JP2018517759A5 - - Google Patents
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- JP2018517759A5 JP2018517759A5 JP2017566021A JP2017566021A JP2018517759A5 JP 2018517759 A5 JP2018517759 A5 JP 2018517759A5 JP 2017566021 A JP2017566021 A JP 2017566021A JP 2017566021 A JP2017566021 A JP 2017566021A JP 2018517759 A5 JP2018517759 A5 JP 2018517759A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- dcp
- subject
- leukemia
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 23
- IIJQICKYWPGJDT-UHFFFAOYSA-L azane;cyclobutane-1,1-dicarboxylate;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound N.N.[Pt+2].OC(=O)C1(C([O-])=O)CCC1.OC(=O)C1(C([O-])=O)CCC1 IIJQICKYWPGJDT-UHFFFAOYSA-L 0.000 claims 5
- 210000004027 cell Anatomy 0.000 claims 4
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims 4
- 230000003211 malignant effect Effects 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 239000004480 active ingredient Substances 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- 229960003180 glutathione Drugs 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 201000001441 melanoma Diseases 0.000 claims 2
- 208000036762 Acute promyelocytic leukaemia Diseases 0.000 claims 1
- 241001116389 Aloe Species 0.000 claims 1
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 claims 1
- 108010024636 Glutathione Proteins 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- 208000006265 Renal cell carcinoma Diseases 0.000 claims 1
- 208000009956 adenocarcinoma Diseases 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 238000009098 adjuvant therapy Methods 0.000 claims 1
- 235000011399 aloe vera Nutrition 0.000 claims 1
- AENCTOAEVOLYHR-UHFFFAOYSA-N azanide cyclobutane-1,1-dicarboxylic acid platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1.OC(=O)C1(C(O)=O)CCC1 AENCTOAEVOLYHR-UHFFFAOYSA-N 0.000 claims 1
- GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 1
- 229960001467 bortezomib Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims 1
- 235000017471 coenzyme Q10 Nutrition 0.000 claims 1
- 229940110767 coenzyme Q10 Drugs 0.000 claims 1
- 229940109262 curcumin Drugs 0.000 claims 1
- 235000012754 curcumin Nutrition 0.000 claims 1
- 239000004148 curcumin Substances 0.000 claims 1
- VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229960002949 fluorouracil Drugs 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 235000003969 glutathione Nutrition 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000001167 myeloblast Anatomy 0.000 claims 1
- 208000025113 myeloid leukemia Diseases 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562182124P | 2015-06-19 | 2015-06-19 | |
| US62/182,124 | 2015-06-19 | ||
| PCT/US2016/038333 WO2016205782A1 (en) | 2015-06-19 | 2016-06-20 | Composition containing carboplatin and use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018517759A JP2018517759A (ja) | 2018-07-05 |
| JP2018517759A5 true JP2018517759A5 (enExample) | 2019-07-11 |
Family
ID=57546650
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017566021A Pending JP2018517759A (ja) | 2015-06-19 | 2016-06-20 | カルボプラチンを含む組成物及び用途 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10980768B2 (enExample) |
| EP (1) | EP3297440A4 (enExample) |
| JP (1) | JP2018517759A (enExample) |
| KR (1) | KR20180014834A (enExample) |
| CN (1) | CN108697093A (enExample) |
| AU (1) | AU2016279096B2 (enExample) |
| BR (1) | BR112017027277A2 (enExample) |
| CA (1) | CA2988989A1 (enExample) |
| WO (1) | WO2016205782A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6851989B2 (ja) | 2015-05-18 | 2021-03-31 | シン−ナット プロダクツ エンタープライズ エルエルシー | 医薬用共結晶及びその用途 |
| WO2016205782A1 (en) | 2015-06-19 | 2016-12-22 | Syn-Nat Products Enterprise LLC | Composition containing carboplatin and use |
| BR112017027285A2 (pt) | 2015-06-19 | 2018-09-11 | Syn Nat Products Entpr Llc | ?cocristal, composição farmacêutica e método para o tratamento de uma doença? |
| CA2989001A1 (en) | 2015-06-25 | 2016-12-29 | Syn-Nat Products Enterprise LLC | Pharmaceutical co-crystal composition and use thereof |
| AU2018372753B2 (en) * | 2017-11-21 | 2024-03-21 | Medoncare Pharmaceutical Co., Ltd | Combination product comprising dicycloplatin and preparation method and use thereof |
| WO2018171371A2 (zh) * | 2018-02-22 | 2018-09-27 | 昆明贵研药业有限公司 | 一种双二羧酸二氨络铂(ii)衍生物的制备方法 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5922689A (en) | 1995-09-11 | 1999-07-13 | Unitech Pharmaceuticals, Inc. | Cisplatin analogs for cancer treatment |
| US6297245B1 (en) | 1998-08-04 | 2001-10-02 | Unitech Pharmaceuticals | Cisplatin and folic acid administered to treat breast cancer |
| KR100317473B1 (ko) | 1999-05-11 | 2001-12-22 | 이계호 | 신규의 백금(ｉｖ)착제 및 그 제조방법 |
| CN1121380C (zh) * | 2000-03-03 | 2003-09-17 | 北京兴大豪斯科技有限公司 | 一种抗肿瘤的双二羧酸二氨络铂衍生物及其药物组合物 |
| CN1314357A (zh) * | 2000-03-16 | 2001-09-26 | 杨旭清 | 双环酸铂抗癌药 |
| AUPQ641100A0 (en) | 2000-03-23 | 2000-04-15 | Australia Nuclear Science & Technology Organisation | Methods of synthesis and use of radiolabelled platinum chemotherapeutic ag ents |
| EP1390027B1 (en) | 2001-05-31 | 2008-04-02 | The Chinese University Of Hong Kong | Composition comprising demethylcantharidin in combination with platinum-containing anticancer agents and use thereof |
| EP1473298B1 (en) | 2001-11-30 | 2009-05-13 | Jingzun Wang | Supermolecular carboplatinum derivatives, their preparation and pharmaceutical composition containing them as active ingredient and applications of the compositions |
| US7927613B2 (en) | 2002-02-15 | 2011-04-19 | University Of South Florida | Pharmaceutical co-crystal compositions |
| PL375713A1 (en) | 2002-08-19 | 2005-12-12 | Pfizer Products Inc. | Combination therapy for hyperproliferative diseases |
| US7566798B2 (en) | 2003-08-13 | 2009-07-28 | University Of South Florida | Platinum complexes and methods of use |
| CA2545815A1 (en) * | 2003-11-14 | 2005-06-09 | Genvec, Inc. | Adenoviral vectored tnf-a and chemoradiation to treat cancer |
| KR101345002B1 (ko) | 2005-01-21 | 2013-12-31 | 아스텍스 테라퓨틱스 리미티드 | 제약 화합물 |
| CN100391437C (zh) * | 2005-09-12 | 2008-06-04 | 重庆医科大学附属第二医院 | 抗急性髓性白血病的gm-csf靶向药物脂质体及制备方法 |
| AU2007209099A1 (en) | 2006-01-30 | 2007-08-02 | Platco Technologies (Proprietary) Limited | Preparation of platinum (ll) complexes |
| CN1857221A (zh) * | 2006-04-14 | 2006-11-08 | 济南帅华医药科技有限公司 | 一种同载铂类化合物及其增效剂的抗癌缓释剂 |
| HUE026693T2 (hu) * | 2006-08-02 | 2016-07-28 | Sunesis Pharmaceuticals Inc | (+)-1,4-dihidro-7-[(3S,4S)-3-metoxi-4-(metilamino)-1-pirrolidinil]-4-oxo-1-(2-tiazolil) -1,8-naftiridin-3-karbonsav és cytarabin (Ara-C) kombinált alkalmazása leukémia kezelésére |
| EP2324006B1 (en) * | 2008-09-15 | 2014-08-13 | Kasina Laila Innova Pharmaceuticals Private Ltd. | Anti-cancer drugs and uses relating thereto for metastatic malignant melanoma and other cancers |
| CZ302618B6 (cs) | 2009-09-10 | 2011-08-03 | Univerzita Palackého | Cyklobutan-1,1-dikarboxylátokomplexy platiny s deriváty N6-benzyladeninu, zpusoby jejich prípravy a použití techto komplexu jako léciv v protinádorové terapii |
| US20110287110A1 (en) * | 2010-04-23 | 2011-11-24 | Mark Wesley Dewhirst | Combination cancer treatment |
| WO2012104241A1 (de) * | 2011-01-31 | 2012-08-09 | LUCOLAS-M.D. Ltd | Kombinationen von aromatase inhibitoren und antioxidanzien |
| CN102924528B (zh) * | 2012-10-29 | 2015-04-15 | 东南大学 | 抗肿瘤二价铂配合物以及该配合物和其配体的制备方法 |
| WO2014075391A1 (zh) * | 2012-11-17 | 2014-05-22 | 北京市丰硕维康技术开发有限责任公司 | 离去基团是含氨基或烷氨基的丙二酸衍生物的铂类化合物 |
| CN103494838B (zh) * | 2013-09-30 | 2016-05-11 | 武汉大学 | 一种化疗药物组合物 |
| SI3424920T1 (sl) | 2013-10-17 | 2020-08-31 | Vertex Pharmaceuticals Incorporated | Kokristali (s)-n-metil-8-(1-((2'-metil-(4,5'-bipirimidin)-6-il)amino)propan-2-il) kinolin-4-karboksamida in devterirani derivati le-teh kot inhibitorji dna-pk |
| CN111638234B (zh) * | 2014-08-13 | 2024-09-03 | 北京默加农生物技术发展有限公司 | 一种以双环铂为有效成分的药物的检测方法 |
| CN104127402B (zh) * | 2014-08-15 | 2019-08-30 | 北京默加农生物技术发展有限公司 | 双环铂在制备抗病毒药物和抗菌药物中的应用 |
| CN104693245A (zh) | 2015-03-13 | 2015-06-10 | 卓越同达医药科技开发（苏州）有限公司 | 超分子抗癌药物双环铂的制备方法 |
| AU2015390714B2 (en) | 2015-04-10 | 2021-02-04 | Medoncare Pharmaceutical Co., Ltd | Process for the preparation of dicycloplatin |
| AU2016250616B2 (en) | 2015-04-22 | 2021-01-21 | Syn-Nat Products Enterprise LLC | Co-crystal composition and its pharmaceutical use |
| JP6851989B2 (ja) | 2015-05-18 | 2021-03-31 | シン−ナット プロダクツ エンタープライズ エルエルシー | 医薬用共結晶及びその用途 |
| BR112017027285A2 (pt) | 2015-06-19 | 2018-09-11 | Syn Nat Products Entpr Llc | ?cocristal, composição farmacêutica e método para o tratamento de uma doença? |
| WO2016205782A1 (en) | 2015-06-19 | 2016-12-22 | Syn-Nat Products Enterprise LLC | Composition containing carboplatin and use |
| CA2989001A1 (en) | 2015-06-25 | 2016-12-29 | Syn-Nat Products Enterprise LLC | Pharmaceutical co-crystal composition and use thereof |
-
2016
- 2016-06-20 WO PCT/US2016/038333 patent/WO2016205782A1/en not_active Ceased
- 2016-06-20 EP EP16812606.8A patent/EP3297440A4/en not_active Withdrawn
- 2016-06-20 KR KR1020187001614A patent/KR20180014834A/ko not_active Ceased
- 2016-06-20 US US15/736,170 patent/US10980768B2/en active Active
- 2016-06-20 AU AU2016279096A patent/AU2016279096B2/en not_active Ceased
- 2016-06-20 JP JP2017566021A patent/JP2018517759A/ja active Pending
- 2016-06-20 BR BR112017027277A patent/BR112017027277A2/pt not_active IP Right Cessation
- 2016-06-20 CA CA2988989A patent/CA2988989A1/en not_active Abandoned
- 2016-06-20 CN CN201680035788.7A patent/CN108697093A/zh active Pending
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