JP2018529631A - 芽胞を取り除くための組成物 - Google Patents
芽胞を取り除くための組成物 Download PDFInfo
- Publication number
- JP2018529631A JP2018529631A JP2017568193A JP2017568193A JP2018529631A JP 2018529631 A JP2018529631 A JP 2018529631A JP 2017568193 A JP2017568193 A JP 2017568193A JP 2017568193 A JP2017568193 A JP 2017568193A JP 2018529631 A JP2018529631 A JP 2018529631A
- Authority
- JP
- Japan
- Prior art keywords
- composition
- monomer
- weight
- acrylate copolymer
- total weight
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 246
- 239000000178 monomer Substances 0.000 claims abstract description 173
- 229920001577 copolymer Polymers 0.000 claims abstract description 123
- 239000002245 particle Substances 0.000 claims abstract description 74
- 239000011541 reaction mixture Substances 0.000 claims abstract description 49
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 41
- 239000007795 chemical reaction product Substances 0.000 claims abstract description 19
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 99
- 238000000034 method Methods 0.000 claims description 51
- 230000009471 action Effects 0.000 claims description 20
- 239000004599 antimicrobial Substances 0.000 claims description 8
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 5
- 125000002091 cationic group Chemical group 0.000 claims description 4
- 125000005233 alkylalcohol group Chemical group 0.000 claims description 2
- 238000007598 dipping method Methods 0.000 claims description 2
- 238000005507 spraying Methods 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 230000002459 sustained effect Effects 0.000 claims 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract description 2
- 210000004215 spore Anatomy 0.000 description 89
- 239000000243 solution Substances 0.000 description 51
- 238000009472 formulation Methods 0.000 description 46
- -1 polyethylenes Polymers 0.000 description 43
- 229920000642 polymer Polymers 0.000 description 23
- 230000000694 effects Effects 0.000 description 22
- 239000000523 sample Substances 0.000 description 21
- 210000003811 finger Anatomy 0.000 description 15
- 239000004094 surface-active agent Substances 0.000 description 15
- 239000003945 anionic surfactant Substances 0.000 description 14
- NIXOWILDQLNWCW-UHFFFAOYSA-M acrylate group Chemical group C(C=C)(=O)[O-] NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 13
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 13
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 12
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 12
- GOXQRTZXKQZDDN-UHFFFAOYSA-N 2-Ethylhexyl acrylate Chemical compound CCCCC(CC)COC(=O)C=C GOXQRTZXKQZDDN-UHFFFAOYSA-N 0.000 description 11
- 125000000217 alkyl group Chemical group 0.000 description 11
- 241000193163 Clostridioides difficile Species 0.000 description 10
- 229910019142 PO4 Inorganic materials 0.000 description 10
- 235000021317 phosphate Nutrition 0.000 description 10
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- 229920000058 polyacrylate Polymers 0.000 description 8
- 239000002562 thickening agent Substances 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 235000014113 dietary fatty acids Nutrition 0.000 description 7
- 239000000194 fatty acid Substances 0.000 description 7
- 229930195729 fatty acid Natural products 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- DXPPIEDUBFUSEZ-UHFFFAOYSA-N 6-methylheptyl prop-2-enoate Chemical compound CC(C)CCCCCOC(=O)C=C DXPPIEDUBFUSEZ-UHFFFAOYSA-N 0.000 description 6
- 230000002378 acidificating effect Effects 0.000 description 6
- 239000011324 bead Substances 0.000 description 6
- 150000004665 fatty acids Chemical class 0.000 description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 5
- 239000000654 additive Substances 0.000 description 5
- 125000003277 amino group Chemical group 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 239000004816 latex Substances 0.000 description 5
- 229920000126 latex Polymers 0.000 description 5
- 239000002736 nonionic surfactant Substances 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 239000000047 product Substances 0.000 description 5
- 238000005070 sampling Methods 0.000 description 5
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- 229920004890 Triton X-100 Polymers 0.000 description 4
- 150000008051 alkyl sulfates Chemical class 0.000 description 4
- 150000001412 amines Chemical class 0.000 description 4
- 239000002280 amphoteric surfactant Substances 0.000 description 4
- 239000007844 bleaching agent Substances 0.000 description 4
- CQEYYJKEWSMYFG-UHFFFAOYSA-N butyl acrylate Chemical compound CCCCOC(=O)C=C CQEYYJKEWSMYFG-UHFFFAOYSA-N 0.000 description 4
- 239000002537 cosmetic Substances 0.000 description 4
- 125000004122 cyclic group Chemical group 0.000 description 4
- 238000010790 dilution Methods 0.000 description 4
- 239000012895 dilution Substances 0.000 description 4
- 150000002148 esters Chemical class 0.000 description 4
- 125000000524 functional group Chemical group 0.000 description 4
- 210000004247 hand Anatomy 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 229920001519 homopolymer Polymers 0.000 description 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 4
- 229920006395 saturated elastomer Polymers 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 125000004434 sulfur atom Chemical group 0.000 description 4
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 4
- 150000003512 tertiary amines Chemical class 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 3
- 150000001408 amides Chemical class 0.000 description 3
- 125000000129 anionic group Chemical group 0.000 description 3
- 230000000845 anti-microbial effect Effects 0.000 description 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 3
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 3
- 239000003974 emollient agent Substances 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 230000009477 glass transition Effects 0.000 description 3
- 244000005700 microbiome Species 0.000 description 3
- 230000003472 neutralizing effect Effects 0.000 description 3
- 125000004433 nitrogen atom Chemical group N* 0.000 description 3
- 125000004430 oxygen atom Chemical group O* 0.000 description 3
- 229920001983 poloxamer Polymers 0.000 description 3
- 229920001451 polypropylene glycol Polymers 0.000 description 3
- 229920002451 polyvinyl alcohol Polymers 0.000 description 3
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 229910052709 silver Inorganic materials 0.000 description 3
- 239000004332 silver Substances 0.000 description 3
- 239000000344 soap Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000758 substrate Substances 0.000 description 3
- 239000012085 test solution Substances 0.000 description 3
- 239000002888 zwitterionic surfactant Substances 0.000 description 3
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 2
- 208000037384 Clostridium Infections Diseases 0.000 description 2
- 206010009657 Clostridium difficile colitis Diseases 0.000 description 2
- 206010054236 Clostridium difficile infection Diseases 0.000 description 2
- 102100026735 Coagulation factor VIII Human genes 0.000 description 2
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical group C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 229920002413 Polyhexanide Polymers 0.000 description 2
- 239000004793 Polystyrene Substances 0.000 description 2
- GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical group CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 2
- 239000013504 Triton X-100 Substances 0.000 description 2
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 2
- 125000002877 alkyl aryl group Chemical group 0.000 description 2
- 150000004996 alkyl benzenes Chemical class 0.000 description 2
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 239000003242 anti bacterial agent Substances 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229920006187 aquazol Polymers 0.000 description 2
- 125000003710 aryl alkyl group Chemical group 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 229920001400 block copolymer Polymers 0.000 description 2
- 150000001767 cationic compounds Chemical class 0.000 description 2
- 229960003260 chlorhexidine Drugs 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 239000006184 cosolvent Substances 0.000 description 2
- 239000012470 diluted sample Substances 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- 229940008099 dimethicone Drugs 0.000 description 2
- 239000004205 dimethyl polysiloxane Substances 0.000 description 2
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 2
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 150000002430 hydrocarbons Chemical group 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 229910052744 lithium Inorganic materials 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 238000006386 neutralization reaction Methods 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- SMGTYJPMKXNQFY-UHFFFAOYSA-N octenidine dihydrochloride Chemical class Cl.Cl.C1=CC(=NCCCCCCCC)C=CN1CCCCCCCCCCN1C=CC(=NCCCCCCCC)C=C1 SMGTYJPMKXNQFY-UHFFFAOYSA-N 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 239000000123 paper Substances 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 2
- 239000010452 phosphate Substances 0.000 description 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 229920000053 polysorbate 80 Polymers 0.000 description 2
- 229920002223 polystyrene Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 230000009467 reduction Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 2
- 238000006748 scratching Methods 0.000 description 2
- 230000002393 scratching effect Effects 0.000 description 2
- 229960004029 silicic acid Drugs 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 150000003871 sulfonates Chemical class 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 150000003626 triacylglycerols Chemical class 0.000 description 2
- 210000003812 trophozoite Anatomy 0.000 description 2
- 239000000080 wetting agent Substances 0.000 description 2
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 description 1
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 description 1
- 125000006702 (C1-C18) alkyl group Chemical group 0.000 description 1
- 125000006526 (C1-C2) alkyl group Chemical group 0.000 description 1
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 description 1
- QGLWBTPVKHMVHM-KTKRTIGZSA-N (z)-octadec-9-en-1-amine Chemical compound CCCCCCCC\C=C/CCCCCCCCN QGLWBTPVKHMVHM-KTKRTIGZSA-N 0.000 description 1
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 1
- NLMKTBGFQGKQEV-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hexadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO NLMKTBGFQGKQEV-UHFFFAOYSA-N 0.000 description 1
- GTJOHISYCKPIMT-UHFFFAOYSA-N 2-methylundecane Chemical compound CCCCCCCCCC(C)C GTJOHISYCKPIMT-UHFFFAOYSA-N 0.000 description 1
- AEDQNOLIADXSBB-UHFFFAOYSA-N 3-(dodecylazaniumyl)propanoate Chemical compound CCCCCCCCCCCCNCCC(O)=O AEDQNOLIADXSBB-UHFFFAOYSA-N 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 1
- 241000193470 Clostridium sporogenes Species 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- PQUCIEFHOVEZAU-UHFFFAOYSA-N Diammonium sulfite Chemical class [NH4+].[NH4+].[O-]S([O-])=O PQUCIEFHOVEZAU-UHFFFAOYSA-N 0.000 description 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 1
- 229920002907 Guar gum Polymers 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- SGVYKUFIHHTIFL-UHFFFAOYSA-N Isobutylhexyl Natural products CCCCCCCC(C)C SGVYKUFIHHTIFL-UHFFFAOYSA-N 0.000 description 1
- NHTMVDHEPJAVLT-UHFFFAOYSA-N Isooctane Chemical compound CC(C)CC(C)(C)C NHTMVDHEPJAVLT-UHFFFAOYSA-N 0.000 description 1
- 240000007049 Juglans regia Species 0.000 description 1
- 235000009496 Juglans regia Nutrition 0.000 description 1
- 239000007836 KH2PO4 Substances 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical class SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 1
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 description 1
- 241000233805 Phoenix Species 0.000 description 1
- ABLZXFCXXLZCGV-UHFFFAOYSA-N Phosphorous acid Chemical class OP(O)=O ABLZXFCXXLZCGV-UHFFFAOYSA-N 0.000 description 1
- 239000004952 Polyamide Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 244000046146 Pueraria lobata Species 0.000 description 1
- 235000010575 Pueraria lobata Nutrition 0.000 description 1
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 1
- 229920001800 Shellac Polymers 0.000 description 1
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Natural products C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical class OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- 229920002359 Tetronic® Polymers 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 229920004482 WACKER® Polymers 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229920006243 acrylic copolymer Polymers 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 229940072056 alginate Drugs 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 150000001335 aliphatic alkanes Chemical group 0.000 description 1
- 125000005600 alkyl phosphonate group Chemical group 0.000 description 1
- 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
- 150000008052 alkyl sulfonates Chemical class 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 229960000458 allantoin Drugs 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 1
- 229940063953 ammonium lauryl sulfate Drugs 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 210000004666 bacterial spore Anatomy 0.000 description 1
- 238000003287 bathing Methods 0.000 description 1
- YSJGOMATDFSEED-UHFFFAOYSA-M behentrimonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCCCCCC[N+](C)(C)C YSJGOMATDFSEED-UHFFFAOYSA-M 0.000 description 1
- 229940075506 behentrimonium chloride Drugs 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000000440 bentonite Substances 0.000 description 1
- 229910000278 bentonite Inorganic materials 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 150000007942 carboxylates Chemical class 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229960001777 castor oil Drugs 0.000 description 1
- 229920006317 cationic polymer Polymers 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229960000800 cetrimonium bromide Drugs 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 229940074979 cetyl palmitate Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 125000006165 cyclic alkyl group Chemical group 0.000 description 1
- 150000004292 cyclic ethers Chemical class 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 229940075894 denatured ethanol Drugs 0.000 description 1
- 125000004386 diacrylate group Chemical group 0.000 description 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 description 1
- JVSWJIKNEAIKJW-UHFFFAOYSA-N dimethyl-hexane Natural products CCCCCC(C)C JVSWJIKNEAIKJW-UHFFFAOYSA-N 0.000 description 1
- 235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
- 229940079868 disodium laureth sulfosuccinate Drugs 0.000 description 1
- 229910000397 disodium phosphate Inorganic materials 0.000 description 1
- 235000019800 disodium phosphate Nutrition 0.000 description 1
- SMVRDGHCVNAOIN-UHFFFAOYSA-L disodium;1-dodecoxydodecane;sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC SMVRDGHCVNAOIN-UHFFFAOYSA-L 0.000 description 1
- YHAIUSTWZPMYGG-UHFFFAOYSA-L disodium;2,2-dioctyl-3-sulfobutanedioate Chemical compound [Na+].[Na+].CCCCCCCCC(C([O-])=O)(C(C([O-])=O)S(O)(=O)=O)CCCCCCCC YHAIUSTWZPMYGG-UHFFFAOYSA-L 0.000 description 1
- YGAXLGGEEQLLKV-UHFFFAOYSA-L disodium;4-dodecoxy-4-oxo-2-sulfonatobutanoate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOC(=O)CC(C([O-])=O)S([O-])(=O)=O YGAXLGGEEQLLKV-UHFFFAOYSA-L 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000003822 epoxy resin Substances 0.000 description 1
- 125000004185 ester group Chemical group 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000013020 final formulation Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- UPBDXRPQPOWRKR-UHFFFAOYSA-N furan-2,5-dione;methoxyethene Chemical compound COC=C.O=C1OC(=O)C=C1 UPBDXRPQPOWRKR-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 125000005456 glyceride group Chemical group 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 239000000665 guar gum Substances 0.000 description 1
- 235000010417 guar gum Nutrition 0.000 description 1
- 229960002154 guar gum Drugs 0.000 description 1
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 description 1
- PXDJXZJSCPSGGI-UHFFFAOYSA-N hexadecanoic acid hexadecyl ester Natural products CCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC PXDJXZJSCPSGGI-UHFFFAOYSA-N 0.000 description 1
- 239000008240 homogeneous mixture Substances 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- 150000002462 imidazolines Chemical class 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 125000003010 ionic group Chemical group 0.000 description 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical class OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- VKPSKYDESGTTFR-UHFFFAOYSA-N isododecane Natural products CC(C)(C)CC(C)CC(C)(C)C VKPSKYDESGTTFR-UHFFFAOYSA-N 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- XJRBAMWJDBPFIM-UHFFFAOYSA-N methyl vinyl ether Chemical compound COC=C XJRBAMWJDBPFIM-UHFFFAOYSA-N 0.000 description 1
- 239000011859 microparticle Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
- 235000019796 monopotassium phosphate Nutrition 0.000 description 1
- VAMFXQBUQXONLZ-UHFFFAOYSA-N n-alpha-eicosene Natural products CCCCCCCCCCCCCCCCCCC=C VAMFXQBUQXONLZ-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- UYDLBVPAAFVANX-UHFFFAOYSA-N octylphenoxy polyethoxyethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCO)C=C1 UYDLBVPAAFVANX-UHFFFAOYSA-N 0.000 description 1
- 125000005702 oxyalkylene group Chemical group 0.000 description 1
- 238000003921 particle size analysis Methods 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920000191 poly(N-vinyl pyrrolidone) Polymers 0.000 description 1
- 229920001308 poly(aminoacid) Polymers 0.000 description 1
- 229920001467 poly(styrenesulfonates) Polymers 0.000 description 1
- 229920002647 polyamide Polymers 0.000 description 1
- 229920000647 polyepoxide Polymers 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 229920005554 polynitrile Polymers 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- GNSKLFRGEWLPPA-UHFFFAOYSA-M potassium dihydrogen phosphate Chemical compound [K+].OP(O)([O-])=O GNSKLFRGEWLPPA-UHFFFAOYSA-M 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- HNJBEVLQSNELDL-UHFFFAOYSA-N pyrrolidin-2-one Chemical compound O=C1CCCN1 HNJBEVLQSNELDL-UHFFFAOYSA-N 0.000 description 1
- 125000001453 quaternary ammonium group Chemical class 0.000 description 1
- 229920005604 random copolymer Polymers 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
- 229940071089 sarcosinate Drugs 0.000 description 1
- 238000007790 scraping Methods 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- 229920005573 silicon-containing polymer Polymers 0.000 description 1
- 229920002050 silicone resin Polymers 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- 229940006186 sodium polystyrene sulfonate Drugs 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- KKDONKAYVYTWGY-UHFFFAOYSA-M sodium;2-(methylamino)ethanesulfonate Chemical compound [Na+].CNCCS([O-])(=O)=O KKDONKAYVYTWGY-UHFFFAOYSA-M 0.000 description 1
- GOJYXPWOUJYXJC-UHFFFAOYSA-M sodium;2-[1-(2-hydroxyethyl)-2-undecyl-4,5-dihydroimidazol-1-ium-1-yl]acetate;hydroxide Chemical compound [OH-].[Na+].CCCCCCCCCCCC1=NCC[N+]1(CCO)CC([O-])=O GOJYXPWOUJYXJC-UHFFFAOYSA-M 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 230000003330 sporicidal effect Effects 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- SFVFIFLLYFPGHH-UHFFFAOYSA-M stearalkonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CC1=CC=CC=C1 SFVFIFLLYFPGHH-UHFFFAOYSA-M 0.000 description 1
- 229940057981 stearalkonium chloride Drugs 0.000 description 1
- 150000003445 sucroses Chemical class 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000003813 thumb Anatomy 0.000 description 1
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 229940072029 trilaureth-4 phosphate Drugs 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 150000003673 urethanes Chemical class 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000004711 α-olefin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
- A01N25/08—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests containing solids as carriers or diluents
- A01N25/10—Macromolecular compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/40—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides
- A01N47/42—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having a double or triple bond to nitrogen, e.g. cyanates, cyanamides containing —N=CX2 groups, e.g. isothiourea
- A01N47/44—Guanidine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0241—Containing particulates characterized by their shape and/or structure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
- A61K8/416—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/43—Guanidines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
- A61L2/0088—Liquid substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/412—Microsized, i.e. having sizes between 0.1 and 100 microns
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Description
本出願は、2015年7月1日出願の米国仮特許出願第62/187,372号の優先権を主張するものであり、この仮出願の開示は、参照によってその全体が本明細書に援用される。
R14−(OCH2CH2)n(OCH(CH3)CH2)p−(Ph)a−(OCH2CH2)m−(O)b−SO3−M+及びR14−CH[SO3−M+]−R15によって表すことができ、式中、a及びb=0又は1であり、n、p、及びm=0〜100であり(一部の実施形態において0〜20であり、一部の実施形態において0〜10である)、R14及びR15は(C1〜C12)アルキル基(飽和直鎖状、分枝状、又は環状基)であり、これは任意にN原子、O原子、若しくはS原子、又はヒドロキシル基、カルボキシル基、アミド基、若しくはアミン基によって置換されていてもよいが、ただし少なくとも1個のR14又はR15が少なくともC8であることを条件とし、Ph=フェニルであり、MはH、Na、K、Li、アンモニウムなどのカチオン性対イオンであるか、あるいはトリエタノールアミンなどのプロトン化第三級アミンであるか、あるいは第四級アンモニウム基である。
[R14−(Ph)a−O(CH2CH2O)n(CH2CH(CH3)O)p]q−P(O)[O−M+]rによって表すことができ、式中、Ph、R14、a、n、p、及びMは上記で定義されており、rは0〜2であり、q=1〜3であるが、ただしq=1である場合、r=2であり、q=2である場合、r=1であり、q=3である場合、r=0であることを条件とする。上記と同様に、エチレンオキシド基(すなわち、「n」基)及びプロピレンオキシド基(すなわち、「p」基)は、逆の順序、及びランダム、連鎖、又はブロック配列で生じてもよい。例としては、Clariant Corp.から商品名HOSTAPHAT 340KXで市販されているトリラウレス−4−ホスフェートなどのモノ−、ジ−、及びトリ−(アルキルアルコキシレート)−o−リン酸エステルの混合物、並びに、Croda Inc.,Parsipanny,NJから商品名CRODAPHOS SGで入手可能であるPPG−5セテス10ホスフェート、並びにこれらの混合物を挙げることができる。アニオン性界面活性剤の商標名としては、Rhodocal DS−10、Stepan Mild、及びComplemixが挙げられる。
Vitro Skinから芽胞を取り除く能力について試験した配合物はすべて、同じ様式で構築した。
このインビトロ方法は、化粧品業界の合成皮膚材料である、IMS Inc.,Portland ME製のVitro−skinを用いて、皮膚からの微生物の取り除きを評価するために設計された。この方法は、皮膚からの微生物の剥離を促進する傾向に関する、配合物の迅速なスクリーニングを可能にし、インビボ活性の予測となり得る。
以下の材料を利用した。クロストリジウム・スポロゲネス芽胞 ATCC 3584 約1.0×10^8CFU/mL;フィルタ滅菌されたTriton−X100サンプリング緩衝液(pH7.4):0.4gのKH2PO4、10.1gのNa2HPO4、1gのTriton−X100、及び1LのdH2O;D/E中和ブロス;使い捨てポリエチレングローブ(VWR 32915−268)の指;滅菌dH2O(WFI品質の水);3M ACペトリフィルム;及び5mL Falconチューブ;1.5mL EPI遠心分離管;ペトリ皿;Vitro−Skin IMS Inc.;並びに両面テープ。
表3の配合物を、上記の実施例1に従って調製し、上記の実施例2に従って試験した。
表4の配合物を、上記の実施例1に従って調製し、上記の実施例2に従って試験した。
表5の配合物を、実施例1に従って調製し、上記の実施例2に従って、それらの芽胞を取り除く効力について試験した。
エマルジョンを安定化するために使用することができるアニオン性界面活性剤を含むいくつかの構成成分が、可能性としては、芽胞の取り除きにおいて、ある役割を果たし得る。これを理解するために、ラウリルエーテル硫酸ナトリウムなどのアニオン性界面活性剤をCPC及びMackamに添加し、配合物を、Dermacryl Cなどの膜形成剤の非存在下で作製した。下の表6に示される配合物を、実施例1に従って調製し、上記の実施例2に従って試験した。
表7に従う配合物を、実施例1に従って作製した。Dermacryl溶液をまず作製し、次いでその溶液にビーズを添加したことに留意されたい。その後、上記の実施例2に従って、これらの配合物を試験した。
表8の配合物を、上記の実施例1に従って調製し、上記の実施例2に従って試験した。
表9の配合物を、上記の実施例1に従って調製し、上記の実施例2に従って試験した。
表11a及び11bの配合物を、上記の実施例10に従って調製し、上記の実施例2に従って試験した。表11aの配合物はTween 80を用いて安定化させ、表11bの配合物はIgepal CO−887を用いて安定化させた。
表12の配合物を、上記の実施例10に従って調製し、上記の実施例2に従って試験した。配合物は、3% DS−10を用いて安定化させた。
実施例13は、ポリマーの調製中にエマルジョンを安定化させるために使用されたことの他に、アニオン性界面活性剤であるcomplemixの増加した濃度の影響、並びに芽胞を取り除く性能に対する、他のアニオン性界面活性剤及びエマルジョンを安定化させるために使用される双性イオン性界面活性剤の影響について決定するように設計された。
実施例14は、配合物中の塩基のタイプの、芽胞を取り除く性能に対する影響、及びアクリル酸濃度の、芽胞を取り除く性能に対する影響について決定するように設計された。
下の表15の配合物を、上記の実施例10に従って調製し、上記の実施例2に従って試験した。
下の表16の配合物を、上記の実施例10に従って調製し、上記の実施例2に従って試験した。
下の表17の配合物を、上記の実施例10に従って調製し、上記の実施例2に従って試験した。
下の表18の配合物を、上記の実施例10に従って調製し、上記の実施例2に従って試験した。
下の表19の配合物を、上記の実施例10に従って調製し、上記の実施例2に従って試験した。
粒径は、4つの異なる溶媒系:水100%(w/w)、エタノール/水 30/70(w/w)、エタノール/水 70/30(w/w)、及びエタノール/水 80/20(w/w)において決定した。各溶媒系の溶液は、適切な重量比で水及びエタノールを混合することにより、10mLのバイアルに調製した。これらの溶液を使用して、分析用に、ポリマーサンプルを希釈した。これらの溶媒系溶液の各々の屈折率を、25.0℃において、Rudolph J357自動屈折計で測定した。希釈液の屈折率は、粒径分析用の入力パラメーターとして必要となる。
温度=20℃
粘度=0.01ポアズ
屈折率=[各希釈液について上で測定したパラメーター]
角度=90.0度
サンプル時間=5.0マイクロ秒
プレスケール=2
ランタイム=60秒間
この実験において、実施例20において調製したサンプル20−5のエタノールを、終夜蒸発させた。エタノールの損失は水で埋め合わせた。このサンプルを、サンプル21−5と呼び、実施例20に説明されるように、粒径及び芽胞を取り除く試験に関して試験した。データを、下の表21a及び21bに提供する。
Claims (39)
- a)少なくとも約85重量%のヒドロアルコール溶液であって、
前記ヒドロアルコール溶液の総重量に基づいて、少なくとも約1重量%の水、及び
前記ヒドロアルコール溶液の総重量に基づいて、約30重量%〜約85重量%の少なくとも1種のC1〜C4アルキルアルコールを含む、前記ヒドロアルコール溶液と、
b)前記ヒドロアルコール溶液中に分散されたアクリレートコポリマー粒子であって、前記アクリレートコポリマー粒子は反応混合物の反応生成物を含み、前記反応混合物はモノマーを含み、前記モノマーは、
約5重量%〜約50重量%の少なくとも1種の高Tgモノマー(ここで、前記高Tgモノマーの重量%は、前記反応混合物中の前記モノマーの総重量に対するものである)、及び
約20重量%〜約80重量%の少なくとも1種の低Tgモノマー(ここで、前記低Tgモノマーの重量%は、前記反応混合物中の前記モノマーの総重量に対するものである)を含む、前記アクリレートコポリマー粒子と、を含む組成物であって、
前記粒子は、少なくとも約100nmの数平均直径を有する、組成物。 - 前記反応混合物における重量で、前記少なくとも1種の低Tgモノマーは、前記少なくとも1種の高Tgモノマーよりも多く存在する、請求項1に記載の組成物。
- 前記組成物中に、前記組成物の総重量に基づいて、約5重量%以下の前記アクリレートコポリマー粒子が存在する、請求項1に記載の組成物。
- 前記組成物中に、前記組成物の総重量に基づいて、約0.5重量%〜約4重量%の前記アクリレートコポリマー粒子が存在する、請求項1に記載の組成物。
- 前記組成物中に、前記組成物の総重量に基づいて、少なくとも約60重量%の前記少なくとも1種のアルコールが存在する、請求項1に記載の組成物。
- 前記アクリレートコポリマーは、前記反応混合物中の前記モノマーの総重量に基づいて、約20重量%〜約40重量%の前記少なくとも1種の高Tgモノマーの反応生成物である、請求項1に記載の組成物。
- 前記アクリレートコポリマーは、前記反応混合物中の前記モノマーの総重量に基づいて、約60重量%〜約80重量%の前記少なくとも1種の低Tgモノマーの反応生成物である、請求項1〜6のいずれか一項に記載の組成物。
- 前記少なくとも1種の低Tgモノマーは、約4〜約10のアルキル炭素鎖長を有する、請求項1に記載の組成物。
- 前記少なくとも1種の低Tgモノマーは、約−20℃〜約−60℃のTgを有する、請求項1に記載の組成物。
- 前記少なくとも1種の高Tgモノマーは、約1〜約3の炭素鎖長を有する、請求項1に記載の組成物。
- 前記少なくとも1種の高Tgモノマーは、約40℃〜約150℃のTgを有する、請求項1に記載の組成物。
- 前記アクリレートコポリマー粒子は、約200〜約500nmの数平均直径を有する、請求項1に記載の組成物。
- 前記少なくとも1種のC1〜C4アルコールは、エタノール、n−プロパノール、2−プロパノール、又はこれらの混合物から選択される、請求項1に記載の組成物。
- 前記アルコールに加えて、抗菌剤を更に含む、請求項1に記載の組成物。
- 前記抗菌剤はカチオン性である、請求項14に記載の組成物。
- 組成物であって、
前記組成物の総重量に基づいて、少なくとも約1重量%の水と、
前記組成物の総重量に基づいて、約30重量%〜約98重量%の少なくとも1種のC1〜C4アルキルアルコールと、
前記組成物の総重量に基づいて、約5重量%以下のアクリレートコポリマー粒子と、を含み、前記アクリレートコポリマー粒子は前記水及びアルコール中に分散されており、前記アクリレートコポリマー粒子は反応混合物の反応生成物を含み、前記反応混合物はモノマーを含み、前記モノマーは、
約5重量%〜約50重量%の少なくとも1種の高Tgモノマー(ここで、前記少なくとも1種の高Tgモノマーの重量%は、前記反応混合物中の前記モノマーの総重量に対するものである)、及び
約20重量%〜約80重量%の少なくとも1種の低Tgモノマー(ここで、前記少なくとも1種の低Tgモノマーの重量%は、前記反応混合物中の前記モノマーの総重量に対するものである)を含み、
前記粒子は、少なくとも100nmの数平均直径を有する、組成物。 - 表面から少なくとも1つの芽胞を除去する方法であって、
a)前記表面を組成物と接触させることであって、前記組成物は、
前記組成物の総重量に基づいて、少なくとも約60重量%の少なくとも1種のC1〜C4アルキルアルコール、及び
前記アルコール中に分散されたアクリレートコポリマー粒子を含む、接触させることと、
b)前記組成物と接触した前記表面を、機械的作用に供することと、を含む、方法。 - 前記機械的作用の少なくとも一部は、前記組成物の一部が前記表面上に存在するときに同時に行う、請求項17に記載の方法。
- 前記表面を前記組成物と接触させる工程は、前記組成物を皮膚に適用することを含む、請求項17に記載の方法。
- 前記組成物を皮膚に適用する工程は、前記皮膚の表面への噴霧、分注、浸漬、注入、又はこれらの何らかの組み合わせを含む、請求項19に記載の方法。
- 前記表面を前記組成物と接触させる工程は、前記表面を、前記組成物であらかじめ処理した物品と接触させることを含む、請求項17に記載の方法。
- 前記機械的作用は少なくとも約5秒間持続させる、請求項17に記載の方法。
- 前記組成物であらかじめ処理した前記物品は、拭き取り布、スポンジ、又はこれらの何らかの組み合わせである、請求項21に記載の方法。
- 前記組成物と接触した前記表面を、機械的作用に供する工程は、前記表面を擦ること、前記表面にわたって物品を動かすこと、又はこれらの何らかの組み合わせを含む、請求項17に記載の方法。
- 前記少なくとも1つの芽胞は、前記アクリレートコポリマー粒子と会合する、請求項17に記載の方法。
- 前記少なくとも1つの芽胞及び会合したアクリレートコポリマー粒子は、皮膚から取り除かれる、請求項25に記載の方法。
- 前記組成物の少なくとも一部を、前記芽胞の少なくとも一部と共に前記表面から取り除くことを更に含む、請求項17に記載の方法。
- 前記組成物は水を更に含む、請求項17に記載の方法。
- 前記組成物中に、前記組成物の総重量に基づいて、約5重量%以下の前記アクリレートコポリマー粒子が存在する、請求項17に記載の方法。
- 前記組成物中に、前記組成物の総重量に基づいて、少なくとも約70重量%の前記少なくとも1種のアルコールが存在する、請求項17に記載の方法。
- 前記アクリレートコポリマー粒子は、反応混合物の反応生成物を含み、前記反応混合物はモノマーを含み、前記モノマーは、
約5重量%〜約50重量%の少なくとも1種の高Tgモノマー(ここで、前記少なくとも1種の高Tgモノマーの重量%は、前記反応混合物中の前記モノマーの総重量に対するものである)、及び
約20重量%〜約80重量%の少なくとも1種の低Tgモノマー(ここで、前記少なくとも1種の低Tgモノマーの重量%は、前記反応混合物中の前記モノマーの総重量に対するものである)を含む、請求項17に記載の方法。 - 前記反応混合物における重量に基づいて、前記少なくとも1種の低Tgモノマーは、前記少なくとも1種の高Tgモノマーよりも多く存在する、請求項31に記載の方法。
- 表面から少なくとも1つの芽胞を取り除く方法であって、
前記表面を組成物と接触させることを含み、前記組成物は、
前記組成物の総重量に基づいて、少なくとも約85重量%のヒドロアルコール溶液であって、
前記ヒドロアルコール溶液の重量に基づいて、少なくとも約1重量%の水、及び
前記ヒドロアルコール溶液の総重量に基づいて、約30重量%〜約95重量%の少なくとも1種のC1〜C4アルキルアルコールを含む、前記ヒドロアルコール溶液と、
前記ヒドロアルコール溶液中に分散されたアクリレートコポリマー粒子であって、前記アクリレートコポリマー粒子は反応混合物の反応生成物を含み、前記反応混合物はモノマーを含み、前記モノマーは、
約5重量%〜約50重量%の少なくとも1種の高Tgモノマー(ここで、前記少なくとも1種の高Tgモノマーの重量%は、前記反応混合物中の前記モノマーの総重量に対するものである)、及び
約20w%〜約80重量%の少なくとも1種の低Tgモノマー(ここで、前記少なくとも1種の低Tgモノマーの重量%は、前記反応混合物中の前記モノマーの総重量に対するものである)を含む、前記アクリレートコポリマー粒子と、を含み、
前記アクリレートコポリマー粒子は、少なくとも約100nmの平均直径を有する、方法。 - 前記表面は前記組成物中に浸漬される、請求項33に記載の方法。
- 前記組成物は前記表面に適用される、請求項33に記載の方法。
- 前記組成物の少なくとも一部を取り除くことを更に含み、前記組成物の少なくとも一部を取り除くことは、前記表面から前記少なくとも1種の芽胞を取り除く、請求項33に記載の方法。
- 前記組成物の少なくとも一部を取り除く工程は、機械的作用を含む、請求項36に記載の方法。
- 前記機械的作用は、前記表面を擦ること、前記表面にわたって物品を動かすこと、又はこれらの何らかの組み合わせを含む、請求項37に記載の方法。
- 前記表面は皮膚を含む、請求項33に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562187372P | 2015-07-01 | 2015-07-01 | |
US62/187,372 | 2015-07-01 | ||
PCT/US2016/039554 WO2017003923A1 (en) | 2015-07-01 | 2016-06-27 | Compositions for spore removal |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2018529631A true JP2018529631A (ja) | 2018-10-11 |
JP2018529631A5 JP2018529631A5 (ja) | 2019-07-25 |
JP6895395B2 JP6895395B2 (ja) | 2021-06-30 |
Family
ID=56507815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017568193A Active JP6895395B2 (ja) | 2015-07-01 | 2016-06-27 | 芽胞を取り除くための組成物 |
Country Status (6)
Country | Link |
---|---|
US (1) | US10555889B2 (ja) |
EP (1) | EP3316855B1 (ja) |
JP (1) | JP6895395B2 (ja) |
CN (1) | CN107735072B (ja) |
BR (1) | BR112018000032B1 (ja) |
WO (1) | WO2017003923A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020503389A (ja) * | 2017-01-04 | 2020-01-30 | スリーエム イノベイティブ プロパティズ カンパニー | 芽胞の除去方法 |
JP2020514405A (ja) * | 2017-01-04 | 2020-05-21 | スリーエム イノベイティブ プロパティズ カンパニー | 芽胞の除去方法 |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070048249A1 (en) | 2005-08-24 | 2007-03-01 | Purdue Research Foundation | Hydrophilized bactericidal polymers |
CN108472505A (zh) | 2015-12-22 | 2018-08-31 | 3M创新有限公司 | 用于孢子移除的方法 |
EP3629731A1 (en) | 2017-05-27 | 2020-04-08 | Poly Group LLC | Dispersible antimicrobial complex and coatings therefrom |
EP3638740A1 (en) | 2017-06-16 | 2020-04-22 | Poly Group LLC | Polymeric antimicrobial surfactant |
US20190230929A1 (en) * | 2018-01-30 | 2019-08-01 | W.M. Barr & Company, Inc. | Composition for residual sanitization |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005079765A1 (en) * | 2004-02-24 | 2005-09-01 | Euroderm Rdc S.P.A. | Compositions for the treatment of nail and skin disorders |
JP2008508189A (ja) * | 2004-06-03 | 2008-03-21 | ブラウン、ジェイ.スティーブン | 除菌用組成物及びその製法 |
US20080102053A1 (en) * | 2002-12-30 | 2008-05-01 | Aplicare, Inc. | Enhanced Antimicrobial Skin Preparation |
Family Cites Families (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE927644C (de) | 1951-09-09 | 1955-05-12 | Mueller C H F Ag | In einem oelgefuellten Behaelter angeordnete einpolige Roentgenroehre |
DE2941586A1 (de) | 1979-10-13 | 1981-04-23 | Bayer Ag, 5090 Leverkusen | Kontaktlinsen aus methacrylsaeuremethylester-copolymerisaten |
JPH04234986A (ja) | 1991-01-10 | 1992-08-24 | Japan Vilene Co Ltd | 微生物吸着材及びその製造方法 |
JP2533723B2 (ja) | 1992-12-28 | 1996-09-11 | 東興薬品工業株式会社 | 速乾性ゲルタイプ手指消毒剤 |
CA2224798A1 (en) | 1995-06-22 | 1997-01-09 | Matthew T. Scholz | Stable hydroalcoholic compositions |
US6582711B1 (en) * | 1997-01-09 | 2003-06-24 | 3M Innovative Properties Company | Hydroalcoholic compositions thickened using polymers |
US6484735B1 (en) | 1997-02-14 | 2002-11-26 | The Procter & Gamble Company | Alkaline liquid hard-surface cleaning compositions comprising N-vinylpyrrolidone copolymer |
GB9704989D0 (en) | 1997-03-11 | 1997-04-30 | Unilever Plc | Improvements relating to hard-surface cleaning compositions |
CO5040136A1 (es) | 1997-09-03 | 2001-05-29 | Johnson & Son Inc S C | Metodo para desinfectar e inhibir el crecimiento de mohos y hongos sobre superficies duras no porosas |
US6083517A (en) | 1997-09-26 | 2000-07-04 | Lever Brothers Company, Division Of Conopco, Inc. | Ultramild antibacterial cleaning composition for frequent use |
WO2000030599A1 (en) | 1998-11-23 | 2000-06-02 | The Procter & Gamble Company | Skin deodorizing and sanitizing compositions |
US7241729B2 (en) | 1999-05-26 | 2007-07-10 | Rhodia Inc. | Compositions and methods for using polymeric suds enhancers |
US6228354B1 (en) | 1999-07-02 | 2001-05-08 | Allegiance Corporation | Water resistant film-forming antimicrobial skin-preparation |
AU784586B2 (en) | 1999-12-13 | 2006-05-04 | Ethicon Inc. | Stabilized antimicrobial systems and methods of making the same |
US6383505B1 (en) | 2000-11-09 | 2002-05-07 | Steris Inc | Fast-acting antimicrobial lotion with enhanced efficacy |
KR100425943B1 (ko) | 2000-11-30 | 2004-04-03 | 구본길 | 로션타입의 피부보호 살균소독제 |
US7799751B2 (en) | 2000-12-14 | 2010-09-21 | The Clorox Company | Cleaning composition |
GB2381531A (en) | 2001-11-02 | 2003-05-07 | Reckitt Benckiser Inc | Hard surface cleaning and disinfecting compositions |
AU2003216213B2 (en) | 2002-02-07 | 2008-10-02 | The Trustees Of Columbia University In The City Of New York | Zinc salt compositions for the prevention of mucosal irritation from spermicides and microbicides |
KR20030085436A (ko) | 2002-04-30 | 2003-11-05 | 김영환 | 무균 세정 도구 |
JP4234986B2 (ja) | 2002-11-28 | 2009-03-04 | 扶桑薬品工業株式会社 | エシェリヒアコリ菌の検出用プローブおよびそれを用いた方法 |
US20050261159A1 (en) | 2003-12-19 | 2005-11-24 | Eric Parris | Detergent composition comprising at least one semi-crystalline polymer and at least one oil |
FR2871470B1 (fr) | 2004-06-11 | 2007-01-12 | Oreal | Copolymere a gradient, composition et procede cosmetique de maquillage ou de soin |
FR2873702B1 (fr) * | 2004-07-29 | 2006-12-22 | Oreal | Copolymere hyperbranche comprenant des monomeres selectionnes, composition le comprenant, et procede cosmetique |
WO2006013315A1 (en) | 2004-08-05 | 2006-02-09 | Ebiox Limited | Antimicrobial skin composition comprising a biguanide or a quaternium compound |
DE102004058143A1 (de) | 2004-11-23 | 2006-05-24 | Bode Chemie Gmbh & Co | Desinfizierendes Substrat |
EP1827464A4 (en) | 2004-12-23 | 2010-06-23 | Swiss American Products Inc | ZINC COMPOSITIONS AND METHODS OF USE |
JP2008530022A (ja) | 2005-02-04 | 2008-08-07 | コーリー ファーマシューティカル グループ,インコーポレイテッド | 免疫反応調節物質を含む水性ゲル処方物 |
US20090301519A1 (en) | 2005-07-25 | 2009-12-10 | Rhodia Chimie | Removal of dirt/make-up form unclean surfaces |
US20070129641A1 (en) | 2005-12-01 | 2007-06-07 | Sweeney Robert J | Posture estimation at transitions between states |
US9629361B2 (en) | 2006-02-09 | 2017-04-25 | Gojo Industries, Inc. | Composition and method for pre-surgical skin disinfection |
CN103992676B (zh) | 2006-02-23 | 2017-08-15 | 纳幕尔杜邦公司 | 可去除的抗微生物涂料组合物和使用的方法 |
WO2008054545A2 (en) * | 2006-05-26 | 2008-05-08 | The Dial Corporation | Method of inhibiting the transmission of viruses |
CA2653347A1 (en) * | 2006-05-31 | 2007-12-13 | The Dial Corporation | Alcohol-containing antimicrobial compositions having improved efficacy |
WO2008003632A1 (de) | 2006-07-07 | 2008-01-10 | Henkel Ag & Co. Kgaa | Desinfizierendes hautbehandlungsmittel |
US7696138B2 (en) * | 2006-07-28 | 2010-04-13 | Afton Chemical Corporation | Alkyl acrylate copolymer dispersants and uses thereof |
WO2008022186A2 (en) | 2006-08-15 | 2008-02-21 | Stack Kevin C | Antimicrobial sanitizing formulations with skin protection properties |
CA2621986A1 (en) | 2007-02-23 | 2008-08-23 | Gojo Industries, Inc. | Foamable alcoholic composition |
CN101463303A (zh) | 2007-12-18 | 2009-06-24 | 侯青顺 | 冷藏箱柜消毒清洁剂 |
BRPI0819567A2 (pt) * | 2007-12-31 | 2015-05-05 | 3M Innovative Properties Co | "composições antimicrobianas, método para aprimorar a adesão molhada do artigo adesivo médico e método para evitar ou tratar uma condição da pele de um mamífero |
GB2458189B (en) | 2008-03-13 | 2012-05-09 | Amity Ltd | Cleaning composition |
US8211406B2 (en) | 2008-11-25 | 2012-07-03 | The Procter & Gamble Company | Oral care compositions with fused silica |
US20110152925A1 (en) | 2009-12-22 | 2011-06-23 | Schorr Phillip A | Skin Preparation That Immobilizes Bacteria |
US20130302385A1 (en) * | 2012-05-08 | 2013-11-14 | L'oreal S.A. | Compositions containing a water-based gel and a water-in-oil emulsion |
US9821066B2 (en) | 2013-03-15 | 2017-11-21 | Carefusion 2200, Inc. | Tinted antiseptic solutions having improved stability |
-
2016
- 2016-06-27 CN CN201680039271.5A patent/CN107735072B/zh active Active
- 2016-06-27 EP EP16741732.8A patent/EP3316855B1/en active Active
- 2016-06-27 BR BR112018000032-9A patent/BR112018000032B1/pt active IP Right Grant
- 2016-06-27 WO PCT/US2016/039554 patent/WO2017003923A1/en active Application Filing
- 2016-06-27 US US15/736,853 patent/US10555889B2/en active Active
- 2016-06-27 JP JP2017568193A patent/JP6895395B2/ja active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080102053A1 (en) * | 2002-12-30 | 2008-05-01 | Aplicare, Inc. | Enhanced Antimicrobial Skin Preparation |
WO2005079765A1 (en) * | 2004-02-24 | 2005-09-01 | Euroderm Rdc S.P.A. | Compositions for the treatment of nail and skin disorders |
JP2008508189A (ja) * | 2004-06-03 | 2008-03-21 | ブラウン、ジェイ.スティーブン | 除菌用組成物及びその製法 |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2020503389A (ja) * | 2017-01-04 | 2020-01-30 | スリーエム イノベイティブ プロパティズ カンパニー | 芽胞の除去方法 |
JP2020514405A (ja) * | 2017-01-04 | 2020-05-21 | スリーエム イノベイティブ プロパティズ カンパニー | 芽胞の除去方法 |
JP7292210B2 (ja) | 2017-01-04 | 2023-06-16 | スリーエム イノベイティブ プロパティズ カンパニー | 芽胞の除去方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2017003923A1 (en) | 2017-01-05 |
US10555889B2 (en) | 2020-02-11 |
EP3316855A1 (en) | 2018-05-09 |
CN107735072A (zh) | 2018-02-23 |
US20180360728A1 (en) | 2018-12-20 |
BR112018000032B1 (pt) | 2021-11-09 |
EP3316855B1 (en) | 2020-09-23 |
JP6895395B2 (ja) | 2021-06-30 |
CN107735072B (zh) | 2023-09-15 |
BR112018000032A2 (pt) | 2018-09-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP6895395B2 (ja) | 芽胞を取り除くための組成物 | |
AU2018227539A1 (en) | Reduced inhalation hazard sanitizers and disinfectants via high molecular weight polymers | |
AU2011348474B2 (en) | Antimicrobial composition having skin care properties | |
RU2722183C1 (ru) | Противомикробные композиции для ухода за полостью рта или ее очистки и способы получения полимеров и покрытий, препятствующих прикреплению | |
JP2006512304A (ja) | 皮膚洗浄剤組成物及び使用方法 | |
CN105050398A (zh) | 改进的抗菌组合物 | |
EP4171761A1 (en) | Sanitizing compositions containing ionic liquid | |
JP2015164904A (ja) | バイオフィルム除去剤組成物 | |
KR20110043661A (ko) | 항미생물 젤 제형물 | |
CN102149392B (zh) | 温和无刺激无醇的皮肤消毒剂 | |
JP5345015B2 (ja) | 手指消毒剤組成物 | |
JP2012144481A (ja) | 手指消毒剤組成物 | |
AU2016377340B2 (en) | Methods for spore removal | |
JPH10324624A (ja) | 殺菌消毒剤組成物 | |
JP2006083111A (ja) | 消毒用組成物 | |
AU2016377338B2 (en) | Methods for spore removal | |
JPH02218605A (ja) | 皮膚又は毛髪用殺菌消毒剤 | |
JP2006083119A (ja) | 殺菌消毒剤組成物 | |
Lens et al. | A scientific study that proves alcohol hand sanitiser is more efficacious when dispensed onto the hands as foam rather than as gel. | |
CN109939039A (zh) | 一种抑菌消炎的中药洗手液及其制备方法 | |
DE10205924A1 (de) | Kosmetische Formulierungen mit antimikrobiellen Polymeren | |
RU2359656C1 (ru) | Средство для сухой дезинфекции и очистки рук | |
CN103690953B (zh) | 动物咬抓伤应急处理液及其组合物、制备方法 | |
JP2005314336A (ja) | 外皮用殺菌剤配合組成物及び、皮膚刺激緩和方法 | |
BR112015012404B1 (pt) | Composição não aquosa, antibacteriana, para remoção de pelos, e seu processo de fabricação |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20190617 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20190617 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20200512 |
|
RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20200522 |
|
RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20200602 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20200811 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20201110 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20210209 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20210408 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20210511 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20210607 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 6895395 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |