JP2018516572A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018516572A5 JP2018516572A5 JP2017562290A JP2017562290A JP2018516572A5 JP 2018516572 A5 JP2018516572 A5 JP 2018516572A5 JP 2017562290 A JP2017562290 A JP 2017562290A JP 2017562290 A JP2017562290 A JP 2017562290A JP 2018516572 A5 JP2018516572 A5 JP 2018516572A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- acid sequence
- grna
- hiv
- complementary
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000007523 nucleic acids Chemical class 0.000 claims 52
- 108020005004 Guide RNA Proteins 0.000 claims 44
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 38
- 241000725303 Human immunodeficiency virus Species 0.000 claims 37
- 108020004414 DNA Proteins 0.000 claims 24
- 230000000295 complement effect Effects 0.000 claims 22
- 239000000203 mixture Substances 0.000 claims 14
- 230000001177 retroviral effect Effects 0.000 claims 14
- 241001430294 unidentified retrovirus Species 0.000 claims 12
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 102100034343 Integrase Human genes 0.000 claims 9
- 108010042407 Endonucleases Proteins 0.000 claims 8
- 102100031780 Endonuclease Human genes 0.000 claims 7
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000000415 inactivating effect Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 230000001566 pro-viral effect Effects 0.000 claims 5
- 239000013604 expression vector Substances 0.000 claims 4
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108091033409 CRISPR Proteins 0.000 claims 3
- 238000010354 CRISPR gene editing Methods 0.000 claims 3
- 208000031886 HIV Infections Diseases 0.000 claims 3
- 208000037357 HIV infectious disease Diseases 0.000 claims 3
- 108010061833 Integrases Proteins 0.000 claims 3
- 108091092195 Intron Proteins 0.000 claims 3
- 108091005804 Peptidases Proteins 0.000 claims 3
- 239000004365 Protease Substances 0.000 claims 3
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 3
- 108010027225 gag-pol Fusion Proteins Proteins 0.000 claims 3
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 239000002243 precursor Substances 0.000 claims 3
- 108091029795 Intergenic region Proteins 0.000 claims 2
- 101710172711 Structural protein Proteins 0.000 claims 2
- 102000034356 gene-regulatory proteins Human genes 0.000 claims 2
- 108091006104 gene-regulatory proteins Proteins 0.000 claims 2
- 238000010362 genome editing Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 239000013598 vector Substances 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 102000004533 Endonucleases Human genes 0.000 claims 1
- -1 Nef Proteins 0.000 claims 1
- 230000002779 inactivation Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000005022 packaging material Substances 0.000 claims 1
- 238000004806 packaging method and process Methods 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562169384P | 2015-06-01 | 2015-06-01 | |
| US62/169,384 | 2015-06-01 | ||
| US201562169633P | 2015-06-02 | 2015-06-02 | |
| US62/169,633 | 2015-06-02 | ||
| US201662308320P | 2016-03-15 | 2016-03-15 | |
| US62/308,320 | 2016-03-15 | ||
| PCT/US2016/035141 WO2016196539A2 (en) | 2015-06-01 | 2016-06-01 | Methods and compositions for rna-guided treatment of hiv infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516572A JP2018516572A (ja) | 2018-06-28 |
| JP2018516572A5 true JP2018516572A5 (enExample) | 2019-07-04 |
| JP6968416B2 JP6968416B2 (ja) | 2021-11-17 |
Family
ID=57442165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017562290A Active JP6968416B2 (ja) | 2015-06-01 | 2016-06-01 | Ｒｎａ誘導性の、ｈｉｖ感染の処置のための、方法および組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US11298410B2 (enExample) |
| EP (2) | EP3302709B1 (enExample) |
| JP (1) | JP6968416B2 (enExample) |
| KR (2) | KR102553518B1 (enExample) |
| CN (1) | CN108025188A (enExample) |
| AU (4) | AU2016270702B2 (enExample) |
| CA (1) | CA2987927C (enExample) |
| DK (1) | DK3302709T3 (enExample) |
| EA (1) | EA037359B1 (enExample) |
| ES (1) | ES2886480T3 (enExample) |
| MX (1) | MX2017015582A (enExample) |
| PL (1) | PL3302709T3 (enExample) |
| SG (1) | SG10201914137YA (enExample) |
| WO (1) | WO2016196539A2 (enExample) |
| ZA (1) | ZA201708236B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013066438A2 (en) | 2011-07-22 | 2013-05-10 | President And Fellows Of Harvard College | Evaluation and improvement of nuclease cleavage specificity |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| AU2014312123A1 (en) | 2013-08-29 | 2016-03-17 | Temple University Of The Commonwealth System Of Higher Education | Methods and compositions for RNA-guided treatment of HIV infection |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| SG10201914137YA (en) | 2015-06-01 | 2020-02-27 | Univ Temple | Methods and compositions for rna-guided treatment of hiv infection |
| EP3356521A4 (en) * | 2015-09-28 | 2019-03-13 | Temple University - Of The Commonwealth System of Higher Education | METHOD AND COMPOSITIONS FOR RNA-TREATED TREATMENT OF HIV INFECTIONS |
| WO2017070632A2 (en) | 2015-10-23 | 2017-04-27 | President And Fellows Of Harvard College | Nucleobase editors and uses thereof |
| WO2018027078A1 (en) | 2016-08-03 | 2018-02-08 | President And Fellows Of Harard College | Adenosine nucleobase editors and uses thereof |
| AU2017308889B2 (en) | 2016-08-09 | 2023-11-09 | President And Fellows Of Harvard College | Programmable Cas9-recombinase fusion proteins and uses thereof |
| WO2018039438A1 (en) | 2016-08-24 | 2018-03-01 | President And Fellows Of Harvard College | Incorporation of unnatural amino acids into proteins using base editing |
| KR20240007715A (ko) | 2016-10-14 | 2024-01-16 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵염기 에디터의 aav 전달 |
| WO2018119359A1 (en) | 2016-12-23 | 2018-06-28 | President And Fellows Of Harvard College | Editing of ccr5 receptor gene to protect against hiv infection |
| KR20190123328A (ko) | 2017-03-09 | 2019-10-31 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 암 백신 |
| WO2018165504A1 (en) | 2017-03-09 | 2018-09-13 | President And Fellows Of Harvard College | Suppression of pain by gene editing |
| CN110914310A (zh) | 2017-03-10 | 2020-03-24 | 哈佛大学的校长及成员们 | 胞嘧啶至鸟嘌呤碱基编辑器 |
| IL306092A (en) | 2017-03-23 | 2023-11-01 | Harvard College | Nucleic base editors that include nucleic acid programmable DNA binding proteins |
| US12644121B2 (en) * | 2017-04-17 | 2026-06-02 | Temple University—Of the Commonwealth System of Higher Education | HIV-1 eradication strategy employing nanoformulated anti-retroviral drugs and gene editing agents |
| US11560566B2 (en) | 2017-05-12 | 2023-01-24 | President And Fellows Of Harvard College | Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation |
| WO2019010422A1 (en) * | 2017-07-07 | 2019-01-10 | The Broad Institute, Inc. | ANTIVIRAL THERAPY BASED ON THE CRISPR SYSTEM |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| EP3676376B1 (en) | 2017-08-30 | 2025-01-15 | President and Fellows of Harvard College | High efficiency base editors comprising gam |
| CA3111479A1 (en) * | 2017-09-26 | 2019-04-04 | The Board Of Trustees Of The University Of Illinois | Crispr/cas system and method for genome editing and modulating transcription |
| CA3082251A1 (en) | 2017-10-16 | 2019-04-25 | The Broad Institute, Inc. | Uses of adenosine base editors |
| US12406749B2 (en) | 2017-12-15 | 2025-09-02 | The Broad Institute, Inc. | Systems and methods for predicting repair outcomes in genetic engineering |
| WO2019226953A1 (en) | 2018-05-23 | 2019-11-28 | The Broad Institute, Inc. | Base editors and uses thereof |
| EP3820495A4 (en) | 2018-07-09 | 2022-07-20 | The Broad Institute Inc. | RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES |
| WO2020092453A1 (en) | 2018-10-29 | 2020-05-07 | The Broad Institute, Inc. | Nucleobase editors comprising geocas9 and uses thereof |
| WO2020150499A1 (en) * | 2019-01-16 | 2020-07-23 | Fred Hutchinson Cancer Research Center | Methods to tag and isolate cells infected with the human immunodeficiency virus |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| WO2020191241A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| WO2020214842A1 (en) | 2019-04-17 | 2020-10-22 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| US12435330B2 (en) | 2019-10-10 | 2025-10-07 | The Broad Institute, Inc. | Methods and compositions for prime editing RNA |
| CA3158555A1 (en) * | 2019-10-23 | 2021-04-29 | Pairwise Plants Services, Inc. | Compositions and methods for rna-templated editing in plants |
| EP4114952A4 (en) * | 2020-03-05 | 2024-05-08 | Board of Regents of the University of Nebraska | CRISPR/CAS9 SYSTEM FOR MULTI-STRAINS HIV-1 TREATMENT |
| CA3177481A1 (en) | 2020-05-08 | 2021-11-11 | David R. Liu | Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence |
| WO2022015702A2 (en) * | 2020-07-13 | 2022-01-20 | Howell Alexandra L | Methods and compositions for crispr/cas9 guide rna efficiency and specificity against genetically diverse hiv-1 isolates |
| CN112322587A (zh) * | 2020-09-17 | 2021-02-05 | 杭州市第一人民医院 | 一种带Cas9基因的人源可诱导多能干细胞系、构建方法、鉴定方法及应用 |
| WO2022198229A1 (en) * | 2021-03-17 | 2022-09-22 | Board Of Regents Of The University Of Nebraska | Lipid nanoparticle formulations and methods of use thereof |
| WO2024103050A1 (en) * | 2022-11-11 | 2024-05-16 | The United States Government As Represented By The Department Of Veterans Affairs | Hbv specific exosomes and uses thereof |
| CN116892064B (zh) * | 2023-07-03 | 2026-07-28 | 墨卓生物科技(浙江)有限公司 | 一种微生物单细胞基因组学测序文库的构建方法 |
Family Cites Families (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| CN116622704A (zh) | 2012-07-25 | 2023-08-22 | 布罗德研究所有限公司 | 可诱导的dna结合蛋白和基因组干扰工具及其应用 |
| MX380562B (es) | 2012-12-12 | 2025-03-12 | Broad Inst Inc | Modificaciones de sistemas, métodos y composiciones guía optimizadas para la manipulación de secuencias. |
| EP2931899A1 (en) | 2012-12-12 | 2015-10-21 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof |
| WO2014093709A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof |
| PT2931898E (pt) | 2012-12-12 | 2016-06-16 | Harvard College | Manipulação e otimização de sistemas, métodos e composições para manipulação de sequências com domínios funcionais |
| KR102955556B1 (ko) | 2012-12-12 | 2026-04-22 | 더 브로드 인스티튜트, 인코퍼레이티드 | 서열 조작을 위한 crispr-cas 성분 시스템, 방법 및 조성물 |
| WO2014093694A1 (en) | 2012-12-12 | 2014-06-19 | The Broad Institute, Inc. | Crispr-cas nickase systems, methods and compositions for sequence manipulation in eukaryotes |
| SG10201707569YA (en) | 2012-12-12 | 2017-10-30 | Broad Inst Inc | Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications |
| EP3064585B1 (en) | 2012-12-12 | 2020-02-05 | The Broad Institute, Inc. | Engineering and optimization of improved systems, methods and enzyme compositions for sequence manipulation |
| US8697359B1 (en) | 2012-12-12 | 2014-04-15 | The Broad Institute, Inc. | CRISPR-Cas systems and methods for altering expression of gene products |
| CN105209621B (zh) | 2012-12-12 | 2021-05-25 | 布罗德研究所有限公司 | 对用于序列操纵的改进的系统、方法和酶组合物进行的工程化和优化 |
| IL308158A (en) | 2012-12-17 | 2023-12-01 | Harvard College | Rna-guided human genome engineering |
| US11332719B2 (en) | 2013-03-15 | 2022-05-17 | The Broad Institute, Inc. | Recombinant virus and preparations thereof |
| ES2747833T3 (es) * | 2013-04-04 | 2020-03-11 | Dartmouth College | Composiciones y procedimientos para la escisión in vivo del ADN proviral del vih-1 |
| EP3603679B1 (en) | 2013-06-04 | 2022-08-10 | President and Fellows of Harvard College | Rna-guided transcriptional regulation |
| JP6738728B2 (ja) | 2013-06-17 | 2020-08-19 | ザ・ブロード・インスティテュート・インコーポレイテッド | 肝臓ターゲティングおよび治療のためのＣＲＩＳＰＲ−Ｃａｓ系、ベクターおよび組成物の送達および使用 |
| ES2777217T3 (es) | 2013-06-17 | 2020-08-04 | Broad Inst Inc | Suministro, modificación y optimización de sistemas de guía en tándem, métodos y composiciones para la manipulación de secuencias |
| KR20250012194A (ko) | 2013-06-17 | 2025-01-23 | 더 브로드 인스티튜트, 인코퍼레이티드 | 바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용 |
| EP3011033B1 (en) | 2013-06-17 | 2020-02-19 | The Broad Institute, Inc. | Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof |
| SG11201510327TA (en) | 2013-06-17 | 2016-01-28 | Broad Inst Inc | Delivery, engineering and optimization of systems, methods and compositions for targeting and modeling diseases and disorders of post mitotic cells |
| WO2014204725A1 (en) | 2013-06-17 | 2014-12-24 | The Broad Institute Inc. | Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation |
| KR20260047646A (ko) | 2013-07-09 | 2026-04-08 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 멀티플렉스 rna-가이드된 게놈 조작 |
| CN105517579B (zh) | 2013-07-10 | 2019-11-15 | 哈佛大学校长及研究员协会 | 用于RNA向导的基因调节和编辑的正交Cas9蛋白 |
| US11306328B2 (en) | 2013-07-26 | 2022-04-19 | President And Fellows Of Harvard College | Genome engineering |
| US9163284B2 (en) | 2013-08-09 | 2015-10-20 | President And Fellows Of Harvard College | Methods for identifying a target site of a Cas9 nuclease |
| AU2014312123A1 (en) | 2013-08-29 | 2016-03-17 | Temple University Of The Commonwealth System Of Higher Education | Methods and compositions for RNA-guided treatment of HIV infection |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US10787684B2 (en) | 2013-11-19 | 2020-09-29 | President And Fellows Of Harvard College | Large gene excision and insertion |
| US9074199B1 (en) | 2013-11-19 | 2015-07-07 | President And Fellows Of Harvard College | Mutant Cas9 proteins |
| US20150166984A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting alpha-antitrypsin point mutations |
| CN103923911B (zh) | 2014-04-14 | 2016-06-08 | 上海金卫生物技术有限公司 | CRISPR-Cas9特异性敲除人CCR5基因的方法以及用于特异性靶向CCR5基因的sgRNA |
| AU2015298571B2 (en) | 2014-07-30 | 2020-09-03 | President And Fellows Of Harvard College | Cas9 proteins including ligand-dependent inteins |
| CN104480144B (zh) | 2014-12-12 | 2017-04-12 | 武汉大学 | 用于艾滋病基因治疗的CRISPR/Cas9重组慢病毒载体及其慢病毒 |
| MA41349A (fr) | 2015-01-14 | 2017-11-21 | Univ Temple | Éradication de l'herpès simplex de type i et d'autres virus de l'herpès associés guidée par arn |
| CN104726449A (zh) | 2015-03-23 | 2015-06-24 | 国家纳米科学中心 | 一种用于预防和/或治疗HIV的CRISPR-Cas9系统及其制备方法和用途 |
| SG10201914137YA (en) | 2015-06-01 | 2020-02-27 | Univ Temple | Methods and compositions for rna-guided treatment of hiv infection |
| CA3012631A1 (en) | 2015-06-18 | 2016-12-22 | The Broad Institute Inc. | Novel crispr enzymes and systems |
| EP3356521A4 (en) | 2015-09-28 | 2019-03-13 | Temple University - Of The Commonwealth System of Higher Education | METHOD AND COMPOSITIONS FOR RNA-TREATED TREATMENT OF HIV INFECTIONS |
| CA3001130A1 (en) | 2015-10-16 | 2017-04-20 | Temple University - Of The Commonwealth System Of Higher Education | Methods and compositions utilizing cpf1 for rna-guided gene editing |
| CA3001351A1 (en) | 2015-10-21 | 2017-04-27 | Editas Medicine, Inc. | Crispr/cas-related methods and compositions for treating hepatitis b virus |
| CN108473527A (zh) | 2015-12-09 | 2018-08-31 | 切除生物治疗公司 | 用于消除免疫抑制疗法期间jc病毒激活和pml(进行性多灶性白质脑病)风险的基因编辑方法和组合物 |
| EP3407918A4 (en) | 2016-01-25 | 2019-09-04 | Excision Biotherapeutics | METHOD AND COMPOSITIONS FOR RNA-TREATED TREATMENT OF HIV INFECTIONS |
| EP3417062B1 (en) | 2016-02-15 | 2024-06-26 | Temple University - Of The Commonwealth System of Higher Education | Excision of retroviral nucleic acid sequences |
| US9925425B2 (en) | 2016-03-17 | 2018-03-27 | Acushnet Company | Golf ball incorporating at least three adjacent ionomeric and/or HNP-based layers having multiple related property gradients there between |
| US20190093091A1 (en) | 2016-04-06 | 2019-03-28 | Temple University - Of The Commonwealth System Of Higher Education | Compositions for eradicating flavivirus infections in subjects |
| US20190093092A1 (en) | 2016-05-05 | 2019-03-28 | Temple University - Of The Commonwealth System Of Higher Education | Rna guided eradication of varicella zoster virus |
| WO2017213898A2 (en) | 2016-06-07 | 2017-12-14 | Temple University - Of The Commonwealth System Of Higher Education | Rna guided compositions for preventing and treating hepatitis b virus infections |
| US20190085326A1 (en) | 2016-09-14 | 2019-03-21 | Temple University - Of The Commonwealth System Of Higher Education | Negative feedback regulation of HIV-1 by gene editing strategy |
| JP2019532644A (ja) | 2016-09-30 | 2019-11-14 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | Ｒｎａ誘導型核酸修飾酵素及びその使用方法 |
| WO2018071623A2 (en) | 2016-10-12 | 2018-04-19 | Temple University - Of The Commonwealth System Of Higher Education | Combination therapies for eradicating flavivirus infections in subjects |
| US11299430B2 (en) | 2016-11-30 | 2022-04-12 | Hrl Laboratories, Llc | Formulations with active functional additives for 3D printing of preceramic polymers, and methods of 3D-printing the formulations |
| WO2018140269A1 (en) | 2017-01-26 | 2018-08-02 | Excision Biotherapeutics, Inc. | Lentivirus and non-integrating lentivirus as viral vector to deliver crispr therapeutic |
| US20190367924A1 (en) | 2017-02-17 | 2019-12-05 | Temple University - Of The Commonwealth System Of Higher Education | Gene editing therapy for hiv infection via dual targeting of hiv genome and ccr5 |
| US12644121B2 (en) | 2017-04-17 | 2026-06-02 | Temple University—Of the Commonwealth System of Higher Education | HIV-1 eradication strategy employing nanoformulated anti-retroviral drugs and gene editing agents |
-
2016
- 2016-06-01 SG SG10201914137YA patent/SG10201914137YA/en unknown
- 2016-06-01 EA EA201890012A patent/EA037359B1/ru unknown
- 2016-06-01 CA CA2987927A patent/CA2987927C/en active Active
- 2016-06-01 EP EP16804274.5A patent/EP3302709B1/en active Active
- 2016-06-01 WO PCT/US2016/035141 patent/WO2016196539A2/en not_active Ceased
- 2016-06-01 CN CN201680045342.2A patent/CN108025188A/zh active Pending
- 2016-06-01 EP EP21172750.8A patent/EP3919622A1/en active Pending
- 2016-06-01 PL PL16804274T patent/PL3302709T3/pl unknown
- 2016-06-01 DK DK16804274.5T patent/DK3302709T3/da active
- 2016-06-01 JP JP2017562290A patent/JP6968416B2/ja active Active
- 2016-06-01 ES ES16804274T patent/ES2886480T3/es active Active
- 2016-06-01 US US15/578,372 patent/US11298410B2/en active Active
- 2016-06-01 KR KR1020177037584A patent/KR102553518B1/ko active Active
- 2016-06-01 MX MX2017015582A patent/MX2017015582A/es unknown
- 2016-06-01 AU AU2016270702A patent/AU2016270702B2/en active Active
- 2016-06-01 KR KR1020237022586A patent/KR20230110368A/ko not_active Withdrawn
-
2017
- 2017-12-04 ZA ZA2017/08236A patent/ZA201708236B/en unknown
-
2020
- 2020-05-15 US US16/875,271 patent/US11273209B2/en active Active
- 2020-09-10 US US17/017,037 patent/US12251429B2/en active Active
-
2022
- 2022-03-17 AU AU2022201875A patent/AU2022201875A1/en not_active Abandoned
-
2025
- 2025-06-05 AU AU2025204187A patent/AU2025204187A1/en not_active Abandoned
-
2026
- 2026-07-16 AU AU2026206145A patent/AU2026206145A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Cullen | Human immunodeficiency virus as a prototypic complex retrovirus | |
| Wang et al. | Genome scale screening identification of SaCas9/gRNAs for targeting HIV-1 provirus and suppression of HIV-1 infection | |
| Talbott et al. | Nucleotide sequence and genomic organization of feline immunodeficiency virus. | |
| Hahn et al. | Genomic diversity of the acquired immune deficiency syndrome virus HTLV-III: different viruses exhibit greatest divergence in their envelope genes. | |
| Sharp et al. | Origins and evolution of AIDS viruses: estimating the time-scale | |
| Ferguson et al. | HIV-1 replication cycle | |
| Goujon et al. | Characterization of the alpha interferon-induced postentry block to HIV-1 infection in primary human macrophages and T cells | |
| Hirsch et al. | Phylogeny and natural history of the primate lentiviruses, SIV and HIV | |
| Ratner et al. | Complete nucleotide sequences of functional clones of the AIDS virus | |
| Ohagen et al. | Apoptosis induced by infection of primary brain cultures with diverse human immunodeficiency virus type 1 isolates: evidence for a role of the envelope | |
| Myers et al. | Evolutionary potential of complex retroviruses | |
| JP2016534125A5 (enExample) | ||
| DE69033896D1 (de) | Gentechnologische herstellung von impfstoffen gegen aids und andere retrovirale krankheiten | |
| Wei et al. | Extensive diversification of human immunodeficiency virus type 1 subtype B strains during dual infection of a chimpanzee that progressed to AIDS | |
| Edmonson et al. | Evolution of a simian immunodeficiency virus pathogen | |
| Dittmar et al. | Biological characterization of human immunodeficiency virus type 1 clones derived from different organs of an AIDS patient by long-range PCR | |
| Oelrichs et al. | Sequence Note: Genomic sequence of HIV type 1 from four members of the Sydney Blood Bank Cohort of long-term nonprogressors | |
| Reddy et al. | Comparative analyses of human immunodeficiency virus type 1 (HIV-1) and HIV-2 Vif mutants | |
| MX354571B (es) | Genomas lentivirales quimericos no integrativos como vacunas innovadoras contra el virus de la inmunodeficiencia humana tipo 1 (vih-1). | |
| Al-Harthi et al. | Molecular inhibition of HIV type 1 by HIV type 2: effectiveness in peripheral blood mononuclear cells | |
| Rigby et al. | Comparative efficiency of feline immunodeficiency virus infection by DNA inoculation | |
| Maggiorella et al. | Multiprotein genetic vaccine in the SIV‐Macaca animal model: a promising approach to generate sterilizing immunity to HIV infection | |
| Sala et al. | HIV-1 gpl20 Sequences from a Doubly Infected Drug User | |
| Kim et al. | Characterization of V3 loop sequences from HIV type 1 subtype B in South Korea: predominance of the GPGS motif | |
| Torimiro et al. | Human immunodeficiency virus type 1 intersubtype recombinants predominate in the AIDS epidemic in Cameroon. |