JP2018528175A - 経皮送達系 - Google Patents

経皮送達系 Download PDF

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Publication number
JP2018528175A
JP2018528175A JP2018504666A JP2018504666A JP2018528175A JP 2018528175 A JP2018528175 A JP 2018528175A JP 2018504666 A JP2018504666 A JP 2018504666A JP 2018504666 A JP2018504666 A JP 2018504666A JP 2018528175 A JP2018528175 A JP 2018528175A
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JP
Japan
Prior art keywords
hours
plasma concentration
dihydroetorphine
patch
average
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2018504666A
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English (en)
Japanese (ja)
Other versions
JP2018528175A5 (enExample
Inventor
スティーヴ・ホワイトロック
デボラ・フィリス・ハーディング
ヘレン・ジョンソン
ケヴィン・スミス
ギル・マンディン
Original Assignee
ユーロ−セルティーク エス．エイ．
ユーロ−セルティーク エス．エイ．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ユーロ−セルティーク エス．エイ．, ユーロ−セルティーク エス．エイ． filed Critical ユーロ−セルティーク エス．エイ．
Publication of JP2018528175A publication Critical patent/JP2018528175A/ja
Publication of JP2018528175A5 publication Critical patent/JP2018528175A5/ja
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2018504666A 2015-07-30 2016-07-28 経皮送達系 Pending JP2018528175A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB1513441.4A GB201513441D0 (en) 2015-07-30 2015-07-30 Transdermal delivery system
GB1513441.4 2015-07-30
PCT/GB2016/052307 WO2017017452A1 (en) 2015-07-30 2016-07-28 Transdermal delivery system

Publications (2)

Publication Number Publication Date
JP2018528175A true JP2018528175A (ja) 2018-09-27
JP2018528175A5 JP2018528175A5 (enExample) 2019-09-12

Family

ID=54062902

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2018504666A Pending JP2018528175A (ja) 2015-07-30 2016-07-28 経皮送達系

Country Status (16)

Country Link
US (1) US20180221299A1 (enExample)
EP (1) EP3328431A1 (enExample)
JP (1) JP2018528175A (enExample)
KR (1) KR20180035859A (enExample)
CN (1) CN108025077A (enExample)
AR (1) AR105533A1 (enExample)
AU (1) AU2016298761A1 (enExample)
BR (1) BR112018001615A2 (enExample)
CA (1) CA2994103A1 (enExample)
GB (1) GB201513441D0 (enExample)
IL (1) IL256995A (enExample)
MA (1) MA42521A (enExample)
MX (1) MX2018001318A (enExample)
SG (1) SG10201913254RA (enExample)
TW (1) TW201713340A (enExample)
WO (1) WO2017017452A1 (enExample)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10231248A (ja) * 1997-02-19 1998-09-02 T T S Gijutsu Kenkyusho:Kk ジヒドロエトルフィン含有経皮吸収型製剤
US20020010127A1 (en) * 2000-02-08 2002-01-24 Benjamin Oshlack Controlled-release compositions containing opioid agonist and antagonist
US20050002997A1 (en) * 2003-04-30 2005-01-06 Howard Stephen A. Tamper resistant transdermal dosage form

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI541246B (zh) * 2008-12-08 2016-07-11 歐陸斯迪公司 二氫羥戊甲嗎啡

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10231248A (ja) * 1997-02-19 1998-09-02 T T S Gijutsu Kenkyusho:Kk ジヒドロエトルフィン含有経皮吸収型製剤
US20020010127A1 (en) * 2000-02-08 2002-01-24 Benjamin Oshlack Controlled-release compositions containing opioid agonist and antagonist
US20050002997A1 (en) * 2003-04-30 2005-01-06 Howard Stephen A. Tamper resistant transdermal dosage form

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
J. PHARM. PHARMACOL., vol. 52, JPN6020018743, 2000, pages 1437 - 1449, ISSN: 0004278923 *

Also Published As

Publication number Publication date
EP3328431A1 (en) 2018-06-06
CN108025077A (zh) 2018-05-11
US20180221299A1 (en) 2018-08-09
AR105533A1 (es) 2017-10-11
BR112018001615A2 (pt) 2018-09-18
SG10201913254RA (en) 2020-03-30
MA42521A (fr) 2018-06-06
GB201513441D0 (en) 2015-09-16
KR20180035859A (ko) 2018-04-06
WO2017017452A1 (en) 2017-02-02
MX2018001318A (es) 2018-08-15
IL256995A (en) 2018-03-29
AU2016298761A1 (en) 2018-02-15
CA2994103A1 (en) 2017-02-02
TW201713340A (zh) 2017-04-16

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