JP2018525462A5 - - Google Patents

Download PDF

Info

Publication number
JP2018525462A5
JP2018525462A5 JP2017566754A JP2017566754A JP2018525462A5 JP 2018525462 A5 JP2018525462 A5 JP 2018525462A5 JP 2017566754 A JP2017566754 A JP 2017566754A JP 2017566754 A JP2017566754 A JP 2017566754A JP 2018525462 A5 JP2018525462 A5 JP 2018525462A5
Authority
JP
Japan
Prior art keywords
polymer
alkyl
independently
formula
nanoparticles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017566754A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018525462A (ja
JP6914860B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/037166 external-priority patent/WO2017003668A1/en
Publication of JP2018525462A publication Critical patent/JP2018525462A/ja
Publication of JP2018525462A5 publication Critical patent/JP2018525462A5/ja
Priority to JP2021116707A priority Critical patent/JP7150945B2/ja
Application granted granted Critical
Publication of JP6914860B2 publication Critical patent/JP6914860B2/ja
Priority to JP2022154411A priority patent/JP7708728B2/ja
Priority to JP2025038440A priority patent/JP2025100542A/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017566754A 2015-07-01 2016-06-13 カチオン性粘液酸ポリマー系デリバリーシステム Active JP6914860B2 (ja)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2021116707A JP7150945B2 (ja) 2015-07-01 2021-07-14 カチオン性粘液酸ポリマー系デリバリーシステム
JP2022154411A JP7708728B2 (ja) 2015-07-01 2022-09-28 カチオン性粘液酸ポリマー系デリバリーシステム
JP2025038440A JP2025100542A (ja) 2015-07-01 2025-03-11 カチオン性粘液酸ポリマー系デリバリーシステム

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562187366P 2015-07-01 2015-07-01
US62/187,366 2015-07-01
PCT/US2016/037166 WO2017003668A1 (en) 2015-07-01 2016-06-13 Cationic mucic acid polymer-based delivery systems

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2021116707A Division JP7150945B2 (ja) 2015-07-01 2021-07-14 カチオン性粘液酸ポリマー系デリバリーシステム

Publications (3)

Publication Number Publication Date
JP2018525462A JP2018525462A (ja) 2018-09-06
JP2018525462A5 true JP2018525462A5 (enExample) 2019-06-13
JP6914860B2 JP6914860B2 (ja) 2021-08-04

Family

ID=57609004

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017566754A Active JP6914860B2 (ja) 2015-07-01 2016-06-13 カチオン性粘液酸ポリマー系デリバリーシステム
JP2021116707A Active JP7150945B2 (ja) 2015-07-01 2021-07-14 カチオン性粘液酸ポリマー系デリバリーシステム
JP2022154411A Active JP7708728B2 (ja) 2015-07-01 2022-09-28 カチオン性粘液酸ポリマー系デリバリーシステム
JP2025038440A Pending JP2025100542A (ja) 2015-07-01 2025-03-11 カチオン性粘液酸ポリマー系デリバリーシステム

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2021116707A Active JP7150945B2 (ja) 2015-07-01 2021-07-14 カチオン性粘液酸ポリマー系デリバリーシステム
JP2022154411A Active JP7708728B2 (ja) 2015-07-01 2022-09-28 カチオン性粘液酸ポリマー系デリバリーシステム
JP2025038440A Pending JP2025100542A (ja) 2015-07-01 2025-03-11 カチオン性粘液酸ポリマー系デリバリーシステム

Country Status (6)

Country Link
US (4) US10287401B2 (enExample)
EP (2) EP3795609B1 (enExample)
JP (4) JP6914860B2 (enExample)
CN (2) CN111643479B (enExample)
ES (2) ES2882255T3 (enExample)
WO (1) WO2017003668A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9468681B2 (en) 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
JP6914860B2 (ja) 2015-07-01 2021-08-04 カリフォルニア インスティチュート オブ テクノロジー カチオン性粘液酸ポリマー系デリバリーシステム
EP3806887A4 (en) * 2018-06-13 2022-04-06 California Institute of Technology Nanoparticles for crossing the blood brain barrier and methods of treatment using the same
JP7536258B2 (ja) * 2019-05-29 2024-08-20 国立大学法人東京工業大学 複合体、医薬、癌治療剤、キット及び結合体
CA3158694A1 (en) 2019-12-04 2021-06-10 Dantari, Inc. Methods and compositions for synthesis of therapeutic nanoparticles
JP7343874B2 (ja) * 2019-12-26 2023-09-13 株式会社島津製作所 データ処理方法及びデータ処理装置
JPWO2024204685A1 (enExample) 2023-03-31 2024-10-03

Family Cites Families (103)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4631190A (en) 1981-06-26 1986-12-23 Shen Wei C Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers
US5217999A (en) 1987-12-24 1993-06-08 Yissum Research Development Company Of The Hebrew University Of Jerusalem Styryl compounds which inhibit EGF receptor protein tyrosine kinase
CA2078214C (en) 1990-04-02 1995-03-28 Robert Lee Dow Benzylphosphonic acid tyrosine kinase inhibitors
US5302606A (en) 1990-04-16 1994-04-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Styryl-substituted pyridyl compounds which inhibit EGF receptor tyrosine kinase
AU658646B2 (en) 1991-05-10 1995-04-27 Rhone-Poulenc Rorer International (Holdings) Inc. Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
WO1992021660A1 (en) 1991-05-29 1992-12-10 Pfizer, Inc. Tricyclic polyhydroxylic tyrosine kinase inhibitors
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
US5936079A (en) 1992-04-06 1999-08-10 Alton Ochsner Medical Foundation Oligonucleotide which binds to a chromosomal binding site for p53 protein
SK283413B6 (sk) 1992-08-06 2003-07-01 Warner-Lambert Company 2-Tioindoly, 2-indolíntióny a polysulfidy, ich selénové analógy a farmaceutické prostriedky na ich báze
US5330992A (en) 1992-10-23 1994-07-19 Sterling Winthrop Inc. 1-cyclopropyl-4-pyridyl-quinolinones
GB9226855D0 (en) 1992-12-23 1993-02-17 Erba Carlo Spa Vinylene-azaindole derivatives and process for their preparation
US5565215A (en) * 1993-07-23 1996-10-15 Massachusettes Institute Of Technology Biodegradable injectable particles for imaging
AU2096895A (en) 1994-03-07 1995-09-25 Sugen, Incorporated Receptor tyrosine kinase inhibitors for inhibiting cell proliferative disorders and compositions thereof
GB9412719D0 (en) 1994-06-24 1994-08-17 Erba Carlo Spa Substituted azaindolylidene compounds and process for their preparation
US6007845A (en) 1994-07-22 1999-12-28 Massachusetts Institute Of Technology Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers
US6610832B1 (en) 1995-03-23 2003-08-26 Biopure Corporation Preserving a hemoglobin blood substitute with a transparent overwrap
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5693631A (en) 1995-05-30 1997-12-02 Buckman Laboratories International, Inc. Potentiation of the microbicide 2-(thiocyanomethylthio) benzothiazole using an N-alkyl heterocyclic compound
US6034081A (en) 1995-05-30 2000-03-07 Buckman Laboratories International Inc Potentiation of biocide activity using an N-alkyl heterocyclic compound
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US5710173A (en) 1995-06-07 1998-01-20 Sugen, Inc. Thienyl compounds for inhibition of cell proliferative disorders
US5596878A (en) 1995-06-26 1997-01-28 Thermo King Corporation Methods and apparatus for operating a refrigeration unit
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
FR2749853B1 (fr) 1996-06-12 1998-10-16 Rhone Poulenc Chimie Formulation amelioree a base d'un compose hydroxyle et d'un compose amphiphile complexant utilisable notamment pour modifier les proprietes rheologiques d'emulsions
JP2000514440A (ja) 1996-07-09 2000-10-31 ザ ジョーンズ ホプキンス ユニバーシティー 遺伝子輸送システム
JP4386967B2 (ja) 1996-07-13 2009-12-16 グラクソ、グループ、リミテッド プロテインチロシンキナーゼ阻害剤としての縮合複素環式化合物
ES2191187T3 (es) 1996-07-13 2003-09-01 Glaxo Group Ltd Compuestos heteroaromaticos biciclicos como inhibidores de la proteina tirosin-quinasa.
US5948878A (en) 1997-04-15 1999-09-07 Burgess; Stephen W. Cationic polymers for nucleic acid transfection and bioactive agent delivery
US6596267B1 (en) 1997-08-27 2003-07-22 California Institute Of Technology Methods and compositions to prevent formation of adhesions in biological tissues
US6225346B1 (en) 1997-10-24 2001-05-01 Sugen, Inc. Tyrphostin like compounds
GB9800569D0 (en) 1998-01-12 1998-03-11 Glaxo Group Ltd Heterocyclic compounds
US6048736A (en) 1998-04-29 2000-04-11 Kosak; Kenneth M. Cyclodextrin polymers for carrying and releasing drugs
US7091192B1 (en) 1998-07-01 2006-08-15 California Institute Of Technology Linear cyclodextrin copolymers
AU5565299A (en) 1998-08-17 2000-03-06 California Institute Of Technology Devices and methods for analysis of non-ionic solutes
EP1107802B1 (en) 1998-08-27 2004-10-13 Eidgenössische Technische Hochschule Zürich Gels and multilayer surface structures from boronic acid containing polymers
UA71945C2 (en) 1999-01-27 2005-01-17 Pfizer Prod Inc Substituted bicyclic derivatives being used as anticancer agents
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
US7087613B2 (en) 1999-11-11 2006-08-08 Osi Pharmaceuticals, Inc. Treating abnormal cell growth with a stable polymorph of N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine hydrochloride
PE20011178A1 (es) 2000-04-07 2001-11-19 Takeda Chemical Industries Ltd Compuestos heterociclicos y su produccion
US6372250B1 (en) 2000-04-25 2002-04-16 The Regents Of The University Of California Non-invasive gene targeting to the brain
US6335342B1 (en) 2000-06-19 2002-01-01 Pharmacia & Upjohn S.P.A. Azaindole derivatives, process for their preparation, and their use as antitumor agents
MXPA02012870A (es) 2000-06-22 2003-05-14 Pfizer Prod Inc Derivados biciclicos sustituidos para el tratamiento del crecimiento celular anormal.
IL153111A0 (en) 2000-06-30 2003-06-24 Glaxo Group Ltd Quinazoline ditosylate salt compounds
TWI321054B (en) 2000-12-19 2010-03-01 California Inst Of Techn Compositions containing inclusion complexes
GB0115109D0 (en) 2001-06-21 2001-08-15 Aventis Pharma Ltd Chemical compounds
US7041280B2 (en) 2001-06-29 2006-05-09 Genzyme Corporation Aryl boronate functionalized polymers for treating obesity
JP2005511761A (ja) 2001-07-10 2005-04-28 ノース・キャロライナ・ステイト・ユニヴァーシティ ナノ粒子送達ビヒクル
WO2003009689A1 (en) 2001-07-23 2003-02-06 Ramot At Tel Aviv University Ltd. Methods and compositions for treating fungal infections
US6737504B2 (en) 2001-07-30 2004-05-18 California Institute Of Technology Synthesis of substituted poly(aniline)s
JP2005508623A (ja) 2001-08-30 2005-04-07 バイオレクシス ファーマシューティカル コーポレイション 改変されたトランスフェリン融合タンパク質
US6984653B2 (en) 2001-10-05 2006-01-10 Takeda Pharmaceutical Company Limited Heterocyclic compounds, oxazole derivatives, process for preparation of the same and use thereof
US7157277B2 (en) 2001-11-28 2007-01-02 Neose Technologies, Inc. Factor VIII remodeling and glycoconjugation of Factor VIII
HRP20040530A2 (en) 2001-12-12 2004-10-31 Pfizer Prod Inc Salt forms of e-2-methoxy-n-(3-(4-(3-methyl-pyridin-3-yloxy)-phenylamino)-quinazolin-6-yl)-allyl)-acetamide, its preparation and its use against cancer
WO2003049740A1 (en) 2001-12-12 2003-06-19 Pfizer Products Inc. Quinazoline derivatives for the treatment of abnormal cell growth
WO2003053446A1 (en) 2001-12-19 2003-07-03 Smithkline Beecham Corporation Thienopyrimidine compounds as protein tyrosine kinase inhibitors
US7591994B2 (en) 2002-12-13 2009-09-22 Immunomedics, Inc. Camptothecin-binding moiety conjugates
US7094427B2 (en) 2002-05-29 2006-08-22 Impax Laboratories, Inc. Combination immediate release controlled release levodopa/carbidopa dosage forms
AU2003241898A1 (en) 2002-06-03 2003-12-19 Mitsubishi Pharma Corporation PREVENTIVES AND/OR REMEDIES FOR SUBJECTS WITH THE EXPRESSION OR ACTIVATION OF Her2 AND/OR EGFR
KR101476067B1 (ko) 2002-09-06 2014-12-23 인설트 테라페틱스, 인코퍼레이티드 공유결합된 치료제 전달을 위한 사이클로덱스트린-기초 중합체
US20060134062A1 (en) 2002-11-19 2006-06-22 Huval Chad C Polymeric boronic acid derivatives as lipase inhibitors
AU2003298749A1 (en) 2002-11-26 2004-06-18 Seacoast Neuroscience, Inc. Buoyant polymer particles delivering therapeutic agents
ZA200506611B (en) 2003-01-29 2006-12-27 Takeda Pharmaceutical Thienopyrimidine compounds and use thereof
JP2005119255A (ja) 2003-10-17 2005-05-12 San Quest:Kk 携帯電話画像取り込み機能付き名刺印刷装置
US20050090732A1 (en) 2003-10-28 2005-04-28 Triton Biosystems, Inc. Therapy via targeted delivery of nanoscale particles
WO2005119255A2 (en) 2004-05-12 2005-12-15 Applera Corporation Constrained cis-diol-borate bioconjugation system
EP1773900A4 (en) 2004-07-30 2007-08-29 Basf Ag POLYMERIC BORONIC ACID DERIVATIVES AND USE IN THE MANUFACTURE OF PAPER
US7413173B2 (en) 2004-09-10 2008-08-19 Ric Investments, Llc Molded water chamber base plate for use in a humidifier and ventilator assembly
EP1802973B1 (en) 2004-10-12 2010-05-05 Luminex Corporation Methods for altering surface characteristics of microspheres
TW200618820A (en) 2004-11-05 2006-06-16 Alza Corp Liposome formulations of boronic acid compounds
JP2008537551A (ja) 2005-03-31 2008-09-18 カランド ファーマシューティカルズ， インコーポレイテッド リボヌクレオチドレダクターゼサブユニット２の阻害剤およびその使用
WO2006116742A2 (en) 2005-04-28 2006-11-02 Ventana Medical Systems, Inc. Fluorescent nanoparticles conjugated to antibodies via a peg linker
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
WO2007034479A2 (en) 2005-09-20 2007-03-29 Yissum Research Development Company Nanoparticles for targeted delivery of active agents
US7988988B2 (en) 2005-11-21 2011-08-02 Bausch & Lomb Incorporated Contact lenses with mucin affinity
CA2658768C (en) 2006-07-21 2016-05-17 Massachusetts Institute Of Technology End-modified poly(beta-amino esters) and uses thereof
BRPI0716046A2 (pt) 2006-08-17 2013-09-17 Novartis Ag composiÇÕes de nanopartÍcula.
WO2008042222A2 (en) 2006-09-29 2008-04-10 Genzyme Corporation Amide dendrimer compositions
US7825127B2 (en) 2006-12-28 2010-11-02 Takeda Pharmaceutical Company, Limited Method for treating cancer
WO2009036022A1 (en) 2007-09-10 2009-03-19 Board Of Regents, The University Of Texas System Enhancement of polysaccharide-mediated nucleic acid delivery
KR101451564B1 (ko) 2007-12-28 2014-11-04 임팩스 라보라토리즈, 인코포레이티드 레보도파 방출 제어형 제제 및 이의 용도
US20100029545A1 (en) 2008-08-04 2010-02-04 Sumerlin Brent S Boronic acid-containing block copolymers for controlled drug delivery
KR101661746B1 (ko) 2008-08-13 2016-09-30 캘리포니아 인스티튜트 오브 테크놀로지 캐리어 나노입자, 그리고 관련된 조성물, 방법 및 시스템
US8367166B2 (en) 2008-10-31 2013-02-05 Chevron U.S.A. Inc. Synthesis of higher diamondoids
US20120156138A1 (en) 2009-04-14 2012-06-21 Smith Larry J Methods and Compositions for the Treatment of Medical Conditions Involving Cellular Reprogramming
CN107252482A (zh) 2009-05-27 2017-10-17 西莱克塔生物科技公司 具有不同释放速率的纳米载体加工组分
FR2946476B1 (fr) 2009-06-05 2014-03-21 Aeg Power Solutions Bv Convertisseur continu-continu a regulation double alternance
US20100330686A1 (en) 2009-06-29 2010-12-30 Seung Bum Park Nanosensor for sugar detection
EP2496614A4 (en) 2009-11-06 2014-02-26 Univ Washington Ct Commerciali SELF-ORDERING PARTICLES OF ZWITTERIONIC POLYMERS AND CORRESPONDING METHODS
US9138418B2 (en) 2009-12-09 2015-09-22 William Marsh Rice University Therapeutic compositions and methods for delivery of active agents cleavably linked to nanoparticles
US20120309691A1 (en) 2010-02-04 2012-12-06 Dapeng Zhou Tumor targeted delivery of immunomodulators by nanopolymers
WO2011159161A2 (en) 2010-06-18 2011-12-22 Universiteit Twente Boronated polymers
EA201390145A1 (ru) 2010-08-20 2013-11-29 Серулин Фарма Инк. Конъюгаты, частицы, композиции и связанные с ними способы
WO2012079047A2 (en) 2010-12-10 2012-06-14 California Institute Of Technology Targeting kidney mesangium with nanoparticles of defined diameter
WO2012158622A2 (en) 2011-05-13 2012-11-22 The Regents Of The University Of California Reversibly crosslinked micelle systems
DE102012017025B4 (de) 2012-08-28 2018-05-30 Kennametal Inc. Werkzeughalter für einen Schneideinsatz und Baugruppe mit einem solchen Werkzeughalter
GB201220474D0 (en) 2012-11-14 2012-12-26 Sagetis Biotech Sl Polypeptides
US9468681B2 (en) * 2013-03-01 2016-10-18 California Institute Of Technology Targeted nanoparticles
US9132097B2 (en) 2013-03-01 2015-09-15 California Institute Of Technology Nanoparticles stabilized with nitrophenylboronic acid compositions
EP3513812B1 (en) * 2013-03-01 2020-07-15 California Institute of Technology Nanoparticles stabilized with nitrophenylboronic acid compositions
EP2961395B1 (en) 2013-03-01 2024-06-19 California Institute Of Technology Targeted nanoparticles
CA3166758A1 (en) 2013-05-14 2014-11-20 California Institute Of Technology Method of delivering therapeutics and imaging agents by nanoparticles that cross the blood brain barrier
WO2016037166A1 (en) 2014-09-07 2016-03-10 Yu Zhang Novel anti-oxidant compositions and methods of delivery
JP6914860B2 (ja) 2015-07-01 2021-08-04 カリフォルニア インスティチュート オブ テクノロジー カチオン性粘液酸ポリマー系デリバリーシステム

Similar Documents

Publication Publication Date Title
JP2018525462A5 (enExample)
Guan et al. A pH-responsive detachable PEG shielding strategy for gene delivery system in cancer therapy
CN103374128B (zh) 两亲性三嵌段共聚物、聚合物纳米载体制剂及制备方法
Muthoosamy et al. Graphene and graphene oxide as a docking station for modern drug delivery system
Mohammadifar et al. Polyamidoamine and polyglycerol; their linear, dendritic and linear–dendritic architectures as anticancer drug delivery systems
CN103251561B (zh) 一种双敏感可崩解式纳米囊泡药物载体制剂及其制备方法
CN103690961B (zh) 一种智能两亲性聚合物纳米胶束及其制备方法和应用
JP2010513526A5 (enExample)
Bono et al. Role of generation on successful DNA delivery of PAMAM–(Guanidino) Neomycin conjugates
US20140234212A1 (en) Targeted Buccal Delivery of Agents
CN101528815A (zh) 药物复合物用嵌段共聚物及医药组合物
CN102920649A (zh) 载药纳米胶束及其制备方法和应用
CN105997880A (zh) 一种基于交联生物可降解聚合物囊泡的抗肿瘤纳米药物及其制备方法
CN110237035A (zh) 一种主动靶向型两亲性多肽纳米药物载体及其制备与应用
KR20050111586A (ko) 드러그 및 유전자 전달 시스템으로서의 다기능의 덴드리머및 다중결합된 폴리머
Mignani et al. Dendritic macromolecular architectures: dendrimer-based polyion complex micelles
Liu et al. Zwitterionic unimolecular micelles with pH and temperature response: enhanced in vivo circulation stability and tumor therapeutic efficiency
Jiang et al. Dendrimer-based nanoparticles in cancer chemotherapy and gene therapy
US9890245B2 (en) Stearic acid derivatives and oleic acid derivatives of multi-arm polyethylene glycol
CN104162166B (zh) pH敏感性多糖纳米载药胶束及其制备方法
KR20080095130A (ko) ｐＨ 민감성 블록공중합체를 이용한 약물전달체 제조 및응용
Chen et al. Nonlinear supramolecular polymers for therapeutic applications
Khakshur et al. An insight into cell-penetrating peptides: perspectives on design, optimization, and targeting in drug delivery systems
V. Theodosopoulos et al. Polymer functionalized graphene oxide: a versatile nanoplatform for drug/gene delivery
Liu et al. Polymer–polymer conjugation to fabricate multi-block polymer as novel drug carriers: Poly (lactic acid)–poly (ethylene glycol)–poly (L-lysine) to enhance paclitaxel target delivery