|
WO2013066438A2
(en)
|
2011-07-22 |
2013-05-10 |
President And Fellows Of Harvard College |
Evaluation and improvement of nuclease cleavage specificity
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
WO2014093709A1
(en)
|
2012-12-12 |
2014-06-19 |
The Broad Institute, Inc. |
Methods, models, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
SG10201707569YA
(en)
|
2012-12-12 |
2017-10-30 |
Broad Inst Inc |
Delivery, Engineering and Optimization of Systems, Methods and Compositions for Sequence Manipulation and Therapeutic Applications
|
|
WO2014113493A1
(en)
|
2013-01-16 |
2014-07-24 |
Emory University |
Cas9-nucleic acid complexes and uses related thereto
|
|
CN105408483A
(zh)
|
2013-03-15 |
2016-03-16 |
通用医疗公司 |
遗传和表观遗传调节蛋白至特定基因组基因座的rna引导的靶向
|
|
US10760064B2
(en)
|
2013-03-15 |
2020-09-01 |
The General Hospital Corporation |
RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci
|
|
DK3456831T3
(da)
|
2013-04-16 |
2021-09-06 |
Regeneron Pharma |
Målrettet modifikation af rottegenom
|
|
JP6738728B2
(ja)
|
2013-06-17 |
2020-08-19 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
肝臓ターゲティングおよび治療のためのＣＲＩＳＰＲ−Ｃａｓ系、ベクターおよび組成物の送達および使用
|
|
KR20250012194A
(ko)
|
2013-06-17 |
2025-01-23 |
더 브로드 인스티튜트, 인코퍼레이티드 |
바이러스 구성성분을 사용하여 장애 및 질환을 표적화하기 위한 crispr-cas 시스템 및 조성물의 전달, 용도 및 치료 적용
|
|
ES2777217T3
(es)
|
2013-06-17 |
2020-08-04 |
Broad Inst Inc |
Suministro, modificación y optimización de sistemas de guía en tándem, métodos y composiciones para la manipulación de secuencias
|
|
WO2014204725A1
(en)
|
2013-06-17 |
2014-12-24 |
The Broad Institute Inc. |
Optimized crispr-cas double nickase systems, methods and compositions for sequence manipulation
|
|
EP3011033B1
(en)
|
2013-06-17 |
2020-02-19 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
US10011850B2
(en)
|
2013-06-21 |
2018-07-03 |
The General Hospital Corporation |
Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing
|
|
US9163284B2
(en)
|
2013-08-09 |
2015-10-20 |
President And Fellows Of Harvard College |
Methods for identifying a target site of a Cas9 nuclease
|
|
US9359599B2
(en)
|
2013-08-22 |
2016-06-07 |
President And Fellows Of Harvard College |
Engineered transcription activator-like effector (TALE) domains and uses thereof
|
|
AU2014312123A1
(en)
*
|
2013-08-29 |
2016-03-17 |
Temple University Of The Commonwealth System Of Higher Education |
Methods and compositions for RNA-guided treatment of HIV infection
|
|
US9526784B2
(en)
|
2013-09-06 |
2016-12-27 |
President And Fellows Of Harvard College |
Delivery system for functional nucleases
|
|
US9322037B2
(en)
|
2013-09-06 |
2016-04-26 |
President And Fellows Of Harvard College |
Cas9-FokI fusion proteins and uses thereof
|
|
US9340799B2
(en)
|
2013-09-06 |
2016-05-17 |
President And Fellows Of Harvard College |
MRNA-sensing switchable gRNAs
|
|
CN111218447B
(zh)
|
2013-11-07 |
2024-10-11 |
爱迪塔斯医药有限公司 |
使用统治型gRNA的CRISPR相关方法和组合物
|
|
MX388127B
(es)
|
2013-12-11 |
2025-03-19 |
Regeneron Pharma |
Metodos y composiciones para la modificacion dirigida de un genoma.
|
|
KR20160097338A
(ko)
|
2013-12-12 |
2016-08-17 |
더 브로드 인스티튜트, 인코퍼레이티드 |
뉴클레오티드 반복 장애에서의 ｃｒｉｓｐｒ-ｃａｓ 시스템의 조성물 및 방법 및 용도
|
|
JP6793547B2
(ja)
|
2013-12-12 |
2020-12-02 |
ザ・ブロード・インスティテュート・インコーポレイテッド |
最適化機能ＣＲＩＳＰＲ−Ｃａｓ系による配列操作のための系、方法および組成物
|
|
CN105899658B
(zh)
|
2013-12-12 |
2020-02-18 |
布罗德研究所有限公司 |
针对hbv和病毒性疾病以及障碍的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
WO2015089473A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Engineering of systems, methods and optimized guide compositions with new architectures for sequence manipulation
|
|
CN111206032B
(zh)
|
2013-12-12 |
2024-07-19 |
布罗德研究所有限公司 |
用于基因组编辑的crispr-cas系统和组合物的递送、用途和治疗应用
|
|
US20150166984A1
(en)
|
2013-12-12 |
2015-06-18 |
President And Fellows Of Harvard College |
Methods for correcting alpha-antitrypsin point mutations
|
|
WO2015089364A1
(en)
|
2013-12-12 |
2015-06-18 |
The Broad Institute Inc. |
Crystal structure of a crispr-cas system, and uses thereof
|
|
WO2015126927A2
(en)
*
|
2014-02-18 |
2015-08-27 |
Duke University |
Compositions for the inactivation of virus replication and methods of making and using the same
|
|
WO2015184262A1
(en)
|
2014-05-30 |
2015-12-03 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods of delivering treatments for latent viral infections
|
|
AU2015277369B2
(en)
|
2014-06-16 |
2021-08-19 |
The Johns Hopkins University |
Compositions and methods for the expression of CRISPR guide RNAs using the H1 promoter
|
|
AU2015298571B2
(en)
|
2014-07-30 |
2020-09-03 |
President And Fellows Of Harvard College |
Cas9 proteins including ligand-dependent inteins
|
|
BR112017007770A2
(pt)
|
2014-10-15 |
2018-01-16 |
Regeneron Pharma |
cultura in vitro, população de hipscs, método para modificar um locus-alvo genômico, e, hipsc.
|
|
EP3221457B1
(en)
|
2014-11-21 |
2019-03-20 |
Regeneron Pharmaceuticals, Inc. |
Methods and compositions for targeted genetic modification using paired guide rnas
|
|
EP3985115A1
(en)
|
2014-12-12 |
2022-04-20 |
The Broad Institute, Inc. |
Protected guide rnas (pgrnas)
|
|
WO2016106244A1
(en)
|
2014-12-24 |
2016-06-30 |
The Broad Institute Inc. |
Crispr having or associated with destabilization domains
|
|
MA41382A
(fr)
|
2015-03-20 |
2017-11-28 |
Univ Temple |
Édition génique basée sur le système crispr/endonucléase à induction par tat
|
|
CN104726449A
(zh)
*
|
2015-03-23 |
2015-06-24 |
国家纳米科学中心 |
一种用于预防和/或治疗HIV的CRISPR-Cas9系统及其制备方法和用途
|
|
EP3300507A4
(en)
*
|
2015-04-02 |
2019-03-13 |
Agenovir Corporation |
GENERIC ADMINISTRATION AND COMPOSITIONS
|
|
AU2016262093B2
(en)
*
|
2015-05-13 |
2022-08-18 |
Seattle Children' S Hospital (Dba Seattle Children 's Research Institute) |
Enhancing endonuclease based gene editing in primary cells
|
|
EP3324999A1
(en)
*
|
2015-05-29 |
2018-05-30 |
Agenovir Corporation |
Compositions and methods for cell targeted hpv treatment
|
|
US10117911B2
(en)
|
2015-05-29 |
2018-11-06 |
Agenovir Corporation |
Compositions and methods to treat herpes simplex virus infections
|
|
WO2016196283A1
(en)
*
|
2015-05-29 |
2016-12-08 |
Agenovir Corporation |
Antiviral methods and compositions
|
|
SG10201914137YA
(en)
*
|
2015-06-01 |
2020-02-27 |
Univ Temple |
Methods and compositions for rna-guided treatment of hiv infection
|
|
CN104894071A
(zh)
*
|
2015-06-08 |
2015-09-09 |
东华大学 |
一种对gt1-7细胞进行基因编辑的方法
|
|
EP3929287A3
(en)
|
2015-06-18 |
2022-04-13 |
The Broad Institute, Inc. |
Crispr enzyme mutations reducing off-target effects
|
|
WO2016205759A1
(en)
|
2015-06-18 |
2016-12-22 |
The Broad Institute Inc. |
Engineering and optimization of systems, methods, enzymes and guide scaffolds of cas9 orthologs and variants for sequence manipulation
|
|
US9926546B2
(en)
|
2015-08-28 |
2018-03-27 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
US9512446B1
(en)
|
2015-08-28 |
2016-12-06 |
The General Hospital Corporation |
Engineered CRISPR-Cas9 nucleases
|
|
WO2017040348A1
(en)
|
2015-08-28 |
2017-03-09 |
The General Hospital Corporation |
Engineered crispr-cas9 nucleases
|
|
EP3356521A4
(en)
*
|
2015-09-28 |
2019-03-13 |
Temple University - Of The Commonwealth System of Higher Education |
METHOD AND COMPOSITIONS FOR RNA-TREATED TREATMENT OF HIV INFECTIONS
|
|
US20170096649A1
(en)
*
|
2015-10-02 |
2017-04-06 |
Agenovir Corporation |
Transgenic nuclease systems and methods
|
|
AU2016335698B2
(en)
|
2015-10-08 |
2022-12-01 |
President And Fellows Of Harvard College |
Multiplexed genome editing
|
|
CA3001130A1
(en)
*
|
2015-10-16 |
2017-04-20 |
Temple University - Of The Commonwealth System Of Higher Education |
Methods and compositions utilizing cpf1 for rna-guided gene editing
|
|
WO2017070632A2
(en)
|
2015-10-23 |
2017-04-27 |
President And Fellows Of Harvard College |
Nucleobase editors and uses thereof
|
|
CN108473527A
(zh)
|
2015-12-09 |
2018-08-31 |
切除生物治疗公司 |
用于消除免疫抑制疗法期间jc病毒激活和pml(进行性多灶性白质脑病)风险的基因编辑方法和组合物
|
|
EP3407918A4
(en)
*
|
2016-01-25 |
2019-09-04 |
Excision Biotherapeutics |
METHOD AND COMPOSITIONS FOR RNA-TREATED TREATMENT OF HIV INFECTIONS
|
|
EP3417062B1
(en)
*
|
2016-02-15 |
2024-06-26 |
Temple University - Of The Commonwealth System of Higher Education |
Excision of retroviral nucleic acid sequences
|
|
SG11201807025SA
(en)
*
|
2016-02-26 |
2018-09-27 |
Lanzatech New Zealand Ltd |
Crispr/cas systems for c-1 fixing bacteria
|
|
EP3219799A1
(en)
|
2016-03-17 |
2017-09-20 |
IMBA-Institut für Molekulare Biotechnologie GmbH |
Conditional crispr sgrna expression
|
|
JP2019519250A
(ja)
*
|
2016-05-10 |
2019-07-11 |
ユナイテッド ステイツ ガバメント アズ リプレゼンテッド バイ ザ デパートメント オブ ベテランズ アフェアーズＵｎｉｔｅｄ Ｓｔａｔｅｓ Ｇｏｖｅｒｎｍｅｎｔ Ａｓ Ｒｅｐｒｅｓｅｎｔｅｄ Ｂｙ Ｔｈｅ Ｄｅｐａｒｔｍｅｎｔ Ｏｆ Ｖｅｔｅｒａｎｓ Ａｆｆａｉｒｓ |
Ｈｉｖ−１感染と複製に必須な遺伝子を切断するｃｒｉｓｐｒ／ｃａｓの構築物のレンチウィルスによる送達
|
|
CN107365786A
(zh)
*
|
2016-05-12 |
2017-11-21 |
中国科学院微生物研究所 |
一种将spacer序列克隆至CRISPR-Cas9系统中的方法及其应用
|
|
SG10202102885UA
(en)
|
2016-05-20 |
2021-05-28 |
Regeneron Pharma |
Methods for breaking immunological tolerance using multiple guide rnas
|
|
RU2018144745A
(ru)
*
|
2016-06-01 |
2020-07-09 |
Эксижн Биотерапьютикс, Инк. |
Композиции и способы лечения, направленные на литические и лизогенные вирусы
|
|
WO2017213896A1
(en)
*
|
2016-06-03 |
2017-12-14 |
Temple University - Of The Commonwealth System Of Higher Education |
Negative feedback regulation of hiv-1 by gene editing strategy
|
|
WO2018027078A1
(en)
|
2016-08-03 |
2018-02-08 |
President And Fellows Of Harard College |
Adenosine nucleobase editors and uses thereof
|
|
AU2017308889B2
(en)
|
2016-08-09 |
2023-11-09 |
President And Fellows Of Harvard College |
Programmable Cas9-recombinase fusion proteins and uses thereof
|
|
WO2018039438A1
(en)
|
2016-08-24 |
2018-03-01 |
President And Fellows Of Harvard College |
Incorporation of unnatural amino acids into proteins using base editing
|
|
CA3034410A1
(en)
*
|
2016-09-12 |
2018-03-15 |
Excision Biotherapeutics Inc |
Hiv clinical plan
|
|
WO2018070850A1
(ko)
*
|
2016-10-14 |
2018-04-19 |
연세대학교 산학협력단 |
Kras 유전자에 상보적인 가이드 rna 및 이의 용도
|
|
KR101997116B1
(ko)
|
2016-10-14 |
2019-07-05 |
연세대학교 산학협력단 |
Kras 유전자에 상보적인 가이드 rna 및 이의 용도
|
|
KR20240007715A
(ko)
|
2016-10-14 |
2024-01-16 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
핵염기 에디터의 aav 전달
|
|
WO2018119359A1
(en)
|
2016-12-23 |
2018-06-28 |
President And Fellows Of Harvard College |
Editing of ccr5 receptor gene to protect against hiv infection
|
|
US20190071673A1
(en)
*
|
2017-01-18 |
2019-03-07 |
Thomas Malcolm |
CRISPRs WITH IMPROVED SPECIFICITY
|
|
US20190367924A1
(en)
*
|
2017-02-17 |
2019-12-05 |
Temple University - Of The Commonwealth System Of Higher Education |
Gene editing therapy for hiv infection via dual targeting of hiv genome and ccr5
|
|
WO2018165504A1
(en)
|
2017-03-09 |
2018-09-13 |
President And Fellows Of Harvard College |
Suppression of pain by gene editing
|
|
KR20190123328A
(ko)
|
2017-03-09 |
2019-10-31 |
프레지던트 앤드 펠로우즈 오브 하바드 칼리지 |
암 백신
|
|
CN110914310A
(zh)
|
2017-03-10 |
2020-03-24 |
哈佛大学的校长及成员们 |
胞嘧啶至鸟嘌呤碱基编辑器
|
|
CN106755268B
(zh)
*
|
2017-03-22 |
2020-07-17 |
中国科学院海洋研究所 |
体外筛选具有改善记忆力的牡蛎活性肽的方法
|
|
IL306092A
(en)
|
2017-03-23 |
2023-11-01 |
Harvard College |
Nucleic base editors that include nucleic acid programmable DNA binding proteins
|
|
US12644121B2
(en)
|
2017-04-17 |
2026-06-02 |
Temple University—Of the Commonwealth System of Higher Education |
HIV-1 eradication strategy employing nanoformulated anti-retroviral drugs and gene editing agents
|
|
CN116732106A
(zh)
|
2017-04-20 |
2023-09-12 |
E开创生物技术股份有限公司 |
产生基因修改的动物的方法
|
|
WO2018195545A2
(en)
|
2017-04-21 |
2018-10-25 |
The General Hospital Corporation |
Variants of cpf1 (cas12a) with altered pam specificity
|
|
US11560566B2
(en)
|
2017-05-12 |
2023-01-24 |
President And Fellows Of Harvard College |
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
|
|
CA3063733A1
(en)
|
2017-05-25 |
2018-11-29 |
The General Hospital Corporation |
Base editors with improved precision and specificity
|
|
EP3658573A1
(en)
|
2017-07-28 |
2020-06-03 |
President and Fellows of Harvard College |
Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace)
|
|
EP3676376B1
(en)
|
2017-08-30 |
2025-01-15 |
President and Fellows of Harvard College |
High efficiency base editors comprising gam
|
|
CA3082251A1
(en)
|
2017-10-16 |
2019-04-25 |
The Broad Institute, Inc. |
Uses of adenosine base editors
|
|
WO2019079819A1
(en)
*
|
2017-10-20 |
2019-04-25 |
City Of Hope |
COMPOSITION AND METHOD FOR ACTIVATION OF LATENT HUMAN IMMUNODEFICIENCY VIRUS (HIV)
|
|
US12406749B2
(en)
|
2017-12-15 |
2025-09-02 |
The Broad Institute, Inc. |
Systems and methods for predicting repair outcomes in genetic engineering
|
|
WO2019226953A1
(en)
|
2018-05-23 |
2019-11-28 |
The Broad Institute, Inc. |
Base editors and uses thereof
|
|
EP3820495A4
(en)
|
2018-07-09 |
2022-07-20 |
The Broad Institute Inc. |
RNA-PROGRAMMABLE EPIGENETIC RNA MODIFIERS AND THEIR USES
|
|
WO2020092453A1
(en)
|
2018-10-29 |
2020-05-07 |
The Broad Institute, Inc. |
Nucleobase editors comprising geocas9 and uses thereof
|
|
US12351837B2
(en)
|
2019-01-23 |
2025-07-08 |
The Broad Institute, Inc. |
Supernegatively charged proteins and uses thereof
|
|
US20220194990A1
(en)
*
|
2019-01-31 |
2022-06-23 |
Board Of Regents Of The University Of Nebraska |
Virus-like particles and methods of use thereof
|
|
WO2020163396A1
(en)
|
2019-02-04 |
2020-08-13 |
The General Hospital Corporation |
Adenine dna base editor variants with reduced off-target rna editing
|
|
WO2020191241A1
(en)
|
2019-03-19 |
2020-09-24 |
The Broad Institute, Inc. |
Methods and compositions for editing nucleotide sequences
|
|
WO2020214842A1
(en)
|
2019-04-17 |
2020-10-22 |
The Broad Institute, Inc. |
Adenine base editors with reduced off-target effects
|
|
US12203070B2
(en)
|
2019-05-23 |
2025-01-21 |
Christiana Care Gene Editing Institute, Inc. |
Gene knockout of NRF2 for treatment of cancer
|
|
JP7585237B2
(ja)
|
2019-05-23 |
2024-11-18 |
クリスティアナ ケア ジーン エディティング インスティテュート，インコーポレーテッド |
がんを処置するためのバリアントｎｒｆ２の遺伝子ノックアウト
|
|
EP4041864A1
(en)
*
|
2019-10-09 |
2022-08-17 |
Bluerock Therapeutics LP |
Cells with sustained transgene expression
|
|
US12435330B2
(en)
|
2019-10-10 |
2025-10-07 |
The Broad Institute, Inc. |
Methods and compositions for prime editing RNA
|
|
WO2021216503A1
(en)
|
2020-04-20 |
2021-10-28 |
Christiana Care Health Services, Inc. |
Aav delivery system for lung cancer treatment
|
|
CA3177481A1
(en)
|
2020-05-08 |
2021-11-11 |
David R. Liu |
Methods and compositions for simultaneous editing of both strands of a target double-stranded nucleotide sequence
|
|
WO2022015702A2
(en)
*
|
2020-07-13 |
2022-01-20 |
Howell Alexandra L |
Methods and compositions for crispr/cas9 guide rna efficiency and specificity against genetically diverse hiv-1 isolates
|
|
IL302830A
(en)
|
2020-11-13 |
2023-07-01 |
Egenesis Inc |
Cells, tissues, organs and animals with one or more genes that have been modified for improved survival and tolerance of a different-sex transplant
|
|
EP4256044A4
(en)
*
|
2020-12-01 |
2025-03-05 |
United States Government as Represented by The Department of Veterans Affairs |
Compositions and methods for cleaving viral genomes
|
|
AU2022216614B2
(en)
|
2021-02-05 |
2026-03-05 |
Christiana Care Gene Editing Institute, Inc. |
Methods of and compositions for reducing gene expression and/or activity
|
|
WO2023091696A1
(en)
|
2021-11-19 |
2023-05-25 |
Christiana Care Gene Editing Institute, Inc. |
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