JP2009535031A5 - - Google Patents
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- Publication number
- JP2009535031A5 JP2009535031A5 JP2009507816A JP2009507816A JP2009535031A5 JP 2009535031 A5 JP2009535031 A5 JP 2009535031A5 JP 2009507816 A JP2009507816 A JP 2009507816A JP 2009507816 A JP2009507816 A JP 2009507816A JP 2009535031 A5 JP2009535031 A5 JP 2009535031A5
- Authority
- JP
- Japan
- Prior art keywords
- isolated dna
- adenovirus
- gene
- promoter
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108020004414 DNA Proteins 0.000 claims 21
- 108090000623 proteins and genes Proteins 0.000 claims 12
- 241000701161 unidentified adenovirus Species 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 102000039446 nucleic acids Human genes 0.000 claims 8
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 7
- 230000000694 effects Effects 0.000 claims 4
- 238000013467 fragmentation Methods 0.000 claims 4
- 238000006062 fragmentation reaction Methods 0.000 claims 4
- 238000012986 modification Methods 0.000 claims 4
- 230000004048 modification Effects 0.000 claims 4
- 238000012217 deletion Methods 0.000 claims 3
- 230000037430 deletion Effects 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 239000000835 fiber Substances 0.000 claims 3
- 238000003780 insertion Methods 0.000 claims 3
- 230000037431 insertion Effects 0.000 claims 3
- 239000002773 nucleotide Substances 0.000 claims 3
- 125000003729 nucleotide group Chemical group 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 239000013603 viral vector Substances 0.000 claims 3
- 108010024878 Adenovirus E1A Proteins Proteins 0.000 claims 2
- 108700026758 Adenovirus hexon capsid Proteins 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 230000000174 oncolytic effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 230000003362 replicative effect Effects 0.000 claims 2
- 108010027410 Adenovirus E3 Proteins Proteins 0.000 claims 1
- 101710199711 Early E1A protein Proteins 0.000 claims 1
- 241001135569 Human adenovirus 5 Species 0.000 claims 1
- 241000193096 Human adenovirus B3 Species 0.000 claims 1
- 206010021143 Hypoxia Diseases 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 108020004440 Thymidine kinase Proteins 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002068 genetic effect Effects 0.000 claims 1
- 230000007954 hypoxia Effects 0.000 claims 1
- 239000012212 insulator Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 241001529453 unidentified herpesvirus Species 0.000 claims 1
- 239000013598 vector Substances 0.000 claims 1
- 108700026220 vif Genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP20060101724 | 2006-04-28 | ||
| ARP060101724A AR053246A1 (es) | 2006-04-28 | 2006-04-28 | Un fragmento aislado de adn del promotor humano de sparc y su uso para dirigir la expresion de un gen heterologo en celulas tumorales |
| PCT/US2007/010196 WO2007127347A2 (en) | 2006-04-28 | 2007-04-26 | An isolated dna fragment of the sparc human promoter and its use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009535031A JP2009535031A (ja) | 2009-10-01 |
| JP2009535031A5 true JP2009535031A5 (enExample) | 2010-06-17 |
| JP5215290B2 JP5215290B2 (ja) | 2013-06-19 |
Family
ID=38006653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009507816A Expired - Fee Related JP5215290B2 (ja) | 2006-04-28 | 2007-04-26 | Ｓｐａｒｃヒトプロモーターの単離されたｄｎａ断片及び腫瘍細胞において異種の遺伝子の発現を駆動するためのその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US8436160B2 (enExample) |
| EP (1) | EP2048954B1 (enExample) |
| JP (1) | JP5215290B2 (enExample) |
| AR (1) | AR053246A1 (enExample) |
| AT (1) | ATE550943T1 (enExample) |
| AU (1) | AU2007243252B2 (enExample) |
| ES (1) | ES2384736T3 (enExample) |
| NZ (1) | NZ572350A (enExample) |
| WO (1) | WO2007127347A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2304281B1 (es) * | 2006-02-01 | 2009-08-12 | Dnatrix Inc. | Adenovirus oncoliticos para el tratamiento del cancer. |
| US9056133B2 (en) * | 2011-05-25 | 2015-06-16 | Cti-S.A. | Pharmaceutical kit and method for treating cancer |
| WO2020172509A1 (en) * | 2019-02-21 | 2020-08-27 | Unleash Immuno Oncolytics, Inc. | Oncolytic adenoviral vector and methods of use |
| EP4172208A2 (en) | 2020-06-26 | 2023-05-03 | Sorrento Therapeutics, Inc. | Oncolytic herpes simplex viruses (hsv) expressing immunomodulatory fusion proteins |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5772993A (en) * | 1997-01-21 | 1998-06-30 | The University Of Virginia Patent Foundation | Osteocalcin promoter-based toxic gene therapy for the treatment of calcified tumors and tissues |
| WO2000072679A1 (en) * | 1999-05-28 | 2000-12-07 | University Of Virginia Patent Foundation | Osteonectin based toxic gene therapy for the treatment of calcified tumors and tissues |
| US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
| CA2530748A1 (en) * | 2003-06-24 | 2005-02-24 | Johns Hopkins University | Methylated gene biomarkers for detecting cancer |
| WO2007000020A1 (en) | 2005-06-29 | 2007-01-04 | Compumedics Limited | Sensor assembly with conductive bridge |
-
2006
- 2006-04-28 AR ARP060101724A patent/AR053246A1/es active IP Right Grant
-
2007
- 2007-04-26 JP JP2009507816A patent/JP5215290B2/ja not_active Expired - Fee Related
- 2007-04-26 NZ NZ572350A patent/NZ572350A/en not_active IP Right Cessation
- 2007-04-26 EP EP07776311A patent/EP2048954B1/en not_active Not-in-force
- 2007-04-26 ES ES07776311T patent/ES2384736T3/es active Active
- 2007-04-26 US US12/298,743 patent/US8436160B2/en not_active Expired - Fee Related
- 2007-04-26 WO PCT/US2007/010196 patent/WO2007127347A2/en not_active Ceased
- 2007-04-26 AU AU2007243252A patent/AU2007243252B2/en not_active Ceased
- 2007-04-26 AT AT07776311T patent/ATE550943T1/de active
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