JP2018515193A5 - - Google Patents

Info

Publication number

JP2018515193A5

JP2018515193A5 JP2017556548A JP2017556548A JP2018515193A5 JP 2018515193 A5 JP2018515193 A5 JP 2018515193A5 JP 2017556548 A JP2017556548 A JP 2017556548A JP 2017556548 A JP2017556548 A JP 2017556548A JP 2018515193 A5 JP2018515193 A5 JP 2018515193A5

Authority

JP

Japan

Prior art keywords

alginate

nanofibers

antimicrobial

odor

calcium

Prior art date

2016-04-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000002121 nanofiber Substances 0.000 claims 31
• 229940072056 alginate Drugs 0.000 claims 22
• 229920000615 alginic acid Polymers 0.000 claims 22
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 16
• 235000010443 alginic acid Nutrition 0.000 claims 16
• 239000000243 solution Substances 0.000 claims 13
• 238000000034 method Methods 0.000 claims 12
• 239000002250 absorbent Substances 0.000 claims 10
• 230000002745 absorbent Effects 0.000 claims 10
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims 9
• 239000003960 organic solvent Substances 0.000 claims 8
• -1 silver ions Chemical class 0.000 claims 8
• 239000004599 antimicrobial Substances 0.000 claims 7
• 239000002202 Polyethylene glycol Substances 0.000 claims 6
• 239000000648 calcium alginate Substances 0.000 claims 6
• 235000010410 calcium alginate Nutrition 0.000 claims 6
• 229960002681 calcium alginate Drugs 0.000 claims 6
• OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims 6
• 230000000844 anti-bacterial effect Effects 0.000 claims 5
• 230000000845 anti-microbial effect Effects 0.000 claims 5
• 239000007864 aqueous solution Substances 0.000 claims 5
• 238000001523 electrospinning Methods 0.000 claims 5
• 238000005406 washing Methods 0.000 claims 5
• BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims 4
• 239000003242 anti bacterial agent Substances 0.000 claims 4
• 229920001222 biopolymer Polymers 0.000 claims 4
• 229910001424 calcium ion Inorganic materials 0.000 claims 4
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
• 229920000858 Cyclodextrin Polymers 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims 3
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 3
• 239000004332 silver Substances 0.000 claims 3
• 229910052709 silver Inorganic materials 0.000 claims 3
• GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 2
• BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 2
• 239000005708 Sodium hypochlorite Substances 0.000 claims 2
• XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims 2
• 230000003115 biocidal effect Effects 0.000 claims 2
• 159000000007 calcium salts Chemical class 0.000 claims 2
• 239000001913 cellulose Substances 0.000 claims 2
• 229920002678 cellulose Polymers 0.000 claims 2
• 229960003260 chlorhexidine Drugs 0.000 claims 2
• 238000000151 deposition Methods 0.000 claims 2
• 238000007787 electrohydrodynamic spraying Methods 0.000 claims 2
• JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 claims 2
• 239000000835 fiber Substances 0.000 claims 2
• BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims 2
• PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 2
• 229920001610 polycaprolactone Polymers 0.000 claims 2
• 229920000642 polymer Polymers 0.000 claims 2
• 239000012286 potassium permanganate Substances 0.000 claims 2
• SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 claims 2
• GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 claims 2
• 239000004094 surface-active agent Substances 0.000 claims 2
• 229960003500 triclosan Drugs 0.000 claims 2
• JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims 1
• ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 claims 1
• UJMHIOBAHVUDGS-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-(2-decoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCO UJMHIOBAHVUDGS-UHFFFAOYSA-N 0.000 claims 1
• JYCQQPHGFMYQCF-UHFFFAOYSA-N 4-tert-Octylphenol monoethoxylate Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCO)C=C1 JYCQQPHGFMYQCF-UHFFFAOYSA-N 0.000 claims 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 1
• 229920001661 Chitosan Polymers 0.000 claims 1
• 102000008186 Collagen Human genes 0.000 claims 1
• 108010035532 Collagen Proteins 0.000 claims 1
• JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 claims 1
• 229920002307 Dextran Polymers 0.000 claims 1
• 108010010803 Gelatin Proteins 0.000 claims 1
• 229920002683 Glycosaminoglycan Polymers 0.000 claims 1
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
• 239000004372 Polyvinyl alcohol Substances 0.000 claims 1
• 229940082500 cetostearyl alcohol Drugs 0.000 claims 1
• 229960000541 cetyl alcohol Drugs 0.000 claims 1
• 239000011248 coating agent Substances 0.000 claims 1
• 238000000576 coating method Methods 0.000 claims 1
• 229920001436 collagen Polymers 0.000 claims 1
• 229940073499 decyl glucoside Drugs 0.000 claims 1
• ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 claims 1
• 229920000159 gelatin Polymers 0.000 claims 1
• 239000008273 gelatin Substances 0.000 claims 1
• 235000019322 gelatine Nutrition 0.000 claims 1
• 235000011852 gelatine desserts Nutrition 0.000 claims 1
• 229940113096 isoceteth 20 Drugs 0.000 claims 1
• LAPRIVJANDLWOK-UHFFFAOYSA-N laureth-5 Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCO LAPRIVJANDLWOK-UHFFFAOYSA-N 0.000 claims 1
• PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 claims 1
• 229940048848 lauryl glucoside Drugs 0.000 claims 1
• YWWHKOHZGJFMIE-UHFFFAOYSA-N monoethyl phthalate Chemical compound CCOC(=O)C1=CC=CC=C1C(O)=O YWWHKOHZGJFMIE-UHFFFAOYSA-N 0.000 claims 1
• GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims 1
• 229920000847 nonoxynol Polymers 0.000 claims 1
• 229950004053 octoxinol Drugs 0.000 claims 1
• HEGSGKPQLMEBJL-RKQHYHRCSA-N octyl beta-D-glucopyranoside Chemical compound CCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O HEGSGKPQLMEBJL-RKQHYHRCSA-N 0.000 claims 1
• UYDLBVPAAFVANX-UHFFFAOYSA-N octylphenoxy polyethoxyethanol Chemical compound CC(C)(C)CC(C)(C)C1=CC=C(OCCOCCOCCOCCO)C=C1 UYDLBVPAAFVANX-UHFFFAOYSA-N 0.000 claims 1
• 229940055577 oleyl alcohol Drugs 0.000 claims 1
• XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 claims 1
• 229960000502 poloxamer Drugs 0.000 claims 1
• 229920001983 poloxamer Polymers 0.000 claims 1
• 229920001432 poly(L-lactide) Polymers 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 229920000223 polyglycerol Polymers 0.000 claims 1
• 229950008882 polysorbate Drugs 0.000 claims 1
• 229920000136 polysorbate Polymers 0.000 claims 1
• 229920002689 polyvinyl acetate Polymers 0.000 claims 1
• 239000011118 polyvinyl acetate Substances 0.000 claims 1
• 229920002451 polyvinyl alcohol Polymers 0.000 claims 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 claims 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 claims 1
• 238000002360 preparation method Methods 0.000 claims 1
• ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 229940100515 sorbitan Drugs 0.000 claims 1
• 229940012831 stearyl alcohol Drugs 0.000 claims 1
• 239000000126 substance Substances 0.000 claims 1
• FBWNMEQMRUMQSO-UHFFFAOYSA-N tergitol NP-9 Chemical compound CCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1 FBWNMEQMRUMQSO-UHFFFAOYSA-N 0.000 claims 1
• OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 claims 1
• 229920002554 vinyl polymer Polymers 0.000 claims 1
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1