JP2018516572A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018516572A5 JP2018516572A5 JP2017562290A JP2017562290A JP2018516572A5 JP 2018516572 A5 JP2018516572 A5 JP 2018516572A5 JP 2017562290 A JP2017562290 A JP 2017562290A JP 2017562290 A JP2017562290 A JP 2017562290A JP 2018516572 A5 JP2018516572 A5 JP 2018516572A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid sequence
- grna
- hiv
- complementary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 52
- 108020005004 Guide RNA Proteins 0.000 claims 44
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 38
- 241000725303 Human immunodeficiency virus Species 0.000 claims 37
- 108020004414 DNA Proteins 0.000 claims 24
- 230000000295 complement effect Effects 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 14
- 230000001177 retroviral effect Effects 0.000 claims 14
- 241001430294 unidentified retrovirus Species 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 102100034343 Integrase Human genes 0.000 claims 9
- 108010042407 Endonucleases Proteins 0.000 claims 8
- 102100031780 Endonuclease Human genes 0.000 claims 7
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000000415 inactivating effect Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000001566 pro-viral effect Effects 0.000 claims 5
- 239000013604 expression vector Substances 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108091033409 CRISPR Proteins 0.000 claims 3
- 238000010354 CRISPR gene editing Methods 0.000 claims 3
- 208000031886 HIV Infections Diseases 0.000 claims 3
- 208000037357 HIV infectious disease Diseases 0.000 claims 3
- 108010061833 Integrases Proteins 0.000 claims 3
- 108091092195 Intron Proteins 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
- 108010027225 gag-pol Fusion Proteins Proteins 0.000 claims 3
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 108091029795 Intergenic region Proteins 0.000 claims 2
- 101710172711 Structural protein Proteins 0.000 claims 2
- 102000034356 gene-regulatory proteins Human genes 0.000 claims 2
- 108091006104 gene-regulatory proteins Proteins 0.000 claims 2
- 238000010362 genome editing Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 102000004533 Endonucleases Human genes 0.000 claims 1
- -1 Nef Proteins 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562169384P | 2015-06-01 | 2015-06-01 | |
| US62/169,384 | 2015-06-01 | ||
| US201562169633P | 2015-06-02 | 2015-06-02 | |
| US62/169,633 | 2015-06-02 | ||
| US201662308320P | 2016-03-15 | 2016-03-15 | |
| US62/308,320 | 2016-03-15 | ||
| PCT/US2016/035141 WO2016196539A2 (en) | 2015-06-01 | 2016-06-01 | Methods and compositions for rna-guided treatment of hiv infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516572A JP2018516572A (ja) | 2018-06-28 |
| JP2018516572A5 true JP2018516572A5 (enExample) | 2019-07-04 |
| JP6968416B2 JP6968416B2 (ja) | 2021-11-17 |
Family
ID=57442165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562290A Active JP6968416B2 (ja) | 2015-06-01 | 2016-06-01 | Ｒｎａ誘導性の、ｈｉｖ感染の処置のための、方法および組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11298410B2 (enExample) |
| EP (2) | EP3919622A1 (enExample) |
| JP (1) | JP6968416B2 (enExample) |
| KR (2) | KR102553518B1 (enExample) |
| CN (1) | CN108025188A (enExample) |
| AU (3) | AU2016270702B2 (enExample) |
| CA (1) | CA2987927C (enExample) |
| DK (1) | DK3302709T3 (enExample) |
| EA (1) | EA037359B1 (enExample) |
| ES (1) | ES2886480T3 (enExample) |
| MX (1) | MX2017015582A (enExample) |
| PL (1) | PL3302709T3 (enExample) |
| SG (1) | SG10201914137YA (enExample) |
| WO (1) | WO2016196539A2 (enExample) |
| ZA (1) | ZA201708236B (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| AU2014312123A1 (en) | 2013-08-29 | 2016-03-17 | Temple University Of The Commonwealth System Of Higher Education | Methods and compositions for RNA-guided treatment of HIV infection |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| KR102553518B1 (ko) | 2015-06-01 | 2023-07-07 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | Hiv 감염의 rna-가이드된 치료를 위한 방법 및 조성물 |
| JP2018527943A (ja) * | 2015-09-28 | 2018-09-27 | テンプル ユニバーシティー オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | Ｒｎａ誘導性の、ｈｉｖ感染の処置のための、方法および組成物 |
| US12043852B2 (en) | 2015-10-23 | 2024-07-23 | President And Fellows Of Harvard College | Evolved Cas9 proteins for gene editing |
| KR20250103795A (ko) | 2016-08-03 | 2025-07-07 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 아데노신 핵염기 편집제 및 그의 용도 |
| CN109804066A (zh) | 2016-08-09 | 2019-05-24 | 哈佛大学的校长及成员们 | 可编程cas9-重组酶融合蛋白及其用途 |
| US11542509B2 (en) | 2016-08-24 | 2023-01-03 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| AU2017342543B2 (en) | 2016-10-14 | 2024-06-27 | President And Fellows Of Harvard College | AAV delivery of nucleobase editors |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| EP3592381A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Cancer vaccine |
| KR20190127797A (ko) | 2017-03-10 | 2019-11-13 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 시토신에서 구아닌으로의 염기 편집제 |
| CA3057192A1 (en) | 2017-03-23 | 2018-09-27 | President And Fellows Of Harvard College | Nucleobase editors comprising nucleic acid programmable dna binding proteins |
| WO2018194876A1 (en) * | 2017-04-17 | 2018-10-25 | Temple University- Of The Commonwealth System Of Higher Education | An hiv-1 eradication strategy employing nanoformulated anti-retroviral drugs and gene editing agents |
| WO2018209320A1 (en) | 2017-05-12 | 2018-11-15 | President And Fellows Of Harvard College | Aptazyme-embedded guide rnas for use with crispr-cas9 in genome editing and transcriptional activation |
| US12415000B2 (en) * | 2017-07-07 | 2025-09-16 | The Broad Institute, Inc. | CRISPR system based antiviral therapy |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| WO2019139645A2 (en) | 2017-08-30 | 2019-07-18 | President And Fellows Of Harvard College | High efficiency base editors comprising gam |
| CN111373041B (zh) * | 2017-09-26 | 2024-10-11 | 伊利诺伊大学理事会 | 用于基因组编辑和调节转录的crispr/cas系统和方法 |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| US12281338B2 (en) | 2018-10-29 | 2025-04-22 | The Broad Institute, Inc. | Nucleobase editors comprising GeoCas9 and uses thereof |
| WO2020150499A1 (en) * | 2019-01-16 | 2020-07-23 | Fred Hutchinson Cancer Research Center | Methods to tag and isolate cells infected with the human immunodeficiency virus |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| DE112020001306T5 (de) | 2019-03-19 | 2022-01-27 | Massachusetts Institute Of Technology | Verfahren und zusammensetzungen zur editierung von nukleotidsequenzen |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| AU2020369599A1 (en) * | 2019-10-23 | 2022-05-12 | Monsanto Technology Llc | Compositions and methods for RNA-templated editing in plants |
| WO2021178924A1 (en) * | 2020-03-05 | 2021-09-10 | Board Of Regents Of The University Of Nebraska | Crispr/cas9 system for multistrain hiv-1 treatment |
| JP2023525304A (ja) | 2020-05-08 | 2023-06-15 | ザ ブロード インスティテュート，インコーポレーテッド | 標的二本鎖ヌクレオチド配列の両鎖同時編集のための方法および組成物 |
| MX2023000661A (es) * | 2020-07-13 | 2023-07-03 | Alexandra L Howell | Métodos y composiciones para la eficiencia y especificidad de arn guía de crispr/cas9 frente a aislados de vih-1 genéticamente diferentes. |
| CN112322587A (zh) * | 2020-09-17 | 2021-02-05 | 杭州市第一人民医院 | 一种带Cas9基因的人源可诱导多能干细胞系、构建方法、鉴定方法及应用 |
| US20240165266A1 (en) * | 2021-03-17 | 2024-05-23 | Board Of Regents Of The University Of Nebraska | Lipid nanoparticle formulations and methods of use thereof |
| WO2024103049A1 (en) * | 2022-11-11 | 2024-05-16 | The United States Government As Represented By The Department Of Veterans Affairs | Cd33 specific exosomes and uses thereof |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| EP2877213B1 (en) | 2012-07-25 | 2020-12-02 | The Broad Institute, Inc. | Inducible dna binding proteins and genome perturbation tools and applications thereof |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| US20140310830A1 (en) | 2012-12-12 | 2014-10-16 | Feng Zhang | CRISPR-Cas Nickase Systems, Methods And Compositions For Sequence Manipulation in Eukaryotes |
| ES2576126T3 (es) | 2012-12-12 | 2016-07-05 | The Broad Institute, Inc. | Modificación por tecnología genética y optimización de sistemas, métodos y composiciones enzimáticas mejorados para la manipulación de secuencias |
| EP2931898B1 (en) | 2012-12-12 | 2016-03-09 | The Broad Institute, Inc. | Engineering and optimization of systems, methods and compositions for sequence manipulation with functional domains |
| PT2784162E (pt) | 2012-12-12 | 2015-08-27 | Broad Inst Inc | Engenharia de sistemas, métodos e composições guia otimizadas para a manipulação de sequências |
| EP4234696A3 (en) | 2012-12-12 | 2023-09-06 | The Broad Institute Inc. | Crispr-cas component systems, methods and compositions for sequence manipulation |
| KR20150105956A (ko) | 2012-12-12 | 2015-09-18 | 더 브로드 인스티튜트, 인코퍼레이티드 | 서열 조작 및 치료적 적용을 위한 시스템, 방법 및 조성물의 전달, 유전자 조작 및 최적화 |
| EP2931899A1 (en) | 2012-12-12 | 2015-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| EP2932421A1 (en) | 2012-12-12 | 2015-10-21 | The Broad Institute, Inc. | Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| EP3434776A1 (en) | 2012-12-12 | 2019-01-30 | The Broad Institute, Inc. | Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| EP4282970A3 (en) | 2012-12-17 | 2024-01-17 | President and Fellows of Harvard College | Rna-guided human genome engineering |
| US11332719B2 (en) | 2013-03-15 | 2022-05-17 | The Broad Institute, Inc. | Recombinant virus and preparations thereof |
| US11274305B2 (en) | 2013-04-04 | 2022-03-15 | Trustees Of Dartmouth College | Compositions and methods for in vivo excision of HIV-1 proviral DNA |
| US20140356956A1 (en) | 2013-06-04 | 2014-12-04 | President And Fellows Of Harvard College | RNA-Guided Transcriptional Regulation |
| RU2690935C2 (ru) | 2013-06-04 | 2019-06-06 | Президент Энд Фэллоуз Оф Харвард Коллидж | Направляемая рнк регуляция транскрипции |
| CN107995927B (zh) | 2013-06-17 | 2021-07-30 | 布罗德研究所有限公司 | 用于肝靶向和治疗的crispr-cas系统、载体和组合物的递送与用途 |
| JP6738729B2 (ja) | 2013-06-17 | 2020-08-12 | ザ・ブロード・インスティテュート・インコーポレイテッド | 分裂終了細胞の疾患および障害をターゲティングおよびモデリングするための系、方法および組成物の送達、エンジニアリングおよび最適化 |
| EP3674411A1 (en) | 2013-06-17 | 2020-07-01 | The Broad Institute, Inc. | Delivery, engineering and optimization of tandem guide systems, methods and compositions for sequence manipulation |
| CA2915795C (en) | 2013-06-17 | 2021-07-13 | The Broad Institute, Inc. | Delivery, use and therapeutic applications of the crispr-cas systems and compositions for targeting disorders and diseases using viral components |
| EP3725885A1 (en) | 2013-06-17 | 2020-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof |
| CN105492611A (zh) | 2013-06-17 | 2016-04-13 | 布罗德研究所有限公司 | 用于序列操纵的优化的crispr-cas双切口酶系统、方法以及组合物 |
| CA2917638C (en) | 2013-07-09 | 2024-09-10 | Harvard College | RNA MULTIPLEX GUIDED GENOMIC ENGINEERING |
| SG10201800213VA (en) | 2013-07-10 | 2018-02-27 | Harvard College | Orthogonal cas9 proteins for rna-guided gene regulation and editing |
| US11306328B2 (en) | 2013-07-26 | 2022-04-19 | President And Fellows Of Harvard College | Genome engineering |
| US20150044192A1 (en) | 2013-08-09 | 2015-02-12 | President And Fellows Of Harvard College | Methods for identifying a target site of a cas9 nuclease |
| AU2014312123A1 (en) | 2013-08-29 | 2016-03-17 | Temple University Of The Commonwealth System Of Higher Education | Methods and compositions for RNA-guided treatment of HIV infection |
| US9737604B2 (en) | 2013-09-06 | 2017-08-22 | President And Fellows Of Harvard College | Use of cationic lipids to deliver CAS9 |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9388430B2 (en) | 2013-09-06 | 2016-07-12 | President And Fellows Of Harvard College | Cas9-recombinase fusion proteins and uses thereof |
| US10787684B2 (en) | 2013-11-19 | 2020-09-29 | President And Fellows Of Harvard College | Large gene excision and insertion |
| US9074199B1 (en) | 2013-11-19 | 2015-07-07 | President And Fellows Of Harvard College | Mutant Cas9 proteins |
| US11053481B2 (en) | 2013-12-12 | 2021-07-06 | President And Fellows Of Harvard College | Fusions of Cas9 domains and nucleic acid-editing domains |
| CN103923911B (zh) * | 2014-04-14 | 2016-06-08 | 上海金卫生物技术有限公司 | CRISPR-Cas9特异性敲除人CCR5基因的方法以及用于特异性靶向CCR5基因的sgRNA |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| CN104480144B (zh) * | 2014-12-12 | 2017-04-12 | 武汉大学 | 用于艾滋病基因治疗的CRISPR/Cas9重组慢病毒载体及其慢病毒 |
| MA41349A (fr) | 2015-01-14 | 2017-11-21 | Univ Temple | Éradication de l'herpès simplex de type i et d'autres virus de l'herpès associés guidée par arn |
| CN104726449A (zh) | 2015-03-23 | 2015-06-24 | 国家纳米科学中心 | 一种用于预防和/或治疗HIV的CRISPR-Cas9系统及其制备方法和用途 |
| KR102553518B1 (ko) * | 2015-06-01 | 2023-07-07 | 템플 유니버시티-오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션 | Hiv 감염의 rna-가이드된 치료를 위한 방법 및 조성물 |
| CA3012631A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| JP2018527943A (ja) | 2015-09-28 | 2018-09-27 | テンプル ユニバーシティー オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | Ｒｎａ誘導性の、ｈｉｖ感染の処置のための、方法および組成物 |
| CN108778343A (zh) | 2015-10-16 | 2018-11-09 | 天普大学-联邦高等教育系统 | 利用cpf1进行rna向导的基因编辑的方法和组合物 |
| AU2016341919A1 (en) | 2015-10-21 | 2018-04-19 | Editas Medicine, Inc. | CRISPR/CAS-related methods and compositions for treating hepatitis b virus |
| RU2018124657A (ru) | 2015-12-09 | 2020-01-09 | Эксижн Биотерапевтикс, Инк. | Способы редактирования генов и композиции для устранения риска активации вируса jc и пмл (прогрессирующая мультифокальная лейкоэнцефалопатия) во время иммуносупрессивной терапии |
| JP2019506156A (ja) | 2016-01-25 | 2019-03-07 | エクシジョン バイオセラピューティクス インコーポレイテッド | Ｈｉｖ感染症のｒｎａ誘導型治療のための方法及び組成物 |
| EP3417062B1 (en) | 2016-02-15 | 2024-06-26 | Temple University - Of The Commonwealth System of Higher Education | Excision of retroviral nucleic acid sequences |
| US9925425B2 (en) | 2016-03-17 | 2018-03-27 | Acushnet Company | Golf ball incorporating at least three adjacent ionomeric and/or HNP-based layers having multiple related property gradients there between |
| WO2017176529A1 (en) | 2016-04-06 | 2017-10-12 | Temple Univesity-Of The Commonwealth System Of Higher Education | Compositions for eradicating flavivirus infections in subjects |
| WO2017192172A1 (en) | 2016-05-05 | 2017-11-09 | Temple University - Of The Commonwealth System Of Higher Education | Rna guided eradication of varicella zoster virus |
| US20190256844A1 (en) | 2016-06-07 | 2019-08-22 | Temple University - Of The Commonwealth System Of Higher Education | Rna guided compositions for preventing and treating hepatitis b virus infections |
| US20190085326A1 (en) | 2016-09-14 | 2019-03-21 | Temple University - Of The Commonwealth System Of Higher Education | Negative feedback regulation of HIV-1 by gene editing strategy |
| CN110023494A (zh) | 2016-09-30 | 2019-07-16 | 加利福尼亚大学董事会 | Rna指导的核酸修饰酶及其使用方法 |
| US20190365862A1 (en) | 2016-10-12 | 2019-12-05 | Temple University - Of The Commonwealth System Of Higher Education | Combination therapies for eradicating flavivirus infections in subjects |
| US11299430B2 (en) | 2016-11-30 | 2022-04-12 | Hrl Laboratories, Llc | Formulations with active functional additives for 3D printing of preceramic polymers, and methods of 3D-printing the formulations |
| CN110431230A (zh) | 2017-01-26 | 2019-11-08 | 切除生物治疗公司 | 慢病毒和非整合型慢病毒作为病毒载体实施crispr治疗 |
| WO2018152418A1 (en) | 2017-02-17 | 2018-08-23 | Temple University - Of The Commonwealth System Of Higher Education | Gene editing therapy for hiv infection via dual targeting of hiv genome and ccr5 |
| WO2018194876A1 (en) | 2017-04-17 | 2018-10-25 | Temple University- Of The Commonwealth System Of Higher Education | An hiv-1 eradication strategy employing nanoformulated anti-retroviral drugs and gene editing agents |
-
2016
- 2016-06-01 KR KR1020177037584A patent/KR102553518B1/ko active Active
- 2016-06-01 MX MX2017015582A patent/MX2017015582A/es unknown
- 2016-06-01 KR KR1020237022586A patent/KR20230110368A/ko not_active Withdrawn
- 2016-06-01 US US15/578,372 patent/US11298410B2/en active Active
- 2016-06-01 EP EP21172750.8A patent/EP3919622A1/en active Pending
- 2016-06-01 CN CN201680045342.2A patent/CN108025188A/zh active Pending
- 2016-06-01 AU AU2016270702A patent/AU2016270702B2/en active Active
- 2016-06-01 DK DK16804274.5T patent/DK3302709T3/da active
- 2016-06-01 EP EP16804274.5A patent/EP3302709B1/en active Active
- 2016-06-01 SG SG10201914137YA patent/SG10201914137YA/en unknown
- 2016-06-01 EA EA201890012A patent/EA037359B1/ru unknown
- 2016-06-01 WO PCT/US2016/035141 patent/WO2016196539A2/en not_active Ceased
- 2016-06-01 ES ES16804274T patent/ES2886480T3/es active Active
- 2016-06-01 JP JP2017562290A patent/JP6968416B2/ja active Active
- 2016-06-01 PL PL16804274T patent/PL3302709T3/pl unknown
- 2016-06-01 CA CA2987927A patent/CA2987927C/en active Active
-
2017
- 2017-12-04 ZA ZA2017/08236A patent/ZA201708236B/en unknown
-
2020
- 2020-05-15 US US16/875,271 patent/US11273209B2/en active Active
- 2020-09-10 US US17/017,037 patent/US12251429B2/en active Active
-
2022
- 2022-03-17 AU AU2022201875A patent/AU2022201875A1/en not_active Abandoned
-
2025
- 2025-06-05 AU AU2025204187A patent/AU2025204187A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018516572A5 (enExample) | ||
| Cullen | Human immunodeficiency virus as a prototypic complex retrovirus | |
| Wang et al. | Genome scale screening identification of SaCas9/gRNAs for targeting HIV-1 provirus and suppression of HIV-1 infection | |
| Talbott et al. | Nucleotide sequence and genomic organization of feline immunodeficiency virus. | |
| Sharp et al. | Origins and evolution of AIDS viruses: estimating the time-scale | |
| Ferguson et al. | HIV-1 replication cycle | |
| Hirsch et al. | Phylogeny and natural history of the primate lentiviruses, SIV and HIV | |
| Ohagen et al. | Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: evidence for a role of the envelope | |
| Moore et al. | HIV-1 RNA dimerization: It takes two to tango | |
| JP2019504868A5 (enExample) | ||
| JP2016534125A5 (enExample) | ||
| DE69033896D1 (de) | Gentechnologische herstellung von impfstoffen gegen aids und andere retrovirale krankheiten | |
| Ali et al. | Cross-and co-packaging of retroviral RNAs and their consequences | |
| Miura et al. | Establishment of a phylogenetic survey system for AIDS-related lentiviruses and demonstration of a new HIV-2 subgroup | |
| Edmonson et al. | Evolution of a simian immunodeficiency virus pathogen | |
| OELRICHS et al. | Sequence Note: Genomic sequence of HIV type 1 from four members of the Sydney Blood Bank Cohort of long-term nonprogressors | |
| Laird et al. | Importance of the V1/V2 loop region of simian-human immunodeficiency virus envelope glycoprotein gp120 in determining the strain specificity of the neutralizing antibody response | |
| Fleury et al. | Therapeutic vaccine against HIV, viral variability, cytotoxic T lymphocyte epitopes, and genetics of patients | |
| JOHNSON et al. | Genetic variation of simian immunodeficiency viruses in nonhuman primates | |
| Wu et al. | Molecular cloning and in vitro evaluation of an infectious simian‐human immunodeficiency virus containing env of a primary Chinese HIV‐1 subtype C isolate | |
| SALA et al. | HIV-1 gpl20 Sequences from a Doubly Infected Drug User | |
| Maggiorella et al. | Multiprotein genetic vaccine in the SIV‐Macaca animal model: a promising approach to generate sterilizing immunity to HIV infection | |
| Torimiro et al. | Human immunodeficiency virus type 1 intersubtype recombinants predominate in the AIDS epidemic in Cameroon. | |
| Tominaga et al. | A high frequency of defective vif genes in peripheral blood mononuclear cells from HIV type 1-infected individuals | |
| Takahoko et al. | Infectious DNA clone of HIV type 1 A/G recombinant (CRF02_AG) replicable in peripheral blood mononuclear cells |