JP2018523980A5 - - Google Patents
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- JP2018523980A5 JP2018523980A5 JP2017564467A JP2017564467A JP2018523980A5 JP 2018523980 A5 JP2018523980 A5 JP 2018523980A5 JP 2017564467 A JP2017564467 A JP 2017564467A JP 2017564467 A JP2017564467 A JP 2017564467A JP 2018523980 A5 JP2018523980 A5 JP 2018523980A5
- Authority
- JP
- Japan
- Prior art keywords
- acid sequence
- amino acid
- seq
- polypeptide
- adenovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 83
- 108091033319 polynucleotide Proteins 0.000 claims 55
- 102000040430 polynucleotide Human genes 0.000 claims 55
- 239000002157 polynucleotide Substances 0.000 claims 55
- 229920001184 polypeptide Polymers 0.000 claims 53
- 108090000765 processed proteins & peptides Proteins 0.000 claims 53
- 102000004196 processed proteins & peptides Human genes 0.000 claims 53
- 241000701161 unidentified adenovirus Species 0.000 claims 42
- 108090000623 proteins and genes Proteins 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 18
- 102000004169 proteins and genes Human genes 0.000 claims 18
- 239000012634 fragment Substances 0.000 claims 12
- 241001135569 Human adenovirus 5 Species 0.000 claims 4
- 101000768957 Acholeplasma phage L2 Uncharacterized 37.2 kDa protein Proteins 0.000 claims 2
- 101000823746 Acidianus ambivalens Uncharacterized 17.7 kDa protein in bps2 3'region Proteins 0.000 claims 2
- 101000916369 Acidianus ambivalens Uncharacterized protein in sor 5'region Proteins 0.000 claims 2
- 101000769342 Acinetobacter guillouiae Uncharacterized protein in rpoN-murA intergenic region Proteins 0.000 claims 2
- 101000823696 Actinobacillus pleuropneumoniae Uncharacterized glycosyltransferase in aroQ 3'region Proteins 0.000 claims 2
- 101000786513 Agrobacterium tumefaciens (strain 15955) Uncharacterized protein outside the virF region Proteins 0.000 claims 2
- 101000618005 Alkalihalobacillus pseudofirmus (strain ATCC BAA-2126 / JCM 17055 / OF4) Uncharacterized protein BpOF4_00885 Proteins 0.000 claims 2
- 102100020724 Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Human genes 0.000 claims 2
- 101000967489 Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / JCM 20966 / LMG 6465 / NBRC 14845 / NCIMB 13405 / ORS 571) Uncharacterized protein AZC_3924 Proteins 0.000 claims 2
- 101000823761 Bacillus licheniformis Uncharacterized 9.4 kDa protein in flaL 3'region Proteins 0.000 claims 2
- 101000819719 Bacillus methanolicus Uncharacterized N-acetyltransferase in lysA 3'region Proteins 0.000 claims 2
- 101000789586 Bacillus subtilis (strain 168) UPF0702 transmembrane protein YkjA Proteins 0.000 claims 2
- 101000792624 Bacillus subtilis (strain 168) Uncharacterized protein YbxH Proteins 0.000 claims 2
- 101000790792 Bacillus subtilis (strain 168) Uncharacterized protein YckC Proteins 0.000 claims 2
- 101000819705 Bacillus subtilis (strain 168) Uncharacterized protein YlxR Proteins 0.000 claims 2
- 101000948218 Bacillus subtilis (strain 168) Uncharacterized protein YtxJ Proteins 0.000 claims 2
- 101000718627 Bacillus thuringiensis subsp. kurstaki Putative RNA polymerase sigma-G factor Proteins 0.000 claims 2
- 101000641200 Bombyx mori densovirus Putative non-structural protein Proteins 0.000 claims 2
- 101000947633 Claviceps purpurea Uncharacterized 13.8 kDa protein Proteins 0.000 claims 2
- 101000948901 Enterobacteria phage T4 Uncharacterized 16.0 kDa protein in segB-ipI intergenic region Proteins 0.000 claims 2
- 101000805958 Equine herpesvirus 4 (strain 1942) Virion protein US10 homolog Proteins 0.000 claims 2
- 101000790442 Escherichia coli Insertion element IS2 uncharacterized 11.1 kDa protein Proteins 0.000 claims 2
- 101000788354 Escherichia phage P2 Uncharacterized 8.2 kDa protein in gpA 5'region Proteins 0.000 claims 2
- 101000770304 Frankia alni UPF0460 protein in nifX-nifW intergenic region Proteins 0.000 claims 2
- 101000797344 Geobacillus stearothermophilus Putative tRNA (cytidine(34)-2'-O)-methyltransferase Proteins 0.000 claims 2
- 101000748410 Geobacillus stearothermophilus Uncharacterized protein in fumA 3'region Proteins 0.000 claims 2
- 101000772675 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) UPF0438 protein HI_0847 Proteins 0.000 claims 2
- 101000631019 Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) Uncharacterized protein HI_0350 Proteins 0.000 claims 2
- 101000768938 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 8.9 kDa protein in int-C1 intergenic region Proteins 0.000 claims 2
- 101000785414 Homo sapiens Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 Proteins 0.000 claims 2
- 101000833492 Homo sapiens Jouberin Proteins 0.000 claims 2
- 101000651236 Homo sapiens NCK-interacting protein with SH3 domain Proteins 0.000 claims 2
- 241000193096 Human adenovirus B3 Species 0.000 claims 2
- 102100024407 Jouberin Human genes 0.000 claims 2
- 101000782488 Junonia coenia densovirus (isolate pBRJ/1990) Putative non-structural protein NS2 Proteins 0.000 claims 2
- 101000811523 Klebsiella pneumoniae Uncharacterized 55.8 kDa protein in cps region Proteins 0.000 claims 2
- 101000818409 Lactococcus lactis subsp. lactis Uncharacterized HTH-type transcriptional regulator in lacX 3'region Proteins 0.000 claims 2
- 101000878851 Leptolyngbya boryana Putative Fe(2+) transport protein A Proteins 0.000 claims 2
- 101000758828 Methanosarcina barkeri (strain Fusaro / DSM 804) Uncharacterized protein Mbar_A1602 Proteins 0.000 claims 2
- 101001122401 Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) Non-structural protein ORF3 Proteins 0.000 claims 2
- 101001055788 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) Pentapeptide repeat protein MfpA Proteins 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 101710087110 ORF6 protein Proteins 0.000 claims 2
- 101000740670 Orgyia pseudotsugata multicapsid polyhedrosis virus Protein C42 Proteins 0.000 claims 2
- 101000769182 Photorhabdus luminescens Uncharacterized protein in pnp 3'region Proteins 0.000 claims 2
- 101710159752 Poly(3-hydroxyalkanoate) polymerase subunit PhaE Proteins 0.000 claims 2
- 101710130262 Probable Vpr-like protein Proteins 0.000 claims 2
- 101000961392 Pseudescherichia vulneris Uncharacterized 29.9 kDa protein in crtE 3'region Proteins 0.000 claims 2
- 101000731030 Pseudomonas oleovorans Poly(3-hydroxyalkanoate) polymerase 2 Proteins 0.000 claims 2
- 101001065485 Pseudomonas putida Probable fatty acid methyltransferase Proteins 0.000 claims 2
- 101000711023 Rhizobium leguminosarum bv. trifolii Uncharacterized protein in tfuA 3'region Proteins 0.000 claims 2
- 101000948156 Rhodococcus erythropolis Uncharacterized 47.3 kDa protein in thcA 5'region Proteins 0.000 claims 2
- 101000917565 Rhodococcus fascians Uncharacterized 33.6 kDa protein in fasciation locus Proteins 0.000 claims 2
- 101000790284 Saimiriine herpesvirus 2 (strain 488) Uncharacterized 9.5 kDa protein in DHFR 3'region Proteins 0.000 claims 2
- 101000936719 Streptococcus gordonii Accessory Sec system protein Asp3 Proteins 0.000 claims 2
- 101000788499 Streptomyces coelicolor Uncharacterized oxidoreductase in mprA 5'region Proteins 0.000 claims 2
- 101001102841 Streptomyces griseus Purine nucleoside phosphorylase ORF3 Proteins 0.000 claims 2
- 101000708557 Streptomyces lincolnensis Uncharacterized 17.2 kDa protein in melC2-rnhH intergenic region Proteins 0.000 claims 2
- 101000649826 Thermotoga neapolitana Putative anti-sigma factor antagonist TM1081 homolog Proteins 0.000 claims 2
- 101710110895 Uncharacterized 7.3 kDa protein in cox-rep intergenic region Proteins 0.000 claims 2
- 101710095001 Uncharacterized protein in nifU 5'region Proteins 0.000 claims 2
- 101000827562 Vibrio alginolyticus Uncharacterized protein in proC 3'region Proteins 0.000 claims 2
- 101000778915 Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633) Uncharacterized membrane protein VP2115 Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 101000621943 Acholeplasma phage L2 Probable integrase/recombinase Proteins 0.000 claims 1
- 108010057856 Adenovirus E2 Proteins Proteins 0.000 claims 1
- 108010027410 Adenovirus E3 Proteins Proteins 0.000 claims 1
- 108010056962 Adenovirus E4 Proteins Proteins 0.000 claims 1
- 101000618348 Allochromatium vinosum (strain ATCC 17899 / DSM 180 / NBRC 103801 / NCIMB 10441 / D) Uncharacterized protein Alvin_0065 Proteins 0.000 claims 1
- 101000781117 Autographa californica nuclear polyhedrosis virus Uncharacterized 12.4 kDa protein in CTL-LEF2 intergenic region Proteins 0.000 claims 1
- 101000708323 Azospirillum brasilense Uncharacterized 28.8 kDa protein in nifR3-like 5'region Proteins 0.000 claims 1
- 101000770311 Azotobacter chroococcum mcd 1 Uncharacterized 19.8 kDa protein in nifW 5'region Proteins 0.000 claims 1
- 101000748761 Bacillus subtilis (strain 168) Uncharacterized MFS-type transporter YcxA Proteins 0.000 claims 1
- 101000765620 Bacillus subtilis (strain 168) Uncharacterized protein YlxP Proteins 0.000 claims 1
- 101000916134 Bacillus subtilis (strain 168) Uncharacterized protein YqxJ Proteins 0.000 claims 1
- 101000754349 Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) UPF0065 protein BP0148 Proteins 0.000 claims 1
- 101000827633 Caldicellulosiruptor sp. (strain Rt8B.4) Uncharacterized 23.9 kDa protein in xynA 3'region Proteins 0.000 claims 1
- 101000947628 Claviceps purpurea Uncharacterized 11.8 kDa protein Proteins 0.000 claims 1
- 101000686796 Clostridium perfringens Replication protein Proteins 0.000 claims 1
- 102100031725 Cortactin-binding protein 2 Human genes 0.000 claims 1
- 101000788129 Escherichia coli Uncharacterized protein in sul1 3'region Proteins 0.000 claims 1
- 101000788370 Escherichia phage P2 Uncharacterized 12.9 kDa protein in GpA 3'region Proteins 0.000 claims 1
- 101710145505 Fiber protein Proteins 0.000 claims 1
- 101000787096 Geobacillus stearothermophilus Uncharacterized protein in gldA 3'region Proteins 0.000 claims 1
- 101000976889 Haemophilus phage HP1 (strain HP1c1) Uncharacterized 19.2 kDa protein in cox-rep intergenic region Proteins 0.000 claims 1
- 101000908757 Human adenovirus C serotype 2 Early 4 ORF4 protein Proteins 0.000 claims 1
- 101000827627 Klebsiella pneumoniae Putative low molecular weight protein-tyrosine-phosphatase Proteins 0.000 claims 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims 1
- 101001130841 Middle East respiratory syndrome-related coronavirus (isolate United Kingdom/H123990006/2012) Non-structural protein ORF5 Proteins 0.000 claims 1
- 101710173835 Penton protein Proteins 0.000 claims 1
- 101710197985 Probable protein Rev Proteins 0.000 claims 1
- 239000004365 Protease Substances 0.000 claims 1
- 102100040307 Protein FAM3B Human genes 0.000 claims 1
- 101000974028 Rhizobium leguminosarum bv. viciae (strain 3841) Putative cystathionine beta-lyase Proteins 0.000 claims 1
- 101000756519 Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) Uncharacterized protein RCAP_rcc00048 Proteins 0.000 claims 1
- 101000948219 Rhodococcus erythropolis Uncharacterized 11.5 kDa protein in thcD 3'region Proteins 0.000 claims 1
- 101000936711 Streptococcus gordonii Accessory secretory protein Asp4 Proteins 0.000 claims 1
- 101000929863 Streptomyces cinnamonensis Monensin polyketide synthase putative ketoacyl reductase Proteins 0.000 claims 1
- 101000788468 Streptomyces coelicolor Uncharacterized protein in mprR 3'region Proteins 0.000 claims 1
- 101000845085 Streptomyces violaceoruber Granaticin polyketide synthase putative ketoacyl reductase 1 Proteins 0.000 claims 1
- 101000711771 Thiocystis violacea Uncharacterized 76.5 kDa protein in phbC 3'region Proteins 0.000 claims 1
- 101710198378 Uncharacterized 10.8 kDa protein in cox-rep intergenic region Proteins 0.000 claims 1
- 101710134973 Uncharacterized 9.7 kDa protein in cox-rep intergenic region Proteins 0.000 claims 1
- 101000711318 Vibrio alginolyticus Uncharacterized 11.6 kDa protein in scrR 3'region Proteins 0.000 claims 1
- 230000000890 antigenic effect Effects 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/EP2015/063248 WO2015189425A1 (en) | 2014-06-13 | 2015-06-12 | Immunogenic combinations |
| GBGB1510357.5A GB201510357D0 (en) | 2015-06-12 | 2015-06-12 | Adenovirus polynucleotides and polypeptides |
| EPPCT/EP2015/063248 | 2015-06-12 | ||
| GB1510357.5 | 2015-06-12 | ||
| GB1514772.1 | 2015-08-19 | ||
| GBGB1514772.1A GB201514772D0 (en) | 2015-08-19 | 2015-08-19 | Adenovirus polynucleotides and polypeptides |
| PCT/EP2016/063329 WO2016198621A1 (en) | 2015-06-12 | 2016-06-10 | Adenovirus polynucleotides and polypeptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018523980A JP2018523980A (ja) | 2018-08-30 |
| JP2018523980A5 true JP2018523980A5 (enExample) | 2018-11-01 |
| JP6873054B2 JP6873054B2 (ja) | 2021-05-19 |
Family
ID=57503533
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017564424A Expired - Fee Related JP6983665B2 (ja) | 2015-06-12 | 2016-06-10 | アデノウイルスポリヌクレオチド及びポリペプチド |
| JP2017564467A Active JP6873054B2 (ja) | 2015-06-12 | 2016-06-10 | アデノウイルスポリヌクレオチド及びポリペプチド |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017564424A Expired - Fee Related JP6983665B2 (ja) | 2015-06-12 | 2016-06-10 | アデノウイルスポリヌクレオチド及びポリペプチド |
Country Status (13)
| Country | Link |
|---|---|
| US (4) | US11254711B2 (enExample) |
| EP (2) | EP3307313A1 (enExample) |
| JP (2) | JP6983665B2 (enExample) |
| KR (2) | KR102535670B1 (enExample) |
| CN (2) | CN108025058B (enExample) |
| AU (4) | AU2016275619B2 (enExample) |
| BE (1) | BE1024420B1 (enExample) |
| BR (1) | BR112017026523A2 (enExample) |
| CA (2) | CA2988654A1 (enExample) |
| EA (1) | EA038402B9 (enExample) |
| IL (2) | IL256069B2 (enExample) |
| MX (2) | MX2017016101A (enExample) |
| WO (2) | WO2016198621A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA038402B9 (ru) | 2015-06-12 | 2021-09-22 | Глаксосмитклайн Байолоджикалс Са | Аденовирусные полинуклеотиды и полипептиды |
| GB201513176D0 (en) | 2015-07-27 | 2015-09-09 | Glaxosmithkline Biolog Sa | Novel methods for inducing an immune response |
| ES2959811T3 (es) * | 2016-12-09 | 2024-02-28 | Glaxosmithkline Biologicals Sa | Construcciones de adenovirus de chimpancé con antígenos de Lyssavirus |
| GB201620968D0 (en) | 2016-12-09 | 2017-01-25 | Glaxosmithkline Biologicals Sa | Adenovirus polynucleotides and polypeptides |
| WO2019016756A1 (en) | 2017-07-21 | 2019-01-24 | Glaxosmithkline Biologicals Sa | ANTIGEN CONSTRUCTS OF CHIKUNGUNYA VIRUSES |
| WO2019076892A1 (en) | 2017-10-16 | 2019-04-25 | Glaxosmithkline Biologicals Sa | ENHANCED PROMOTER |
| CN111479926A (zh) | 2017-10-16 | 2020-07-31 | 葛兰素史密丝克莱恩生物有限公司 | 具有两个表达盒的猿猴腺病毒载体 |
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| GB201721068D0 (en) | 2017-12-15 | 2018-01-31 | Glaxosmithkline Biologicals Sa | Hepatitis B immunisation regimen and compositions |
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| CN112638936A (zh) * | 2018-06-12 | 2021-04-09 | 葛兰素史密丝克莱恩生物有限公司 | 腺病毒多核苷酸和多肽 |
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| EP3587581A1 (en) | 2018-06-26 | 2020-01-01 | GlaxoSmithKline Biologicals S.A. | Formulations for simian adenoviral vectors having enhanced storage stability |
| EP3810277A1 (en) * | 2018-07-20 | 2021-04-28 | Janssen Vaccines & Prevention B.V. | Recombinant adenoviral vector expressing zika antigen with improved productivity |
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| US20220339281A1 (en) | 2019-03-05 | 2022-10-27 | GalxoSmithKline Biologicals SA | Hepatitis b immunisation regimen and compositions |
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| WO2025038011A1 (en) * | 2023-08-11 | 2025-02-20 | Joint Stock Company «Biocad» | Modified sequence of adenovirus e2a gene for producing vectors based on adeno-associated viruses (aav) (variants) |
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| DE102012221236A1 (de) | 2012-11-21 | 2014-05-22 | Zf Friedrichshafen Ag | Getriebe |
| GB201303406D0 (en) * | 2013-02-26 | 2013-04-10 | Health Prot Agency | Crimean-Congo Haemorrhagic Fever Virus Antigenic Composition |
| KR102039520B1 (ko) | 2013-04-18 | 2019-11-01 | 이뮨 디자인 코포레이션 | 암 치료에 이용하기 위한 gla 단일요법 |
| CN103937835A (zh) * | 2013-08-19 | 2014-07-23 | 中国科学院上海巴斯德研究所 | 一种基于腺病毒AdC68的表达载体及其构建方法 |
| CN103923943B (zh) * | 2013-08-19 | 2019-01-22 | 中国科学院上海巴斯德研究所 | 一种基于腺病毒AdC7的表达载体及其构建方法 |
| GB201318084D0 (en) * | 2013-10-11 | 2013-11-27 | Isis Innovation | Malaria vaccination |
| CN106659777A (zh) | 2014-06-13 | 2017-05-10 | 葛兰素史密丝克莱恩生物有限公司 | 免疫原性组合产品 |
| EA038402B9 (ru) | 2015-06-12 | 2021-09-22 | Глаксосмитклайн Байолоджикалс Са | Аденовирусные полинуклеотиды и полипептиды |
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2016
- 2016-06-10 EA EA201792651A patent/EA038402B9/ru unknown
- 2016-06-10 EP EP16730315.5A patent/EP3307313A1/en active Pending
- 2016-06-10 JP JP2017564424A patent/JP6983665B2/ja not_active Expired - Fee Related
- 2016-06-10 KR KR1020177037436A patent/KR102535670B1/ko active Active
- 2016-06-10 EP EP16730773.5A patent/EP3307314A1/en not_active Withdrawn
- 2016-06-10 WO PCT/EP2016/063329 patent/WO2016198621A1/en not_active Ceased
- 2016-06-10 WO PCT/EP2016/063297 patent/WO2016198599A1/en not_active Ceased
- 2016-06-10 US US15/735,872 patent/US11254711B2/en active Active
- 2016-06-10 AU AU2016275619A patent/AU2016275619B2/en active Active
- 2016-06-10 CN CN201680047775.1A patent/CN108025058B/zh not_active Expired - Fee Related
- 2016-06-10 MX MX2017016101A patent/MX2017016101A/es unknown
- 2016-06-10 MX MX2017016105A patent/MX2017016105A/es unknown
- 2016-06-10 AU AU2016275601A patent/AU2016275601A1/en not_active Abandoned
- 2016-06-10 US US15/735,839 patent/US11254710B2/en active Active
- 2016-06-10 KR KR1020187000991A patent/KR20180012857A/ko not_active Ceased
- 2016-06-10 JP JP2017564467A patent/JP6873054B2/ja active Active
- 2016-06-10 CA CA2988654A patent/CA2988654A1/en active Pending
- 2016-06-10 BR BR112017026523A patent/BR112017026523A2/pt not_active IP Right Cessation
- 2016-06-10 CA CA2988481A patent/CA2988481A1/en active Pending
- 2016-06-10 BE BE2016/5434A patent/BE1024420B1/fr active IP Right Grant
- 2016-06-10 CN CN201680047373.1A patent/CN107921118B/zh active Active
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2017
- 2017-12-03 IL IL256069A patent/IL256069B2/en unknown
- 2017-12-05 IL IL256121A patent/IL256121B2/en unknown
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2019
- 2019-03-26 AU AU2019202081A patent/AU2019202081B2/en active Active
- 2019-11-27 AU AU2019271972A patent/AU2019271972B2/en not_active Ceased
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2021
- 2021-12-30 US US17/565,796 patent/US20220204566A1/en not_active Abandoned
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2022
- 2022-01-25 US US17/583,511 patent/US20220220157A1/en not_active Abandoned
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