JP2021502806A5 - - Google Patents
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- Publication number
- JP2021502806A5 JP2021502806A5 JP2020523795A JP2020523795A JP2021502806A5 JP 2021502806 A5 JP2021502806 A5 JP 2021502806A5 JP 2020523795 A JP2020523795 A JP 2020523795A JP 2020523795 A JP2020523795 A JP 2020523795A JP 2021502806 A5 JP2021502806 A5 JP 2021502806A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- cells
- region
- cpg
- methylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 17
- 210000001616 monocyte Anatomy 0.000 claims 10
- 230000011987 methylation Effects 0.000 claims 8
- 238000007069 methylation reaction Methods 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 6
- 230000010076 replication Effects 0.000 claims 5
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 4
- 210000004369 blood Anatomy 0.000 claims 4
- 239000008280 blood Substances 0.000 claims 4
- 238000012544 monitoring process Methods 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 239000012634 fragment Substances 0.000 claims 2
- 210000002443 helper t lymphocyte Anatomy 0.000 claims 2
- 210000000056 organ Anatomy 0.000 claims 2
- 230000003362 replicative effect Effects 0.000 claims 2
- 108091093088 Amplicon Proteins 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 108091029523 CpG island Proteins 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108700039691 Genetic Promoter Regions Proteins 0.000 claims 1
- 102100031181 Glyceraldehyde-3-phosphate dehydrogenase Human genes 0.000 claims 1
- 206010020751 Hypersensitivity Diseases 0.000 claims 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091036066 Three prime untranslated region Proteins 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 102000004142 Trypsin Human genes 0.000 claims 1
- 108090000631 Trypsin Proteins 0.000 claims 1
- 230000007815 allergy Effects 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 239000012620 biological material Substances 0.000 claims 1
- 238000001369 bisulfite sequencing Methods 0.000 claims 1
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 239000013068 control sample Substances 0.000 claims 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 230000017858 demethylation Effects 0.000 claims 1
- 238000010520 demethylation reaction Methods 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000001976 enzyme digestion Methods 0.000 claims 1
- 230000003325 follicular Effects 0.000 claims 1
- 108020004445 glyceraldehyde-3-phosphate dehydrogenase Proteins 0.000 claims 1
- 210000003714 granulocyte Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 210000004698 lymphocyte Anatomy 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 210000000822 natural killer cell Anatomy 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 230000005026 transcription initiation Effects 0.000 claims 1
- 238000012546 transfer Methods 0.000 claims 1
- 239000012588 trypsin Substances 0.000 claims 1
- 238000011144 upstream manufacturing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102017125335.1 | 2017-10-27 | ||
| DE102017125335.1A DE102017125335B4 (de) | 2017-10-27 | 2017-10-27 | Amplikon-Region als epigenetischer Marker zur Identifizierung von Immunzellen, insbesondere nicht-klassischer Monozyten |
| PCT/EP2018/079406 WO2019081707A1 (en) | 2017-10-27 | 2018-10-26 | AMPLICON REGION AS AN EPIGENETIC MARKER FOR THE IDENTIFICATION OF NON-CLASSIC MONOCYTES |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2021502806A JP2021502806A (ja) | 2021-02-04 |
| JP2021502806A5 true JP2021502806A5 (https=) | 2021-11-25 |
Family
ID=64024040
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020523795A Pending JP2021502806A (ja) | 2017-10-27 | 2018-10-26 | 免疫細胞、特に非古典的単球の同定のためのエピジェネティックマーカーとしての単位複製配列領域 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11680294B2 (https=) |
| EP (1) | EP3669001B1 (https=) |
| JP (1) | JP2021502806A (https=) |
| CN (1) | CN111247253A (https=) |
| AU (1) | AU2018356572A1 (https=) |
| CA (1) | CA3079477A1 (https=) |
| DE (1) | DE102017125335B4 (https=) |
| WO (1) | WO2019081707A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPWO2022191293A1 (https=) * | 2021-03-12 | 2022-09-15 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2869295A1 (en) | 2011-05-25 | 2012-11-29 | Brown University | Methods using dna methylation for identifying a cell or a mixture of cells for prognosis and diagnosis of diseases, and for cell remediation therapies |
| JP6590790B2 (ja) * | 2013-04-19 | 2019-10-16 | エピオンティス ゲーエムベーハー | 生体サンプルにおける定量的細胞組成を特定する方法 |
| CN105377273A (zh) * | 2013-05-22 | 2016-03-02 | 耶达研究与发展公司 | 用于治疗眼睛疾病或病症的人类单核细胞亚群 |
| GB201516975D0 (en) * | 2015-09-25 | 2015-11-11 | Epiontis Gmbh | PARK2 as epigenetic marker for the identification of immune cells, in particular monocytes |
-
2017
- 2017-10-27 DE DE102017125335.1A patent/DE102017125335B4/de active Active
-
2018
- 2018-10-26 US US16/758,992 patent/US11680294B2/en active Active
- 2018-10-26 CN CN201880068476.5A patent/CN111247253A/zh not_active Withdrawn
- 2018-10-26 JP JP2020523795A patent/JP2021502806A/ja active Pending
- 2018-10-26 WO PCT/EP2018/079406 patent/WO2019081707A1/en not_active Ceased
- 2018-10-26 EP EP18793655.4A patent/EP3669001B1/en active Active
- 2018-10-26 AU AU2018356572A patent/AU2018356572A1/en not_active Abandoned
- 2018-10-26 CA CA3079477A patent/CA3079477A1/en active Pending
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