JP2018527005A5 - - Google Patents
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- Publication number
- JP2018527005A5 JP2018527005A5 JP2018514376A JP2018514376A JP2018527005A5 JP 2018527005 A5 JP2018527005 A5 JP 2018527005A5 JP 2018514376 A JP2018514376 A JP 2018514376A JP 2018514376 A JP2018514376 A JP 2018514376A JP 2018527005 A5 JP2018527005 A5 JP 2018527005A5
- Authority
- JP
- Japan
- Prior art keywords
- human mammal
- eif2s3y
- uty
- ddx3y
- expression
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims description 187
- 238000000034 method Methods 0.000 claims description 140
- 101150077884 Eif2s3y gene Proteins 0.000 claims description 93
- 230000000694 effects Effects 0.000 claims description 77
- 239000002609 medium Substances 0.000 claims description 68
- 239000007640 basal medium Substances 0.000 claims description 43
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 40
- 210000001161 mammalian embryo Anatomy 0.000 claims description 33
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 24
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims description 20
- 239000011780 sodium chloride Substances 0.000 claims description 20
- 241000283984 Rodentia Species 0.000 claims description 16
- 229910052783 alkali metal Inorganic materials 0.000 claims description 16
- 150000001340 alkali metals Chemical class 0.000 claims description 16
- -1 halide salts Chemical class 0.000 claims description 16
- 238000003556 assay Methods 0.000 claims description 15
- 150000001875 compounds Chemical class 0.000 claims description 15
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 12
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 12
- 108020004999 messenger RNA Proteins 0.000 claims description 10
- 238000012258 culturing Methods 0.000 claims description 8
- 230000001135 feminizing effect Effects 0.000 claims description 7
- 230000001568 sexual effect Effects 0.000 claims description 7
- 239000000654 additive Substances 0.000 claims description 6
- 210000002459 blastocyst Anatomy 0.000 claims description 6
- 238000009395 breeding Methods 0.000 claims description 6
- 230000001488 breeding effect Effects 0.000 claims description 6
- 238000012239 gene modification Methods 0.000 claims description 6
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 claims description 4
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical group [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 claims description 4
- 210000002593 Y chromosome Anatomy 0.000 claims description 4
- 230000000996 additive effect Effects 0.000 claims description 4
- 229910001508 alkali metal halide Inorganic materials 0.000 claims description 4
- 150000004820 halides Chemical class 0.000 claims description 4
- 108090000623 proteins and genes Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 4
- 206010049290 Feminisation acquired Diseases 0.000 claims description 3
- 208000034793 Feminization Diseases 0.000 claims description 3
- 230000003247 decreasing effect Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 230000035772 mutation Effects 0.000 claims description 2
- 238000012216 screening Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 description 7
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 239000012533 medium component Substances 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 241000124008 Mammalia Species 0.000 description 2
- 230000005017 genetic modification Effects 0.000 description 2
- 235000013617 genetically modified food Nutrition 0.000 description 2
- 210000000472 morula Anatomy 0.000 description 2
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562219927P | 2015-09-17 | 2015-09-17 | |
| US62/219,927 | 2015-09-17 | ||
| PCT/US2016/052345 WO2017049240A1 (en) | 2015-09-17 | 2016-09-16 | Selection of pluripotent cells for production of fertile xy female mice |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018527005A JP2018527005A (ja) | 2018-09-20 |
| JP2018527005A5 true JP2018527005A5 (cg-RX-API-DMAC7.html) | 2019-10-10 |
| JP6868615B2 JP6868615B2 (ja) | 2021-05-12 |
Family
ID=57113699
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018514376A Active JP6868615B2 (ja) | 2015-09-17 | 2016-09-16 | 繁殖可能なｘｙ雌マウスを生成するための多能性細胞の選択 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10893666B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3349573A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6868615B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102382458B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN108697068B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2016324305B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2998642C (cg-RX-API-DMAC7.html) |
| HK (1) | HK1256687A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL257982B2 (cg-RX-API-DMAC7.html) |
| MX (1) | MX388475B (cg-RX-API-DMAC7.html) |
| RU (1) | RU2729407C1 (cg-RX-API-DMAC7.html) |
| SG (1) | SG10201913789VA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017049240A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10893666B2 (en) | 2015-09-17 | 2021-01-19 | Regeneron Pharmaceuticals, Inc. | Production of fertile XY female animals by silencing of genes on the Y chromosome |
| CN108998540A (zh) * | 2018-08-18 | 2018-12-14 | 兰州大学 | 绵羊eif2s3y基因的单核苷酸多态性标记及其检测引物、试剂盒、方法及应用 |
| CN110656167A (zh) * | 2019-09-27 | 2020-01-07 | 中国科学院苏州生物医学工程技术研究所 | 用于y染色体微缺失检测的引物组、试剂盒及基于数字pcr的检测方法 |
| CN111321232B (zh) * | 2020-03-18 | 2022-08-16 | 西北农林科技大学 | 一种快速检测肉牛eif4a2基因拷贝数变异的方法及其应用 |
| CN113558012A (zh) * | 2021-08-05 | 2021-10-29 | 陈米米 | 一种哺乳动物繁育雌性多胎的方法 |
| CN114015705A (zh) * | 2021-11-28 | 2022-02-08 | 华中科技大学同济医学院附属协和医院 | 一种小鼠体外受精繁育性别选择方法 |
| CN115251007B (zh) * | 2022-09-02 | 2024-01-26 | 山西医科大学 | 一种新品系裸大鼠、其培育方法及应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2892997A (en) | 1996-04-29 | 1997-11-19 | Leuven Research & Development Vzw | Pluripotent rabbit embryonic stem (es) cell lines and their use in the generation of chimeric rabbits |
| EP1067141A1 (en) | 1999-06-11 | 2001-01-10 | Rijksuniversiteit te Leiden | A male-specific protein homologue involved in histocompatibility |
| EP1227719A4 (en) | 1999-11-02 | 2003-01-15 | Univ Massachusetts | USE OF HAPLOID GENOMES FOR GENETIC DIAGNOSIS, MODIFICATION AND MULTIPLICATION |
| JP2003517317A (ja) | 1999-12-20 | 2003-05-27 | ペリー、アンソニー、シー．エフ． | 培養細胞からクローン化胚及び成体を作製する方法 |
| WO2003071869A1 (fr) | 2002-02-27 | 2003-09-04 | Yasumitsu Nagao | Procede de construction d'animal chimere a lignee germinale |
| AU2003210405A1 (en) | 2002-03-05 | 2003-09-16 | Artemis Pharmaceuticals Gmbh | Inbred embryonic stem-cell derived mice |
| EP1516924A1 (en) | 2003-09-17 | 2005-03-23 | Fundacion IVI para el Estudio de la reproduccion Humana (FIVIER) | Generation of human embryonic stem cells from triploid zygotes |
| CA2560581C (en) | 2004-03-23 | 2013-06-11 | Toshihiro Akaike | Pluripotent stem cell growing method |
| PL1802193T3 (pl) | 2004-10-19 | 2014-09-30 | Regeneron Pharma | Sposób wytwarzania myszy homozygotycznej pod względem modyfikacji genetycznej |
| CA2660035A1 (en) | 2006-08-09 | 2008-02-14 | Vivalis | Method of production of transgenic avian using embryonic stem cells |
| GB0623635D0 (en) | 2006-11-27 | 2007-01-03 | Stem Cell Sciences Uk Ltd | Pluripotent cell growth media |
| WO2009037337A1 (en) | 2007-09-20 | 2009-03-26 | Novartis Ag | Robust and tissue independent gender-specific transcript markers for molecular gender determination |
| CA2751596A1 (en) | 2009-02-08 | 2010-08-12 | The University Of Melbourne | Sex-determination and methods of specifying same |
| WO2011044684A1 (en) | 2009-10-13 | 2011-04-21 | Stemcell Technologies Inc. | Manipulation of osmolality for differentiating stem cells |
| CN102933074B (zh) * | 2010-06-11 | 2015-04-08 | 瑞泽恩制药公司 | 由xy es细胞制备能育的xy雌性动物 |
| WO2012022634A1 (en) * | 2010-08-16 | 2012-02-23 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Classification, diagnosis and prognosis of multiple myeloma |
| EP3461885B1 (en) * | 2014-06-26 | 2021-10-20 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for targeted genetic modifications and methods of use |
| JP2017536811A (ja) | 2014-10-15 | 2017-12-14 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 多能性細胞の樹立又は維持のための方法及び組成物 |
| US10893666B2 (en) | 2015-09-17 | 2021-01-19 | Regeneron Pharmaceuticals, Inc. | Production of fertile XY female animals by silencing of genes on the Y chromosome |
-
2016
- 2016-09-16 US US15/268,452 patent/US10893666B2/en active Active
- 2016-09-16 WO PCT/US2016/052345 patent/WO2017049240A1/en not_active Ceased
- 2016-09-16 MX MX2018003354A patent/MX388475B/es unknown
- 2016-09-16 SG SG10201913789VA patent/SG10201913789VA/en unknown
- 2016-09-16 CA CA2998642A patent/CA2998642C/en active Active
- 2016-09-16 RU RU2018113330A patent/RU2729407C1/ru active
- 2016-09-16 CN CN201680067024.6A patent/CN108697068B/zh active Active
- 2016-09-16 JP JP2018514376A patent/JP6868615B2/ja active Active
- 2016-09-16 AU AU2016324305A patent/AU2016324305B2/en active Active
- 2016-09-16 KR KR1020187009166A patent/KR102382458B1/ko active Active
- 2016-09-16 HK HK18115672.3A patent/HK1256687A1/zh unknown
- 2016-09-16 EP EP16778528.6A patent/EP3349573A1/en active Pending
-
2018
- 2018-03-08 IL IL257982A patent/IL257982B2/en unknown
-
2020
- 2020-12-11 US US17/119,076 patent/US12041918B2/en active Active
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