JP2018515566A5 - - Google Patents
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- Publication number
- JP2018515566A5 JP2018515566A5 JP2017560675A JP2017560675A JP2018515566A5 JP 2018515566 A5 JP2018515566 A5 JP 2018515566A5 JP 2017560675 A JP2017560675 A JP 2017560675A JP 2017560675 A JP2017560675 A JP 2017560675A JP 2018515566 A5 JP2018515566 A5 JP 2018515566A5
- Authority
- JP
- Japan
- Prior art keywords
- weight
- pharmaceutical composition
- composition according
- drug substance
- lubricant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 22
- 239000008186 active pharmaceutical agent Substances 0.000 claims 13
- 229940088679 drug related substance Drugs 0.000 claims 13
- 239000000314 lubricant Substances 0.000 claims 12
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 12
- 239000000945 filler Substances 0.000 claims 10
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 9
- 229930195725 Mannitol Natural products 0.000 claims 9
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 9
- 239000000594 mannitol Substances 0.000 claims 9
- 235000010355 mannitol Nutrition 0.000 claims 9
- 239000008108 microcrystalline cellulose Substances 0.000 claims 9
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 9
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 9
- 239000007884 disintegrant Substances 0.000 claims 8
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims 7
- 229960000913 crospovidone Drugs 0.000 claims 7
- 239000012458 free base Substances 0.000 claims 7
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 claims 7
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 6
- 229940075614 colloidal silicon dioxide Drugs 0.000 claims 6
- 235000019359 magnesium stearate Nutrition 0.000 claims 6
- LKGCPYOBWLSCTK-UHFFFAOYSA-N methanesulfonic acid;trihydrate Chemical compound O.O.O.CS(O)(=O)=O LKGCPYOBWLSCTK-UHFFFAOYSA-N 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 239000003826 tablet Substances 0.000 claims 5
- -1 1- (4- (dimethylamino) but-2-enoyl) azepan-3-yl Chemical group 0.000 claims 4
- 150000008064 anhydrides Chemical class 0.000 claims 4
- 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 claims 4
- 239000002552 dosage form Substances 0.000 claims 3
- 239000002775 capsule Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 239000011248 coating agent Substances 0.000 claims 2
- 238000000576 coating method Methods 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- 229960003943 hypromellose Drugs 0.000 claims 2
- 239000000463 material Substances 0.000 claims 2
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- 235000021355 Stearic acid Nutrition 0.000 claims 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical group [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 235000013539 calcium stearate Nutrition 0.000 claims 1
- 239000008116 calcium stearate Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical group CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 239000008117 stearic acid Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562165333P | 2015-05-22 | 2015-05-22 | |
| US62/165,333 | 2015-05-22 | ||
| PCT/IB2016/052943 WO2016189435A1 (en) | 2015-05-22 | 2016-05-19 | Pharmaceutical compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2018515566A JP2018515566A (ja) | 2018-06-14 |
| JP2018515566A5 true JP2018515566A5 (enExample) | 2019-06-20 |
Family
ID=56081526
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017560675A Pending JP2018515566A (ja) | 2015-05-22 | 2016-05-19 | 医薬組成物 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20180153899A1 (enExample) |
| EP (1) | EP3297609A1 (enExample) |
| JP (1) | JP2018515566A (enExample) |
| KR (1) | KR20180008511A (enExample) |
| CN (1) | CN107847448A (enExample) |
| AU (1) | AU2016268477B2 (enExample) |
| BR (1) | BR112017024337A2 (enExample) |
| CA (1) | CA2986522A1 (enExample) |
| CL (1) | CL2017002948A1 (enExample) |
| HK (1) | HK1245073A1 (enExample) |
| IL (1) | IL255510A (enExample) |
| MX (1) | MX2017014987A (enExample) |
| PH (1) | PH12017502017A1 (enExample) |
| RU (1) | RU2017145095A (enExample) |
| WO (1) | WO2016189435A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20200024890A (ko) * | 2017-07-05 | 2020-03-09 | 노파르티스 아게 | 신규한 약학적 조성물 |
| KR20190089668A (ko) | 2018-01-23 | 2019-07-31 | 현대모비스 주식회사 | 브레이크 장치용 패드 라이너 |
| KR20200043618A (ko) | 2018-10-18 | 2020-04-28 | 주식회사유한양행 | 아미노피리미딘 유도체 또는 이의 염을 포함하는 경구투여용 약학 조성물 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8846628B2 (en) * | 2008-05-15 | 2014-09-30 | Celgene Corporation | Oral formulations of cytidine analogs and methods of use thereof |
| CA2764438A1 (en) * | 2009-06-15 | 2010-12-23 | Merck Sharp & Dohme Corp. | Pharmaceutical compositions of combinations of dipeptidyl peptidase-4 inhibitors with pioglitazone |
| AR081776A1 (es) * | 2010-06-30 | 2012-10-17 | Novartis Ag | Composiciones farmaceuticas que comprenden monohidrato de lactato de 4-amino-5-fluoro-3-[6-(4-metil-piperazin-1-il)-1h-bencimidazol-2-il]-1h-quinolin-2-ona, proceso para la produccion de la composicion |
| JO3300B1 (ar) | 2012-06-06 | 2018-09-16 | Novartis Ag | مركبات وتركيبات لتعديل نشاط egfr |
| US9675587B2 (en) * | 2013-03-14 | 2017-06-13 | Allergan Holdings Unlimited Company | Opioid receptor modulator dosage formulations |
-
2016
- 2016-05-19 BR BR112017024337-7A patent/BR112017024337A2/pt not_active Application Discontinuation
- 2016-05-19 MX MX2017014987A patent/MX2017014987A/es unknown
- 2016-05-19 CA CA2986522A patent/CA2986522A1/en not_active Abandoned
- 2016-05-19 AU AU2016268477A patent/AU2016268477B2/en not_active Ceased
- 2016-05-19 RU RU2017145095A patent/RU2017145095A/ru not_active Application Discontinuation
- 2016-05-19 EP EP16725242.8A patent/EP3297609A1/en not_active Withdrawn
- 2016-05-19 KR KR1020177033602A patent/KR20180008511A/ko not_active Withdrawn
- 2016-05-19 JP JP2017560675A patent/JP2018515566A/ja active Pending
- 2016-05-19 HK HK18104248.2A patent/HK1245073A1/zh unknown
- 2016-05-19 WO PCT/IB2016/052943 patent/WO2016189435A1/en not_active Ceased
- 2016-05-19 CN CN201680043060.9A patent/CN107847448A/zh active Pending
- 2016-05-19 US US15/576,001 patent/US20180153899A1/en not_active Abandoned
-
2017
- 2017-11-07 PH PH12017502017A patent/PH12017502017A1/en unknown
- 2017-11-07 IL IL255510A patent/IL255510A/en unknown
- 2017-11-21 CL CL2017002948A patent/CL2017002948A1/es unknown
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