JP2018516092A5 - - Google Patents
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- JP2018516092A5 JP2018516092A5 JP2018503725A JP2018503725A JP2018516092A5 JP 2018516092 A5 JP2018516092 A5 JP 2018516092A5 JP 2018503725 A JP2018503725 A JP 2018503725A JP 2018503725 A JP2018503725 A JP 2018503725A JP 2018516092 A5 JP2018516092 A5 JP 2018516092A5
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 129
- 229920001184 polypeptide Polymers 0.000 claims description 123
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 123
- 230000027455 binding Effects 0.000 claims description 104
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- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 44
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- 102100033493 Interleukin-3 receptor subunit alpha Human genes 0.000 claims description 15
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- 235000018417 cysteine Nutrition 0.000 claims description 12
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Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021068754A JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2023007753A JP2023052563A (ja) | 2015-04-06 | 2023-01-23 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2024049923A JP2024075751A (ja) | 2015-04-06 | 2024-03-26 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562143772P | 2015-04-06 | 2015-04-06 | |
| US62/143,772 | 2015-04-06 | ||
| PCT/US2016/025868 WO2016164305A1 (en) | 2015-04-06 | 2016-04-04 | De novo binding domain containing polypeptides and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021068754A Division JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516092A JP2018516092A (ja) | 2018-06-21 |
| JP2018516092A5 true JP2018516092A5 (cg-RX-API-DMAC7.html) | 2019-05-09 |
| JP6871232B2 JP6871232B2 (ja) | 2021-05-12 |
Family
ID=57072017
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503725A Active JP6871232B2 (ja) | 2015-04-06 | 2016-04-04 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2018503726A Active JP6873101B2 (ja) | 2015-04-06 | 2016-04-04 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2021068754A Active JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2023007753A Withdrawn JP2023052563A (ja) | 2015-04-06 | 2023-01-23 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2024049923A Pending JP2024075751A (ja) | 2015-04-06 | 2024-03-26 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018503726A Active JP6873101B2 (ja) | 2015-04-06 | 2016-04-04 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2021068754A Active JP7244567B2 (ja) | 2015-04-06 | 2021-04-15 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2023007753A Withdrawn JP2023052563A (ja) | 2015-04-06 | 2023-01-23 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
| JP2024049923A Pending JP2024075751A (ja) | 2015-04-06 | 2024-03-26 | 新規結合ドメイン含有ポリペプチドおよびその使用 |
Country Status (26)
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| PT3280432T (pt) * | 2015-04-06 | 2021-04-22 | Subdomain Llc | Polipéptidos que contêm domínio de ligação de novo e seus usos |
| WO2018075586A1 (en) * | 2016-10-18 | 2018-04-26 | Memorial Sloan-Kettering Cancer Center | Antigen-binding proteins targeting melanoma differentiation antigens and uses thereof |
| CA3221995C (en) | 2017-02-08 | 2024-05-28 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| US20190375838A1 (en) * | 2017-02-10 | 2019-12-12 | Dragonfly Therapeutics, Inc. | Proteins binding bcma, nkg2d and cd16 |
| WO2018148610A1 (en) * | 2017-02-10 | 2018-08-16 | Adimab, Llc | Proteins binding psma, nkg2d and cd16 |
| SG11201907646YA (en) | 2017-02-20 | 2019-09-27 | Dragonfly Therapeutics Inc | Proteins binding her2, nkg2d and cd16 |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| JP2020510439A (ja) | 2017-03-10 | 2020-04-09 | プレジデント アンド フェローズ オブ ハーバード カレッジ | シトシンからグアニンへの塩基編集因子 |
| KR102839445B1 (ko) | 2017-05-10 | 2025-07-28 | 파마 싱크, 엘엘씨 | 암 치료용 보체 불활성화 내성의 외피 바이러스 |
| CN107216395B (zh) * | 2017-07-03 | 2018-07-20 | 上海科医联创生物科技有限公司 | 一种tm4sf1特异性嵌合抗原受体及其应用 |
| EP3658573A1 (en) | 2017-07-28 | 2020-06-03 | President and Fellows of Harvard College | Methods and compositions for evolving base editors using phage-assisted continuous evolution (pace) |
| AU2018338322B2 (en) | 2017-09-23 | 2025-07-17 | Memorial Sloan Kettering Cancer Center | A33 antibody compositions and methods of using the same in radioimmunotherapy |
| WO2019094648A1 (en) | 2017-11-08 | 2019-05-16 | L.E.A.F. Holdings Group Llc | Platinum complexes and uses thereof |
| TWI701259B (zh) * | 2017-11-09 | 2020-08-11 | 大陸商上海懷越生物科技有限公司 | ４﹘１ｂｂ抗體及其製備方法和應用 |
| CA3082410A1 (en) | 2017-11-14 | 2019-05-23 | Arcellx, Inc. | Multifunctional immune cell therapies |
| IL274652B2 (en) * | 2017-11-14 | 2025-08-01 | Arcellx Inc | D-domain containing polypeptides and uses thereof |
| US11464803B2 (en) | 2017-11-14 | 2022-10-11 | Arcellx, Inc. | D-domain containing polypeptides and uses thereof |
| EP3724214A4 (en) | 2017-12-15 | 2021-09-01 | The Broad Institute Inc. | SYSTEMS AND METHODS FOR PREDICTING REPAIR RESULTS IN GENETIC ENGINEERING |
| KR20200118824A (ko) | 2018-02-08 | 2020-10-16 | 드래곤플라이 쎄라퓨틱스, 인크. | 자연 살해 세포를 활성화시키는 다중-특이성 결합 단백질을 수반하는 암의 병용 요법 |
| PT3749346T (pt) | 2018-02-08 | 2024-09-05 | Dragonfly Therapeutics Inc | Combinações de domínios variáveis de anticorpos dirigidas ao receptor nkg2d |
| CA3091424A1 (en) | 2018-02-20 | 2019-08-29 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use |
| US20210017248A1 (en) * | 2018-03-16 | 2021-01-21 | The Regents Of The University Of California | Cellular signaling domain engineering in chimeric antigen receptor-modified regulatory t cells |
| MA52571A (fr) | 2018-05-08 | 2021-03-17 | Amgen Inc | Anticorps bispécifiques ayant des étiquettes appairées à des charges c-terminales clivables |
| AU2019318083A1 (en) * | 2018-08-08 | 2021-02-25 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind BCMA, NKG2D and CD16, and methods of use |
| CA3108646A1 (en) * | 2018-08-08 | 2020-02-13 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and a tumor-associated antigen |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| US12331320B2 (en) | 2018-10-10 | 2025-06-17 | The Research Foundation For The State University Of New York | Genome edited cancer cell vaccines |
| US12351837B2 (en) | 2019-01-23 | 2025-07-08 | The Broad Institute, Inc. | Supernegatively charged proteins and uses thereof |
| GB201903479D0 (en) * | 2019-03-14 | 2019-05-01 | Univ Oxford Innovation Ltd | Polypeptide with enchanced rate of spontaneous isopeptide bond formation with it's peptide tag partner and uses thereof |
| WO2020205836A1 (en) * | 2019-04-02 | 2020-10-08 | Eli Lilly And Company | Methods of selecting and detecting binding peptides |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| CN111848733B (zh) * | 2019-04-30 | 2024-03-12 | 上海细胞治疗集团有限公司 | 一种多肽组合物及疫苗 |
| US12312607B2 (en) * | 2019-05-24 | 2025-05-27 | Avitide LLC | AAV9 affinity agents |
| JP2022535511A (ja) | 2019-05-31 | 2022-08-09 | ルーブリック・セラピューティクス・インコーポレイテッド | メソスケール操作されたペプチドおよび選択方法 |
| EP4010031A1 (en) | 2019-08-06 | 2022-06-15 | L.E.A.F Holdings Group LLC | Processes of preparing polyglutamated antifolates and uses of their compositions |
| WO2021100585A1 (ja) * | 2019-11-20 | 2021-05-27 | 国立大学法人東海国立大学機構 | キメラ抗原受容体遺伝子改変リンパ球の調製方法 |
| WO2021115333A1 (zh) * | 2019-12-10 | 2021-06-17 | 苏州克睿基因生物科技有限公司 | 一种融合蛋白及表达此蛋白的工程化免疫细胞及其应用 |
| MX2022013944A (es) | 2020-05-06 | 2022-11-30 | Dragonfly Therapeutics Inc | Proteinas que se unen al receptor activador de celulas asesinas naturales grupo 2 miembro d (nkg2d), cumulo de diferenciacion (cd16) y miembro a de la familia de dominios de lectina tipo c 12 (clec12a). |
| CN111560391B (zh) * | 2020-05-21 | 2022-02-11 | 北京大学 | 一种蛋白质异质索烃的生物合成方法 |
| CN111732635B (zh) * | 2020-06-22 | 2022-03-22 | 中国医学科学院基础医学研究所 | 与cd123蛋白特异性结合的多肽、多肽复合物、共递送系统及其制备方法与应用 |
| JP2023532973A (ja) * | 2020-07-03 | 2023-08-01 | ザ・トラスティーズ・オブ・コロンビア・ユニバーシティ・イン・ザ・シティ・オブ・ニューヨーク | 多官能直交タンパク質キメラ |
| CN114380907B (zh) * | 2020-10-16 | 2024-06-18 | 中国科学院上海药物研究所 | 靶向cmtm6的纳米抗体及其制备方法和应用 |
| WO2022157500A1 (en) * | 2021-01-20 | 2022-07-28 | Coding Bio Limited | Methods for high throughput screening of chimeric antigen receptors |
| JP2024508894A (ja) | 2021-03-03 | 2024-02-28 | ドラゴンフライ セラピューティクス， インコーポレイテッド | Ｎｋｇ２ｄ、ｃｄ１６、及び腫瘍関連抗原に結合する多特異性結合タンパク質を使用して癌を治療する方法 |
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