JP2020505394A5 - - Google Patents
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- JP2020505394A5 JP2020505394A5 JP2019540033A JP2019540033A JP2020505394A5 JP 2020505394 A5 JP2020505394 A5 JP 2020505394A5 JP 2019540033 A JP2019540033 A JP 2019540033A JP 2019540033 A JP2019540033 A JP 2019540033A JP 2020505394 A5 JP2020505394 A5 JP 2020505394A5
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- JP
- Japan
- Prior art keywords
- group
- alkyl
- cycloalkyl
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- replaced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17153381 | 2017-01-26 | ||
| EP17153381.3 | 2017-01-26 | ||
| PCT/EP2018/051383 WO2018138026A1 (en) | 2017-01-26 | 2018-01-22 | Indanylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020505394A JP2020505394A (ja) | 2020-02-20 |
| JP2020505394A5 true JP2020505394A5 (enExample) | 2021-01-21 |
| JP6968181B2 JP6968181B2 (ja) | 2021-11-17 |
Family
ID=57906574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019540033A Active JP6968181B2 (ja) | 2017-01-26 | 2018-01-22 | インダニルアミノピラジニルシクロプロパンカルボン酸、その医薬組成物及び使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10253004B2 (enExample) |
| EP (1) | EP3573965B1 (enExample) |
| JP (1) | JP6968181B2 (enExample) |
| CN (1) | CN110214135B (enExample) |
| AR (1) | AR110777A1 (enExample) |
| TW (1) | TW201840541A (enExample) |
| WO (1) | WO2018138026A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10793530B2 (en) * | 2017-01-26 | 2020-10-06 | Boehringer Ingelheim International Gmbh | Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| CN110312714B (zh) * | 2017-01-26 | 2022-12-09 | 勃林格殷格翰国际有限公司 | 苄基氧基吡嗪基环丙烷甲酸、其药物组合物和用途 |
| US10913720B2 (en) * | 2017-01-26 | 2021-02-09 | Boehringer Ingelheim International Gmbh | Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| WO2019160882A1 (en) | 2018-02-13 | 2019-08-22 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| WO2019204609A1 (en) | 2018-04-19 | 2019-10-24 | Gilead Sciences, Inc. | Pd-1/pd-l1 inhibitors |
| BR112020026746A2 (pt) | 2018-07-13 | 2021-03-30 | Gilead Sciences, Inc. | Composto, composição farmacêutica, métodos para inibir pd-1, pd-l1 e/ou a interação de pd-1/pd-l1 e para tratar câncer, e, kit para tratar ou prevenir câncer ou uma doença ou condição. |
| CN112955435B (zh) | 2018-10-24 | 2024-09-06 | 吉利德科学公司 | Pd-1/pd-l1抑制剂 |
| JP2022552655A (ja) | 2019-10-07 | 2022-12-19 | キャリーオペ，インク． | Ｇｐｒ１１９アゴニスト |
| PH12022552277A1 (en) | 2020-02-28 | 2024-03-04 | Kallyope Inc | Gpr40 agonists |
| JP2023526625A (ja) | 2020-05-19 | 2023-06-22 | キャリーオペ，インク． | Ａｍｐｋアクチベーター |
| CN116390925A (zh) | 2020-06-26 | 2023-07-04 | 卡尔优普公司 | Ampk活化剂 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US628476A (en) | 1898-03-18 | 1899-07-11 | Joseph Howard Kirk | Junction of cycle, motor-car, or other frames, &c. |
| US7704995B2 (en) * | 2002-05-03 | 2010-04-27 | Exelixis, Inc. | Protein kinase modulators and methods of use |
| AU2003277576A1 (en) | 2002-11-08 | 2004-06-07 | Takeda Pharmaceutical Company Limited | Receptor function controlling agent |
| DE102004017930A1 (de) | 2004-04-14 | 2005-11-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel |
| CN101111486A (zh) * | 2005-01-31 | 2008-01-23 | 默克公司 | 抗糖尿病二环化合物 |
| TW200640863A (en) | 2005-02-15 | 2006-12-01 | Glaxo Group Ltd | Compounds which potentiate glutamate receptor and uses thereof in medicine |
| EP1866278A1 (en) | 2005-03-28 | 2007-12-19 | Pfizer, Inc. | Substituted aryloxoethyl cyclopropanecarboxamide compounds as vr1 receptor antagonists |
| WO2007033002A1 (en) | 2005-09-14 | 2007-03-22 | Amgen Inc. | Conformationally constrained 3- (4-hydroxy-phenyl) - substituted-propanoic acids useful for treating metabolic disorders |
| JP2009530237A (ja) | 2006-03-15 | 2009-08-27 | ノイロサーチ アクティーゼルスカブ | キナゾリノン及びカリウムチャネル活性化剤としてのその使用 |
| MX2010014571A (es) | 2008-06-25 | 2011-03-25 | Daiichi Sankyo Co Ltd | Compuestos de acido carboxilico. |
| US20110269783A1 (en) | 2008-11-10 | 2011-11-03 | Neurosearch A/S | Novel 2,3-diamino-quinazolinone derivatives and their medical use |
| WO2011094890A1 (en) | 2010-02-02 | 2011-08-11 | Argusina Inc. | Phenylalanine derivatives and their use as non-peptide glp-1 receptor modulators |
| US20120077814A1 (en) * | 2010-09-10 | 2012-03-29 | Zhong Wang | Sulfonamide, sulfamate, and sulfamothioate derivatives |
| US8642585B2 (en) | 2012-03-26 | 2014-02-04 | Boehringer Ingelheim International Gmbh | Indanyloxydihydrobenzofuranylacetic acids |
| US8633182B2 (en) * | 2012-05-30 | 2014-01-21 | Boehringer Ingelheim International Gmbh | Indanyloxyphenylcyclopropanecarboxylic acids |
| JP6533778B2 (ja) | 2013-09-26 | 2019-06-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｇｐｒ４０アゴニストとしてのインダニルオキシジヒドロベンゾフラニル酢酸誘導体を調製するための方法および中間体 |
| JP6441928B2 (ja) * | 2013-11-28 | 2018-12-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規インダニルオキシフェニルシクロプロパンカルボン酸 |
| WO2017025368A1 (en) * | 2015-08-07 | 2017-02-16 | Boehringer Ingelheim International Gmbh | Indanylaminopyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| WO2017042121A1 (en) * | 2015-09-09 | 2017-03-16 | Boehringer Ingelheim International Gmbh | [{[2,3-dihydro-1h-inden-1-yl]amino}-2h,3h-furo[3,2-b]pyridin-3-yl]acetic acids, pharmaceutical compositions and uses thereof |
| CN110312714B (zh) * | 2017-01-26 | 2022-12-09 | 勃林格殷格翰国际有限公司 | 苄基氧基吡嗪基环丙烷甲酸、其药物组合物和用途 |
| US10913720B2 (en) * | 2017-01-26 | 2021-02-09 | Boehringer Ingelheim International Gmbh | Benzyloxypyridylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| US10793530B2 (en) * | 2017-01-26 | 2020-10-06 | Boehringer Ingelheim International Gmbh | Benzylaminopyrazinylcyclopropanecarboxylic acids, pharmaceutical compositions and uses thereof |
| CN110177773B (zh) * | 2017-01-26 | 2023-08-25 | 勃林格殷格翰国际有限公司 | 苄基氨基吡啶基环丙烷羧酸、其药物组合物及其用途 |
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2018
- 2018-01-22 JP JP2019540033A patent/JP6968181B2/ja active Active
- 2018-01-22 WO PCT/EP2018/051383 patent/WO2018138026A1/en not_active Ceased
- 2018-01-22 EP EP18703219.8A patent/EP3573965B1/en active Active
- 2018-01-22 US US15/876,237 patent/US10253004B2/en active Active
- 2018-01-22 CN CN201880007924.0A patent/CN110214135B/zh active Active
- 2018-01-25 AR ARP180100172A patent/AR110777A1/es unknown
- 2018-01-25 TW TW107102700A patent/TW201840541A/zh unknown