CN102631699A - Antibacterial fiber dressing containing nanometer metal and preparation method thereof - Google Patents
Antibacterial fiber dressing containing nanometer metal and preparation method thereof Download PDFInfo
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- CN102631699A CN102631699A CN2011100361383A CN201110036138A CN102631699A CN 102631699 A CN102631699 A CN 102631699A CN 2011100361383 A CN2011100361383 A CN 2011100361383A CN 201110036138 A CN201110036138 A CN 201110036138A CN 102631699 A CN102631699 A CN 102631699A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
- A61L2300/104—Silver, e.g. silver sulfadiazine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
Abstract
The invention relates to an antibacterial fiber dressing containing nanometer metal and a preparation method thereof. Nanometer metal particles are distributed on the fiber surface of the dressing. The content of the nanometer metal is 0.5-10 wt%. As a dressing for wound treatment, the fiber wound dressing has the capability of continuously releasing sufficient nanometer metal particles, is especially suitable for chronic wound treatment, can provide long-term and effective antibacterial functions, and can effectively prevent wound infection caused by various bacteria and microbe.
Description
Technical field
The present invention relates to a kind of antibiotic fiber class dressing that contains nano metal and preparation method thereof.
Background technology
As everyone knows, silver and copper, especially silver have been identified it for a long time and have had effective anti-microbial property, are effective to killing some common antibacterials in nursing chronic wounds process particularly.And, shown the sterilization effect of silver to the antibacterial of some antibiotic-resistant.At present; Modal antibiotic property silver dressings is divided into ion-type and nanometer gold genotype; Adopting the silver ion technology is through a kind of silver compound silver ion to be provided to employed wound dressing, and adopt the nano metal technology be through make nano metal for example nano silver particles put on the wound dressing.
When preparation antibiotic fiber class wound dressing, prior art mainly adopts following two kinds of methods.The one, it is inner antibacterial to be dissolved in (perhaps dissolving in) fibrous polymeric materials, i.e. blending antibacterial and it is retained in the fiber of processing in spinning solution.
U.S. Pat 6,897,349 disclose the method that prepare the silver-containing antibacterial material with European patent EP 1216065, and this method is scattered among the fiber silver chloride through in preparing the fiber process.
Chinese patent CN1308509C discloses a kind of argentiferous chitosan fiber with antibacterial action and preparation method thereof; This method is that silver compound granule below 1 micron is that silver zirconium phosphate hydrogen sodium (commodity are called Alphasan) is mixed in the spinning solution with particle diameter, and this silver compound silver content is 3.0-4.0 weight %.
Chinese patent CN1060235C discloses a kind of antibacterial tacryl and manufacturing approach thereof, and this method is through containing antibacterial master batch and fiber is processed in polypropylene blend spinning, containing the antibacterial of 500-1000ppm (weight) in this fiber.
European patent EP 1849464 and U.S. Pat 2007275043 are presented in and a kind ofly are added in the way of fibrous inside to silver compound (silver-colored carbonate), promptly the silver compound blending in fiber spinning solution.
One Chinese patent application CN1673425A has introduced a kind of method of the 0.1-1 of containing weight % nanometer silver antimicrobial viscose rayon, and wherein nanometer silver is added in the spinning solution.But this method will be used colloid protective agent, uses the colloid protective agent amount can reach 2 weight %.All these colloid protective agents can only be present in fibrous inside with the form of suspended substance, and can not become the part that macromole is cross-linked with each other in the fiber.This has reduced the ratio of spinning poly compound in the fiber in fact again, thereby has also limited the high-load of nanometer silver, and this method can only be accomplished 1 weight % content of nanometer silver.
The 2nd, antibacterial is put on the surface of fiber or fabric, promptly infiltrate into the top layer of fiber or fabric, perhaps be attached to the surface of fiber or fabric.
One Chinese patent application CN1895683A discloses a kind of nano silver antibiotic dressing and preparation method thereof, and method is padded in this invention employing is coated on the fabric coating liquid that contains nanometer silver, and the content of processing nanometer silver is the dressing of 0.05-2.9 weight %.
Chinese patent CN100346840C discloses a kind of composite nano anti-biotic medical dressing, this invention compound argentiferous nano-particle on non-woven fabrics or absorbing carbon fiber enclosure material, and particle diameter is the 1-15 nanometer.
One Chinese patent application CN1066783A discloses the method that a kind of preparation contains the anti-biotic material of antibacterial metal, and this method is the anti-biotic material that forms the antibacterial metal that contains silver, copper etc. and alloy thereof through physical methods such as vapour depositions.
U.S. Pat 7; 462,753 disclose a kind of nanometer silver wound dressing, and this dressing is four-layer structure; Ground floor is made up of hydrophilic cloth; The second layer is made up of the active carbon cloth that has flooded nanometer silver, and the 3rd layer of non-woven fabrics that is made up of super water absorbent polymer forms, and the 4th layer constitutes by being covered in trilaminar pore shape fabric.
European patent EP 1095179 discloses a kind of manufacturing approach that is used for the adhesive-bonded fabric of wound dressing, and this method adopts the lamination combination process alginate fleece to be compounded in the two sides of the fibrous mesh cloth that scribbles silver.
U.S. Pat 7,385,101 disclose a kind of antibiotic textile material and wound dressing thereof that is applicable to wound dressing, and this antiseptic dressing is textile fabric and the alginate fiber mixing that the surface is had the argent coating, makes through nonwoven processes.
U.S. Pat 20030180346 discloses a kind of argentiferous medical dressing with European patent application EP 1318842, and this dressing makes through argentiferous fiber and silver free fiber blend, and the gained wound dressing contains the silver ion of 0.01-5.0 weight %.
Hence one can see that; Can be blending silver compound or nano silver particles and it is retained in the fiber of processing in spinning solution adopting silver ion or nano silver particles that method to the employed wound dressing is provided as antibacterial in the prior art; Or the antibacterial of silver ion or nano silver particles put on the surface of fiber or fabric, make its infiltration or be attached to the surface of fiber or fabric.But, add metallic compound or nano metal particles in the spinning liquid, thereby the manufacturing approach production cycle of the antibiotic fiber class dressing that whole fibre structure is all had be evenly distributed with metal ion or nano metal particles is long, is unfavorable for reducing production costs.In addition; With metallic; Even the manufacturing approach that nano metal particles puts on the antibiotic fiber class dressing of fiber or fabric face all is to adopt to pad method, dipping method and CVD method, metallic, even nano metal particles only is adsorbed in the top layer of fiber or fabric; Surface from fiber or fabric comes off easily, and can't be used for colloidal sol property fiber.
The present invention adopts nano metal particles in order to solve the problem of above-mentioned existence, and preferably nano silver particles sprays to fiber or fabric face with spraying method.Because nano metal has higher surface potential; For reducing surface energy; Particle surface atom and fiber surface exposed groups (like hydroxyl, carboxyl) are through approximate chemical bond and the mutual adsorbed close of Van der Waals force; Nanoparticle also can form Electrostatic Absorption with some fiber surface simultaneously, and the physics groove of fiber surface, slit etc. also can form nano-particle embedding bag in addition, also make granule attached to fiber surface.Through above-mentioned effect finally make spraying back nano metal relatively securely " adhesions " simultaneously,, can not exert an influence at fiber or fabric face to fiber or fabric structure owing to nano metal particles only adheres to fiber or fabric face.For changing frequency as the wound dressing one of which is 24 hours, and longer has 7 days even 21 days, but it's 21 days does not past the president, and therefore, the dressing that adopts spraying method to process does not influence the antibacterial effect of dressing.
This method is specially adapted to those wound dressings that is made into by colloidal sol property fiber.This material is as good as with general fiber under normal operation, but fiber will become colloid when running into water or aqueous solution.This material is very valuable as wound dressing.The one, this material generally all has high moisture pick-up properties, generally can absorb the moisture of 1000%-2000%; The 2nd, in a single day this material absorbs water into glue after, dressing just has fabulous moisture retention, can keep wound that a moistening micro climate is arranged for a long time.The colloidal sol property fiber that generally is used as wound dressing has alginate fiber, carboxymethyl chitosan fiber, acylation chitosan fiber, carboxymethyl cellulose fiber, water-fast cellulose alkylsulfonate fiber etc.
General spraying be water as medium, be dispersed in nano metal particles in the aqueous solution.But it is not all right that this method has high soluble fiber dressing to part, such as carboxymethyl chitosan fiber, acylation chitosan fiber, carboxymethyl cellulose fiber or cellulose alkylsulfonate fiber.These fibers can become colloid after meeting water, though the dry again back fiber of a small amount of nano aqueous solution of spraying or dressing feel very firmly, not soft, on wound, can't to remake be that wound dressing uses thereby be difficult to post.We have studied the spraying way of this fiber dressing especially, promptly use organic solvent as medium, and such as acetone, ethanol etc. just can address these problems.As long as adopt proper method to be dispersed in a certain proportion of nano metal in the organic solvent, again this solution spraying at fiber or fabric face.Organic solvent can volatilize in follow-up operation, just makes nano metal be coated in fiber or fabric face.
Certainly the aqueous solution spraying is not high even not have the material of colloidal sol property be operable to those colloidal sol property.
Therefore, the objective of the invention is to make the higher nano metal particles of content to be uniformly distributed in effectively in the surface of fiber or fabric, thereby obtain containing the antibiotic fiber class wound dressing of nano metal particles in high density.
Summary of the invention
The invention provides a kind of antibiotic fiber class wound dressing that contains nano metal, and this wound dressing method for preparing.
Because nano metal particles particle diameter used in the present invention is generally about the 5-10 nanometer; Only account for fibre diameter less than one thousandth; And the silver compound particle grain size of using in the prior art (for example CN1308509C and EP1849464A1) will account for the 5-10% of fibre diameter, is difficult to be coated in fiber surface.And, after spraying to fiber surface, can be distributed on the fiber surface equably because nano metal particles is extremely small.
In dressing involved in the present invention, the content of said nano metal particles is 0.5-10 weight %, is preferably 0.6-9 weight %, most preferably 0.8-8 weight %.
The particle diameter of the nano metal particles that the present invention uses is 1nm-500nm, is preferably 1nm-400nm.
The nano metal particles that the present invention uses is nano silver particles or nanometer copper particle or nanometer zinc particles.
In dressing involved in the present invention; Employed fiber can be any fiber and fabric thereof that is suitable for dressing; Preferred alginate fiber or chitin fiber or cellulose fibre (comprising the cellulose fibre that the solvent method spinning makes), said alginate fiber are high mannuronic acid (M) type or high guluronic acid (G) type or mannuronic acid/guluronic acid (M/G) mixed type.Said alginate fiber is calcium alginate fibre or calcium alginate/sodium fiber.Said chitin fiber can be chitin fiber or carboxymethyl chitosan fiber or the acylation chitosan fiber of deacetylation more than 80%.Said cellulose fibre can be a carboxymethyl cellulose fiber, also can be water-fast cellulose alkylsulfonate fiber, contain the carboxymethyl cellulose solvent and spin fiber, and perhaps also can be that water-immiscible solvent spins cellulose alkylsulfonate fiber.
The fiber that the present invention uses is short fiber, can long filament or fibre cutting be become certain length according to the structure of wound dressing, and said fibre length is 3-100mm.
The fiber that the present invention uses has certain line density and crimpness, and the line density of said fiber is the 1-5 dtex, is preferably the 1.5-3 dtex.
Dressing involved in the present invention is for passing through needling non-woven technology or chemical adhesion nonwovens process or weaving or the made fabric of knitting.If when adopting needling non-woven technology, fibre length can be grown, and is 30-100mm, if during employing chemical adhesion nonwovens process, fibre length can be lacked, and is 3-15mm, if when woven or knitting, fibre length can be 20-85mm.
The present invention provides the method for preparing of the antibiotic fiber that contains nano metal, at first, nano metal material is dispersed in aqueous solution or the organic solvent in proportion.Can utilize low frequency ultrasound appearance (25-50 hertz) to make dispersive process more effective during dispersion.The solution spraying that will contain nano metal according to process conditions then is on fiber or fabric face.
The concentration of nanometer solution will decide according to process conditions and material, and the final content of nano metal in fiber or fabric should be between 0.5-10% weight.
If the continous way spinning technique then will calculate the spraying flow according to spinning speed and fibre bundle line density.If the staple in bulk spraying then will be calculated the fiber total amount.If fabric then will calculate fabric gross weight and area.
The present invention provides a kind of method for preparing that contains the antibiotic fiber of nano metal, specifically comprises the following steps:
Nano metal is scattered in aqueous solution or a kind of organic solution in proportion, is mixed with the solution that contains nano metal;
Spray to the resulting solution that contains nano metal on the tow of continuous spinning by process conditions;
Resultant fibre bundle is curling, cutting;
Resulting fiber is processed into fabric through non-woven, woven or knitting.
The present invention also provides a kind of method for preparing that contains the antibiotic fiber of nano metal, specifically comprises the following steps:
Nano metal is scattered in aqueous solution or a kind of organic solution in proportion, is mixed with the solution that contains nano metal;
Be sprayed at the resulting solution that contains nano metal on the short fiber surface for preparing by fibre weight;
Resulting fiber is processed into fabric through non-woven, woven or knitting.
The present invention provides a kind of antibiotic property process for making such fabric that contains nano metal, specifically comprises the following steps:
Nano metal is scattered in aqueous solution or a kind of organic solution in proportion, is mixed with the solution that contains nano metal;
The resulting solution that contains nano metal is sprayed to fabric face by fabric weight, can be only spraying one side, also can be to be sprayed on the fabric two sides;
A kind of method for preparing that contains the fiber-like antibiotic property wound dressing of nano metal provided by the invention further comprises the following steps: resultant fabric is cut, and packs, sterilizes, and obtains described dressing.
Employed said nano metal particles is nano silver particles or nanometer copper particle or nanometer zinc particles in above-mentioned each method provided by the invention.
The particle diameter of nano metal particles is 1nm-500nm described in above-mentioned each method provided by the invention, is preferably 1nm-400nm.
Therefore, when adopting above-mentioned spraying method, because the electric charge of nano metal particles is high, so nanometer silver " adhesion " is at fiber surface and can tolerate general nonwoven process.In addition; Because the wound dressing that the present invention relates to is for there being the fiber-like fabric of nano metal particles in surface distributed; As wound treatment dressing, this fiber-like wound dressing has the ability of the nano metal particles that discharges q.s very soon, is particularly suitable for chronic wound treatment; For a long time and effectively antibacterial functions can be provided, can prevent various antibacterials and microorganism infection effectively wound.
Description of drawings
Fig. 1 is for showing the dressing inhibition zone after 1 day in the escherichia coli culture dish that contains 0.5 weight % nanometer silver.
Fig. 2 is for showing the dressing inhibition zone after 7 days in the escherichia coli culture dish that contains 0.5 weight % nanometer silver.
Fig. 3 is for showing the dressing inhibition zone after 1 day in the escherichia coli culture dish that contains 10 weight % nanometer copper.
Fig. 4 is for showing the dressing inhibition zone after 7 days in the escherichia coli culture dish that contains 10 weight % nanometer copper.
Fig. 5 is for showing the dressing inhibition zone after 1 day in the staphylococcus aureus culture dish that contains 1 weight % nanometer silver.
Fig. 6 is for showing the dressing inhibition zone after 7 days in the staphylococcus aureus culture dish that contains 1 weight % nanometer silver.
The specific embodiment
Through accompanying drawing and specific embodiment, technical scheme of the present invention is further specified below.
Embodiment 1
Preparation contains the antibiotic property chitin fiber of 0.5% nanometer silver and the method for wound dressing thereof:
1. in common chitosan spinning process, calculate the dry weight of tow, for example, 6 gram/rice.
2. inspection linear velocity, unit is meter/minute, for example, 20 meters/minute.Can draw the gross dry weight of per minute endless tow, i.e. 120 Grams Per Minutes.
3. be ready to the required water yield of solution, this solution can be sprayed onto in spinning process on the tow surface.Silver concentration in the solution is high more good more.In this example, the solution concentration of being prepared that contains nanometer silver is 20%, and the nominal particle size of silver particles is 5nm.
4. (particle diameter 5nm D95=3.7-6.9) is dispersed in the aqueous solution with Ultrasound Instrument (25-50 hertz) earlier, and aqueous solution contains 20 weight % nanometer silvers with the nanometer silver powder.。
5. the translational speed of adjustment nozzle is so that spraying rate is about 3 gram/minute, and solution at the uniform velocity is sprayed on the tow surface through out-of-date at tow.
6. tow will be through super-dry, and curling, to process length with cutting be 50 millimeters short fiber.Spun fiber is a canescence, and the about 0.5 weight % of content of nanometer silver wherein.
7. use traditional no spinning process that fiber is processed non-woven fabrics.The cloth that makes is cut into 10 * 10cm, and be packaged in the paper bag.This dressing that obtains will be sterilized through the gamma irradiation of 25-40 kilogray.
Embodiment 2
In order to observe the anti-microbial property of dressing; In culture dish, be coated with a certain amount of escherichia coli equably; Respectively the dressing of embodiment 1 gained is cut into 2 * 2cm then and puts into wherein,, observe the bacterial growth situation on each flat board every day 37 ℃ of following continuous culture of constant temperature 7 days.Fig. 1 has shown the dressing inhibition zone after 1 day in the escherichia coli culture dish that contains 0.5 weight % nanometer silver, and Fig. 2 has shown the dressing inhibition zone after 7 days in the escherichia coli culture dish that contains 0.5 weight % nanometer silver.Can find out that the dressing that contains 0.5 weight % nanometer silver still had antibiotic resistance performance after 7 days.
Embodiment 3
Preparation contains the antibiotic property calcium alginate fibre of 10% nanometer copper and the method for wound dressing thereof:
1. in common calcium alginate spinning process, calculate the dry weight of tow, for example, 11.5 gram/rice.
2. inspection linear velocity, unit is meter/minute, for example, 22 meters/minute.Can draw the gross dry weight of per minute tow, i.e. 253 Grams Per Minutes.
3. because meeting water, calcium alginate can become glue, and therefore will be with acetone or other organic solvents as medium.Be ready to the copper nanoparticle body (size range of copper silver particles is 10-40nm) of 500 gram acetone liquid and 200 grams.
4. the copper nanoparticle end is dispersed in the acetone soln with Ultrasound Instrument (25-50 hertz) earlier, solution contains 40 weight % nanometer copper.
5. the adjustment nozzle is so that spraying rate is about 63 Grams Per Minutes.And through out-of-date solution at the uniform velocity is sprayed on the tow surface at tow.
6. tow will be through super-dry, and curling, to process length with cutting be 50 millimeters short fiber.Spun fiber is a canescence, and about 10 weight % of copper content wherein.
7. use traditional no spinning process that fiber is processed non-woven fabrics.The cloth that makes is cut into 10 * 10cm, and be packaged in the paper bag.This dressing that obtains will be sterilized through the gamma irradiation of 25-40 kilogray.
Embodiment 4
In order to observe the anti-microbial property of dressing; In culture dish, be coated with a certain amount of escherichia coli equably; Respectively the dressing of embodiment 3 gained is cut into 2 * 2cm then and puts into wherein,, observe the bacterial growth situation on each flat board every day 37 ℃ of following continuous culture of constant temperature 7 days.Fig. 3 has shown the dressing inhibition zone after 1 day in the escherichia coli culture dish that contains 10 weight % nanometer copper, and Fig. 4 has shown the dressing inhibition zone after 7 days in the escherichia coli culture dish that contains 10 weight % nanometer copper.Can find out that the dressing that contains 10 weight % nanometer copper still had antibiotic resistance performance after 7 days.
Embodiment 5
The method for preparing the wound dressing of the antibiotic property modified cellulose fibre that contains 1% nanometer silver:
With 1 Gram Mass be 120 the gram/square metre fabric entirely be positioned on the plane;
2. the acetone of weighing 180 grams and 20 grams contain the nano-silver water solution of nanometer silver 20%, are hybridly prepared into solution.The demarcation particle diameter of nano silver particles is 100 nanometers, and actual particle size is distributed as the 50-150 nanometer;
3. the solution spraying that will be about 30 grams is on the one side of carboxymethyl cellulose cellulose fabric.Resulting fabric contains the nanometer silver of 0.5 weight %.
The upset fabric and with above-mentioned 3 in identical share spraying another side.Total content of nanometer silver of resulting fabric is about 1 weight %.
5. before being for further processing, should guarantee that solvent is fully by volatilization or fabric bone dry.
6. this fabric branch cuts into 10 * 10cm, and is packaged in the paper bag.This dressing that obtains will be sterilized by oxirane.
Embodiment 6
In order to observe the anti-microbial property of dressing; In culture dish, be coated with a certain amount of staphylococcus aureus equably; Respectively the dressing of embodiment 5 gained is cut into 2 * 2cm then and puts into wherein,, observe the bacterial growth situation on each flat board every day 37 ℃ of following continuous culture of constant temperature 7 days.Fig. 5 has shown the dressing inhibition zone after 1 day in the staphylococcus aureus culture dish that contains 1 weight % nanometer silver, and Fig. 6 has shown the dressing inhibition zone after 7 days in the staphylococcus aureus culture dish that contains 1 weight % nanometer silver.Can find out that the dressing that contains 1 weight % nanometer silver still had antibiotic resistance performance after 7 days.
Claims (17)
1. antibiotic fiber class dressing that contains nano metal, it is characterized in that: fiber-like dressing surface is coated with nano metal equably, and described fiber is a colloidal sol property fiber.
2. the antibiotic fiber class dressing that contains nano metal according to claim 1, it is characterized in that: described colloidal sol property fiber surface is coated with equably and adheres to nano metal.
3. the antibiotic fiber class dressing that contains nano metal according to claim 1, it is characterized in that: the content of said nano metal particles is 0.5-10 weight %, is preferably 0.6-9 weight %, most preferably 0.8-8 weight %.
4. according to claim 1 or the 2 or 3 described antibiotic fiber class dressing that contain nano metal, it is characterized in that: the particle diameter of said nano metal particles is 1nm-500nm, is preferably 1nm-400nm.
5. according to claim 1 or the 2 or 3 described antibiotic fiber class dressing that contain nano metal, it is characterized in that: said nano metal particles is nano silver particles or nanometer copper particle or nanometer zinc particles.
6. according to claim 1 or the 2 or 3 described antibiotic fiber class dressing that contain nano metal, said fiber is alginate fiber or chitin fiber or cellulose fibre.
7. the antibiotic fiber class dressing that contains nano metal according to claim 6 is characterized in that: said alginate fiber is high mannuronic acid type, high guluronic acid type or mannuronic acid/guluronic acid mixed fiber.
8. the antibiotic fiber class dressing that contains nano metal according to claim 6 is characterized in that: said alginate fiber is calcium alginate fibre or calcium alginate/sodium fiber.
9. the antibiotic fiber class dressing that contains nano metal according to claim 6 is characterized in that: said chitin fiber is carboxymethyl chitosan fiber or acylation chitosan fiber.
10. the antibiotic fiber class dressing that contains nano metal according to claim 6 is characterized in that: said cellulose fibre is carboxymethyl cellulose fiber or water-fast cellulose alkylsulfonate fiber, contain that the carboxymethyl cellulose solvent spins fiber or water-immiscible solvent spins cellulose alkylsulfonate fiber.
11. according to claim 1 or the 2 or 3 described antibiotic fiber class dressing that contain nano metal, it is characterized in that: said fiber-like dressing is woven fabric, knitted fabric or supatex fabric.
12. claim 1 or the 2 or 3 described method for preparinies that contain the antibiotic fiber class dressing of nano metal is characterized in that this method comprises the following steps:
Nano metal particles is scattered in aqueous solution or a kind of organic solvent in proportion;
Be sprayed in proportion then on the fibre bundle surface of continuous spinning;
Fibre bundle is curled, cuts off;
The gained fiber is made into supatex fabric through nonwovens process, cuts into bulk, packaging sterilizing again.
13. claim 1 or the 2 or 3 described method for preparinies that contain the antibiotic fiber class dressing of nano metal is characterized in that this method comprises the following steps:
Nano metal particles is scattered in aqueous solution or a kind of organic solvent in proportion;
Be sprayed in proportion then on the short fiber surface that has cut off;
The gained fiber is made into supatex fabric through nonwovens process, cuts into bulk, packaging sterilizing again.
14. claim 1 or the 2 or 3 described method for preparinies that contain the dressing of nano-metal antibacterial property fiber-like is characterized in that this method comprises the following steps:
Nano metal particles is scattered in aqueous solution or a kind of organic solvent in proportion;
Be sprayed on the fabric face of having processed then in proportion;
To spray back gained dressing, cut into bulk again, packaging sterilizing.
15. according to each described method for preparing that contains the dressing of nano-metal antibacterial property fiber-like in the claim 12 to 14, it is characterized in that: the particle diameter of said nano metal particles is 1nm-500nm, is preferably 1nm-400nm.
16. according to each described method for preparing that contains the dressing of nano-metal antibacterial property fiber-like in the claim 12 to 14, it is characterized in that: said nano metal particles is nano silver particles or nanometer copper particle or nanometer zinc particles.
17. according to each described method for preparing that contains the dressing of nano-metal antibacterial property fiber-like in the claim 12 to 14, it is characterized in that: said fiber is that alginate fiber, carboxymethyl chitosan fiber, acylation chitosan fiber, carboxymethyl cellulose fiber, water-fast cellulose alkylsulfonate fiber or blending have the above-mentioned fiber of non-colloidal sol property fiber as reinforcing fibre.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100361383A CN102631699A (en) | 2011-02-11 | 2011-02-11 | Antibacterial fiber dressing containing nanometer metal and preparation method thereof |
| PCT/CN2012/070378 WO2012106983A1 (en) | 2011-02-11 | 2012-01-16 | Antibacterial fibrous dressing containing nano-sized metal and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011100361383A CN102631699A (en) | 2011-02-11 | 2011-02-11 | Antibacterial fiber dressing containing nanometer metal and preparation method thereof |
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| CN102631699A true CN102631699A (en) | 2012-08-15 |
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| CN2011100361383A Pending CN102631699A (en) | 2011-02-11 | 2011-02-11 | Antibacterial fiber dressing containing nanometer metal and preparation method thereof |
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| WO (1) | WO2012106983A1 (en) |
Cited By (21)
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| CN106178079A (en) * | 2016-07-20 | 2016-12-07 | 国家纳米科学中心 | A kind of antibacterial chitosan dressing containing nanometer gold and preparation method thereof |
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| CN107260759A (en) * | 2017-05-17 | 2017-10-20 | 柯泽豪 | A kind of manufacture method of bactericidal composition and a kind of dressing |
| CN107375993A (en) * | 2017-08-15 | 2017-11-24 | 重庆科技学院 | A kind of preparation method of copper silver nanoclusters composite aquogel |
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| CN108578752A (en) * | 2018-04-26 | 2018-09-28 | 京东方科技集团股份有限公司 | A kind of manufacturing method of dressing and its basement membrane |
| CN110935056A (en) * | 2019-12-30 | 2020-03-31 | 山东星之诚生物科技有限公司 | Preparation method of alginate dressing with high hygroscopicity |
| CN113417168A (en) * | 2021-07-06 | 2021-09-21 | 东莞市鼎丰印刷有限公司 | Paper with function of silver ion automatic degerming paper and manufacturing method thereof |
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| CN101096424A (en) * | 2007-06-27 | 2008-01-02 | 东华大学 | Glutin nano fabric film containing nano silver and preparation and application thereof |
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Cited By (26)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102921035A (en) * | 2012-11-09 | 2013-02-13 | 无锡中科光远生物材料有限公司 | Antiseptic dressing for deep infected wounds |
| CN104069533A (en) * | 2013-03-27 | 2014-10-01 | 惠州华阳医疗器械有限公司 | Medical dressing and preparing method thereof |
| CN104069533B (en) * | 2013-03-27 | 2016-09-28 | 惠州华阳医疗器械有限公司 | A kind of medical dressing and preparation method thereof |
| CN103494672A (en) * | 2013-09-29 | 2014-01-08 | 戎静华 | Medical active carbon fiber dressing |
| CN104958135A (en) * | 2014-11-28 | 2015-10-07 | 林镇祥 | Alginate blending gauze |
| CN108064152A (en) * | 2015-04-24 | 2018-05-22 | 医学研究理事会 | Bactericidal composition comprising oxygroup-Kocide SD nano particle and its purposes as biocide |
| CN106267300A (en) * | 2015-05-14 | 2017-01-04 | 北京化工大学 | A kind of multifunctional material having bactericidal haemostatic and biochemical war agent protective concurrently and preparation method thereof |
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| CN105287106A (en) * | 2015-11-03 | 2016-02-03 | 中国人民解放军第四军医大学 | Bandage dressing special for limb war wound first aid |
| CN106049060A (en) * | 2016-06-28 | 2016-10-26 | 苏州大学 | Gold-bearing viscose and preparation method thereof |
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| CN106178079A (en) * | 2016-07-20 | 2016-12-07 | 国家纳米科学中心 | A kind of antibacterial chitosan dressing containing nanometer gold and preparation method thereof |
| CN106139224A (en) * | 2016-07-20 | 2016-11-23 | 国家纳米科学中心 | A kind of containing nanometer gold antiseptic dressing and preparation method thereof |
| CN105999364A (en) * | 2016-07-20 | 2016-10-12 | 国家纳米科学中心 | Antibacterial chitosan dressing containing nano-gold |
| CN106139227A (en) * | 2016-07-20 | 2016-11-23 | 国家纳米科学中心 | A kind of antibacterial absorbable cellulose dressing containing nanometer gold |
| CN106890353A (en) * | 2017-03-31 | 2017-06-27 | 应剑波 | A kind of medical accessory with antibacterial nutritve function |
| CN107260759A (en) * | 2017-05-17 | 2017-10-20 | 柯泽豪 | A kind of manufacture method of bactericidal composition and a kind of dressing |
| CN107375993B (en) * | 2017-08-15 | 2020-04-14 | 重庆科技学院 | Preparation method of copper-silver nano-cluster composite hydrogel |
| CN107375993A (en) * | 2017-08-15 | 2017-11-24 | 重庆科技学院 | A kind of preparation method of copper silver nanoclusters composite aquogel |
| CN108578752A (en) * | 2018-04-26 | 2018-09-28 | 京东方科技集团股份有限公司 | A kind of manufacturing method of dressing and its basement membrane |
| US11793906B2 (en) | 2018-04-26 | 2023-10-24 | Boe Technology Group Co., Ltd. | Base film for dressing and manufacturing method therefor, and dressing comprising the base film |
| CN108434506A (en) * | 2018-04-27 | 2018-08-24 | 夏思文 | A kind of expandable sponges, the Preparation method and use of load nano controlled-release drug micelles |
| CN108434506B (en) * | 2018-04-27 | 2021-06-25 | 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） | Expanded sponge loaded with nano sustained-release drug micelles, preparation method and application |
| CN110935056A (en) * | 2019-12-30 | 2020-03-31 | 山东星之诚生物科技有限公司 | Preparation method of alginate dressing with high hygroscopicity |
| CN113417168A (en) * | 2021-07-06 | 2021-09-21 | 东莞市鼎丰印刷有限公司 | Paper with function of silver ion automatic degerming paper and manufacturing method thereof |
| CN113456881A (en) * | 2021-07-07 | 2021-10-01 | 深圳市阿尔法材料科技有限公司 | Nano bone adhesive and preparation method thereof |
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