JP2018526420A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018526420A5 JP2018526420A5 JP2018513004A JP2018513004A JP2018526420A5 JP 2018526420 A5 JP2018526420 A5 JP 2018526420A5 JP 2018513004 A JP2018513004 A JP 2018513004A JP 2018513004 A JP2018513004 A JP 2018513004A JP 2018526420 A5 JP2018526420 A5 JP 2018526420A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclopentyl
- phenyl
- hydroxyacetoxy
- methylpyrrolidinium bromide
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims description 66
- 150000001875 compounds Chemical class 0.000 claims description 62
- BYLYKBTVPVGVIU-UHFFFAOYSA-M [1-(2-methoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] 2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide Chemical compound [Br-].C1[N+](CC(=O)OC)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 BYLYKBTVPVGVIU-UHFFFAOYSA-M 0.000 claims description 49
- FIAFMTCUJCWADZ-UHFFFAOYSA-M [1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] 2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide Chemical compound [Br-].C1[N+](CC(=O)OCC)(C)CCC1OC(=O)C(O)(C=1C=CC=CC=1)C1CCCC1 FIAFMTCUJCWADZ-UHFFFAOYSA-M 0.000 claims description 48
- 206010039424 Salivary hypersecretion Diseases 0.000 claims description 17
- 229920000858 Cyclodextrin Polymers 0.000 claims description 12
- 208000008630 Sialorrhea Diseases 0.000 claims description 11
- 210000000214 mouth Anatomy 0.000 claims description 11
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 9
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 9
- FIAFMTCUJCWADZ-NRQRHMLOSA-M [1-(2-ethoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] (2r)-2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide Chemical compound [Br-].C1[N+](CC(=O)OCC)(C)CCC1OC(=O)[C@](O)(C=1C=CC=CC=1)C1CCCC1 FIAFMTCUJCWADZ-NRQRHMLOSA-M 0.000 claims description 7
- BYLYKBTVPVGVIU-MZXPGCLASA-M [1-(2-methoxy-2-oxoethyl)-1-methylpyrrolidin-1-ium-3-yl] (2r)-2-cyclopentyl-2-hydroxy-2-phenylacetate;bromide Chemical compound [Br-].C1[N+](CC(=O)OC)(C)CCC1OC(=O)[C@](O)(C=1C=CC=CC=1)C1CCCC1 BYLYKBTVPVGVIU-MZXPGCLASA-M 0.000 claims description 7
- 231100000252 nontoxic Toxicity 0.000 claims description 6
- 230000003000 nontoxic effect Effects 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 4
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims description 4
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims description 4
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 4
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 4
- 230000003232 mucoadhesive effect Effects 0.000 claims description 4
- 208000026451 salivation Diseases 0.000 claims description 4
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- YZOUYRAONFXZSI-SBHWVFSVSA-N (1S,3R,5R,6R,8R,10R,11R,13R,15R,16R,18R,20R,21R,23R,25R,26R,28R,30R,31S,33R,35R,36R,37S,38R,39S,40R,41S,42R,43S,44R,45S,46R,47S,48R,49S)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-37,39,40,41,42,43,44,45,46,47,48,49-dodecamethoxy-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,38-diol Chemical compound O([C@@H]([C@H]([C@@H]1OC)OC)O[C@H]2[C@@H](O)[C@@H]([C@@H](O[C@@H]3[C@@H](CO)O[C@@H]([C@H]([C@@H]3O)OC)O[C@@H]3[C@@H](CO)O[C@@H]([C@H]([C@@H]3OC)OC)O[C@@H]3[C@@H](CO)O[C@@H]([C@H]([C@@H]3OC)OC)O[C@@H]3[C@@H](CO)O[C@@H]([C@H]([C@@H]3OC)OC)O3)O[C@@H]2CO)OC)[C@H](CO)[C@H]1O[C@@H]1[C@@H](OC)[C@H](OC)[C@H]3[C@@H](CO)O1 YZOUYRAONFXZSI-SBHWVFSVSA-N 0.000 claims description 2
- PCWPQSDFNIFUPO-VDQKLNDWSA-N (1S,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21S,23R,25R,26S,28R,30R,31S,33R,35R,36R,37S,38R,39S,40R,41S,42R,43S,44R,45S,46R,47S,48R,49S)-37,39,41,43,45,47,49-heptakis(2-hydroxyethoxy)-5,10,15,20,25,30,35-heptakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontane-36,38,40,42,44,46,48-heptol Chemical compound OCCO[C@H]1[C@H](O)[C@@H]2O[C@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@H](CO)[C@@H](O[C@H]5O[C@H](CO)[C@@H](O[C@H]6O[C@H](CO)[C@@H](O[C@H]7O[C@H](CO)[C@@H](O[C@H]8O[C@H](CO)[C@@H](O[C@H]1O[C@@H]2CO)[C@@H](O)[C@@H]8OCCO)[C@@H](O)[C@@H]7OCCO)[C@@H](O)[C@@H]6OCCO)[C@@H](O)[C@@H]5OCCO)[C@@H](O)[C@@H]4OCCO)[C@@H](O)[C@@H]3OCCO PCWPQSDFNIFUPO-VDQKLNDWSA-N 0.000 claims description 2
- 229920001450 Alpha-Cyclodextrin Polymers 0.000 claims description 2
- 239000001116 FEMA 4028 Substances 0.000 claims description 2
- JVFGXECLSQXABC-UHFFFAOYSA-N ac1l3obq Chemical compound O1C(C(C2O)O)C(COCC(C)O)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC(C(O)C2O)C(COCC(O)C)OC2OC(C(C2O)O)C(COCC(C)O)OC2OC2C(O)C(O)C1OC2COCC(C)O JVFGXECLSQXABC-UHFFFAOYSA-N 0.000 claims description 2
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 claims description 2
- 229940043377 alpha-cyclodextrin Drugs 0.000 claims description 2
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims description 2
- 229960004853 betadex Drugs 0.000 claims description 2
- 229940002226 buccal film Drugs 0.000 claims description 2
- 235000009508 confectionery Nutrition 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims description 2
- 239000008203 oral pharmaceutical composition Substances 0.000 claims description 2
- 239000000725 suspension Substances 0.000 claims description 2
- ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims description 2
- 238000000034 method Methods 0.000 description 13
- -1 2-cyclopentyl-2-phenyl-2-hydroxyacetoxy Chemical group 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562217362P | 2015-09-11 | 2015-09-11 | |
| US62/217,362 | 2015-09-11 | ||
| PCT/US2016/050385 WO2017044412A1 (en) | 2015-09-11 | 2016-09-06 | Methods and compositions for soft anticholinergic esters |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020171891A Division JP2021001238A (ja) | 2015-09-11 | 2020-10-12 | 低中毒性抗コリン作動性エステルのための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018526420A JP2018526420A (ja) | 2018-09-13 |
| JP2018526420A5 true JP2018526420A5 (cg-RX-API-DMAC7.html) | 2019-10-10 |
| JP7270958B2 JP7270958B2 (ja) | 2023-05-11 |
Family
ID=58239861
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018513004A Active JP7270958B2 (ja) | 2015-09-11 | 2016-09-06 | 低中毒性抗コリン作動性エステルのための方法および組成物 |
| JP2020171891A Withdrawn JP2021001238A (ja) | 2015-09-11 | 2020-10-12 | 低中毒性抗コリン作動性エステルのための方法および組成物 |
| JP2022113088A Active JP7723417B2 (ja) | 2015-09-11 | 2022-07-14 | 低中毒性抗コリン作動性エステルのための方法および組成物 |
| JP2023154001A Pending JP2023164671A (ja) | 2015-09-11 | 2023-09-20 | 低中毒性抗コリン作動性エステルのための方法および組成物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020171891A Withdrawn JP2021001238A (ja) | 2015-09-11 | 2020-10-12 | 低中毒性抗コリン作動性エステルのための方法および組成物 |
| JP2022113088A Active JP7723417B2 (ja) | 2015-09-11 | 2022-07-14 | 低中毒性抗コリン作動性エステルのための方法および組成物 |
| JP2023154001A Pending JP2023164671A (ja) | 2015-09-11 | 2023-09-20 | 低中毒性抗コリン作動性エステルのための方法および組成物 |
Country Status (12)
| Country | Link |
|---|---|
| US (3) | US11534422B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3347007B1 (cg-RX-API-DMAC7.html) |
| JP (4) | JP7270958B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR102889909B1 (cg-RX-API-DMAC7.html) |
| CN (4) | CN118021797A (cg-RX-API-DMAC7.html) |
| AU (2) | AU2016318595B2 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2942361T3 (cg-RX-API-DMAC7.html) |
| IL (1) | IL257970B (cg-RX-API-DMAC7.html) |
| MX (1) | MX388831B (cg-RX-API-DMAC7.html) |
| MY (1) | MY197265A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2017044412A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201801685B (cg-RX-API-DMAC7.html) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109044965A (zh) * | 2018-10-17 | 2018-12-21 | 广州大光制药有限公司 | 格隆溴铵的眼用药物组合物及医药用途 |
| JPWO2021177256A1 (cg-RX-API-DMAC7.html) * | 2020-03-03 | 2021-09-10 | ||
| US12048763B2 (en) | 2021-11-01 | 2024-07-30 | University Of Utah Research Foundation | Compositions and methods for treating sialorrhea |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000047203A1 (en) | 1999-02-12 | 2000-08-17 | Mqs, Inc. | Formulation and system for intra-oral delivery of pharmaceutical agents |
| AU7389300A (en) | 1999-08-02 | 2001-02-19 | First Horizon Pharmaceutical Corporation | Methods of administration of glycopyrrolate compositions |
| WO2006078998A2 (en) * | 2005-01-19 | 2006-07-27 | Neurohealing Pharmaceuticals, Inc. | Methods and compositions for decreasing saliva production |
| WO2007058971A2 (en) | 2005-11-10 | 2007-05-24 | Bodor Nicholas S | Soft anticholinergic esters |
| EP1957451B1 (en) | 2005-11-10 | 2011-10-19 | Nicholas S. Bodor | Soft anticholinergic zwitterions |
| US8071693B2 (en) | 2006-06-22 | 2011-12-06 | Sabic Innovative Plastics Ip B.V. | Polysiloxane/polyimide copolymers and blends thereof |
| US20080260823A1 (en) * | 2007-04-20 | 2008-10-23 | Sciele Pharma, Inc. | Orally disintegrating tablet comprising glycopyrrolate for treating sialorrhea |
| JP2010530902A (ja) * | 2007-06-22 | 2010-09-16 | サイエル ファーマ，インコーポレイティド | 流涎症治療のためのグリコピロレートを含む経皮送達システム |
| AU2009228091B2 (en) | 2008-03-27 | 2015-05-21 | President And Fellows Of Harvard College | Three-dimensional microfluidic devices |
| CN105050596A (zh) * | 2013-03-15 | 2015-11-11 | 博多尔实验仪器公司 | 用于治疗多汗症的抗胆碱能格隆溴铵酯 |
-
2016
- 2016-09-06 CN CN202410181300.8A patent/CN118021797A/zh active Pending
- 2016-09-06 US US15/758,190 patent/US11534422B2/en active Active
- 2016-09-06 CN CN201680065967.5A patent/CN108348502A/zh active Pending
- 2016-09-06 MY MYPI2018700940A patent/MY197265A/en unknown
- 2016-09-06 CN CN202410181298.4A patent/CN118021770A/zh active Pending
- 2016-09-06 AU AU2016318595A patent/AU2016318595B2/en active Active
- 2016-09-06 KR KR1020187009786A patent/KR102889909B1/ko active Active
- 2016-09-06 MX MX2018003002A patent/MX388831B/es unknown
- 2016-09-06 CN CN202410181296.5A patent/CN118045082A/zh active Pending
- 2016-09-06 EP EP16844930.4A patent/EP3347007B1/en active Active
- 2016-09-06 JP JP2018513004A patent/JP7270958B2/ja active Active
- 2016-09-06 WO PCT/US2016/050385 patent/WO2017044412A1/en not_active Ceased
- 2016-09-06 ES ES16844930T patent/ES2942361T3/es active Active
-
2018
- 2018-03-08 IL IL257970A patent/IL257970B/en active IP Right Grant
- 2018-03-12 ZA ZA2018/01685A patent/ZA201801685B/en unknown
-
2020
- 2020-10-12 JP JP2020171891A patent/JP2021001238A/ja not_active Withdrawn
-
2021
- 2021-06-24 AU AU2021204306A patent/AU2021204306B2/en active Active
-
2022
- 2022-06-23 US US17/848,386 patent/US11951093B2/en active Active
- 2022-07-14 JP JP2022113088A patent/JP7723417B2/ja active Active
-
2023
- 2023-09-20 JP JP2023154001A patent/JP2023164671A/ja active Pending
-
2024
- 2024-03-08 US US18/600,632 patent/US12458625B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019131596A5 (cg-RX-API-DMAC7.html) | ||
| TWI426928B (zh) | 鼻內組成物 | |
| CN103260617B (zh) | 包含nsaid和环糊精的药物制剂 | |
| ES2947572T3 (es) | Composiciones de diferentes densidades para comprimidos multicapa de desintegración rápida | |
| JPS61500788A (ja) | 水に不安定なまたは僅かに溶解性の薬物を含有する医薬調製物およびその製造方法 | |
| RU2009146580A (ru) | Состав, содержащий никотин, с покрытием для перорального применения с буферными свойствами, приданными аминокислотой | |
| HRP20170021T1 (hr) | Formulacije koje sadrže 2-amino-2-[2-(4-oktilfenil)etil]propan-1,3-diol | |
| TW201206908A (en) | Pharmaceutical compositions and methods of making same | |
| JP6820116B2 (ja) | レボセチリジンを含む医薬組成物 | |
| JP2013513612A5 (cg-RX-API-DMAC7.html) | ||
| JP6246715B2 (ja) | ブレクスピプラゾール及び置換β−シクロデキストリンを含む薬学的製剤 | |
| CN101657203B (zh) | 抗癌药的组合物及递送方法 | |
| CN105530921A (zh) | 不含表面活性剂或多元醇的即时可湿性口服薄膜剂型 | |
| JP2018526420A5 (cg-RX-API-DMAC7.html) | ||
| JP2014521641A5 (cg-RX-API-DMAC7.html) | ||
| TWI286942B (en) | Rapidly disintegrating tablet and preparing method thereof | |
| JP2012255018A (ja) | 感覚器官的に許容されるイブプロフェン経口投与用製剤、該製剤の製法並びに使用法 | |
| JP2006500367A (ja) | ブチルフタリドとシクロデキストリンまたはその誘導体との包接複合体、それらの調製のためのプロセスおよびその使用 | |
| JP2015503549A (ja) | モンテルカストまたはその薬学的に許容可能な塩を含む経口投与用フィルム | |
| JP2021504384A5 (cg-RX-API-DMAC7.html) | ||
| JP2022125226A (ja) | 口腔用組成物の製造方法、口腔用組成物の口腔内塗布部との密着性を向上させる方法および口腔用組成物の口腔内塗布部における滞留性を向上させる方法。 | |
| JP2008505935A5 (cg-RX-API-DMAC7.html) | ||
| CN103405387B (zh) | 一种新的头孢克肟干混悬剂及其制备方法 | |
| CN114569742B (zh) | 一种组合物及其制备方法和应用 | |
| JPWO2010119851A1 (ja) | 口腔内崩壊錠 |