JP2018516920A5 - - Google Patents

Info

Publication number

JP2018516920A5

JP2018516920A5 JP2017561971A JP2017561971A JP2018516920A5 JP 2018516920 A5 JP2018516920 A5 JP 2018516920A5 JP 2017561971 A JP2017561971 A JP 2017561971A JP 2017561971 A JP2017561971 A JP 2017561971A JP 2018516920 A5 JP2018516920 A5 JP 2018516920A5

Authority

JP

Japan

Prior art keywords

trastuzumab

administered

pharmaceutical

medicament

medicament according

Prior art date

2016-05-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000003814 drug Substances 0.000 claims 13
• 229960001612 trastuzumab emtansine Drugs 0.000 claims 5
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 3
• 229930012538 Paclitaxel Natural products 0.000 claims 3
• 229940123237 Taxane Drugs 0.000 claims 3
• 229960003668 docetaxel Drugs 0.000 claims 3
• VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
• 229960001592 paclitaxel Drugs 0.000 claims 3
• DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 claims 3
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 3
• 206010006187 Breast cancer Diseases 0.000 claims 2
• 206010055113 Breast cancer metastatic Diseases 0.000 claims 2
• 208000026310 Breast neoplasm Diseases 0.000 claims 2
• 230000003442 weekly effect Effects 0.000 claims 2
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
• 238000009098 adjuvant therapy Methods 0.000 claims 1
• 238000002203 pretreatment Methods 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 229960000575 trastuzumab Drugs 0.000 claims 1