CN108026578A - Lrp5作为用于鉴定免疫细胞特别是b细胞的表观遗传标志物 - Google Patents

Lrp5作为用于鉴定免疫细胞特别是b细胞的表观遗传标志物 Download PDF

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Publication number
CN108026578A
CN108026578A CN201680052685.1A CN201680052685A CN108026578A CN 108026578 A CN108026578 A CN 108026578A CN 201680052685 A CN201680052685 A CN 201680052685A CN 108026578 A CN108026578 A CN 108026578A
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cell
cells
seq
cpg
mammal
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Chinese (zh)
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斯文·欧莱克
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Precision for Medicine GmbH
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Epiontis GmbH
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6881—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for tissue or cell typing, e.g. human leukocyte antigen [HLA] probes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201680052685.1A 2015-09-25 2016-09-22 Lrp5作为用于鉴定免疫细胞特别是b细胞的表观遗传标志物 Pending CN108026578A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1516972.5A GB201516972D0 (en) 2015-09-25 2015-09-25 LRP5 as epigenetic marker for the identification of immune cells, in particular B-cells
GB1516972.5 2015-09-25
PCT/EP2016/072579 WO2017050916A1 (en) 2015-09-25 2016-09-22 Lrp5 as epigenetic marker for the identification of immune cells, in particular b-cells

Publications (1)

Publication Number Publication Date
CN108026578A true CN108026578A (zh) 2018-05-11

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CN201680052685.1A Pending CN108026578A (zh) 2015-09-25 2016-09-22 Lrp5作为用于鉴定免疫细胞特别是b细胞的表观遗传标志物

Country Status (7)

Country Link
US (1) US11643687B2 (https=)
EP (1) EP3353318B1 (https=)
JP (1) JP2018529345A (https=)
CN (1) CN108026578A (https=)
GB (1) GB201516972D0 (https=)
HK (1) HK1257122A1 (https=)
WO (1) WO2017050916A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119372296A (zh) * 2024-12-24 2025-01-28 北京致谱医学检验实验室有限公司 基于基因甲基化检测实现人b淋巴细胞计数的试剂盒

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3652344A1 (en) * 2017-07-13 2020-05-20 Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. Dna targets as tissue-specific methylation markers
US12005080B2 (en) 2018-03-26 2024-06-11 Oricell Therapeutics Co., Ltd. Method for promoting proliferation of immune cells
DE102018112644B4 (de) 2018-05-25 2020-06-10 Epiontis Gmbh CXCR3 als epigenetischer Marker zur Identifizierung von inflammatorischen Immunzellen, insbesondere CD8+ Gedächnis-T-Zellen
DE102018116353B4 (de) * 2018-07-05 2020-06-10 Epiontis Gmbh Verfahren zum Nachweis und zur Zählung epigenetischer Immunzellen in humanen Blutproben für Immundiagnostik und Neugeborenen-Screening
DE102020108560B4 (de) 2020-03-27 2022-03-03 Precision For Medicine Gmbh CBX6 als epigenetischer Marker für die Identifizierung von Immunzellen, insbesondere Gedächtnis-B-Zellen

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1444601A (zh) * 2000-05-26 2003-09-24 基因组治疗公司 通过Zmax1或HBM基因调节脂质水平
US20070269823A1 (en) * 2006-02-28 2007-11-22 Jochen Huehn Detection and quality control of regulatory T cells through DNA-methylation analysis of the Foxp3 gene
CN101909630A (zh) * 2007-11-02 2010-12-08 新加坡科技研究局 预防和治疗肿瘤的方法和化合物
US20110104695A1 (en) * 2009-11-05 2011-05-05 Epigenomics Ag Methods of predicting therapeutic efficacy of cancer therapy
WO2013033627A2 (en) * 2011-09-01 2013-03-07 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics
US20130260378A1 (en) * 2010-10-08 2013-10-03 Epiontis Gmbh Method for determining cancer patient survival based on analyzing tumorinfiltrating overall t-lymphocytes
WO2014170497A2 (en) * 2013-04-19 2014-10-23 Epiontis Gmbh Method for identifying the quantitative cellular composition in a biological sample

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EP3149206B1 (en) * 2014-05-30 2020-09-02 Robert Philibert Dna methylation status as a biomarker of alcohol use and abstinence

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1444601A (zh) * 2000-05-26 2003-09-24 基因组治疗公司 通过Zmax1或HBM基因调节脂质水平
US20070269823A1 (en) * 2006-02-28 2007-11-22 Jochen Huehn Detection and quality control of regulatory T cells through DNA-methylation analysis of the Foxp3 gene
CN101909630A (zh) * 2007-11-02 2010-12-08 新加坡科技研究局 预防和治疗肿瘤的方法和化合物
US20110104695A1 (en) * 2009-11-05 2011-05-05 Epigenomics Ag Methods of predicting therapeutic efficacy of cancer therapy
US20130260378A1 (en) * 2010-10-08 2013-10-03 Epiontis Gmbh Method for determining cancer patient survival based on analyzing tumorinfiltrating overall t-lymphocytes
WO2013033627A2 (en) * 2011-09-01 2013-03-07 The Regents Of The University Of California Diagnosis and treatment of arthritis using epigenetics
WO2014170497A2 (en) * 2013-04-19 2014-10-23 Epiontis Gmbh Method for identifying the quantitative cellular composition in a biological sample

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
COREY J CAIN等: ""Absence of Sclerostin Adversely Affects B-Cell Survival"", 《JBMR》 *
LEANNE K KUPERS等: ""DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring"", 《INTERNATIONAL JOURNAL OF EPIDEMIOLOGY》 *
MARKUS VIEWEG等: ""Methylation analysis of histone H4K12ac-associated promoters in sperm of healthy donors and subfertile patients"", 《CLINICAL EPIGENETICS》 *
MICHAEL T. BOCKER等: ""Genome-wide promoter DNAmethylation dynamics of human hematopoietic progenitor cells during differentiation and aging"", 《HEMATOPOIESIS AND STEM CELLS》 *
SONJA ZEILINGER等: ""Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation"", 《PLOS ONE》 *
曲琦等: ""经典Wnt信号通路在恶性淋巴瘤中的研究进展"", 《肿瘤》 *
董雷等: ""淋巴瘤发病机制与相关信号通路研究"", 《现代生物医学进展》 *
高永甫等: ""哺乳动物精原干细胞自我更新调控的研究进展"", 《中国细胞生物学学报》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119372296A (zh) * 2024-12-24 2025-01-28 北京致谱医学检验实验室有限公司 基于基因甲基化检测实现人b淋巴细胞计数的试剂盒

Also Published As

Publication number Publication date
GB201516972D0 (en) 2015-11-11
HK1257122A1 (zh) 2019-10-11
CA2999611A1 (en) 2017-03-30
US20180216185A1 (en) 2018-08-02
WO2017050916A1 (en) 2017-03-30
EP3353318B1 (en) 2021-03-10
JP2018529345A (ja) 2018-10-11
EP3353318A1 (en) 2018-08-01
US11643687B2 (en) 2023-05-09

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