JP2018529345A5 - - Google Patents
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- JP2018529345A5 JP2018529345A5 JP2018515528A JP2018515528A JP2018529345A5 JP 2018529345 A5 JP2018529345 A5 JP 2018529345A5 JP 2018515528 A JP2018515528 A JP 2018515528A JP 2018515528 A JP2018515528 A JP 2018515528A JP 2018529345 A5 JP2018529345 A5 JP 2018529345A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- seq
- sample
- mammal
- cpg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 17
- 210000003719 b-lymphocyte Anatomy 0.000 claims 10
- 241000124008 Mammalia Species 0.000 claims 7
- 230000011987 methylation Effects 0.000 claims 7
- 238000007069 methylation reaction Methods 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 7
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 108091093088 Amplicon Proteins 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 5
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 4
- 238000004458 analytical method Methods 0.000 claims 4
- 238000012544 monitoring process Methods 0.000 claims 4
- 102000001770 Low Density Lipoprotein Receptor-Related Protein-5 Human genes 0.000 claims 3
- 108010015167 Low Density Lipoprotein Receptor-Related Protein-5 Proteins 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 108091029523 CpG island Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 1
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091036066 Three prime untranslated region Proteins 0.000 claims 1
- 108700009124 Transcription Initiation Site Proteins 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 208000026935 allergic disease Diseases 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 239000012620 biological material Substances 0.000 claims 1
- 238000001369 bisulfite sequencing Methods 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 230000017858 demethylation Effects 0.000 claims 1
- 238000010520 demethylation reaction Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000001976 enzyme digestion Methods 0.000 claims 1
- 230000003325 follicular Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 210000001616 monocyte Anatomy 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000035897 transcription Effects 0.000 claims 1
- 238000013518 transcription Methods 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1516972.5 | 2015-09-25 | ||
| GBGB1516972.5A GB201516972D0 (en) | 2015-09-25 | 2015-09-25 | LRP5 as epigenetic marker for the identification of immune cells, in particular B-cells |
| PCT/EP2016/072579 WO2017050916A1 (en) | 2015-09-25 | 2016-09-22 | Lrp5 as epigenetic marker for the identification of immune cells, in particular b-cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018529345A JP2018529345A (ja) | 2018-10-11 |
| JP2018529345A5 true JP2018529345A5 (https=) | 2019-10-31 |
Family
ID=54544102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018515528A Pending JP2018529345A (ja) | 2015-09-25 | 2016-09-22 | 免疫細胞、特にｂ細胞の同定のためのエピジェネティックマーカーとしてのｌｒｐ５ |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11643687B2 (https=) |
| EP (1) | EP3353318B1 (https=) |
| JP (1) | JP2018529345A (https=) |
| CN (1) | CN108026578A (https=) |
| GB (1) | GB201516972D0 (https=) |
| HK (1) | HK1257122A1 (https=) |
| WO (1) | WO2017050916A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3652344A1 (en) * | 2017-07-13 | 2020-05-20 | Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. | Dna targets as tissue-specific methylation markers |
| WO2019184886A1 (zh) * | 2018-03-26 | 2019-10-03 | 上海原能细胞医学技术有限公司 | 促进免疫细胞增殖的方法 |
| DE102018112644B4 (de) * | 2018-05-25 | 2020-06-10 | Epiontis Gmbh | CXCR3 als epigenetischer Marker zur Identifizierung von inflammatorischen Immunzellen, insbesondere CD8+ Gedächnis-T-Zellen |
| DE102018116353B4 (de) * | 2018-07-05 | 2020-06-10 | Epiontis Gmbh | Verfahren zum Nachweis und zur Zählung epigenetischer Immunzellen in humanen Blutproben für Immundiagnostik und Neugeborenen-Screening |
| DE102020108560B4 (de) | 2020-03-27 | 2022-03-03 | Precision For Medicine Gmbh | CBX6 als epigenetischer Marker für die Identifizierung von Immunzellen, insbesondere Gedächtnis-B-Zellen |
| CN119372296B (zh) * | 2024-12-24 | 2025-06-13 | 北京致谱医学检验实验室有限公司 | 基于基因甲基化检测实现人b淋巴细胞计数的试剂盒 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60129433T2 (de) * | 2000-05-26 | 2008-04-17 | Oscient Pharmaceuticals Corp., Waltham | Regulation des lipidniveaus über die gene zmax1 oder hbm |
| DK1826279T3 (da) * | 2006-02-28 | 2011-09-05 | Charite Universitaetsmedizin | Detektering og kvalitetskontrol af regulatoriske t-celler vha. DNA-metyleringsanalyse af FoxP3--genet |
| CN101909630A (zh) * | 2007-11-02 | 2010-12-08 | 新加坡科技研究局 | 预防和治疗肿瘤的方法和化合物 |
| US20110104695A1 (en) * | 2009-11-05 | 2011-05-05 | Epigenomics Ag | Methods of predicting therapeutic efficacy of cancer therapy |
| WO2012045888A1 (en) * | 2010-10-08 | 2012-04-12 | Epiontis Gmbh | Method for determining cancer patient survival based on analyzing tumor-infiltrating overall t-lymphocytes |
| WO2013033627A2 (en) | 2011-09-01 | 2013-03-07 | The Regents Of The University Of California | Diagnosis and treatment of arthritis using epigenetics |
| US10208346B2 (en) * | 2013-04-19 | 2019-02-19 | Epiontis Gmbh | Method for identifying the quantitative cellular composition in a biological sample |
| ES2827241T3 (es) * | 2014-05-30 | 2021-05-20 | Robert Philibert | Estado de metilación del ADN como un biomarcador del consumo y la abstinencia del alcohol |
-
2015
- 2015-09-25 GB GBGB1516972.5A patent/GB201516972D0/en not_active Ceased
-
2016
- 2016-09-22 WO PCT/EP2016/072579 patent/WO2017050916A1/en not_active Ceased
- 2016-09-22 HK HK18116376.0A patent/HK1257122A1/zh unknown
- 2016-09-22 EP EP16770025.1A patent/EP3353318B1/en active Active
- 2016-09-22 US US15/752,072 patent/US11643687B2/en active Active
- 2016-09-22 CN CN201680052685.1A patent/CN108026578A/zh active Pending
- 2016-09-22 JP JP2018515528A patent/JP2018529345A/ja active Pending
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