JP2018517900A5 - - Google Patents
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- Publication number
- JP2018517900A5 JP2018517900A5 JP2017557438A JP2017557438A JP2018517900A5 JP 2018517900 A5 JP2018517900 A5 JP 2018517900A5 JP 2017557438 A JP2017557438 A JP 2017557438A JP 2017557438 A JP2017557438 A JP 2017557438A JP 2018517900 A5 JP2018517900 A5 JP 2018517900A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- medium
- stem cells
- tgfβ1
- measuring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims 17
- 238000000034 method Methods 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 11
- 239000002609 medium Substances 0.000 claims 6
- 238000002560 therapeutic procedure Methods 0.000 claims 4
- 239000001963 growth medium Substances 0.000 claims 3
- 238000002965 ELISA Methods 0.000 claims 2
- 206010061246 Intervertebral disc degeneration Diseases 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 238000012258 culturing Methods 0.000 claims 2
- 208000018180 degenerative disc disease Diseases 0.000 claims 2
- 208000021600 intervertebral disc degenerative disease Diseases 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 1
- 241001137251 Corvidae Species 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 239000007640 basal medium Substances 0.000 claims 1
- 229940098773 bovine serum albumin Drugs 0.000 claims 1
- 230000002648 chondrogenic effect Effects 0.000 claims 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 claims 1
- 229940099552 hyaluronan Drugs 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 238000010899 nucleation Methods 0.000 claims 1
- 210000000130 stem cell Anatomy 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020190850A JP7335222B2 (ja) | 2015-05-05 | 2020-11-17 | 効力検定 |
| JP2023132587A JP7754893B2 (ja) | 2015-05-05 | 2023-08-16 | 効力検定 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2015901605 | 2015-05-05 | ||
| AU2015901605A AU2015901605A0 (en) | 2015-05-05 | Potency assay | |
| PCT/EP2016/060049 WO2016177805A1 (en) | 2015-05-05 | 2016-05-04 | Potency assay |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020190850A Division JP7335222B2 (ja) | 2015-05-05 | 2020-11-17 | 効力検定 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018517900A JP2018517900A (ja) | 2018-07-05 |
| JP2018517900A5 true JP2018517900A5 (OSRAM) | 2019-06-06 |
| JP6797833B2 JP6797833B2 (ja) | 2020-12-09 |
Family
ID=56087237
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017557438A Active JP6797833B2 (ja) | 2015-05-05 | 2016-05-04 | 効力検定 |
| JP2020190850A Active JP7335222B2 (ja) | 2015-05-05 | 2020-11-17 | 効力検定 |
| JP2023132587A Active JP7754893B2 (ja) | 2015-05-05 | 2023-08-16 | 効力検定 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020190850A Active JP7335222B2 (ja) | 2015-05-05 | 2020-11-17 | 効力検定 |
| JP2023132587A Active JP7754893B2 (ja) | 2015-05-05 | 2023-08-16 | 効力検定 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US11795435B2 (OSRAM) |
| EP (2) | EP3292199B1 (OSRAM) |
| JP (3) | JP6797833B2 (OSRAM) |
| KR (2) | KR102885856B1 (OSRAM) |
| CN (2) | CN115141872A (OSRAM) |
| AU (3) | AU2016258980B2 (OSRAM) |
| CA (1) | CA2984987C (OSRAM) |
| ES (2) | ES2911266T3 (OSRAM) |
| WO (1) | WO2016177805A1 (OSRAM) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3714038A1 (en) | 2017-11-22 | 2020-09-30 | Mesoblast International Sàrl | Cellular compositions and methods of treatment i |
| KR102506822B1 (ko) * | 2018-09-20 | 2023-03-06 | 시토스핀, 에스.엘. | 기능적 중간엽 줄기 세포의 농축된 집단을 수득하는 방법, 이의 수득된 세포 및 이를 포함하는 조성물 |
| JP2022515916A (ja) * | 2019-01-02 | 2022-02-22 | メゾブラスト・インターナショナル・エスアーエールエル | 腰痛を治療するための方法 |
| CN115605754A (zh) * | 2020-04-20 | 2023-01-13 | 美商生命科学有限公司（Us） | 效价测定 |
| CN120418656A (zh) * | 2022-12-23 | 2025-08-01 | 康干细胞生物科技有限公司 | 用于选择具有增强的软骨分化能力的干细胞的方法及包括其的细胞疗法产品 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3089815A (en) | 1951-10-11 | 1963-05-14 | Lieb Hans | Injectable pharmaceutical preparation, and a method of making same |
| US4593089A (en) | 1980-07-30 | 1986-06-03 | Abbott Laboratories | Fluorescent polarization immunoassay utilizing substituted triazinylaminofluorescein aminoglycosides |
| US4751190A (en) | 1985-07-22 | 1988-06-14 | Abbott Laboratories | Fluorescence polarization immunoassay and reagents for use therein |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US4983393A (en) | 1987-07-21 | 1991-01-08 | Maximed Corporation | Intra-vaginal device and method for sustained drug release |
| AU8200191A (en) | 1990-07-09 | 1992-02-04 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | High efficiency packaging of mutant adeno-associated virus using amber suppressions |
| US5173414A (en) | 1990-10-30 | 1992-12-22 | Applied Immune Sciences, Inc. | Production of recombinant adeno-associated virus vectors |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| DK0648271T3 (da) | 1991-08-20 | 2003-07-21 | Us Gov Health & Human Serv | Adenovirusmedieret overførsel af gener til mave-/tarmkanal |
| DE4211351A1 (de) | 1992-04-04 | 1993-10-07 | Behringwerke Ag | Verfahren zur Analyse partikelverstärkter Agglutinationsreaktionen auf Zentrifugalanalysatoren durch Bestimmung der Trübungsaufhellung |
| JPH08510134A (ja) | 1993-05-17 | 1996-10-29 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Ｈｉｖ感染およびエイズを対象としたリボザイム遺伝子治療 |
| US6541213B1 (en) | 1996-03-29 | 2003-04-01 | University Of Washington | Microscale diffusion immunoassay |
| CA2244326C (en) | 1997-08-11 | 2006-03-28 | Shinichi Eda | Microparticle enhanced light scattering agglutination assay and microparticle reagents therefor |
| WO2000042430A1 (en) | 1999-01-15 | 2000-07-20 | Medtox Scientific, Inc. | Lateral flow test strip |
| AU2003901668A0 (en) | 2003-03-28 | 2003-05-01 | Medvet Science Pty. Ltd. | Non-haemopoietic precursor cells |
| CA2413337C (en) | 2000-06-22 | 2009-11-24 | Thomas E. Davis | Bioadhesive compositions and methods of preparation and use |
| EP1419387B1 (en) | 2001-08-20 | 2012-01-04 | Proteome Systems Ltd. | Diagnostic testing process |
| US20040265926A1 (en) | 2002-11-21 | 2004-12-30 | Leong Ng | Bodily fluid markers of tissue hypoxia |
| KR101446634B1 (ko) | 2005-04-12 | 2014-10-16 | 메소블라스트, 아이엔씨. | 조직 비특이적인 알카리 포스파타제에 의한 다분화성 성체세포의 분리 |
| KR100802011B1 (ko) | 2005-08-10 | 2008-02-12 | 인하대학교 산학협력단 | 층분리배양법을 이용한 골수에서의 중간엽 줄기세포분리방법 |
| JP2011196840A (ja) * | 2010-03-19 | 2011-10-06 | Univ Of Tokyo | 急性大動脈解離の検査方法 |
| US20140286916A1 (en) * | 2011-10-11 | 2014-09-25 | Bone Therapeutics | Uses of Growth and Differentiation Factor 8 (GDF-8) |
| NZ715203A (en) * | 2013-05-16 | 2019-07-26 | Agency Science Tech & Res | Heparan sulphates |
| KR20150016117A (ko) | 2013-07-30 | 2015-02-11 | 코아스템(주) | 인간 골수 유래 중간엽 줄기세포를 유효성분으로 포함하는 자가면역질환의 예방 또는 치료용 약제학적 조성물 |
| CN103990181B (zh) * | 2014-05-26 | 2015-07-08 | 中国人民解放军第四军医大学 | 一种具有诱导活性微载体-细胞复合物的制备方法及其应用 |
-
2016
- 2016-05-04 ES ES16725775T patent/ES2911266T3/es active Active
- 2016-05-04 KR KR1020237032315A patent/KR102885856B1/ko active Active
- 2016-05-04 CN CN202210727621.4A patent/CN115141872A/zh active Pending
- 2016-05-04 KR KR1020177034098A patent/KR102582602B1/ko active Active
- 2016-05-04 ES ES22150277T patent/ES3018944T3/es active Active
- 2016-05-04 CA CA2984987A patent/CA2984987C/en active Active
- 2016-05-04 WO PCT/EP2016/060049 patent/WO2016177805A1/en not_active Ceased
- 2016-05-04 JP JP2017557438A patent/JP6797833B2/ja active Active
- 2016-05-04 US US15/571,178 patent/US11795435B2/en active Active
- 2016-05-04 EP EP16725775.7A patent/EP3292199B1/en active Active
- 2016-05-04 EP EP22150277.6A patent/EP4015624B1/en active Active
- 2016-05-04 CN CN201680030528.0A patent/CN107771220B/zh active Active
- 2016-05-04 AU AU2016258980A patent/AU2016258980B2/en active Active
-
2020
- 2020-11-17 JP JP2020190850A patent/JP7335222B2/ja active Active
-
2022
- 2022-05-11 AU AU2022203140A patent/AU2022203140B2/en active Active
-
2023
- 2023-08-16 JP JP2023132587A patent/JP7754893B2/ja active Active
- 2023-09-06 US US18/461,866 patent/US20240076621A1/en not_active Abandoned
-
2024
- 2024-08-20 US US18/810,282 patent/US20240409898A1/en active Pending
-
2025
- 2025-07-02 AU AU2025205043A patent/AU2025205043A1/en active Pending
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