MX2016002586A - Métodos y composiciones para el tratamiento guiado por rna de infección por hiv. - Google Patents

Métodos y composiciones para el tratamiento guiado por rna de infección por hiv.

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Publication number
MX2016002586A
MX2016002586A MX2016002586A MX2016002586A MX2016002586A MX 2016002586 A MX2016002586 A MX 2016002586A MX 2016002586 A MX2016002586 A MX 2016002586A MX 2016002586 A MX2016002586 A MX 2016002586A MX 2016002586 A MX2016002586 A MX 2016002586A
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MX
Mexico
Prior art keywords
compositions
rna
methods
hiv infection
guided treatment
Prior art date
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MX2016002586A
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English (en)
Inventor
Kamel Khalili
Wenhui Hu
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Univ Temple
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Application filed by Univ Temple filed Critical Univ Temple
Publication of MX2016002586A publication Critical patent/MX2016002586A/es

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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C12N15/102—Mutagenizing nucleic acids
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases RNAses, DNAses
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPRs]
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16061—Methods of inactivation or attenuation
    • C12N2740/16063—Methods of inactivation or attenuation by chemical treatment
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    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)

Abstract

La presente invención describe métodos y composiciones para el tratamiento de infección por virus de inmunodeficiencia. Las composiciones incluyen secuencias de ácido nucleico aislado que comprenden endonucleasa asociada con CRISPR y un ARN de guía, en donde el ARN de guía es complementario a una secuencia objetivo en un virus de inmunodeficiencia humana.
MX2016002586A 2013-08-29 2014-08-29 Métodos y composiciones para el tratamiento guiado por rna de infección por hiv. MX2016002586A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361871626P 2013-08-29 2013-08-29
US201462018441P 2014-06-27 2014-06-27
US201462026103P 2014-07-18 2014-07-18
PCT/US2014/053441 WO2015031775A1 (en) 2013-08-29 2014-08-29 Methods and compositions for rna-guided treatment of hiv infection

Publications (1)

Publication Number Publication Date
MX2016002586A true MX2016002586A (es) 2016-06-14

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MX2016002586A MX2016002586A (es) 2013-08-29 2014-08-29 Métodos y composiciones para el tratamiento guiado por rna de infección por hiv.

Country Status (15)

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US (23) US9925248B2 (es)
EP (1) EP3038661B1 (es)
JP (3) JP7118588B2 (es)
KR (2) KR20230017364A (es)
CN (1) CN106102781A (es)
AU (2) AU2014312123A1 (es)
BR (1) BR112016004091A2 (es)
CA (1) CA2922428A1 (es)
CL (1) CL2016000424A1 (es)
EA (1) EA037850B1 (es)
IL (1) IL244220B (es)
MX (1) MX2016002586A (es)
SG (2) SG10201801658XA (es)
WO (1) WO2015031775A1 (es)
ZA (1) ZA201601344B (es)

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