JP2018529389A - 神経前駆細胞集団およびそれらの使用 - Google Patents

神経前駆細胞集団およびそれらの使用 Download PDF

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Publication number
JP2018529389A
JP2018529389A JP2018538528A JP2018538528A JP2018529389A JP 2018529389 A JP2018529389 A JP 2018529389A JP 2018538528 A JP2018538528 A JP 2018538528A JP 2018538528 A JP2018538528 A JP 2018538528A JP 2018529389 A JP2018529389 A JP 2018529389A
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cells
neural progenitor
cell
enriched
cell population
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JP2018538528A
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English (en)
Japanese (ja)
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JP2018529389A5 (enExample
Inventor
ニコラス、コリー
フエンテアルバ、ルイス
カー トン、チュク
カー トン、チュク
ベルシュテイン、マリーナ
クリクス、ソーニャ
チェンバーズ、スチュアート
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Neurona Therapeutics Inc
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Neurona Therapeutics Inc
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Publication of JP2018529389A publication Critical patent/JP2018529389A/ja
Publication of JP2018529389A5 publication Critical patent/JP2018529389A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
JP2018538528A 2015-10-08 2016-10-10 神経前駆細胞集団およびそれらの使用 Pending JP2018529389A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562239042P 2015-10-08 2015-10-08
US62/239,042 2015-10-08
PCT/US2016/056316 WO2017062971A1 (en) 2015-10-08 2016-10-10 Neural precursor cell populations and uses thereof

Related Child Applications (1)

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JP2020150010A Division JP7138959B2 (ja) 2015-10-08 2020-09-07 神経前駆細胞集団を作出する方法

Publications (2)

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JP2018529389A true JP2018529389A (ja) 2018-10-11
JP2018529389A5 JP2018529389A5 (enExample) 2019-04-25

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JP2018538528A Pending JP2018529389A (ja) 2015-10-08 2016-10-10 神経前駆細胞集団およびそれらの使用
JP2020150010A Active JP7138959B2 (ja) 2015-10-08 2020-09-07 神経前駆細胞集団を作出する方法
JP2022137961A Active JP7598655B2 (ja) 2015-10-08 2022-08-31 神経前駆細胞集団を含むインビトロ組成物およびその使用
JP2024204447A Pending JP2025022948A (ja) 2015-10-08 2024-11-25 神経前駆細胞集団を含むインビトロ組成物およびその使用

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JP2020150010A Active JP7138959B2 (ja) 2015-10-08 2020-09-07 神経前駆細胞集団を作出する方法
JP2022137961A Active JP7598655B2 (ja) 2015-10-08 2022-08-31 神経前駆細胞集団を含むインビトロ組成物およびその使用
JP2024204447A Pending JP2025022948A (ja) 2015-10-08 2024-11-25 神経前駆細胞集団を含むインビトロ組成物およびその使用

Country Status (8)

Country Link
US (1) US20180369287A1 (enExample)
EP (1) EP3359647A1 (enExample)
JP (4) JP2018529389A (enExample)
CN (1) CN108291207A (enExample)
AU (2) AU2016335563B2 (enExample)
CA (1) CA3001316A1 (enExample)
HK (1) HK1258172A1 (enExample)
WO (1) WO2017062971A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020138510A1 (ja) * 2018-12-28 2020-07-02 国立大学法人京都大学 大脳皮質細胞からのｌ１ｃａｍ陽性細胞の取得および細胞製剤としてのその使用

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11767507B2 (en) 2013-11-08 2023-09-26 The Mclean Hospital Corporation Methods for efficient generation of GABAergic interneurons from pluripotent stem cells
US12343359B2 (en) 2019-05-23 2025-07-01 Dignity Health Inhibitory interneuron treatment methods, uses and compositions for diabetes
US20250082689A1 (en) * 2021-07-21 2025-03-13 University Of Washington Compositions and methods for enhancing cardiomyocyte transplant engraftment
KR102684884B1 (ko) * 2021-08-05 2024-07-15 성균관대학교산학협력단 신경줄기세포의 줄기세포능 증진을 위한 gng2의 용도
CN113826564A (zh) * 2021-08-31 2021-12-24 南通大学 一种检测小鼠运动能力的方法
CN114736957B (zh) * 2022-04-15 2024-03-12 中国人民解放军空军军医大学 外泌体介导rna casc15干预阿尔茨海默症突触损失的应用
WO2025075929A1 (en) * 2023-10-02 2025-04-10 Neurona Therapeutics Inc. Methods of treating seizure activity
CN117092354B (zh) * 2023-10-18 2023-12-29 亿航(苏州)生物医药有限公司 一种用于识别脑源性细胞的细胞外囊泡的蛋白标志物

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US6309853B1 (en) 1994-08-17 2001-10-30 The Rockfeller University Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
CA2409698C (en) 2000-05-17 2010-10-26 Geron Corporation Neural progenitor cell populations
EP2298867A3 (en) 2000-06-20 2013-01-16 ES Cell International Pte Ltd. Method of controlling differentiation of embryonic stem (ES) cells by culturing ES cells in the presence of bmp-2 pathway antagonists
AU2003281309A1 (en) 2002-07-05 2004-01-23 Kirin Beer Kabushiki Kaisha Novel undifferentiated stem cells contained in cord blood, bone marrow, peripheral blood or the like
US20060211111A1 (en) 2002-12-18 2006-09-21 Maisam Mitalipova Compositions and methods for neural cell production and stabilization
ZA200401646B (en) * 2003-03-12 2004-06-07 Reliance Life Sciences Pvt Ltd Derivation of terminally differentiated dopaminergic neurons from human embryonic stem cells.
WO2004099395A2 (en) 2003-05-08 2004-11-18 Cellartis Ab A method for the generation of neural progenitor cells
US7820439B2 (en) 2003-09-03 2010-10-26 Reliance Life Sciences Pvt Ltd. In vitro generation of GABAergic neurons from pluripotent stem cells
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
JP2008501320A (ja) 2004-06-02 2008-01-24 イーエス・セル・インターナショナル・プライヴェート・リミテッド 細胞保存方法
WO2006014551A2 (en) 2004-07-06 2006-02-09 Michigan State University In vivo methods for effecting tissue specific differentiation of embryonic stem cells
EP1856248A4 (en) 2005-02-09 2010-01-20 Burnham Inst Medical Research HOMOGENEOUS NEURALE CURRENT CELLS
US7642091B2 (en) 2005-02-24 2010-01-05 Jau-Nan Lee Human trophoblast stem cells and use thereof
US7803364B2 (en) 2005-11-17 2010-09-28 The Cleveland Clinic Foundation Multipotent neural stem cells
CN103952373A (zh) 2005-12-08 2014-07-30 路易斯维尔大学研究基金会有限公司 非常小的胚胎样(vsel)干细胞及分离和利用其的方法
US9192630B2 (en) 2006-01-20 2015-11-24 The Regents Of The University Of California Transplantation of neural cells
RS57083B1 (sr) 2006-11-03 2018-06-29 Multiple Sclerosis Res Center Of New York Mezenhimske matične ćelije dobijene iz koštane srži kao izvor progenitora neuralnih ćelija
EP2607477B1 (en) 2007-05-03 2020-09-23 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
US8574567B2 (en) 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
US20100287638A1 (en) 2007-10-01 2010-11-11 The Hospital For Sick Children Neural tumor stem cells and methods of use thereof
US20110165129A1 (en) 2008-05-06 2011-07-07 Arnold Kriegstein Ameliorating Nervous Systems Disorders
US20110002897A1 (en) 2009-06-11 2011-01-06 Burnham Institute For Medical Research Directed differentiation of stem cells
KR20110015739A (ko) 2009-08-10 2011-02-17 삼성전자주식회사 Ｅｍｉ방사 저감을 위한 플라즈마 디스플레이 장치
WO2011079307A2 (en) 2009-12-23 2011-06-30 The Salk Institute For Biological Studies Methods and compositions for treating neurological disorders
US9057053B2 (en) 2010-01-19 2015-06-16 The Board Of Trustees Of The Leland Stanford Junior University Direct conversion of cells to cells of other lineages
US9717761B2 (en) 2011-11-21 2017-08-01 Ramot At Tel-Aviv University Ltd. Stem cell-derived neural cells for cell therapy in neurological disorders
KR101429217B1 (ko) 2012-02-06 2014-08-12 동국대학교 산학협력단 줄기세포를 신경세포로 분화시키는 방법
WO2013139429A1 (en) 2012-03-21 2013-09-26 Merck Patent Gmbh Induced neural stem cells
WO2013155222A2 (en) 2012-04-10 2013-10-17 The Regents Of The University Of California Brain-specific enhancers for cell-based therapy
JP2014082956A (ja) 2012-10-19 2014-05-12 Somar Corp 細胞培養基材、およびそれを用いた細胞培養方法並びに多能性幹細胞の分化誘導方法
JP2016520291A (ja) * 2013-03-14 2016-07-14 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア ｉｎｖｉｔｒｏでの内側神経節隆起前駆細胞の作製
EP2989198A4 (en) 2013-04-26 2016-10-26 Sloan Kettering Inst Cancer CORTICAL INTERNETS AND OTHER NEURONAL CELLS MADE BY TARGETED DIFFERENTIATION OF PLURIPOTENTAL AND MULTIPOTENTIAL CELLS
EP3690032A1 (en) 2013-09-20 2020-08-05 Lonza Ltd. Methods for nuclear reprogramming of cells
US11767507B2 (en) 2013-11-08 2023-09-26 The Mclean Hospital Corporation Methods for efficient generation of GABAergic interneurons from pluripotent stem cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLARE FAUX ET AL.: "Differential Gene Expression in Migrating Cortical Interneurons During Mouse Forebrain Development", THE JOURNAL OF COMPARATIVE NEUROLOGY, vol. 518, JPN6020018603, 2010, pages 1232 - 1248, ISSN: 0004277817 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020138510A1 (ja) * 2018-12-28 2020-07-02 国立大学法人京都大学 大脳皮質細胞からのｌ１ｃａｍ陽性細胞の取得および細胞製剤としてのその使用

Also Published As

Publication number Publication date
AU2016335563A1 (en) 2018-05-24
AU2023200389A1 (en) 2023-02-23
US20180369287A1 (en) 2018-12-27
JP7598655B2 (ja) 2024-12-12
HK1258172A1 (zh) 2019-11-08
AU2016335563B2 (en) 2022-10-27
AU2023200389B2 (en) 2025-09-25
JP2020202865A (ja) 2020-12-24
JP2022169768A (ja) 2022-11-09
CA3001316A1 (en) 2017-04-13
CN108291207A (zh) 2018-07-17
EP3359647A1 (en) 2018-08-15
JP2025022948A (ja) 2025-02-14
JP7138959B2 (ja) 2022-09-20
WO2017062971A1 (en) 2017-04-13

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