JP2018529389A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018529389A5 JP2018529389A5 JP2018538528A JP2018538528A JP2018529389A5 JP 2018529389 A5 JP2018529389 A5 JP 2018529389A5 JP 2018538528 A JP2018538528 A JP 2018538528A JP 2018538528 A JP2018538528 A JP 2018538528A JP 2018529389 A5 JP2018529389 A5 JP 2018529389A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cell
- enriched
- neural
- neuronal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 24
- 210000002569 neuron Anatomy 0.000 claims 21
- 210000004027 cell Anatomy 0.000 claims 13
- -1 ENSG000002260391 Proteins 0.000 claims 8
- 210000003061 neural cell Anatomy 0.000 claims 7
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 5
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 5
- 101000650697 Homo sapiens Roundabout homolog 2 Proteins 0.000 claims 4
- 102100027739 Roundabout homolog 2 Human genes 0.000 claims 4
- 102100024075 Alpha-internexin Human genes 0.000 claims 3
- 102100022716 Atypical chemokine receptor 3 Human genes 0.000 claims 3
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims 3
- 101000833549 Homo sapiens Alpha-internexin Proteins 0.000 claims 3
- 101000678890 Homo sapiens Atypical chemokine receptor 3 Proteins 0.000 claims 3
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims 3
- 101001067178 Homo sapiens Plexin-A4 Proteins 0.000 claims 3
- 102100034385 Plexin-A4 Human genes 0.000 claims 3
- 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 claims 3
- 101710100963 Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 claims 3
- 210000000130 stem cell Anatomy 0.000 claims 3
- 102100027935 Attractin-like protein 1 Human genes 0.000 claims 2
- 102100025980 BMP/retinoic acid-inducible neural-specific protein 2 Human genes 0.000 claims 2
- 102000017924 CHRM4 Human genes 0.000 claims 2
- 102100040807 CUB and sushi domain-containing protein 3 Human genes 0.000 claims 2
- 102100035671 Cadherin EGF LAG seven-pass G-type receptor 3 Human genes 0.000 claims 2
- 102100040497 Contactin-associated protein-like 4 Human genes 0.000 claims 2
- 102100037712 Down syndrome cell adhesion molecule-like protein 1 Human genes 0.000 claims 2
- 101150025643 Epha5 gene Proteins 0.000 claims 2
- 102100021605 Ephrin type-A receptor 5 Human genes 0.000 claims 2
- 102100030652 Glutamate receptor 1 Human genes 0.000 claims 2
- 102100030668 Glutamate receptor 4 Human genes 0.000 claims 2
- 102100022630 Glutamate receptor ionotropic, NMDA 2B Human genes 0.000 claims 2
- 102100022767 Glutamate receptor ionotropic, kainate 3 Human genes 0.000 claims 2
- 102100035349 Homeobox protein DLX-6 Human genes 0.000 claims 2
- 101000697938 Homo sapiens Attractin-like protein 1 Proteins 0.000 claims 2
- 101000933348 Homo sapiens BMP/retinoic acid-inducible neural-specific protein 2 Proteins 0.000 claims 2
- 101000892045 Homo sapiens CUB and sushi domain-containing protein 3 Proteins 0.000 claims 2
- 101000715671 Homo sapiens Cadherin EGF LAG seven-pass G-type receptor 3 Proteins 0.000 claims 2
- 101000749880 Homo sapiens Contactin-associated protein-like 4 Proteins 0.000 claims 2
- 101000880951 Homo sapiens Down syndrome cell adhesion molecule-like protein 1 Proteins 0.000 claims 2
- 101001010445 Homo sapiens Glutamate receptor 1 Proteins 0.000 claims 2
- 101001010438 Homo sapiens Glutamate receptor 4 Proteins 0.000 claims 2
- 101000972850 Homo sapiens Glutamate receptor ionotropic, NMDA 2B Proteins 0.000 claims 2
- 101000903337 Homo sapiens Glutamate receptor ionotropic, kainate 3 Proteins 0.000 claims 2
- 101000804582 Homo sapiens Homeobox protein DLX-6 Proteins 0.000 claims 2
- 101000981639 Homo sapiens LHFPL tetraspan subfamily member 3 protein Proteins 0.000 claims 2
- 101000720512 Homo sapiens Muscarinic acetylcholine receptor M4 Proteins 0.000 claims 2
- 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 claims 2
- 101000969961 Homo sapiens Neurexin-3 Proteins 0.000 claims 2
- 101000969963 Homo sapiens Neurexin-3-beta Proteins 0.000 claims 2
- 101001007703 Homo sapiens Neurexophilin-1 Proteins 0.000 claims 2
- 101001108364 Homo sapiens Neuronal cell adhesion molecule Proteins 0.000 claims 2
- 101001098352 Homo sapiens OX-2 membrane glycoprotein Proteins 0.000 claims 2
- 101001123492 Homo sapiens Prolactin-releasing peptide receptor Proteins 0.000 claims 2
- 101000813163 Homo sapiens Protein ELFN1 Proteins 0.000 claims 2
- 101000591236 Homo sapiens Receptor-type tyrosine-protein phosphatase R Proteins 0.000 claims 2
- 101000704874 Homo sapiens Rho family-interacting cell polarization regulator 2 Proteins 0.000 claims 2
- 102100024107 LHFPL tetraspan subfamily member 3 protein Human genes 0.000 claims 2
- 108010012255 Neural Cell Adhesion Molecule L1 Proteins 0.000 claims 2
- 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 claims 2
- 102100024964 Neural cell adhesion molecule L1 Human genes 0.000 claims 2
- 102100021310 Neurexin-3 Human genes 0.000 claims 2
- 102100027527 Neurexophilin-1 Human genes 0.000 claims 2
- 102100021852 Neuronal cell adhesion molecule Human genes 0.000 claims 2
- 102100037589 OX-2 membrane glycoprotein Human genes 0.000 claims 2
- 102100029002 Prolactin-releasing peptide receptor Human genes 0.000 claims 2
- 102100039245 Protein ELFN1 Human genes 0.000 claims 2
- 102100034101 Receptor-type tyrosine-protein phosphatase R Human genes 0.000 claims 2
- 102100032023 Rho family-interacting cell polarization regulator 2 Human genes 0.000 claims 2
- 108060007759 SLC6A1 Proteins 0.000 claims 2
- 102000005028 SLC6A1 Human genes 0.000 claims 2
- 239000002458 cell surface marker Substances 0.000 claims 2
- 102100033400 4F2 cell-surface antigen heavy chain Human genes 0.000 claims 1
- 108091005663 ADAMTS5 Proteins 0.000 claims 1
- 102000051389 ADAMTS5 Human genes 0.000 claims 1
- 101150009379 AS1 gene Proteins 0.000 claims 1
- 102100021836 Alpha-2,8-sialyltransferase 8E Human genes 0.000 claims 1
- 102100024504 Bone morphogenetic protein 3 Human genes 0.000 claims 1
- 102100032312 Brevican core protein Human genes 0.000 claims 1
- 102100032582 Calcium-dependent secretion activator 1 Human genes 0.000 claims 1
- 102100021849 Calretinin Human genes 0.000 claims 1
- ZEOWTGPWHLSLOG-UHFFFAOYSA-N Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F Chemical compound Cc1ccc(cc1-c1ccc2c(n[nH]c2c1)-c1cnn(c1)C1CC1)C(=O)Nc1cccc(c1)C(F)(F)F ZEOWTGPWHLSLOG-UHFFFAOYSA-N 0.000 claims 1
- 102100037677 Cell surface hyaluronidase Human genes 0.000 claims 1
- 102100038503 Cellular retinoic acid-binding protein 1 Human genes 0.000 claims 1
- 101100324551 Chlamydomonas reinhardtii ARSA1 gene Proteins 0.000 claims 1
- 102100031615 Ciliary neurotrophic factor receptor subunit alpha Human genes 0.000 claims 1
- 101000923091 Danio rerio Aristaless-related homeobox protein Proteins 0.000 claims 1
- 102100034568 E3 ubiquitin-protein ligase PDZRN3 Human genes 0.000 claims 1
- 108010008795 ELAV-Like Protein 2 Proteins 0.000 claims 1
- 102000007303 ELAV-Like Protein 2 Human genes 0.000 claims 1
- 108091008794 FGF receptors Proteins 0.000 claims 1
- 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 claims 1
- 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 claims 1
- 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 claims 1
- 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 claims 1
- 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 claims 1
- 101710182396 Fibroblast growth factor receptor 3 Proteins 0.000 claims 1
- 102100026535 Fibronectin type III domain-containing protein 5 Human genes 0.000 claims 1
- 102100035902 Glutamate decarboxylase 1 Human genes 0.000 claims 1
- 102100035857 Glutamate decarboxylase 2 Human genes 0.000 claims 1
- 102100036669 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic Human genes 0.000 claims 1
- 102100035910 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Human genes 0.000 claims 1
- 102100031470 Homeobox protein ARX Human genes 0.000 claims 1
- 102100030087 Homeobox protein DLX-1 Human genes 0.000 claims 1
- 102100022377 Homeobox protein DLX-2 Human genes 0.000 claims 1
- 102100022373 Homeobox protein DLX-5 Human genes 0.000 claims 1
- 102100027893 Homeobox protein Nkx-2.1 Human genes 0.000 claims 1
- 101000800023 Homo sapiens 4F2 cell-surface antigen heavy chain Proteins 0.000 claims 1
- 101000616703 Homo sapiens Alpha-2,8-sialyltransferase 8E Proteins 0.000 claims 1
- 101000762375 Homo sapiens Bone morphogenetic protein 3 Proteins 0.000 claims 1
- 101000731086 Homo sapiens Brevican core protein Proteins 0.000 claims 1
- 101000867747 Homo sapiens Calcium-dependent secretion activator 1 Proteins 0.000 claims 1
- 101000898072 Homo sapiens Calretinin Proteins 0.000 claims 1
- 101000880605 Homo sapiens Cell surface hyaluronidase Proteins 0.000 claims 1
- 101001099865 Homo sapiens Cellular retinoic acid-binding protein 1 Proteins 0.000 claims 1
- 101000993348 Homo sapiens Ciliary neurotrophic factor receptor subunit alpha Proteins 0.000 claims 1
- 101001131834 Homo sapiens E3 ubiquitin-protein ligase PDZRN3 Proteins 0.000 claims 1
- 101000866286 Homo sapiens Excitatory amino acid transporter 1 Proteins 0.000 claims 1
- 101000913653 Homo sapiens Fibronectin type III domain-containing protein 5 Proteins 0.000 claims 1
- 101000616435 Homo sapiens Gamma-sarcoglycan Proteins 0.000 claims 1
- 101000873546 Homo sapiens Glutamate decarboxylase 1 Proteins 0.000 claims 1
- 101000873786 Homo sapiens Glutamate decarboxylase 2 Proteins 0.000 claims 1
- 101001072574 Homo sapiens Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic Proteins 0.000 claims 1
- 101001073272 Homo sapiens Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Proteins 0.000 claims 1
- 101000923090 Homo sapiens Homeobox protein ARX Proteins 0.000 claims 1
- 101000864690 Homo sapiens Homeobox protein DLX-1 Proteins 0.000 claims 1
- 101000901635 Homo sapiens Homeobox protein DLX-2 Proteins 0.000 claims 1
- 101000901627 Homo sapiens Homeobox protein DLX-5 Proteins 0.000 claims 1
- 101000632178 Homo sapiens Homeobox protein Nkx-2.1 Proteins 0.000 claims 1
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 claims 1
- 101001027634 Homo sapiens Kinesin-like protein KIF21B Proteins 0.000 claims 1
- 101000619910 Homo sapiens LIM/homeobox protein Lhx6 Proteins 0.000 claims 1
- 101000605020 Homo sapiens Large neutral amino acids transporter small subunit 1 Proteins 0.000 claims 1
- 101000573526 Homo sapiens Membrane protein MLC1 Proteins 0.000 claims 1
- 101000891579 Homo sapiens Microtubule-associated protein tau Proteins 0.000 claims 1
- 101000635885 Homo sapiens Myosin light chain 1/3, skeletal muscle isoform Proteins 0.000 claims 1
- 101000634538 Homo sapiens Neuronal PAS domain-containing protein 1 Proteins 0.000 claims 1
- 101000720704 Homo sapiens Neuronal migration protein doublecortin Proteins 0.000 claims 1
- 101000996058 Homo sapiens Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 Proteins 0.000 claims 1
- 101001131830 Homo sapiens PDZ domain-containing RING finger protein 4 Proteins 0.000 claims 1
- 101000595513 Homo sapiens Phosphatidylinositol 4-phosphate 5-kinase type-1 beta Proteins 0.000 claims 1
- 101000596119 Homo sapiens Plastin-3 Proteins 0.000 claims 1
- 101000600766 Homo sapiens Podoplanin Proteins 0.000 claims 1
- 101000997280 Homo sapiens Potassium voltage-gated channel subfamily C member 2 Proteins 0.000 claims 1
- 101001129365 Homo sapiens Prepronociceptin Proteins 0.000 claims 1
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 claims 1
- 101000876829 Homo sapiens Protein C-ets-1 Proteins 0.000 claims 1
- 101100078258 Homo sapiens RUNX1T1 gene Proteins 0.000 claims 1
- 101001104083 Homo sapiens Rabphilin-3A Proteins 0.000 claims 1
- 101000738772 Homo sapiens Receptor-type tyrosine-protein phosphatase beta Proteins 0.000 claims 1
- 101000695844 Homo sapiens Receptor-type tyrosine-protein phosphatase zeta Proteins 0.000 claims 1
- 101001100103 Homo sapiens Retinoic acid-induced protein 2 Proteins 0.000 claims 1
- 101000650694 Homo sapiens Roundabout homolog 1 Proteins 0.000 claims 1
- 101000873658 Homo sapiens Secretogranin-3 Proteins 0.000 claims 1
- 101000829203 Homo sapiens Serine/arginine repetitive matrix protein 4 Proteins 0.000 claims 1
- 101000885387 Homo sapiens Serine/threonine-protein kinase DCLK2 Proteins 0.000 claims 1
- 101000707241 Homo sapiens Seven in absentia homolog 3 Proteins 0.000 claims 1
- 101000753197 Homo sapiens Sodium/potassium-transporting ATPase subunit alpha-2 Proteins 0.000 claims 1
- 101000697510 Homo sapiens Stathmin-2 Proteins 0.000 claims 1
- 101000712600 Homo sapiens Thyroid hormone receptor beta Proteins 0.000 claims 1
- 101000962461 Homo sapiens Transcription factor Maf Proteins 0.000 claims 1
- 101000979190 Homo sapiens Transcription factor MafB Proteins 0.000 claims 1
- 101000642517 Homo sapiens Transcription factor SOX-6 Proteins 0.000 claims 1
- 101000642459 Homo sapiens Transcription factor Sp9 Proteins 0.000 claims 1
- 101000685104 Homo sapiens Transcriptional repressor scratch 1 Proteins 0.000 claims 1
- 101000685107 Homo sapiens Transcriptional repressor scratch 2 Proteins 0.000 claims 1
- 101000652720 Homo sapiens Transgelin-3 Proteins 0.000 claims 1
- 101000655155 Homo sapiens Transmembrane protein 158 Proteins 0.000 claims 1
- 101000801254 Homo sapiens Tumor necrosis factor receptor superfamily member 16 Proteins 0.000 claims 1
- 101000803714 Homo sapiens V-set and transmembrane domain-containing protein 2A Proteins 0.000 claims 1
- 102100037852 Insulin-like growth factor I Human genes 0.000 claims 1
- 102100037690 Kinesin-like protein KIF21B Human genes 0.000 claims 1
- 102100022098 LIM/homeobox protein Lhx6 Human genes 0.000 claims 1
- 108010018650 MEF2 Transcription Factors Proteins 0.000 claims 1
- 102100026290 Membrane protein MLC1 Human genes 0.000 claims 1
- 102100040243 Microtubule-associated protein tau Human genes 0.000 claims 1
- 102100039229 Myocyte-specific enhancer factor 2C Human genes 0.000 claims 1
- 102100029052 Neuronal PAS domain-containing protein 1 Human genes 0.000 claims 1
- 102100025929 Neuronal migration protein doublecortin Human genes 0.000 claims 1
- 102100035069 Neuronal vesicle trafficking-associated protein 2 Human genes 0.000 claims 1
- 101710085178 Neuronal vesicle trafficking-associated protein 2 Proteins 0.000 claims 1
- 102100034450 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 Human genes 0.000 claims 1
- 102000001759 Notch1 Receptor Human genes 0.000 claims 1
- 108010029755 Notch1 Receptor Proteins 0.000 claims 1
- 102000001760 Notch3 Receptor Human genes 0.000 claims 1
- 108010029756 Notch3 Receptor Proteins 0.000 claims 1
- 102100034575 PDZ domain-containing RING finger protein 4 Human genes 0.000 claims 1
- 102100036081 Phosphatidylinositol 4-phosphate 5-kinase type-1 beta Human genes 0.000 claims 1
- 102100035220 Plastin-3 Human genes 0.000 claims 1
- 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 claims 1
- 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 claims 1
- 102100037265 Podoplanin Human genes 0.000 claims 1
- 101100146539 Podospora anserina RPS15 gene Proteins 0.000 claims 1
- 102100034307 Potassium voltage-gated channel subfamily C member 2 Human genes 0.000 claims 1
- 102100031292 Prepronociceptin Human genes 0.000 claims 1
- 102100040120 Prominin-1 Human genes 0.000 claims 1
- 102100035251 Protein C-ets-1 Human genes 0.000 claims 1
- 102100024952 Protein CBFA2T1 Human genes 0.000 claims 1
- 108700040655 RUNX1 Translocation Partner 1 Proteins 0.000 claims 1
- 102100040040 Rabphilin-3A Human genes 0.000 claims 1
- 101000613608 Rattus norvegicus Monocyte to macrophage differentiation factor Proteins 0.000 claims 1
- 102100037424 Receptor-type tyrosine-protein phosphatase beta Human genes 0.000 claims 1
- 102100028508 Receptor-type tyrosine-protein phosphatase zeta Human genes 0.000 claims 1
- 102100038452 Retinoic acid-induced protein 2 Human genes 0.000 claims 1
- 102100027702 Roundabout homolog 1 Human genes 0.000 claims 1
- 102000012977 SLC1A3 Human genes 0.000 claims 1
- 102000012987 SLC1A5 Human genes 0.000 claims 1
- 108060002241 SLC1A5 Proteins 0.000 claims 1
- 108091006569 SLC32A1 Proteins 0.000 claims 1
- 102100035897 Secretogranin-3 Human genes 0.000 claims 1
- 102100023663 Serine/arginine repetitive matrix protein 4 Human genes 0.000 claims 1
- 102100039775 Serine/threonine-protein kinase DCLK2 Human genes 0.000 claims 1
- 102100031749 Seven in absentia homolog 3 Human genes 0.000 claims 1
- 102100021955 Sodium/potassium-transporting ATPase subunit alpha-2 Human genes 0.000 claims 1
- 102100028051 Stathmin-2 Human genes 0.000 claims 1
- 102100033451 Thyroid hormone receptor beta Human genes 0.000 claims 1
- 102100039189 Transcription factor Maf Human genes 0.000 claims 1
- 102100023234 Transcription factor MafB Human genes 0.000 claims 1
- 102100036694 Transcription factor SOX-6 Human genes 0.000 claims 1
- 102100036395 Transcription factor Sp9 Human genes 0.000 claims 1
- 102100023185 Transcriptional repressor scratch 1 Human genes 0.000 claims 1
- 102100023178 Transcriptional repressor scratch 2 Human genes 0.000 claims 1
- 102100030986 Transgelin-3 Human genes 0.000 claims 1
- 102100033036 Transmembrane protein 158 Human genes 0.000 claims 1
- 102100033725 Tumor necrosis factor receptor superfamily member 16 Human genes 0.000 claims 1
- 102100035142 V-set and transmembrane domain-containing protein 2A Human genes 0.000 claims 1
- 101150096238 VAX1 gene Proteins 0.000 claims 1
- 102100038170 Vesicular inhibitory amino acid transporter Human genes 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 102000052178 fibroblast growth factor receptor activity proteins Human genes 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 210000005171 mammalian brain Anatomy 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 230000008672 reprogramming Effects 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562239042P | 2015-10-08 | 2015-10-08 | |
| US62/239,042 | 2015-10-08 | ||
| PCT/US2016/056316 WO2017062971A1 (en) | 2015-10-08 | 2016-10-10 | Neural precursor cell populations and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020150010A Division JP7138959B2 (ja) | 2015-10-08 | 2020-09-07 | 神経前駆細胞集団を作出する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018529389A JP2018529389A (ja) | 2018-10-11 |
| JP2018529389A5 true JP2018529389A5 (enExample) | 2019-04-25 |
Family
ID=57200130
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018538528A Pending JP2018529389A (ja) | 2015-10-08 | 2016-10-10 | 神経前駆細胞集団およびそれらの使用 |
| JP2020150010A Active JP7138959B2 (ja) | 2015-10-08 | 2020-09-07 | 神経前駆細胞集団を作出する方法 |
| JP2022137961A Active JP7598655B2 (ja) | 2015-10-08 | 2022-08-31 | 神経前駆細胞集団を含むインビトロ組成物およびその使用 |
| JP2024204447A Pending JP2025022948A (ja) | 2015-10-08 | 2024-11-25 | 神経前駆細胞集団を含むインビトロ組成物およびその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020150010A Active JP7138959B2 (ja) | 2015-10-08 | 2020-09-07 | 神経前駆細胞集団を作出する方法 |
| JP2022137961A Active JP7598655B2 (ja) | 2015-10-08 | 2022-08-31 | 神経前駆細胞集団を含むインビトロ組成物およびその使用 |
| JP2024204447A Pending JP2025022948A (ja) | 2015-10-08 | 2024-11-25 | 神経前駆細胞集団を含むインビトロ組成物およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20180369287A1 (enExample) |
| EP (1) | EP3359647A1 (enExample) |
| JP (4) | JP2018529389A (enExample) |
| CN (1) | CN108291207A (enExample) |
| AU (2) | AU2016335563B2 (enExample) |
| CA (1) | CA3001316A1 (enExample) |
| HK (1) | HK1258172A1 (enExample) |
| WO (1) | WO2017062971A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11767507B2 (en) | 2013-11-08 | 2023-09-26 | The Mclean Hospital Corporation | Methods for efficient generation of GABAergic interneurons from pluripotent stem cells |
| JP2022043373A (ja) * | 2018-12-28 | 2022-03-16 | 国立大学法人京都大学 | 大脳皮質細胞からのｌ１ｃａｍ陽性細胞の取得およびその細胞製剤としての使用 |
| US12343359B2 (en) | 2019-05-23 | 2025-07-01 | Dignity Health | Inhibitory interneuron treatment methods, uses and compositions for diabetes |
| US20250082689A1 (en) * | 2021-07-21 | 2025-03-13 | University Of Washington | Compositions and methods for enhancing cardiomyocyte transplant engraftment |
| KR102684884B1 (ko) * | 2021-08-05 | 2024-07-15 | 성균관대학교산학협력단 | 신경줄기세포의 줄기세포능 증진을 위한 gng2의 용도 |
| CN113826564A (zh) * | 2021-08-31 | 2021-12-24 | 南通大学 | 一种检测小鼠运动能力的方法 |
| CN114736957B (zh) * | 2022-04-15 | 2024-03-12 | 中国人民解放军空军军医大学 | 外泌体介导rna casc15干预阿尔茨海默症突触损失的应用 |
| WO2025075929A1 (en) * | 2023-10-02 | 2025-04-10 | Neurona Therapeutics Inc. | Methods of treating seizure activity |
| CN117092354B (zh) * | 2023-10-18 | 2023-12-29 | 亿航(苏州)生物医药有限公司 | 一种用于识别脑源性细胞的细胞外囊泡的蛋白标志物 |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| US6667176B1 (en) | 2000-01-11 | 2003-12-23 | Geron Corporation | cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells |
| CA2409698C (en) | 2000-05-17 | 2010-10-26 | Geron Corporation | Neural progenitor cell populations |
| EP2298867A3 (en) | 2000-06-20 | 2013-01-16 | ES Cell International Pte Ltd. | Method of controlling differentiation of embryonic stem (ES) cells by culturing ES cells in the presence of bmp-2 pathway antagonists |
| AU2003281309A1 (en) | 2002-07-05 | 2004-01-23 | Kirin Beer Kabushiki Kaisha | Novel undifferentiated stem cells contained in cord blood, bone marrow, peripheral blood or the like |
| US20060211111A1 (en) | 2002-12-18 | 2006-09-21 | Maisam Mitalipova | Compositions and methods for neural cell production and stabilization |
| ZA200401646B (en) * | 2003-03-12 | 2004-06-07 | Reliance Life Sciences Pvt Ltd | Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells. |
| WO2004099395A2 (en) | 2003-05-08 | 2004-11-18 | Cellartis Ab | A method for the generation of neural progenitor cells |
| US7820439B2 (en) | 2003-09-03 | 2010-10-26 | Reliance Life Sciences Pvt Ltd. | In vitro generation of GABAergic neurons from pluripotent stem cells |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| JP2008501320A (ja) | 2004-06-02 | 2008-01-24 | イーエス・セル・インターナショナル・プライヴェート・リミテッド | 細胞保存方法 |
| WO2006014551A2 (en) | 2004-07-06 | 2006-02-09 | Michigan State University | In vivo methods for effecting tissue specific differentiation of embryonic stem cells |
| EP1856248A4 (en) | 2005-02-09 | 2010-01-20 | Burnham Inst Medical Research | HOMOGENEOUS NEURALE CURRENT CELLS |
| US7642091B2 (en) | 2005-02-24 | 2010-01-05 | Jau-Nan Lee | Human trophoblast stem cells and use thereof |
| US7803364B2 (en) | 2005-11-17 | 2010-09-28 | The Cleveland Clinic Foundation | Multipotent neural stem cells |
| CN103952373A (zh) | 2005-12-08 | 2014-07-30 | 路易斯维尔大学研究基金会有限公司 | 非常小的胚胎样(vsel)干细胞及分离和利用其的方法 |
| US9192630B2 (en) | 2006-01-20 | 2015-11-24 | The Regents Of The University Of California | Transplantation of neural cells |
| RS57083B1 (sr) | 2006-11-03 | 2018-06-29 | Multiple Sclerosis Res Center Of New York | Mezenhimske matične ćelije dobijene iz koštane srži kao izvor progenitora neuralnih ćelija |
| EP2607477B1 (en) | 2007-05-03 | 2020-09-23 | The Brigham and Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| US8574567B2 (en) | 2007-05-03 | 2013-11-05 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| US20100287638A1 (en) | 2007-10-01 | 2010-11-11 | The Hospital For Sick Children | Neural tumor stem cells and methods of use thereof |
| US20110165129A1 (en) | 2008-05-06 | 2011-07-07 | Arnold Kriegstein | Ameliorating Nervous Systems Disorders |
| US20110002897A1 (en) | 2009-06-11 | 2011-01-06 | Burnham Institute For Medical Research | Directed differentiation of stem cells |
| KR20110015739A (ko) | 2009-08-10 | 2011-02-17 | 삼성전자주식회사 | Ｅｍｉ방사 저감을 위한 플라즈마 디스플레이 장치 |
| WO2011079307A2 (en) | 2009-12-23 | 2011-06-30 | The Salk Institute For Biological Studies | Methods and compositions for treating neurological disorders |
| US9057053B2 (en) | 2010-01-19 | 2015-06-16 | The Board Of Trustees Of The Leland Stanford Junior University | Direct conversion of cells to cells of other lineages |
| US9717761B2 (en) | 2011-11-21 | 2017-08-01 | Ramot At Tel-Aviv University Ltd. | Stem cell-derived neural cells for cell therapy in neurological disorders |
| KR101429217B1 (ko) | 2012-02-06 | 2014-08-12 | 동국대학교 산학협력단 | 줄기세포를 신경세포로 분화시키는 방법 |
| WO2013139429A1 (en) | 2012-03-21 | 2013-09-26 | Merck Patent Gmbh | Induced neural stem cells |
| WO2013155222A2 (en) | 2012-04-10 | 2013-10-17 | The Regents Of The University Of California | Brain-specific enhancers for cell-based therapy |
| JP2014082956A (ja) | 2012-10-19 | 2014-05-12 | Somar Corp | 細胞培養基材、およびそれを用いた細胞培養方法並びに多能性幹細胞の分化誘導方法 |
| JP2016520291A (ja) * | 2013-03-14 | 2016-07-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ｉｎｖｉｔｒｏでの内側神経節隆起前駆細胞の作製 |
| EP2989198A4 (en) | 2013-04-26 | 2016-10-26 | Sloan Kettering Inst Cancer | CORTICAL INTERNETS AND OTHER NEURONAL CELLS MADE BY TARGETED DIFFERENTIATION OF PLURIPOTENTAL AND MULTIPOTENTIAL CELLS |
| EP3690032A1 (en) | 2013-09-20 | 2020-08-05 | Lonza Ltd. | Methods for nuclear reprogramming of cells |
| US11767507B2 (en) | 2013-11-08 | 2023-09-26 | The Mclean Hospital Corporation | Methods for efficient generation of GABAergic interneurons from pluripotent stem cells |
-
2016
- 2016-10-10 WO PCT/US2016/056316 patent/WO2017062971A1/en not_active Ceased
- 2016-10-10 HK HK19100528.0A patent/HK1258172A1/zh unknown
- 2016-10-10 CN CN201680071312.9A patent/CN108291207A/zh active Pending
- 2016-10-10 CA CA3001316A patent/CA3001316A1/en active Pending
- 2016-10-10 AU AU2016335563A patent/AU2016335563B2/en active Active
- 2016-10-10 JP JP2018538528A patent/JP2018529389A/ja active Pending
- 2016-10-10 EP EP16785645.9A patent/EP3359647A1/en active Pending
- 2016-10-10 US US15/766,792 patent/US20180369287A1/en active Pending
-
2020
- 2020-09-07 JP JP2020150010A patent/JP7138959B2/ja active Active
-
2022
- 2022-08-31 JP JP2022137961A patent/JP7598655B2/ja active Active
-
2023
- 2023-01-25 AU AU2023200389A patent/AU2023200389B2/en active Active
-
2024
- 2024-11-25 JP JP2024204447A patent/JP2025022948A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018529389A5 (enExample) | ||
| Hockemeyer et al. | Induced pluripotent stem cells meet genome editing | |
| Ben-David et al. | Expanding the boundaries of embryonic stem cells | |
| JP2014533491A5 (enExample) | ||
| WO2006027229A8 (de) | Skalierbarer prozess zur kultivierung undifferenzierter stammzellen in suspension | |
| Petros et al. | Pluripotent stem cells for the study of CNS development | |
| CA2821065C (en) | Culture method to obtain and maintain a pure or enriched population of mammalian neural stem cells and/or neural progenitor cells that are prone to differentiate into oligodendrocyte-lineage cells in vitro | |
| Dever et al. | CRISPR/Cas9 genome engineering in engraftable human brain-derived neural stem cells | |
| EP2438161A4 (en) | PROCESS FOR THE PRODUCTION OF PLURIPOTENT STEM CELLS AND THEIR CULTURE PROCESS | |
| JP2016528894A5 (enExample) | ||
| Shahbazi et al. | Reprogramming of somatic cells to induced neural stem cells | |
| Zhang et al. | Roles of microRNAs in establishing and modulating stem cell potential | |
| MX2017011220A (es) | Metodos para hacer celulas madre neurales y usos de las mismas. | |
| Moon et al. | A more accessible, time-saving, and efficient method for in vitro plant regeneration from potato protoplasts | |
| Pazzin et al. | Induced pluripotent stem cells and organoids in advancing neuropathology research and therapies | |
| Maher et al. | Marching towards regenerative cardiac therapy with human pluripotent stem cells | |
| JP2008512107A (ja) | 体細胞変異を促進する方法とプロテオミクスにおけるその使用 | |
| Gattegno-Ho et al. | Stem cells and veterinary medicine: tools to understand diseases and enable tissue regeneration and drug discovery | |
| JP7125394B2 (ja) | ＲＮＡでの幹細胞分化による膵臓β細胞の誘導 | |
| US10655100B2 (en) | Method for inducing ectodermal differentiation of embryoid bodies derived from human pluripotent stem cells by CXCR2 stimulation | |
| WO2018026212A3 (ko) | 섬유증 질환 모델의 제조방법 및 섬유증 질환 모델의 용도 | |
| CN103031272A (zh) | 一种用于大鼠胚胎干细胞的培养基 | |
| Bhattacharyya | Advancing knowledge of down syndrome brain development and function with human stem cells | |
| US20150361391A1 (en) | Method for inducing tailored pluripotent stem cells using extract of plant stem cells or plant dedifferentiated stem cells, and pluripotent stem cells produced by means of the method | |
| CN103849635B (zh) | 平邑甜茶无融合生殖MhSERK4基因植物表达载体构建方法与应用 |