JP2018518522A - 癌を治療するための組成物及び方法 - Google Patents

癌を治療するための組成物及び方法 Download PDF

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Publication number
JP2018518522A
JP2018518522A JP2017567214A JP2017567214A JP2018518522A JP 2018518522 A JP2018518522 A JP 2018518522A JP 2017567214 A JP2017567214 A JP 2017567214A JP 2017567214 A JP2017567214 A JP 2017567214A JP 2018518522 A JP2018518522 A JP 2018518522A
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Japan
Prior art keywords
cancer
pp2a
inhibitor
kinase inhibitor
protein kinase
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JP2017567214A
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English (en)
Japanese (ja)
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JP2018518522A5 (https=
Inventor
ナルラ，ゴーサム
オールメイヤー，マイケル
マクアイド，ダニエル
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Icahn School of Medicine at Mount Sinai
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Icahn School of Medicine at Mount Sinai
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Publication of JP2018518522A publication Critical patent/JP2018518522A/ja
Publication of JP2018518522A5 publication Critical patent/JP2018518522A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2017567214A 2015-06-23 2016-06-23 癌を治療するための組成物及び方法 Pending JP2018518522A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562183517P 2015-06-23 2015-06-23
US62/183,517 2015-06-23
PCT/US2016/039022 WO2016210134A1 (en) 2015-06-23 2016-06-23 Compositions and methods for treating cancer

Publications (2)

Publication Number Publication Date
JP2018518522A true JP2018518522A (ja) 2018-07-12
JP2018518522A5 JP2018518522A5 (https=) 2019-07-25

Family

ID=57586472

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2017567214A Pending JP2018518522A (ja) 2015-06-23 2016-06-23 癌を治療するための組成物及び方法

Country Status (8)

Country Link
US (1) US10744141B2 (https=)
EP (1) EP3313819A1 (https=)
JP (1) JP2018518522A (https=)
CN (1) CN108779073A (https=)
AU (1) AU2016281646A1 (https=)
CA (1) CA2990835A1 (https=)
IL (1) IL256523A (https=)
WO (1) WO2016210134A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023519931A (ja) * 2020-04-01 2023-05-15 エンジン バイオサイエンシズ プライベート リミテッド 癌を治療するための方法及び組成物

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EP3352753A4 (en) 2015-09-24 2019-03-13 The Regents of The University of California SYNTHETIC SPHINGOLIPIDE-SIMILAR MOLECULES, MEDICAMENTS, METHODS FOR THEIR SYNTHESIS AND TREATMENT PROCEDURES
WO2021138391A1 (en) 2019-12-30 2021-07-08 Tyra Biosciences, Inc. Indazole compounds
EP4121031A4 (en) * 2020-03-20 2024-03-27 Atux Iskay LLC 3-DIARYLMETHYLENE AND THEIR USE
WO2022094615A1 (en) * 2020-10-29 2022-05-05 The Regents Of The University Of California Compounds and methods for increased antisense activity
CN114617969B (zh) * 2020-12-14 2023-08-25 上海市肿瘤研究所 乐伐替尼和Aurora-A激酶抑制剂在制备抑制癌症的药物中的应用
CN116806217A (zh) * 2021-02-08 2023-09-26 拉帕塔疗法公司 蛋白磷酸酶2a(pp2a)的取代的环状调节剂及其使用方法
AU2022216880A1 (en) * 2021-02-08 2023-08-10 Rappta Therapeutics Oy Substituted cyclic modulators of protein phosphatase 2a (pp2a) and methods using same
CN112816453B (zh) * 2021-02-09 2022-07-08 黑龙江大学 蛋白在预测药物性能上的应用
US20240368105A1 (en) 2021-08-18 2024-11-07 Atux Iskay Llc 2-diarylmethyl-4-aminotetrahydropyran derivatives and related compounds as anticancer, antiinflammatory, antifibrotic and neuroprotective agents
CN113616795B (zh) * 2021-08-31 2023-06-20 上海交通大学医学院附属瑞金医院 Pp2a激动剂防治由正常衰老或pp2a活性或表达降低所导致的精神障碍
CN114984221A (zh) * 2022-05-25 2022-09-02 浙江大学 Pp2a及其激活剂在急性缺血性脑卒中制药、标记的应用
CN116421726A (zh) * 2023-04-14 2023-07-14 中国海洋大学 一种基于分子预测的靶向plk1纳米药物的开发方法
WO2025230951A1 (en) * 2024-04-29 2025-11-06 Icahn School Of Medicine At Mount Sinai Method of treating adenoid cystic carcinoma

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US20030045515A1 (en) * 2001-05-24 2003-03-06 Lise Binderup Combination medicament for treatment of neoplastic diseases
EP1996193A2 (en) * 2006-03-13 2008-12-03 OSI Pharmaceuticals, Inc. Combined treatment with an egfr kinase inhibitor and an agent that sensitizes tumor cells to the effects of egfr kinase inhibitors
US20090020197A1 (en) * 2007-07-16 2009-01-22 Key Safety Systems, Inc. Gas generating compositions and airbag inflators
WO2009114703A2 (en) * 2008-03-12 2009-09-17 Fox Chase Cancer Center Combination therapy for the treatment of cancer
WO2009117769A1 (en) 2008-03-25 2009-10-01 Newcastle Innovation Limited Inhibition of c-kit cancers
JP2012523458A (ja) * 2009-04-13 2012-10-04 ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション タンパク質ホスファターゼ２ａ活性化剤
US9134297B2 (en) * 2011-01-11 2015-09-15 Icahn School Of Medicine At Mount Sinai Method and compositions for treating cancer and related methods
HK1198384A1 (en) * 2011-08-16 2015-04-17 Mt. Sinai School Of Medicine Tricyclic compounds as anticancer agents
WO2013096687A1 (en) * 2011-12-22 2013-06-27 Threshold Pharmaceuticals, Inc. Administration of hypoxia activated prodrugs in combination with chk1 inhibitors for treating cancer
WO2014151955A1 (en) * 2013-03-15 2014-09-25 Life Technologies Corporation Prognostic assay for squamous cell lung carcinoma
WO2015138500A1 (en) 2014-03-11 2015-09-17 Icahn School Of Medicine At Mount Sinai Sulfonamides derived from tricyclyl-2-aminocycloalkanols as anticancer agents
WO2015138496A1 (en) 2014-03-11 2015-09-17 Icahn School Of Medicine At Mount Sinai Constrained tricyclic sulfonamides

Non-Patent Citations (3)

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CLIN CANCER RES, vol. 20, no. 8, JPN6020020499, 2014, pages 2092 - 103, ISSN: 0004284881 *
LANCET ONCOL, vol. 14, no. 6, JPN6020020501, 2013, pages 229 - 38, ISSN: 0004284882 *
MOL ONCOL, vol. 9, no. 4, JPN6020020498, April 2015 (2015-04-01), pages 889 - 905, ISSN: 0004284880 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023519931A (ja) * 2020-04-01 2023-05-15 エンジン バイオサイエンシズ プライベート リミテッド 癌を治療するための方法及び組成物

Also Published As

Publication number Publication date
WO2016210134A1 (en) 2016-12-29
IL256523A (en) 2018-02-28
EP3313819A1 (en) 2018-05-02
AU2016281646A1 (en) 2018-02-01
US10744141B2 (en) 2020-08-18
US20180185382A1 (en) 2018-07-05
CA2990835A1 (en) 2016-12-29
CN108779073A (zh) 2018-11-09

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