JP2018526352A5 - - Google Patents
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- Publication number
- JP2018526352A5 JP2018526352A5 JP2018506301A JP2018506301A JP2018526352A5 JP 2018526352 A5 JP2018526352 A5 JP 2018526352A5 JP 2018506301 A JP2018506301 A JP 2018506301A JP 2018506301 A JP2018506301 A JP 2018506301A JP 2018526352 A5 JP2018526352 A5 JP 2018526352A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- substituted
- optionally
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SMXLVZARNMVEKM-FJFCPSMQSA-N Cc1cc(OC2CCOCC2)cc(C)c1-c(cc1)c(CCC2CNc3ncc([C@@H](C4)[C@H]4C(O)=O)cc3)c2c1F Chemical compound Cc1cc(OC2CCOCC2)cc(C)c1-c(cc1)c(CCC2CNc3ncc([C@@H](C4)[C@H]4C(O)=O)cc3)c2c1F SMXLVZARNMVEKM-FJFCPSMQSA-N 0.000 description 1
- WUEFBSDYTXRVSZ-VJQNXJLFSA-N Cc1cc(OCC2COCC2)cc(C)c1-c(c(CC1)c2C1Nc1ncc([C@@H](C3)[C@H]3C(O)=O)cc1)ccc2F Chemical compound Cc1cc(OCC2COCC2)cc(C)c1-c(c(CC1)c2C1Nc1ncc([C@@H](C3)[C@H]3C(O)=O)cc1)ccc2F WUEFBSDYTXRVSZ-VJQNXJLFSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15180175.0 | 2015-08-07 | ||
| EP15180175 | 2015-08-07 | ||
| EP15199739 | 2015-12-14 | ||
| EP15199739.2 | 2015-12-14 | ||
| PCT/EP2016/068291 WO2017025368A1 (en) | 2015-08-07 | 2016-08-01 | Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018526352A JP2018526352A (ja) | 2018-09-13 |
| JP2018526352A5 true JP2018526352A5 (enExample) | 2020-11-05 |
| JP6816107B2 JP6816107B2 (ja) | 2021-01-20 |
Family
ID=56618142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018506301A Expired - Fee Related JP6816107B2 (ja) | 2015-08-07 | 2016-08-01 | インダニルアミノピリジルシクロプロパンカルボン酸、医薬組成物及びこれらの使用 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US9617251B2 (enExample) |
| EP (1) | EP3331860B1 (enExample) |
| JP (1) | JP6816107B2 (enExample) |
| WO (1) | WO2017025368A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018095877A1 (en) * | 2016-11-28 | 2018-05-31 | Boehringer Ingelheim International Gmbh | Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| US10253004B2 (en) * | 2017-01-26 | 2019-04-09 | Boehringer Ingelheim International Gmbh | Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| BR102018007822A2 (pt) * | 2017-04-20 | 2018-11-06 | Gilead Sciences, Inc. | composto, métodos para inibir pd-1, pd-l1 e/ou interação de pd-1/pd-l1 e para tratamento de câncer, composição farmacêutica, e, kit para tratamento de ou prevenção de câncer ou uma doença ou condição |
| KR102708681B1 (ko) | 2018-02-13 | 2024-09-26 | 길리애드 사이언시즈, 인코포레이티드 | Pd-1/pd-l1 억제제 |
| US10568874B2 (en) | 2018-02-22 | 2020-02-25 | Chemocentryx, Inc. | Indane-amines as PD-L1 antagonists |
| CA3093851A1 (en) | 2018-03-29 | 2019-10-03 | Arbutus Biopharma Corporation | Substituted 1,1'-biphenyl compounds, analogues thereof, and methods using same |
| EP4600247A3 (en) | 2018-04-19 | 2025-11-19 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| UA126421C2 (uk) | 2018-07-13 | 2022-09-28 | Гіліад Сайєнсіз, Інк. | Інгібітори pd-1/pd-l1 |
| EP3865477B1 (en) * | 2018-10-10 | 2023-07-12 | Korea Research Institute of Bioscience and Biotechnology | Carbene compound, carbene-metal nanoparticle complex and preparation method thereof |
| US11236085B2 (en) | 2018-10-24 | 2022-02-01 | Gilead Sciences, Inc. | PD-1/PD-L1 inhibitors |
| BR112022006546A2 (pt) | 2019-10-07 | 2022-08-30 | Kallyope Inc | Agonistas de gpr119 |
| CA3173731A1 (en) | 2020-02-28 | 2021-09-02 | Kallyope, Inc. | Gpr40 agonists |
| CN116323608A (zh) | 2020-05-19 | 2023-06-23 | 卡尔优普公司 | Ampk活化剂 |
| EP4172162A4 (en) | 2020-06-26 | 2024-08-07 | Kallyope, Inc. | AMPK ACTIVATORS |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1559422B1 (en) * | 2002-11-08 | 2014-04-30 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
| WO2005087710A1 (ja) * | 2004-03-15 | 2005-09-22 | Takeda Pharmaceutical Company Limited | アミノフェニルプロパン酸誘導体 |
| EP1924546A1 (en) | 2005-09-14 | 2008-05-28 | Amgen, Inc | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| US8633182B2 (en) * | 2012-05-30 | 2014-01-21 | Boehringer Ingelheim International Gmbh | Indanyloxyphenylcyclopropanecarboxylic acids |
| EP3036237A4 (en) | 2013-08-23 | 2017-01-25 | Fujian Haixi Pharmaceuticals Co. Ltd | Carboxylic acid compounds in treatment of diabetes mellitus |
-
2016
- 2016-08-01 EP EP16750134.5A patent/EP3331860B1/en active Active
- 2016-08-01 WO PCT/EP2016/068291 patent/WO2017025368A1/en not_active Ceased
- 2016-08-01 JP JP2018506301A patent/JP6816107B2/ja not_active Expired - Fee Related
- 2016-08-01 US US15/225,038 patent/US9617251B2/en active Active