JP2018525342A5 - - Google Patents
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- Publication number
- JP2018525342A5 JP2018525342A5 JP2017567632A JP2017567632A JP2018525342A5 JP 2018525342 A5 JP2018525342 A5 JP 2018525342A5 JP 2017567632 A JP2017567632 A JP 2017567632A JP 2017567632 A JP2017567632 A JP 2017567632A JP 2018525342 A5 JP2018525342 A5 JP 2018525342A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- compound
- alkylene
- cycloalkyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 28
- 125000000217 alkyl group Chemical group 0.000 claims 21
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 229910052799 carbon Inorganic materials 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 7
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 5
- 125000002947 alkylene group Chemical group 0.000 claims 5
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 4
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 claims 3
- 125000000753 cycloalkyl group Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000006568 (C4-C7) heterocycloalkyl group Chemical group 0.000 claims 2
- 208000024412 Friedreich ataxia Diseases 0.000 claims 2
- 125000006580 bicyclic heterocycloalkyl group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 208000002320 spinal muscular atrophy Diseases 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 102000014461 Ataxins Human genes 0.000 claims 1
- 108010078286 Ataxins Proteins 0.000 claims 1
- 206010068597 Bulbospinal muscular atrophy congenital Diseases 0.000 claims 1
- 206010008025 Cerebellar ataxia Diseases 0.000 claims 1
- 208000001914 Fragile X syndrome Diseases 0.000 claims 1
- 201000011240 Frontotemporal dementia Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000027747 Kennedy disease Diseases 0.000 claims 1
- 206010068871 Myotonic dystrophy Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 208000014060 Niemann-Pick disease Diseases 0.000 claims 1
- 208000009415 Spinocerebellar Ataxias Diseases 0.000 claims 1
- 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 claims 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 1
- 201000004562 autosomal dominant cerebellar ataxia Diseases 0.000 claims 1
- 125000002393 azetidinyl group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013663 drug dependence Diseases 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 125000003566 oxetanyl group Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004193 piperazinyl group Chemical group 0.000 claims 1
- 125000003386 piperidinyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 208000011117 substance-related disease Diseases 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562188139P | 2015-07-02 | 2015-07-02 | |
| US62/188,139 | 2015-07-02 | ||
| PCT/US2016/040705 WO2017004522A1 (en) | 2015-07-02 | 2016-07-01 | Histone deacetylase inhibtors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018525342A JP2018525342A (ja) | 2018-09-06 |
| JP2018525342A5 true JP2018525342A5 (https=) | 2019-08-08 |
Family
ID=56413909
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017567632A Pending JP2018525342A (ja) | 2015-07-02 | 2016-07-01 | ヒストンデアセチラーゼ阻害剤 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US10851058B2 (https=) |
| EP (1) | EP3317253A1 (https=) |
| JP (1) | JP2018525342A (https=) |
| KR (1) | KR20180022840A (https=) |
| CN (1) | CN107922342A (https=) |
| AU (1) | AU2016288606A1 (https=) |
| BR (1) | BR112017028139A2 (https=) |
| CA (1) | CA2990660A1 (https=) |
| HK (1) | HK1250367A1 (https=) |
| IL (1) | IL256438B (https=) |
| MX (1) | MX2017017127A (https=) |
| RU (1) | RU2720678C2 (https=) |
| SG (1) | SG10201913192VA (https=) |
| WO (1) | WO2017004522A1 (https=) |
| ZA (1) | ZA201800058B (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11241428B2 (en) | 2017-07-10 | 2022-02-08 | Medibiofarma, S.L. | Heteroaryl amide derivatives as selective inhibitors of histone deacetylases 1 and/or 2(HDAC1-2) |
| CN108795867A (zh) * | 2018-06-05 | 2018-11-13 | 华东理工大学 | 用于构建结肠癌细胞腹膜转移体外三维模型的方法 |
| WO2021117759A1 (ja) | 2019-12-10 | 2021-06-17 | 塩野義製薬株式会社 | 含窒素芳香族複素環式基を有するヒストン脱アセチル化酵素阻害剤 |
| GB202001023D0 (en) * | 2020-01-24 | 2020-03-11 | Univ Leicester | HDAC Degrader |
| CN112239422B (zh) * | 2020-10-16 | 2022-07-22 | 河北化工医药职业技术学院 | 一种布格替尼中间体、其盐、其制备方法以及布格替尼的制备方法 |
| WO2024245060A1 (zh) * | 2023-06-02 | 2024-12-05 | 苏州浦合医药科技有限公司 | HDAC1-CoREST高选择性抑制剂 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1429765A2 (en) | 2001-09-14 | 2004-06-23 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
| AU2005225471B2 (en) | 2004-03-26 | 2011-05-12 | Methylgene Inc. | Inhibitors of histone deacetylase |
| AR057579A1 (es) * | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
| KR101495611B1 (ko) | 2006-04-07 | 2015-02-25 | 메틸진 인코포레이티드 | 히스톤 데아세틸라아제의 억제제 |
| US8030344B2 (en) | 2007-03-13 | 2011-10-04 | Methylgene Inc. | Inhibitors of histone deacetylase |
| EP2170882A1 (en) * | 2007-06-26 | 2010-04-07 | Gilead Colorado, Inc. | Imidazopyridinyl thiazolyl histone deacetylase inhibitors |
| JP5469604B2 (ja) | 2007-09-19 | 2014-04-16 | ４エスツェー アクチェンゲゼルシャフト | 新規テトラヒドロ融合ピリジン |
| EP2209765A4 (en) | 2007-10-22 | 2010-12-01 | Orchid Res Lab Ltd | HISTONE DEACETYLASE INHIBITORS |
| CN102477001B (zh) | 2010-11-29 | 2015-07-15 | 江苏先声药物研究有限公司 | 一种苯甲酰胺类组蛋白去乙酰化酶抑制剂 |
| US8404738B2 (en) * | 2011-01-21 | 2013-03-26 | Hoffmann-La Roche Inc. | 4-amino-N-hydroxy-benzamides for the treatment of cancer |
| US8957066B2 (en) * | 2011-02-28 | 2015-02-17 | Biomarin Pharmaceutical Inc. | Histone deacetylase inhibitors |
| GB201111630D0 (en) * | 2011-07-07 | 2011-08-24 | Cancer Rec Tech Ltd | Novel compounds and their use |
-
2016
- 2016-07-01 RU RU2018103753A patent/RU2720678C2/ru active
- 2016-07-01 CN CN201680037989.0A patent/CN107922342A/zh active Pending
- 2016-07-01 US US15/740,437 patent/US10851058B2/en active Active
- 2016-07-01 SG SG10201913192VA patent/SG10201913192VA/en unknown
- 2016-07-01 HK HK18109798.5A patent/HK1250367A1/zh unknown
- 2016-07-01 AU AU2016288606A patent/AU2016288606A1/en not_active Abandoned
- 2016-07-01 BR BR112017028139-2A patent/BR112017028139A2/pt not_active Application Discontinuation
- 2016-07-01 KR KR1020187002149A patent/KR20180022840A/ko not_active Withdrawn
- 2016-07-01 EP EP16739365.1A patent/EP3317253A1/en not_active Withdrawn
- 2016-07-01 CA CA2990660A patent/CA2990660A1/en not_active Abandoned
- 2016-07-01 MX MX2017017127A patent/MX2017017127A/es unknown
- 2016-07-01 WO PCT/US2016/040705 patent/WO2017004522A1/en not_active Ceased
- 2016-07-01 JP JP2017567632A patent/JP2018525342A/ja active Pending
-
2017
- 2017-12-20 IL IL256438A patent/IL256438B/en active IP Right Grant
-
2018
- 2018-01-04 ZA ZA2018/00058A patent/ZA201800058B/en unknown
- 2018-07-27 US US16/047,179 patent/US10308608B2/en active Active
-
2020
- 2020-09-22 US US17/028,444 patent/US20210009519A1/en not_active Abandoned
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