JP2018528206A5 - - Google Patents
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- JP2018528206A5 JP2018528206A5 JP2018510877A JP2018510877A JP2018528206A5 JP 2018528206 A5 JP2018528206 A5 JP 2018528206A5 JP 2018510877 A JP2018510877 A JP 2018510877A JP 2018510877 A JP2018510877 A JP 2018510877A JP 2018528206 A5 JP2018528206 A5 JP 2018528206A5
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- JP
- Japan
- Prior art keywords
- combination
- inhibitor
- cancer
- pharmaceutically acceptable
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- CLRSLRWKONPSRQ-CPOWQTMSSA-N (1s)-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl-[[4-(4-methyl-3-oxopiperazin-1-yl)cyclohexyl]methyl]amino]phenyl]-7-propan-2-yloxy-1,4-dihydroisoquinolin-3-one Chemical compound C1([C@@H]2N(C(=O)CC=3C=C(C(=CC=32)OC(C)C)OC)C=2C=CC(=CC=2)N(C)CC2CCC(CC2)N2CC(=O)N(C)CC2)=CC=C(Cl)C=C1 CLRSLRWKONPSRQ-CPOWQTMSSA-N 0.000 claims description 6
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- FIMYFEGKMOCQKT-UHFFFAOYSA-N 3,4-difluoro-2-(2-fluoro-4-iodoanilino)-n-(2-hydroxyethoxy)-5-[(3-oxooxazinan-2-yl)methyl]benzamide Chemical compound FC=1C(F)=C(NC=2C(=CC(I)=CC=2)F)C(C(=O)NOCCO)=CC=1CN1OCCCC1=O FIMYFEGKMOCQKT-UHFFFAOYSA-N 0.000 claims description 3
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- MWUFVYLAWAXDHQ-HMNLTAHHSA-N (2e,5s,6s,8z,10r,11s)-17-(ethylamino)-5,6,15-trihydroxy-10,11-dimethyl-12-oxabicyclo[12.4.0]octadeca-1(18),2,8,14,16-pentaene-7,13-dione Chemical compound O([C@@H](C)[C@H](C)\C=C/C(=O)[C@@H](O)[C@@H](O)C/C=C/1)C(=O)C=2C\1=CC(NCC)=CC=2O MWUFVYLAWAXDHQ-HMNLTAHHSA-N 0.000 claims description 2
- YABJJWZLRMPFSI-UHFFFAOYSA-N 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-2-benzimidazolamine Chemical group N=1C2=CC(OC=3C=C(N=CC=3)C=3NC(=CN=3)C(F)(F)F)=CC=C2N(C)C=1NC1=CC=C(C(F)(F)F)C=C1 YABJJWZLRMPFSI-UHFFFAOYSA-N 0.000 claims description 2
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- ACWZRVQXLIRSDF-UHFFFAOYSA-N binimetinib Chemical compound OCCONC(=O)C=1C=C2N(C)C=NC2=C(F)C=1NC1=CC=C(Br)C=C1F ACWZRVQXLIRSDF-UHFFFAOYSA-N 0.000 claims 1
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Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562211080P | 2015-08-28 | 2015-08-28 | |
| US62/211,080 | 2015-08-28 | ||
| US201562243337P | 2015-10-19 | 2015-10-19 | |
| US62/243,337 | 2015-10-19 | ||
| US201562250574P | 2015-11-04 | 2015-11-04 | |
| US62/250,574 | 2015-11-04 | ||
| PCT/IB2016/055050 WO2017037579A1 (en) | 2015-08-28 | 2016-08-24 | Mdm2 inhibitors and combinations thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020190870A Division JP2021042222A (ja) | 2015-08-28 | 2020-11-17 | Ｍｄｍ２阻害剤およびその組み合わせ物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018528206A JP2018528206A (ja) | 2018-09-27 |
| JP2018528206A5 true JP2018528206A5 (enExample) | 2019-10-03 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018510877A Pending JP2018528206A (ja) | 2015-08-28 | 2016-08-24 | Ｍｄｍ２阻害剤およびその組み合わせ物 |
| JP2020190870A Pending JP2021042222A (ja) | 2015-08-28 | 2020-11-17 | Ｍｄｍ２阻害剤およびその組み合わせ物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020190870A Pending JP2021042222A (ja) | 2015-08-28 | 2020-11-17 | Ｍｄｍ２阻害剤およびその組み合わせ物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US20190060309A1 (enExample) |
| EP (2) | EP4241850A3 (enExample) |
| JP (2) | JP2018528206A (enExample) |
| KR (1) | KR20180041677A (enExample) |
| CN (2) | CN111821306A (enExample) |
| AU (2) | AU2016314082B2 (enExample) |
| CA (1) | CA2992221C (enExample) |
| ES (1) | ES2962460T3 (enExample) |
| IL (2) | IL257015B (enExample) |
| RU (2) | RU2740091C2 (enExample) |
| WO (1) | WO2017037579A1 (enExample) |
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| TW201613576A (en) | 2014-06-26 | 2016-04-16 | Novartis Ag | Intermittent dosing of MDM2 inhibitor |
| AU2017345574A1 (en) | 2016-10-19 | 2019-05-23 | United States Government As Represented By The Department Of Veterans Affairs | Compositions and methods for treating cancer |
| MX393780B (es) | 2017-01-17 | 2025-03-24 | Heparegenix Gmbh | Inhibidores de proteina cinasa para promover la regeneracion hepatica o reducir o prevenir la muerte de hepatocitos |
| WO2018183762A1 (en) * | 2017-03-29 | 2018-10-04 | United States Government As Represented By The Department Of Veterans Affairs | Methods and compositions for treating cancer |
| EP3600326B1 (en) * | 2017-03-31 | 2023-01-25 | Novartis AG | Dose and regimen for an hdm2-p53 interaction inhibitor in hematological tumors |
| WO2019040511A1 (en) * | 2017-08-22 | 2019-02-28 | University Of Maryland Batimore | DOUBLE INHIBITORS OF BCL-2 AND HDM2 FAMILIES BY CO-MIMETTISM OF ALPHA BH3 AND P53 PROPELLERS |
| JP2020536855A (ja) * | 2017-09-26 | 2020-12-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | がんを治療するための組成物及び方法 |
| US11406627B2 (en) | 2017-10-12 | 2022-08-09 | Novartis Ag | Combinations of MDM2 inhibitors with inhibitors of ERK for treating cancers |
| AU2018395543A1 (en) * | 2017-12-31 | 2020-07-23 | Evergreen Biosciences | Compositions for cryopreservation and methods of use thereof |
| JP7358372B2 (ja) * | 2018-03-12 | 2023-10-10 | 羅欣薬業（上海）有限公司 | イミダゾピロロン化合物及びその使用 |
| US20210363254A1 (en) * | 2018-03-20 | 2021-11-25 | Novartis Ag | Pharmaceutical combinations |
| EP3672594B1 (en) * | 2018-07-31 | 2021-09-29 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of bcl-2 inhibitor and mdm2 inhibitor and use thereof in the prevention and/or treatment of diseases |
| CN110772640B (zh) | 2018-07-31 | 2023-02-03 | 苏州亚盛药业有限公司 | Bcl-2抑制剂与利妥昔单抗和/或苯达莫司汀或与CHOP联合的协同抗肿瘤作用 |
| EP3672595B1 (en) | 2018-07-31 | 2021-07-21 | Ascentage Pharma (Suzhou) Co., Ltd. | Combination product of bcl-2 inhibitor and chemotherapeutic agent and use thereof in the prevention and/or treatment of diseases |
| CN114522167A (zh) | 2018-07-31 | 2022-05-24 | 苏州亚盛药业有限公司 | Bcl-2抑制剂或Bcl-2/Bcl-xL抑制剂与BTK抑制剂的组合产品及其用途 |
| CA3123356A1 (en) | 2018-12-20 | 2020-06-25 | Novartis Ag | Combinations of a hdm2-p53 interaction inhibitor and a bcl2 inhibitor and their use for treating cancer |
| TW202118488A (zh) * | 2019-07-26 | 2021-05-16 | 大陸商蘇州亞盛藥業有限公司 | Mdm2抑制劑的藥物組合物及其在預防和/或治療疾病中的用途 |
| US12343352B2 (en) | 2019-12-03 | 2025-07-01 | Ascentage Pharma (Suzhou) Co., Ltd. | N-(phenylsulfonyl)benzamides and related compounds as Bcl-2 inhibitors |
| JP2023531375A (ja) * | 2020-05-26 | 2023-07-24 | ハンミ ファーム．カンパニー リミテッド | がん治療における使用のためのベルバラフェニブ |
| CN115124533A (zh) * | 2021-03-26 | 2022-09-30 | 浙江海正药业股份有限公司 | 四环类衍生物、其制备方法和其医药上的用途 |
| JP2024157057A (ja) * | 2021-06-29 | 2024-11-07 | 国立大学法人 東京大学 | バレット食道の治療用組成物 |
| CN117562907B (zh) * | 2023-11-17 | 2025-08-22 | 广州医科大学 | 一种提升抗癌效果的可口服吉非替尼复合物及其制备方法与应用 |
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| CA2416685C (en) | 2000-07-19 | 2008-10-07 | Warner-Lambert Company | Oxygenated esters of 4-iodo phenylamino benzhydroxamic acids |
| DE60330227D1 (de) | 2002-03-13 | 2010-01-07 | Array Biopharma Inc | N3-alkylierte benzimidazol-derivate als mek-hemmer |
| JP4163738B2 (ja) | 2004-06-11 | 2008-10-08 | 日本たばこ産業株式会社 | 癌の治療用の５−アミノ−２，４，７−トリオキソ−３，４，７，８−テトラヒドロ−２Ｈ−ピリド’２，３−ｄ！ピリミジン誘導体及び関連化合物 |
| US8299076B2 (en) | 2005-05-18 | 2012-10-30 | Array Biopharma Inc. | Crystalline forms of 2-(2-flouro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| UA104147C2 (uk) | 2008-09-10 | 2014-01-10 | Новартис Аг | Похідна піролідиндикарбонової кислоти та її застосування у лікуванні проліферативних захворювань |
| EP2370566A1 (en) * | 2008-12-03 | 2011-10-05 | Università Degli Studi Di Torino | Isogenic human cell lines comprising mutated cancer alleles and process using the cell lines |
| CU24130B1 (es) | 2009-12-22 | 2015-09-29 | Novartis Ag | Isoquinolinonas y quinazolinonas sustituidas |
| US8440693B2 (en) | 2009-12-22 | 2013-05-14 | Novartis Ag | Substituted isoquinolinones and quinazolinones |
| US8859535B2 (en) * | 2011-06-20 | 2014-10-14 | Novartis Ag | Hydroxy substituted isoquinolinone derivatives |
| WO2012178038A1 (en) * | 2011-06-24 | 2012-12-27 | The Broad Institute, Inc. | Methods of treating cancer |
| US8815926B2 (en) * | 2012-01-26 | 2014-08-26 | Novartis Ag | Substituted pyrrolo[3,4-D]imidazoles for the treatment of MDM2/4 mediated diseases |
| EP2752191A1 (en) * | 2013-01-07 | 2014-07-09 | Sanofi | Compositions and methods using hdm2 antagonist and mek inhibitor |
| MX391859B (es) * | 2013-11-11 | 2025-03-12 | Amgen Inc | Terapia de combinacion que incluye un inhibidor mdm2 y uno o mas agentes farmaceuticamente activos adicionales para el tratamiento de canceres |
| TW201605450A (zh) * | 2013-12-03 | 2016-02-16 | 諾華公司 | Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途 |
| WO2015095834A2 (en) * | 2013-12-20 | 2015-06-25 | Biomed Valley Discoveries, Inc. | Cancer treatments using erk1/2 and bcl-2 family inhibitors |
| RU2016129953A (ru) | 2013-12-23 | 2018-01-30 | Новартис Аг | Фармацевтические комбинации |
-
2016
- 2016-08-24 ES ES16760803T patent/ES2962460T3/es active Active
- 2016-08-24 CN CN202010783071.9A patent/CN111821306A/zh not_active Withdrawn
- 2016-08-24 KR KR1020187005360A patent/KR20180041677A/ko not_active Ceased
- 2016-08-24 WO PCT/IB2016/055050 patent/WO2017037579A1/en not_active Ceased
- 2016-08-24 US US15/756,094 patent/US20190060309A1/en not_active Abandoned
- 2016-08-24 RU RU2018110770A patent/RU2740091C2/ru active
- 2016-08-24 JP JP2018510877A patent/JP2018528206A/ja active Pending
- 2016-08-24 EP EP23177095.9A patent/EP4241850A3/en not_active Withdrawn
- 2016-08-24 RU RU2020142739A patent/RU2020142739A/ru unknown
- 2016-08-24 AU AU2016314082A patent/AU2016314082B2/en not_active Ceased
- 2016-08-24 CA CA2992221A patent/CA2992221C/en active Active
- 2016-08-24 EP EP16760803.3A patent/EP3340989B1/en not_active Revoked
- 2016-08-24 CN CN201680062336.8A patent/CN108348520A/zh active Pending
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2018
- 2018-01-18 IL IL257015A patent/IL257015B/en unknown
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2019
- 2019-07-09 AU AU2019204938A patent/AU2019204938B2/en not_active Ceased
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2020
- 2020-09-09 IL IL277239A patent/IL277239B/en unknown
- 2020-11-17 JP JP2020190870A patent/JP2021042222A/ja active Pending
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2021
- 2021-03-01 US US17/188,726 patent/US20210260059A1/en not_active Abandoned
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2023
- 2023-01-13 US US18/154,717 patent/US20230398115A1/en not_active Abandoned
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