JP2018519359A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018519359A5 JP2018519359A5 JP2018516407A JP2018516407A JP2018519359A5 JP 2018519359 A5 JP2018519359 A5 JP 2018519359A5 JP 2018516407 A JP2018516407 A JP 2018516407A JP 2018516407 A JP2018516407 A JP 2018516407A JP 2018519359 A5 JP2018519359 A5 JP 2018519359A5
- Authority
- JP
- Japan
- Prior art keywords
- gcsf
- peg
- pegx
- patient
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 40
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 claims description 39
- 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 claims description 39
- 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims description 30
- 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims description 18
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims description 8
- 208000004235 neutropenia Diseases 0.000 claims description 8
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 5
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 claims description 4
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims description 4
- 210000000265 leukocyte Anatomy 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 3
- 150000001412 amines Chemical class 0.000 claims description 3
- 150000001413 amino acids Chemical class 0.000 claims description 3
- 201000011510 cancer Diseases 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 206010040047 Sepsis Diseases 0.000 claims description 2
- 206010040070 Septic Shock Diseases 0.000 claims description 2
- 201000006491 bone marrow cancer Diseases 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 230000036303 septic shock Effects 0.000 claims description 2
- 201000006681 severe congenital neutropenia Diseases 0.000 claims description 2
- 238000011476 stem cell transplantation Methods 0.000 claims description 2
- 238000004820 blood count Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 238000011026 diafiltration Methods 0.000 description 4
- 239000012528 membrane Substances 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 3
- 230000005855 radiation Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562174373P | 2015-06-11 | 2015-06-11 | |
| US62/174,373 | 2015-06-11 | ||
| US201562184042P | 2015-06-24 | 2015-06-24 | |
| US62/184,042 | 2015-06-24 | ||
| PCT/US2016/037278 WO2016201448A2 (en) | 2015-06-11 | 2016-06-13 | Pegylated granulocyte colony stimulating factor (gcsf) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018519359A JP2018519359A (ja) | 2018-07-19 |
| JP2018519359A5 true JP2018519359A5 (https=) | 2019-07-18 |
Family
ID=57504855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018516407A Pending JP2018519359A (ja) | 2015-06-11 | 2016-06-13 | Ｐｅｇ化顆粒球コロニー刺激因子（ｇｃｓｆ） |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20160361426A1 (https=) |
| EP (1) | EP3307757A4 (https=) |
| JP (1) | JP2018519359A (https=) |
| KR (1) | KR20180017104A (https=) |
| CN (1) | CN107949565A (https=) |
| AU (1) | AU2016277147A1 (https=) |
| CA (1) | CA2988988A1 (https=) |
| IL (1) | IL256167A (https=) |
| MX (1) | MX2017016103A (https=) |
| RU (1) | RU2018100425A (https=) |
| WO (1) | WO2016201448A2 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023518412A (ja) * | 2020-03-20 | 2023-05-01 | アムジェン インコーポレイテッド | 酸性プロテアーゼを使用するペグフィルグラスチムの遊離ｎ末端の決定 |
| EP4326266A1 (en) * | 2021-04-21 | 2024-02-28 | Celgene Corporation | Methods of treating b-cell lymphoma using combination therapy |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020177688A1 (en) * | 1988-12-22 | 2002-11-28 | Kirin-Amgen, Inc., | Chemically-modified G-CSF |
| US6565841B1 (en) * | 1991-03-15 | 2003-05-20 | Amgen, Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| WO1992016555A1 (en) * | 1991-03-18 | 1992-10-01 | Enzon, Inc. | Hydrazine containing conjugates of polypeptides and glycopolypeptides with polymers |
| US5581476A (en) * | 1993-01-28 | 1996-12-03 | Amgen Inc. | Computer-based methods and articles of manufacture for preparing G-CSF analogs |
| US5981709A (en) * | 1997-12-19 | 1999-11-09 | Enzon, Inc. | α-interferon-polymer-conjugates having enhanced biological activity and methods of preparing the same |
| US6555660B2 (en) * | 2000-01-10 | 2003-04-29 | Maxygen Holdings Ltd. | G-CSF conjugates |
| US6646110B2 (en) * | 2000-01-10 | 2003-11-11 | Maxygen Holdings Ltd. | G-CSF polypeptides and conjugates |
| PL371781A1 (en) * | 2001-07-11 | 2005-06-27 | Maxygen Holdings, Ltd. | G-csf conjugates |
| US7144978B2 (en) * | 2002-01-15 | 2006-12-05 | Pan Asia Bio Co., Ltd. | Multidrop tree branching functional polyethylene glycol, methods of preparing and using same |
| US7410955B2 (en) * | 2002-03-25 | 2008-08-12 | Biosynergen, Inc. | Therapeutic use of agonist ligands specific to G2A receptor |
| US7892745B2 (en) * | 2003-04-24 | 2011-02-22 | Xdx, Inc. | Methods and compositions for diagnosing and monitoring transplant rejection |
| KR101237884B1 (ko) * | 2003-12-03 | 2013-02-27 | 바이오제너릭스 에이지 | 글리코 peg화 과립구 콜로니 자극인자 |
| EP1888119B1 (en) * | 2005-06-01 | 2011-03-09 | Maxygen, Inc. | Pegylated g-csf polypeptides and methods of producing same |
| MX2008001706A (es) * | 2005-08-04 | 2008-04-07 | Nektar Therapeutics Al Corp | Conjugados de una porcion g-csf y un polimero. |
| CU23556A1 (es) * | 2005-11-30 | 2010-07-20 | Ct Ingenieria Genetica Biotech | Estructura polimérica semejante a dendrímero para la obtención de conjugados de interés farmacéutico |
| WO2009046377A2 (en) * | 2007-10-04 | 2009-04-09 | Medistem Laboratories, Inc. | Compositions and methods of stem cell therapy for autism |
| CN101602801A (zh) * | 2008-06-13 | 2009-12-16 | 杭州九源基因工程有限公司 | 聚乙二醇单修饰的重组人粒细胞集落刺激因子突变体 |
| WO2011041376A1 (en) * | 2009-09-30 | 2011-04-07 | Prolong Pharmaceuticals | Modified granulocyte colony stimulating factor (g-csf) |
| WO2011075606A2 (en) * | 2009-12-18 | 2011-06-23 | Alios Biopharma, Inc. | Hyperglycosylated polypeptide variants and methods of use |
| CN104109235B (zh) * | 2014-05-30 | 2017-07-18 | 厦门赛诺邦格生物科技股份有限公司 | 一种具有氮原子支化中心的单一官能化聚乙二醇、制备方法及其生物相关物质 |
-
2016
- 2016-06-13 JP JP2018516407A patent/JP2018519359A/ja active Pending
- 2016-06-13 EP EP16808533.0A patent/EP3307757A4/en not_active Withdrawn
- 2016-06-13 CA CA2988988A patent/CA2988988A1/en not_active Abandoned
- 2016-06-13 KR KR1020187000596A patent/KR20180017104A/ko not_active Withdrawn
- 2016-06-13 AU AU2016277147A patent/AU2016277147A1/en not_active Abandoned
- 2016-06-13 WO PCT/US2016/037278 patent/WO2016201448A2/en not_active Ceased
- 2016-06-13 US US15/181,333 patent/US20160361426A1/en not_active Abandoned
- 2016-06-13 MX MX2017016103A patent/MX2017016103A/es unknown
- 2016-06-13 RU RU2018100425A patent/RU2018100425A/ru not_active Application Discontinuation
- 2016-06-13 CN CN201680047209.0A patent/CN107949565A/zh active Pending
-
2017
- 2017-12-07 IL IL256167A patent/IL256167A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6676589B2 (ja) | 薬物動態特性の改善されたコンプスタチンアナログ | |
| KR102811896B1 (ko) | 병리학적 석회화 병태를 치료하기 위한 조성물, 및 이의 사용 방법 | |
| CN102458478B (zh) | 白蛋白-淀粉样肽缀合物及其用途 | |
| US20040071691A1 (en) | Pharmaceutical formulation | |
| JP2018519359A5 (https=) | ||
| JP2023525276A (ja) | 延長された酸化還元酵素モチーフを有する免疫原性ペプチド | |
| EP4393959A1 (en) | Human transferrin receptor-binding antibody-peptide conjugate | |
| RU2018100425A (ru) | Пегилированный гранулоцитарный колониестимулирующий фактор (гксф) | |
| US20190040106A1 (en) | Use of human derived immunosuppressive proteins and peptides as medicaments | |
| US20250025559A1 (en) | Irf-4 engineered t cells and uses thereof in treating cancer | |
| US20170202961A1 (en) | Combined therapy of alpha-1-antitrypsin and temporal t-cell depletion for preventing graft rejection | |
| WO2019104353A1 (en) | Stimulator of interferon genes (sting) ligands and uses thereof | |
| US10913780B2 (en) | Conjugates, their compositions, their uses, and their methods of making | |
| ES2877553T3 (es) | Uso de dominios inmunosupresores como medicamentos | |
| CN104945514A (zh) | 一种胰高血糖样素肽-1的融合蛋白、其制备方法及其药物组合物 | |
| CN107412741B (zh) | 矿化艾塞那肽缓释体系及其制备方法和应用 | |
| WO2024088213A1 (en) | Combination to induce specific immune tolerance | |
| KR20230074753A (ko) | 헤지호그 신호전달 경로의 활성화를 위한 강력한 결합제 | |
| US20190234933A1 (en) | Compositions and assays | |
| KR20030077950A (ko) | 생리활성 복합체 | |
| CA3017824C (en) | Conjugates of tacrolimus, their compositions, and their uses | |
| JP2004149507A (ja) | 免疫抑制剤 | |
| CA3225640A1 (en) | Car t/nk-cells for use in the treatment of invasive fungal infections | |
| WO2025246701A1 (zh) | 编码pten蛋白的环状rna及其联合免疫检查点抑制剂的组合物在肿瘤治疗中的应用 | |
| BR122024000903B1 (pt) | Composto, composição, e, uso do composto |