| JP (3) | JP6866385B2 (OSRAM) |
| KR (1) | KR20180073679A (OSRAM) |
| CN (1) | CN108463227A (OSRAM) |
| AU (2) | AU2016349280B2 (OSRAM) |
| BR (1) | BR112018009098A8 (OSRAM) |
| CA (1) | CA3004053A1 (OSRAM) |
| CL (1) | CL2018001198A1 (OSRAM) |
| EA (1) | EA201891092A1 (OSRAM) |
| HK (1) | HK1259151A1 (OSRAM) |
| IL (1) | IL259084A (OSRAM) |
| MX (1) | MX2018005612A (OSRAM) |
| MY (1) | MY185961A (OSRAM) |
| PH (1) | PH12018500965A1 (OSRAM) |
| SG (2) | SG10202107602XA (OSRAM) |
| WO (1) | WO2017079400A1 (OSRAM) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3613852A3 (en) | 2011-07-22 | 2020-04-22 | President and Fellows of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| ES2692206T3 (es) | 2014-11-26 | 2018-11-30 | Miltenyi Biotec Gmbh | Inmunoterapia combinada de receptores de reconocimiento de antígenos y células hematopoyéticas para el tratamiento de enfermedades |
| CN116712535A (zh) | 2015-10-16 | 2023-09-08 | 纽约市哥伦比亚大学理事会 | 用于抑制谱系特异性抗原的组合物和方法 |
| US12043852B2 (en) | 2015-10-23 | 2024-07-23 | President And Fellows Of Harvard College | Evolved Cas9 proteins for gene editing |
| SG10202107602XA (en) * | 2015-11-04 | 2021-08-30 | Univ Pennsylvania | Methods and compositions for gene editing in hematopoietic stem cells |
| CN108495640B (zh) * | 2016-02-19 | 2022-11-04 | 加利福尼亚大学董事会 | 短发夹rna(shrna734)及其用于阳性选择和消除遗传修饰的细胞的用途 |
| GB2568182A (en) | 2016-08-03 | 2019-05-08 | Harvard College | Adenosine nucleobase editors and uses thereof |
| WO2018031683A1 (en) | 2016-08-09 | 2018-02-15 | President And Fellows Of Harvard College | Programmable cas9-recombinase fusion proteins and uses thereof |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| GB2573062A (en) | 2016-10-14 | 2019-10-23 | Harvard College | AAV delivery of nucleobase editors |
| SG11201903454VA (en) * | 2016-11-02 | 2019-05-30 | Univ Basel | Immunologically discernible cell surface variants for use in cell therapy |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| AU2018229351B2 (en) | 2017-02-28 | 2024-01-04 | Vor Biopharma, Inc. | Compositions and methods for inhibition of lineage specific proteins |
| WO2018165631A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Cancer vaccine |
| US11898179B2 (en) | 2017-03-09 | 2024-02-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| US11268082B2 (en) | 2017-03-23 | 2022-03-08 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable DNA binding proteins |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| JP2020534795A (ja) | 2017-07-28 | 2020-12-03 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ファージによって支援される連続的進化(pace)を用いて塩基編集因子を進化させるための方法および組成物 |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| CN112654710A (zh) | 2018-05-16 | 2021-04-13 | 辛瑟高公司 | 用于指导rna设计和使用的方法和系统 |
| US12157760B2 (en) | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| IL260445B (en) * | 2018-07-05 | 2019-08-29 | Lempo Therapeutics Ltd | Methods and compositions for modulating myeloperoxidase (mpo) expression |
| WO2020047164A1 (en) | 2018-08-28 | 2020-03-05 | Vor Biopharma, Inc | Genetically engineered hematopoietic stem cells and uses thereof |
| IL281413B2 (en) * | 2018-09-19 | 2024-09-01 | Fujifilm Cellular Dynamics Inc | Protein l for activation and expansion of chimeric antigen receptor-modified immune cells |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| EP3873205A4 (en) * | 2018-10-31 | 2022-05-11 | Humanigen, Inc. | MATERIALS AND METHODS FOR TREATMENT OF CANCER |
| CN109852627B (zh) * | 2018-12-26 | 2022-07-05 | 中国人民解放军军事科学院军事医学研究院 | 用于CRISPRi系统的质粒、其构建方法及其在使鼠疫菌目的基因定向沉默中的应用 |
| EP3911371A4 (en) * | 2019-01-18 | 2023-04-26 | University of Southern California | METHODS AND COMPOSITIONS FOR IMPROVING THE SAFETY AND EFFICACY OF CELL THERAPY |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020172638A1 (en) * | 2019-02-22 | 2020-08-27 | The Trustees Of The University Of Pennsylvania | Crispr/cas9 knock-out of cd33 in human hematopoietic stem/ progenitor cells for allogenic transplantation |
| WO2020181101A1 (en) * | 2019-03-07 | 2020-09-10 | The Regents Of The University Of California | Crispr-cas effector polypeptides and methods of use thereof |
| AU2020240109A1 (en) | 2019-03-19 | 2021-09-30 | President And Fellows Of Harvard College | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| KR20220047381A (ko) * | 2019-08-28 | 2022-04-15 | 보르 바이오파마 인크. | Cd123 변형을 위한 조성물 및 방법 |
| MX2022002462A (es) * | 2019-08-28 | 2022-06-02 | Vor Biopharma Inc | Composiciones y métodos para la modificación de cll1. |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| US12383581B2 (en) | 2019-10-11 | 2025-08-12 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting CD13 and TIM-3 with CAR T cells to treat acute myeloid leukemia |
| KR20210109971A (ko) | 2020-02-28 | 2021-09-07 | 현대자동차주식회사 | 리튬이온 전지 음극 제조방법 및 이에 의해 제조된 리튬이온 전지 음극을 포함하는 리튬이온 전지 |
| BR112022022603A2 (pt) | 2020-05-08 | 2023-01-17 | Broad Inst Inc | Métodos e composições para edição simultânea de ambas as fitas de sequência alvo de nucleotídeos de fita dupla |
| US20240366675A1 (en) * | 2020-12-31 | 2024-11-07 | Vor Biopharma Inc. | Compositions and methods for cd34 gene modification |
| CN120249215A (zh) * | 2021-04-27 | 2025-07-04 | 上海驯鹿生物技术有限公司 | 一种基因编辑的造血干细胞及其与car-t细胞的联合应用 |
| KR20240004702A (ko) * | 2021-04-28 | 2024-01-11 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 안티센스 올리고뉴클레오티드 및 신경퇴행성 장애의 치료를 위한 이들의 용도 |
| JP2024543369A (ja) * | 2021-11-09 | 2024-11-21 | ブイオーアール バイオファーマ インコーポレーテッド | Emr2修飾のための化合物及び方法 |
| WO2023091954A2 (en) | 2021-11-19 | 2023-05-25 | The Trustees Of The University Of Pennsylvania | Engineered pan-leukocyte antigen cd45 to facilitate car t cell therapy |
| EP4463190A2 (en) * | 2022-01-11 | 2024-11-20 | Actinium Pharmaceuticals, Inc. | Methods for treating cd33-positive hematological malignancies |
| WO2025030010A1 (en) | 2023-08-01 | 2025-02-06 | Vor Biopharma Inc. | Compositions comprising genetically engineered hematopoietic stem cells and methods of use thereof |
| WO2025059062A1 (en) * | 2023-09-11 | 2025-03-20 | The Trustees Of The University Of Pennsylvania | Genetic engineering of human hematopoietic stem/progenitor cells (hspcs) for locus-specific expression of therapeutic proteins |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2008086529A2 (en) * | 2007-01-11 | 2008-07-17 | Yale University | Compositions and methods for targeted inactivation of hiv cell surface receptors |
| EP3763810A3 (en) * | 2012-10-10 | 2021-07-14 | Sangamo Therapeutics, Inc. | T cell modifying compounds and uses thereof |
| WO2014130635A1 (en) * | 2013-02-20 | 2014-08-28 | Novartis Ag | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
| AU2014273490B2 (en) * | 2013-05-29 | 2019-05-09 | Cellectis | Methods for engineering T cells for immunotherapy by using RNA-guided Cas nuclease system |
| PL3888674T3 (pl) * | 2014-04-07 | 2024-09-23 | Novartis Ag | Leczenie nowotworu złośliwego z zastosowaniem chimerycznego receptora antygenowego anty-CD19 |
| CN116712535A (zh) * | 2015-10-16 | 2023-09-08 | 纽约市哥伦比亚大学理事会 | 用于抑制谱系特异性抗原的组合物和方法 |
| SG10202107602XA (en) * | 2015-11-04 | 2021-08-30 | Univ Pennsylvania | Methods and compositions for gene editing in hematopoietic stem cells |
-
2016
- 2016-11-03 SG SG10202107602XA patent/SG10202107602XA/en unknown
- 2016-11-03 HK HK19101177.2A patent/HK1259151A1/zh unknown
- 2016-11-03 KR KR1020187015530A patent/KR20180073679A/ko not_active Withdrawn
- 2016-11-03 WO PCT/US2016/060273 patent/WO2017079400A1/en not_active Ceased
- 2016-11-03 CN CN201680076538.8A patent/CN108463227A/zh active Pending
- 2016-11-03 CA CA3004053A patent/CA3004053A1/en active Pending
- 2016-11-03 AU AU2016349280A patent/AU2016349280B2/en not_active Ceased
- 2016-11-03 EA EA201891092A patent/EA201891092A1/ru unknown
- 2016-11-03 BR BR112018009098A patent/BR112018009098A8/pt not_active Application Discontinuation
- 2016-11-03 JP JP2018543036A patent/JP6866385B2/ja not_active Expired - Fee Related
- 2016-11-03 SG SG11201803701YA patent/SG11201803701YA/en unknown
- 2016-11-03 EP EP16862941.8A patent/EP3370741B1/en active Active
- 2016-11-03 MX MX2018005612A patent/MX2018005612A/es unknown
- 2016-11-03 MY MYPI2018701723A patent/MY185961A/en unknown
-
2018
- 2018-05-01 IL IL259084A patent/IL259084A/en unknown
- 2018-05-03 US US15/970,605 patent/US10548922B2/en active Active
- 2018-05-03 CL CL2018001198A patent/CL2018001198A1/es unknown
- 2018-05-04 PH PH12018500965A patent/PH12018500965A1/en unknown
-
2019
- 2019-12-19 US US16/721,156 patent/US11771719B2/en active Active
-
2021
- 2021-04-07 JP JP2021065361A patent/JP7378439B2/ja active Active
-
2023
- 2023-06-14 JP JP2023097365A patent/JP2023115069A/ja active Pending
- 2023-09-14 US US18/467,223 patent/US20240066064A1/en active Pending
-
2024
- 2024-01-01 AU AU2024200000A patent/AU2024200000A1/en not_active Abandoned
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