GB2604055A - Antimicrobial material - Google Patents

Antimicrobial material Download PDF

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Publication number
GB2604055A
GB2604055A GB2205894.5A GB202205894A GB2604055A GB 2604055 A GB2604055 A GB 2604055A GB 202205894 A GB202205894 A GB 202205894A GB 2604055 A GB2604055 A GB 2604055A
Authority
GB
United Kingdom
Prior art keywords
iodine
substrate
complex
compound
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB2205894.5A
Other versions
GB202205894D0 (en
GB2604055B (en
Inventor
Ochayi Agboh Christopher
Farrar David
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Io Cyte Ltd
Original Assignee
Io Cyte Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Io Cyte Ltd filed Critical Io Cyte Ltd
Publication of GB202205894D0 publication Critical patent/GB202205894D0/en
Publication of GB2604055A publication Critical patent/GB2604055A/en
Application granted granted Critical
Publication of GB2604055B publication Critical patent/GB2604055B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28Polysaccharides or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/425Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/44Medicaments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/60Liquid-swellable gel-forming materials, e.g. super-absorbents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L17/00Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
    • A61L17/005Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters containing a biologically active substance, e.g. a medicament or a biocide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/106Halogens or compounds thereof, e.g. iodine, chlorite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/04Materials for stopping bleeding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Materials Engineering (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)

Abstract

A biocompatible material the method of making the same. The material comprises constituent fibres, yarns or filaments forming a woven, non-woven, gauze, film or knitted material incorporating an antimicrobial agent. The present material finds particular application as a wound dressing for the controlled and sustained release of a complexed form of iodine such as povidone-iodine or Cadexomer-iodine.

Claims (25)

Claims
1. A biocompatible material formed by a method of: providing a powdered iodine-complex; providing a fibre, yarn, filament or multifilament-based substrate having an open structure containing voids or interstitial regions; and introducing the powdered iodine-complex to the substrate to incorporate the iodine-complex within the structure of the substrate.
2. The material as claimed in claim 1 wherein the powdered iodine-complex comprises an iodophor, povidone-iodine, a starch-iodine-complex, a modified starch iodine-complex or the reaction product of dextrin, epichlorohydrin and iodine.
3. The material as claimed in claims 1 or 2 wherein the substrate is woven, non- woven, a gauze, a film or knitted.
4. The material as claimed in any preceding claim wherein the substrate comprises a water-absorbing swellable polymer.
5. The material as claimed in claim 4 wherein the material comprises any one or a combination of: â ¢ a polysaccharide â ¢ a polysaccharide-based material â ¢ a hydrocolloid forming compound â ¢ an alginate â ¢ chitosan â ¢ chitin â ¢ pectin â ¢ carboxymethyl cellulose â ¢ hydroxypropyl methylcellulose â ¢ gellan â ¢ konjac; â ¢ psyllium.
6. The material as claimed in any one of claims 1 to 3 wherein the substrate comprises a polyester, a polyamide, a cellulosic, an acrylic or a biopolymer.
7. The material as claimed in any preceding claim further comprising a membrane provided over at least one external surface of the substrate, the membrane having an open structure to allow the iodine to be released from the material.
8. The material as claimed in claim 7 wherein the membrane is a gauze or mesh.
9. The material as claimed in claim 7 or 8 wherein the membrane encapsulates the substrate.
10. The material as claimed in any preceding claim wherein the substrate is a singular piece or comprises a layered structure.
11. The material as claimed in any preceding claim wherein the iodine-complex is adsorbed at a surface of the fibres, yarns, filaments or multifilaments of the substrate.
12. The material as claimed in any preceding claim further comprising a water- soluble control compound configured to control a release of the iodine from the material.
13. The material as claimed in claim 12 wherein the water-soluble control compound comprises a polyether, an alkyl ether, a glycol, a polyol or a compound having a C-O-C linkage.
14. The material as claimed in claim 12 wherein the water-soluble control compound comprises propylene glycol and/or polyethylene glycol.
15. The material as claimed in any preceding claim further comprising a polar organic compound comprising any one or a combination of an aldehyde, a ketone, an alcohol, an acetal or a compound with a hydroxyl group or a carbonyl group or acetone and/or isopropanol.
16. A biocompatible material comprising: a fibre, yam or filament-based substrate having an open structure containing voids or interstitial regions; and an iodine-complex releasably retained at the substrate and/or within the voids or interstitial regions.
17. The material as claimed in claim 16 wherein the iodine-complex is adsorbed at a surface of the fibres, yams, filaments or multifilaments of the substrate.
18. A method of forming a biocompatible antimicrobial material comprising: providing a powdered iodine-complex; providing a fibre, yarn, filament or multifilament-based substrate having an open structure containing voids or interstitial regions; and introducing the powdered iodine-complex to the substrate and allowing the powdered iodine-complex to be releasably retained at the substrate and/or within the voids or interstitial regions.
19. The method as claimed in claim 18 wherein the step of introducing the powered iodine-complex to the substrate comprises sonically agitating the substrate to facilitate entry of the iodine-complex into the voids.
20. The method as claimed in claims 18 or 19 further comprising prior to or after the step of introducing the iodine-complex to the substrate, applying an aqueous-based liquid to the substrate in which the iodine-complex is at least partially soluble.
21. The method as claimed in claim 20 wherein the aqueous liquid comprises any one or a combination of: water; a polar organic solvent; a water-soluble control compound configured to control a release of the iodine from the material.
22. The method as claimed in claim 21 wherein the aqueous liquid comprises an aldehyde, a ketone, an alcohol, an acetal or a compound with a hydroxyl group or a carbonyl group, acetone and/or isopropanol.
23. The method as claimed in claims 21 or 22 wherein the water-soluble control compound comprises any one or a combination of a polyether, an alkyl ether, a glycol, a polyol or a compound having a C-O-C linkage, propylene glycol and/or polyethylene glycol.
24. A wound dressing comprising the material as claimed in any one of claims 1 to 17.
25. The material as claimed in any one of claims 1 to 17 being any one of the following: â ¢ a nasal packing material; or â ¢ a dental packing material.
GB2205894.5A 2019-10-24 2020-10-22 Antimicrobial material Active GB2604055B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1915428.5A GB2588442A (en) 2019-10-24 2019-10-24 Antimicrobial material
PCT/GB2020/052664 WO2021079126A1 (en) 2019-10-24 2020-10-22 Antimicrobial material

Publications (3)

Publication Number Publication Date
GB202205894D0 GB202205894D0 (en) 2022-06-08
GB2604055A true GB2604055A (en) 2022-08-24
GB2604055B GB2604055B (en) 2024-09-11

Family

ID=68768980

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1915428.5A Withdrawn GB2588442A (en) 2019-10-24 2019-10-24 Antimicrobial material
GB2205894.5A Active GB2604055B (en) 2019-10-24 2020-10-22 Antimicrobial material

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB1915428.5A Withdrawn GB2588442A (en) 2019-10-24 2019-10-24 Antimicrobial material

Country Status (2)

Country Link
GB (2) GB2588442A (en)
WO (1) WO2021079126A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116212084A (en) * 2023-02-01 2023-06-06 中国科学院深圳先进技术研究院 Degradable wound dressing with double antibacterial effects and preparation method and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN203576752U (en) * 2013-07-06 2014-05-07 圣光医用制品有限公司 Novel calcium-alginate povidone-iodine-powder spunlaced non-woven fabrics dressing
WO2019012069A1 (en) * 2017-07-12 2019-01-17 Smith & Nephew Plc Antimicrobial or wound care materials, devices and uses

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3254013B2 (en) 1991-09-10 2002-02-04 ジョンソン・アンド・ジョンソン・メディカル・インコーポレイテッド Dressing material and its manufacturing method
AU722246B2 (en) * 1995-06-07 2000-07-27 Johnson & Johnson Consumer Products, Inc. Stable complexes of crosslinked polyvinylpyrrolidone and iodine and method of making the same
US6605751B1 (en) 1997-11-14 2003-08-12 Acrymed Silver-containing compositions, devices and methods for making
US8828424B2 (en) 2001-09-12 2014-09-09 Convatec Limited Antibacterial wound dressing
US20110171284A1 (en) 2010-01-11 2011-07-14 Gilman Miles E Povidone-iodine and sucrose wound healing dressing
CN102429862B (en) 2011-11-29 2013-05-01 江苏德达医药科技有限公司 Sustained-release povidone iodine eye drops
ITTO20120258A1 (en) 2012-03-21 2013-09-22 Fond Istituto Italiano Di Tecnologia POLYMERIC COMPOSITE MATERIALS WITH ANTIMICROBIAL AND BIODEGRADABLE PROPERTIES AND THEIR USES.
ES2703533T3 (en) 2012-08-30 2019-03-11 Zhejiang Jm Ind Co Ltd Powder dispenser
US20180236020A1 (en) * 2017-02-22 2018-08-23 San Melix Laboratories, Inc. Buckwheat honey and povidone-iodine wound healing dressing

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN203576752U (en) * 2013-07-06 2014-05-07 圣光医用制品有限公司 Novel calcium-alginate povidone-iodine-powder spunlaced non-woven fabrics dressing
WO2019012069A1 (en) * 2017-07-12 2019-01-17 Smith & Nephew Plc Antimicrobial or wound care materials, devices and uses

Also Published As

Publication number Publication date
WO2021079126A1 (en) 2021-04-29
GB202205894D0 (en) 2022-06-08
GB201915428D0 (en) 2019-12-11
GB2588442A (en) 2021-04-28
GB2604055B (en) 2024-09-11

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