JP2018531891A5 - - Google Patents

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Publication number
JP2018531891A5
JP2018531891A5 JP2018506976A JP2018506976A JP2018531891A5 JP 2018531891 A5 JP2018531891 A5 JP 2018531891A5 JP 2018506976 A JP2018506976 A JP 2018506976A JP 2018506976 A JP2018506976 A JP 2018506976A JP 2018531891 A5 JP2018531891 A5 JP 2018531891A5
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JP
Japan
Prior art keywords
inhibitor
inhibitors
bet
bcl
cancer
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018506976A
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English (en)
Japanese (ja)
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JP2018531891A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/046318 external-priority patent/WO2017027571A1/en
Publication of JP2018531891A publication Critical patent/JP2018531891A/ja
Publication of JP2018531891A5 publication Critical patent/JP2018531891A5/ja
Pending legal-status Critical Current

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JP2018506976A 2015-08-10 2016-08-10 Ｂｅｔブロモドメインインヒビターに対する抵抗性の機構 Pending JP2018531891A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562203128P 2015-08-10 2015-08-10
US62/203,128 2015-08-10
PCT/US2016/046318 WO2017027571A1 (en) 2015-08-10 2016-08-10 Mechanism of resistance to bet bromodomain inhibitors

Publications (2)

Publication Number Publication Date
JP2018531891A JP2018531891A (ja) 2018-11-01
JP2018531891A5 true JP2018531891A5 (enExample) 2019-09-19

Family

ID=57984534

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018506976A Pending JP2018531891A (ja) 2015-08-10 2016-08-10 Ｂｅｔブロモドメインインヒビターに対する抵抗性の機構

Country Status (16)

Country Link
US (1) US11666580B2 (enExample)
EP (2) EP4585273A3 (enExample)
JP (1) JP2018531891A (enExample)
KR (1) KR20180035905A (enExample)
CN (1) CN108137550A (enExample)
AU (2) AU2016304856B8 (enExample)
BR (1) BR112018002550A2 (enExample)
CA (1) CA2995374A1 (enExample)
CL (1) CL2018000377A1 (enExample)
HK (1) HK1254201A1 (enExample)
IL (1) IL257386A (enExample)
MX (1) MX2018001737A (enExample)
PE (1) PE20181088A1 (enExample)
RU (1) RU2018108165A (enExample)
WO (1) WO2017027571A1 (enExample)
ZA (1) ZA201800969B (enExample)

Families Citing this family (13)

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KR20180035905A (ko) 2015-08-10 2018-04-06 다나-파버 캔서 인스티튜트 인크. Bet 브로모도메인 억제제에 대한 저항성의 메카니즘
GB201704536D0 (en) * 2017-03-22 2017-05-03 Univ Malta Method
US11712439B2 (en) 2017-08-09 2023-08-01 Mayo Foundation For Medical Education And Research Methods and materials for identifying and treating bet inhibitor-resistant cancers
CN109503618A (zh) * 2017-09-14 2019-03-22 成都海创药业有限公司 一种brd4抑制剂
CN108084193A (zh) * 2017-12-19 2018-05-29 郭守东 一种brd4蛋白抑制剂
WO2020023768A1 (en) 2018-07-25 2020-01-30 Mayo Foundation For Medical Education And Research Methods and materials for identifying and treating bet inhibitor-resistant cancers
US20220062291A1 (en) * 2018-12-21 2022-03-03 Dana-Farber Cancer Institute, Inc. Compositions and methods of treating cancers by administering a phenothiazine-related drug that activates protein phosphatase 2a (pp2a) with reduced inhibitory activity targeted to the dopamine d2 receptor and accompanying toxicity
PT116050B (pt) * 2020-01-09 2022-06-15 Hovione Farm S A Conjugados fármaco-ligando e inibidores das proteínas da família bromodomínio e domínio extraterminal -(bet) modificados
AU2021298154A1 (en) * 2020-06-25 2023-02-23 Tolremo Therapeutics Ag Combination of a CBP/p300 bromodomain inhibitor and a KRAS inhibitor for the treatment of cancer
WO2023041744A1 (en) 2021-09-17 2023-03-23 Institut Curie Bet inhibitors for treating pab1 deficient cancer
EP4480494A4 (en) * 2022-02-16 2026-03-11 Univ Nat Corp Tokyo Medical & Dental COMPOSITION INTENDED FOR USE IN THE TREATMENT OF CANCER, INFLAMMATORY DISEASES OR OBESITY, AND ITS USE
CN114617878A (zh) * 2022-05-16 2022-06-14 深圳大学 Ck2抑制剂在制备抗衰药物中的应用
CN115894678B (zh) * 2022-07-15 2023-10-20 新疆赛尔托马斯生物科技有限公司 一种干细胞细胞因子的制备方法及其在制备药品中的用途

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