WO2012106983A1 - Antibacterial fibrous dressing containing nano-sized metal and preparation method thereof - Google Patents

Antibacterial fibrous dressing containing nano-sized metal and preparation method thereof Download PDF

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Publication number
WO2012106983A1
WO2012106983A1 PCT/CN2012/070378 CN2012070378W WO2012106983A1 WO 2012106983 A1 WO2012106983 A1 WO 2012106983A1 CN 2012070378 W CN2012070378 W CN 2012070378W WO 2012106983 A1 WO2012106983 A1 WO 2012106983A1
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Prior art keywords
fiber
fibers
nano
nano metal
antimicrobial
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PCT/CN2012/070378
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French (fr)
Chinese (zh)
Inventor
王晓东
莫小慧
史福军
Original Assignee
佛山市优特医疗科技有限公司
南方医科大学珠江医院
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Priority to CN2011100361383A priority Critical patent/CN102631699A/en
Priority to CN201110036138.3 priority
Application filed by 佛山市优特医疗科技有限公司, 南方医科大学珠江医院 filed Critical 佛山市优特医疗科技有限公司
Publication of WO2012106983A1 publication Critical patent/WO2012106983A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L15/00Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42Use of materials characterised by their function or physical properties
    • A61L15/46Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104Silver, e.g. silver sulfadiazine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents

Abstract

An antibacterial fibrous dressing containing nano-sized metal and a preparation method thereof. On the surfaces of the fibers of the dressing are distributed nano-sized metal particles in an amount of 0.5 to 10 wt%. The dressing can persistently release sufficient amounts of nano-sized metal particles to provide long term and effective antibacterial capability, suitable for use as a dressing for chronic wounds.

Description

Dressings comprising antimicrobial fiber and its preparation method of nano metal

FIELD

The present invention relates to an antimicrobial fibrous dressing and preparation method of nano metals. Background technique

Is well known, silver and copper, especially silver have long been confirmed to have effective antimicrobial properties, especially for killing bacteria in some common chronic wound care process is effective. Moreover, silver has been shown that the sterilization effect on bacteria resistant to certain antibiotics. Currently, the most common silver-containing antimicrobial dressing into ionic and nano metal mold, a silver ion technology is achieved by a silver compound to silver ions to provide a wound dressing is used, the technique employed by the nano metal nano metal particles such as nano-silver is applied to the wound dressing.

In the preparation of antimicrobial fibrous wound dressing, the prior art mainly in the following two methods. First, the antibacterial agent is dissolved (or dissolved) within the fiber polymer material, i.e., blending an antibacterial agent in the spinning solution and allowed to remain in the fibers.

U.S. Patent No. US6,897,349 and European Patent No. EP1216065 discloses a process for preparing silver-containing antibacterial material, which was prepared by the process of the fibers, silver chloride dispersed in the fibers.

Sodium hydrogen zirconium phosphate, silver (tradename Alphasan) Chinese patent CN1308509C discloses a method for preparing silver-containing fibers and chitosan having antibacterial effect of silver compound which will be less than 1 micron particle size, i.e., mixed spinning solution, and the silver-containing compound in an amount of 3.0-4.0 wt% silver.

Chinese patent CN1060235C discloses an antimicrobial acrylic fiber and a manufacturing method, which is obtained by mixing with the polypropylene masterbatch containing bacteriostatic spun into fibers, the fibers containing 500-1000 ppm (by weight) of antimicrobial agent.

European Patent No. EP1849464 and U.S. Patent No. US2007275043 describes added inside the fiber In one approach the silver compound (silver carbonate), i.e., the silver compound in blended fiber spinning solution.

Chinese patent application CN1673425A describes a method of 0.1-1% by weight of nano-silver antimicrobial viscose fiber, wherein the nano-silver is added to the spinning dope. However this method to use protective colloids, colloidal protective dose of up to 2 wt%. All of the protective colloidal agent is present only in the form of suspension inside the fibers, the fibers can not be part of another macromolecular crosslinked. This fact, in turn reducing the proportion of the polymer fiber spinning, thus limiting the maximum content of silver nanoparticles, the method can only do nano silver content of 1 wt%.

Second, the antimicrobial agent is applied to the surface of the fiber or fabric, i.e., a surface layer penetrates into the fiber or fabric, or adhered to the surface of the fiber or fabric.

Chinese patent application CN1895683A discloses a nano silver antimicrobial dressing and its preparation method, padding method of the invention is employed to make the coating liquid containing nano silver coated on the fabric, made of nano silver content of 0.05-2.9% by weight dressing.

Chinese patent discloses a composite nano CN100346840C antimicrobial medical dressing, the invention is a composite containing silver nanoparticles on a nonwoven fabric or carbon fiber adsorbent particle size of 1-15 nm.

Chinese patent application CN1066783A discloses a method for antimicrobial material containing the antimicrobial metal is prepared, which is to form the antimicrobial material containing the antimicrobial metal silver, copper, and alloys thereof by physical vapor deposition method.

U.S. Patent No. US7,462,753 discloses a nanosilver wound dressing, the dressing is a four-layer structure, a first layer composed of a hydrophilic fabric, a second layer composed of activated carbon impregnated with silver nano-fabric, the third layer is made of super nonwoven fabric made of water-absorbing polymer is formed, a fourth layer covering the third layer is composed of pore-like fabric.

A method for producing a nonwoven fabric for European Patent EP1095179 discloses a wound dressing, the method uses a composite lamination process of the alginate composite web coated on both sides with silver fiber mesh cloth.

U.S. Patent No. US7,385,101 discloses a wound dressing suitable for antimicrobial textile materials and wound dressings, antimicrobial dressing that is mixed textile fibers with alginate fibers surface coated with metallic silver, prepared by the method of the nonwoven .

U.S. Patent No. US20030180346 and European Patent Application EP1318842 discloses a silver-containing medical dressing, the dressing through the non-silver-containing fibers and fiber blends containing silver prepared, the resulting wound dressing contains 0.01 to 5.0 wt% silver ion.

It can be seen, the prior art silver ions or nano silver particles as an antimicrobial agent to the wound dressing is provided a method used in the spinning solution may be blended silver compound or silver nanoparticles and allowed to remain in the system into fibers, or silver ions or silver nanoparticles antimicrobial agent applied to the surface of the fibers or fabric to make it penetrate or adhere to the surface of the fiber or fabric. However, the nano metal particles or metal compound the spinning solution was added, so that the entire fiber has a uniform structure with a metal ion or an antimicrobial fibrous nano metal particles of the dressing method of manufacturing a long production cycle is not conducive to lower production costs. Furthermore, metal particles, even nano metal particles applied to a method for producing an antimicrobial fibrous dressing surface fibers or fabrics are employed padding method, a dipping method and a vapor deposition method, metal particles, nano metal particles adsorbed even only fibers fabric or skin, easy to fall off from the surface of the fibers or fabric, and can not be used for the sol fibers.

The present invention is to solve the above problems, the use of nano metal particles, preferably nano silver particles coating by spraying onto the fiber or fabric surface. Since the nano-metal has a higher surface potential, in order to reduce the surface energy, atomic particle surfaces with the fiber surface exposed groups (e.g., hydroxyl group, carboxyl group) is chemically and Fan Dehua forces approximate closely to each other by adsorption, while some of the fibers with the nanoparticle surface will forming an electrostatic adsorption, physical trench addition, the fiber surface like slits may be formed of nanoparticles embedded in the package, but also the particles adhered to the fiber surface. Such that the final action by the above metal coating Hou Nami relatively firmly "stick" in the fiber or fabric surface, and since only the nano metal particles adhered to the fibers or fabric surface, does not affect the internal structure of the fiber or fabric. For the frequency of replacement of the wound dressing which is typically 24 hours, seven days or longer for 21 days but not longer than 21 days, therefore, made use of the dressing does not affect the antibacterial effect spraying dressing.

This method is particularly suitable for those fibers prepared from a sol into a wound dressing. Such fibrous material generally no different under normal conditions, but when subjected to water or an aqueous solution containing fibers becomes colloidal. This material is very valuable as a wound dressing. First, such materials generally have a high hygroscopic property, generally can absorb water 1000% -2000%; Second, once the water-absorbing material such as rubber, have excellent moisture dressing, the wound can be maintained for a long time there is a humid microclimate. Usually used as a wound dressing sol alginate fibers with a fiber, carboxymethyl chitosan fiber, acylated chitosan, carboxymethyl cellulose fibers, water-insoluble cellulose fibers embankment sulfonate Wait.

The spraying is generally water as a medium, the nano metal particles dispersed in an aqueous solution. However, this method has a very high portion of the dressing is not enough soluble fiber, such as carboxymethyl chitosan fiber, acylated chitosan, carboxymethylcellulose or cellulose fibers embankment sulfonates. These fibers will later become colloidal water, even when used in a small amount of nano-spray drying an aqueous solution after re-dressing or fiber feel stiff, inflexible, hard to stick to the wound as it can no longer wound dressing. In particular, we studied the way the fiber spraying dressing, which uses an organic solvent as a medium, such as acetone, alcohol, etc., we can solve these problems. Appropriate method as long as a certain percentage of metal nano-dispersed in an organic solvent, in the fiber or the fabric surface and then spraying the solution. The organic solvent may be volatilized in the subsequent step, so that the nano metal coating on the fiber or fabric surface.

Of course spraying an aqueous sol of a material that is not high even sol can not be used.

Accordingly, an object of the present invention is to enable a higher level of effective nano metal particles uniformly distributed on the surface of the fiber or fabric, to thereby obtain antimicrobial fibrous wound dressing containing a high concentration of nano metal particles. SUMMARY

The present invention provides an antimicrobial fibrous wound dressing containing nano metal, and a method of preparing the wound dressing.

Since the particle size of nano metal particles used in the present invention is generally about 5-10 nm and a fiber diameter of less than one thousandth only, while the diameter of the silver compound particles used in the prior art (e.g. CN1308509C and EP1849464A1) to accounting for 5-10% of the fiber diameter, the fiber is difficult to coat the surface. And since the nano metal particles is extremely small, after spraying onto the fiber surface can be uniformly distributed on the surface of the fiber.

In the dressing of the present invention, the content of the nano metal particles is from 0.5 to 10 wt%, preferably 0.6-9 wt%, most preferably 0.8-8 wt%.

Particle size of nano metal particles of the present invention is used as lnm-500nm, preferably lnm-400nm.

Nano metal particles of the present invention is a nano silver particles or copper particles or nano zinc nano particles.

In the dressing of the present invention, the fibers used may be any suitable for the fiber and fabric of the dressing, preferably alginate fibers or cellulose fibers or the chitosan fibers

(Including solvent-spun cellulose fiber obtained), the alginate fibers are high mannuronic acid (M) type or high guluronic acid (G) type or a mannuronic acid / guluronic aldehyde acid

(M / G) hybrid. The alginate fibers are calcium alginate or calcium alginate fibers / sodium fibers. The chitosan fibers may be more than 80% degree of deacetylation of chitosan fiber or carboxymethyl chitosan fiber or acylated chitosan. The fibers may be cellulosic fibers carboxymethyl cellulose, it may also be water-insoluble cellulose fibers embankment sulfonates containing carboxymethyl solvent spun cellulose fibers, or may be a water-insoluble solvent spinning embankment sulfonate cellulose fibers.

Fibers of the present invention is used as the short fibers, the structure of the wound dressing may be cut into filaments or fibers of a certain length, the fiber length of 3-100mm.

Fibers of the present invention has a certain degree of curvature and the line density, line density of the fibers of 1-5 dtex, preferably 1.5-3 dtex.

The dressing of the invention relates to a process for bonding nonwoven process, or by needling a nonwoven or chemical process or a woven fabric made of the knitting process. If acupuncture nonwoven processes, the fiber length can be longer, as 30-100mm, if a chemical bonded nonwoven processes, the fiber length can be shorter, as 3-15mm, if the weaving or knitting process, fibers length may be 20-85mm.

The present invention provides a method for antimicrobial fiber comprising preparing nano metal, first, the metallic nano-scaled material dispersed in an aqueous solution or an organic solvent. Low frequency ultrasound may be utilized (25-50 Hz) dispersed so that the dispersion process more efficient. The process conditions and the nano metal-containing solution is sprayed onto the fibers or fabric surface.

Nano concentration of the solution to be determined according to the material and the process conditions, the final content of the nano metal fibers or fabric should be between 0.5 to 10% by weight.

If a continuous spinning process, will have to calculate the flow rate of the spray and the spinning speed according to the linear density of the fiber bundle. If it is loose fiber spraying, will have to calculate the total amount of fiber. If the fabric is, will have to calculate the total fabric weight and area.

The present invention provides a method for preparing an antimicrobial metal-containing nano-fibers, comprises the following steps:

The metal nano-scale dispersed in an aqueous solution or an organic solution to prepare a solution containing nano metal;

The resulting solution containing nano metal spraying process conditions according to the tow of continuous spinning;

The resulting crimped tow, cut into sections;

The fibers obtained by a nonwoven, woven or knitted into a fabric processing technology. The present invention also provides a method of preparing an antimicrobial metal-containing nano-fibers, comprises the following steps:

The metal nano-scale dispersed in an aqueous solution or an organic solution to prepare a solution containing nano metal;

The resulting solution containing the metal nano-fibers by weight is sprayed on the prepared surface of the short fiber;

The fibers obtained by a nonwoven, woven or knitted into a fabric processing technology.

The present invention provides a method for preparing an antimicrobial metal-containing nano-fabrics, including the following steps:

The metal nano-scale dispersed in an aqueous solution or an organic solution to prepare a solution containing nano metal;

The resulting solution containing nano metal coating weight of the fabric to the textile surface may be sprayed on one side only, or may be sprayed on both surfaces of the fabric;

A method of preparing fibers containing antibacterial nano metal wound dressing The present invention provides further comprising the steps of: The resulting fabric was cut and packaged, sterilized, to obtain the dressing.

The above-mentioned nano metal particles used in the method of the present invention is to provide silver nanoparticles or copper nanoparticles or nano zinc particles.

The above-described method of the present invention provides a nano-metal particles in a particle size of

Bandit bandit 1 -500, preferably 1 -400 bandit bandit.

Therefore, the above-described spraying method, since the highly charged nano metal particles, so nanosilver "stick" on the surface of the fiber and nonwoven processes generally tolerated. Further, since the wound dressing of the present invention is distributed on the surface of fiber web of nano metal particles, as a wound treatment dressing, the wound dressing fiber having the ability to quickly release a sufficient amount of the nano-metal particles are particularly suitable for the treatment of chronic wounds ', we can provide long-term and effective antibacterial function, can effectively prevent a variety of bacterial and microbial infection of the wound. BRIEF DESCRIPTION

1 is shown to contain 0.5% by weight of nano silver dressing in E. coli dish inhibitory at 1 day.

FIG 2 is a dressing containing 0.5% by weight of nano silver in E. coli dish zone of inhibition after 7 days.

3 is shown to contain 10% by weight of the dressing in E. coli nanocopper dish inhibitory at 1 day.

FIG 4 is shown to contain 10% by weight of the dressing in E. coli nanocopper dish zone of inhibition after 7 days.

5 is shown to contain 1% by weight of nano silver dressing in S. aureus Zone of Inhibition dish 1 day.

FIG 6 is a dressing containing 1 wt% of nanosilver S. aureus Zone of Inhibition dish after 7 days. detailed description

The following specific embodiments and the accompanying drawings, the technical solution of the present invention will be further described in detail. Example 1

Antibacterial chitosan fiber and process for preparing a wound dressing containing 0.5% nanosilver:

1. In the spinning process normally chitosan, calculated on the dry weight tow, e.g., 6 g / m.

2. Check the line speed in meters / min, e.g., 20 m / min. It can be drawn filament bundles per minute of the total dry weight, or 120 g / min.

3. The amount of water required ready solution which can be sprayed onto the surface of the tow spinning process. The silver concentration in the solution the higher the better. In the present example, the concentration of the solution containing the prepared nano silver is 20%, the nominal diameter of the silver particles is 5nm.

4. The nano silver powder (particle diameter of 5 nm, D95 = 3.7-6.9) first with ultrasound (25-50 Hz) was dispersed in an aqueous solution, an aqueous solution containing 20% ​​by weight of nano silver.

The adjustment of the nozzle so that the moving speed of the spray rate of about 3 g / min, and the solution was uniform tow after the tow sprayed surface.

6. The dried tow, crimped and cut into sections having a length of 50 mm staple fibers. Fibers spun off-white, and wherein the nano silver content of about 0.5 wt%.

7. The process of using a conventional nonwoven fibrous nonwoven fabric made of. The resulting cut into Bucher lOxlOcm, and packed into a paper bag. The resulting dressing will be sterilized by 25-40 kGy gamma irradiation. Example 2

In order to observe the antibacterial properties of the dressing, even in a dish coated amount of E. coli, and the embodiment were obtained in Example 1 was cut into dressings 2x2cm into which continuous culture at a constant temperature 37 ° C 7 days and observed daily for bacterial growth on each plate. Figure 1 shows a 0.5% by weight of nano silver dressing in E. coli dish inhibitory at 1 day, Figure 2 shows a 0.5 wt.% Nano silver dressing in E. coli dish zone of inhibition after 7 days. It can be seen containing 0.5% by weight of nano silver dressing still has good antibacterial properties after 7 days. Example 3

The method of preparing a calcium alginate fibers, and an antimicrobial wound dressing 10% nanocopper of:

1. In the conventional spinning calcium alginate, calculated dry weight of the tow, for example, 11.5 g

/Meter.

2. Check the line speed in meters / min, e.g., 22 m / min. Per minute can be drawn tow total dry weight, i.e., 253 g / min.

3. As can be calcium alginate gel-forming water, so use of acetone or other organic solvent as a medium. Ready to 500 g of acetone and 200 g of liquid Cu nano powder (size range of copper and silver particles is 10-40nm).

4. The nano copper powder first with a sonicator (25-50 Hz) was dispersed in an acetone solution, a solution containing 40 wt% copper nanometers.

The adjustment of the nozzle so that the spray rate about 63 g / min. When the tow passes and uniform solution is sprayed onto the surface of the tow.

6. The dried tow, crimped and cut into sections having a length of 50 mm staple fibers. Fibers spun off-white, and wherein the copper content of about 10 wt%.

7. The process of using a conventional nonwoven fibrous nonwoven fabric made of. The resulting cloths are cut into 10 X 10cm, and packed into a paper bag. The resulting dressing will be sterilized by 25-40 kGy gamma irradiation. Example 4

In order to observe the antibacterial properties of the dressing, even in a dish coated amount of E. coli, and were obtained in Example 3 was cut into 2 X 2cm dressing into which the continuous culture at a constant temperature 37 ° C 7 days bacterial growth was observed on each plate per day. Figure 3 shows a dressing containing 10% by weight in E. coli nanocopper dish inhibitory at 1 day, Figure 4 shows a dressing containing 10% by weight in E. coli nanocopper dish zone of inhibition after 7 days. As can be seen the dressing containing 10% by weight of copper nano still has good antibacterial properties after 7 days. Example 5

Antibacterial wound dressing method of preparing modified cellulosic fibers containing 1% of nanosilver:

1. 1 m2 grammage of 120 grams / square meter of fabric is placed on a flat plane;

2. Weigh 180 g of acetone, and Ag-containing aqueous solution of 20 g of 20% of nanosilver, prepared by mixing a solution. Nominal diameter of the nano silver particles of 100 nanometers, the actual size distribution of 50 to 150 nanometers;

3. Place approximately 30 grams was sprayed on one surface of the fabric of carboxymethyl cellulose. The resulting fabric contains 0.5% by weight of nano silver.

4. Turn the fabric in the same manner described above and 3 share the other surface coating. The total content of the obtained silver nanoparticles fabric of about 1% by weight.

5. Before proceeding process ensure that the solvent is completely volatilized or completely drying fabric.

6. The fabric was cut into sub-lO X lOcm, and packed into a paper bag. The resulting dressing is sterilized by ethylene embankment. Example 6

In order to observe the antibacterial properties of the dressing, even in a dish coated amount of S. aureus, respectively, and the embodiments obtained in Example 5 was cut into 2 X 2cm into the dressing wherein 7 continuous culture at a constant temperature 37 ° C days to observe the growth of the bacteria on each plate per day. 5 shows a dressing containing 1 wt% of nanosilver S. aureus Zone of Inhibition dish 1 day, Figure 6 shows containing 1 wt% of nano silver dressing aureus dish 7 days zone of inhibition. As can be seen the dressing containing 1 wt% of nanosilver still has good antibacterial properties after 7 days.

Claims

Claims
1. A dressing containing an antimicrobial fibrous nano metal, wherein: the fiber surface dressings uniformly sprayed with nano metal, a sol of the fibrous fiber.
2. The antimicrobial fiber as claimed in claim dressings containing nano metal according to claim 1, wherein: said sol fiber surface uniformly sprayed with nano metal adhesion.
3. The antimicrobial fiber as claimed in claim dressings containing nano metal according to claim 1, wherein: the content of the nano metal particles is 0.5 to 10 wt%, preferably 0.6-9 wt%, most preferably 0.8-8 weight%.
4. The antimicrobial fiber containing nano metal dressings 1 or claim 2 or claim 3, wherein: the particle size of the metal nano-particles is lnm-500nm, preferably lnm-400nm.
5. The antimicrobial fiber containing nano metal dressings 1 or claim 2 or claim 3, wherein: said nano metal particles of silver nanoparticles or copper nanoparticles or nano zinc particles.
6. The antimicrobial fiber containing nano metal dressings 1 or claim 2 or claim 3, the fibers are alginate fibers or chitosan fibers, or cellulose fibers.
7, according to claim 6 comprising antimicrobial fiber dressings nano metal, wherein: the alginate fibers are high mannuronic acid, high guluronic acid or mannuronic acid type / guluronic acid hybrid fibers.
8, according to claim 6 comprising antimicrobial fiber dressings nano metal, wherein: the alginate fibers are calcium alginate or calcium alginate fibers / sodium fibers.
9, according to claim 6 comprising antimicrobial fiber dressings nano metal, characterized in that: the chitosan fiber or carboxymethyl chitosan fiber acylated chitosan.
10, according to claim 6 comprising antimicrobial fiber dressings nano metal, wherein: the cellulosic fibers are carboxymethyl cellulose fibers, or water-insoluble cellulose fibers embankment sulfonates containing carboxymethyl cellulose fiber spinning solvent or water-insoluble solvent-spun cellulose fibers embankment sulfonate.
11. The antimicrobial fiber containing nano metal dressings 1 or claim 2 or claim 3, wherein: said applicator is a fiber woven fabric, knit or nonwoven fabric.
The method of preparing an antimicrobial fiber containing nano metal of dressing 12, of claims 1 or 2 or 3, characterized in that the method comprises the steps of:
The nano metal particles dispersed in an aqueous solution according to ratio or one organic solvent; and the ratio of surface coating of fiber tow in a continuous spinning;
The crimped fiber tow, cutting;
The resulting nonwoven fiber through nonwoven fabric production process into, and then cut into blocks, sterilized package.
The method of preparing an antimicrobial metal-containing nano fiber dressing 13, of claims 1 or 2 or 3, characterized in that the method comprises the steps of:
The nano metal particles dispersed in an aqueous solution according to ratio or one organic solvent; and then, to staple fibers sprayed on the surface has been cut;
The resulting nonwoven fiber through nonwoven fabric production process into, and then cut into blocks, sterilized package.
The method of preparing nano metal containing antimicrobial fibrous dressing 14, of claims 1 or 2 or 3, characterized in that the method comprises the steps of:
The nano metal particles dispersed in an aqueous solution according to ratio or one organic solvent; and then, to have been sprayed on the surface of the fabric made;
The resulting dressing after spraying, and then cut into blocks, sterilized package.
15. The process according to any one of nano metal-containing antimicrobial fibrous dressing in claim 12 to 14, wherein: said nano metal particles of a particle size of 1 -500 bandit bandit, preferably 1 bandit -400 bandit.
16. The process according to any one of nano metal-containing antimicrobial fibrous dressing in claim 12 to 14, wherein: said nano metal particles of silver nanoparticles or copper nanoparticles or nano zinc particles.
17. The method of preparing an antimicrobial metal nano fiber dressings containing 12-14 claimed in claim 1, wherein: said fibers are alginate fibers, carboxymethyl chitosan fiber, acylation chitosan fiber, carboxymethyl cellulose fiber, water-insoluble cellulose fibers embankment sulfonate, or non-sol blended fiber as the fiber reinforcement fibers.
PCT/CN2012/070378 2011-02-11 2012-01-16 Antibacterial fibrous dressing containing nano-sized metal and preparation method thereof WO2012106983A1 (en)

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CN2011100361383A CN102631699A (en) 2011-02-11 2011-02-11 Antibacterial fiber dressing containing nanometer metal and preparation method thereof
CN201110036138.3 2011-02-11

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CN106049060A (en) * 2016-06-28 2016-10-26 苏州大学 Gold-bearing viscose and preparation method thereof
CN105999364A (en) * 2016-07-20 2016-10-12 国家纳米科学中心 Antibacterial chitosan dressing containing nano-gold
CN106178079A (en) * 2016-07-20 2016-12-07 国家纳米科学中心 Antibacterial chitosan dressing containing nanogold and preparation method of dressing
CN106421867A (en) * 2016-07-20 2017-02-22 国家纳米科学中心 Antibacterial calcium alginate dressing containing nanogold
CN106139227A (en) * 2016-07-20 2016-11-23 国家纳米科学中心 Nanogold-containing antibacterial absorbable cellulose dressing
CN106139224A (en) * 2016-07-20 2016-11-23 国家纳米科学中心 Antiseptic dressing containing nanogold and preparing method thereof
CN106890353A (en) * 2017-03-31 2017-06-27 应剑波 Medical auxiliary material with antibacterial nourishing function

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1723778A (en) * 2004-07-20 2006-01-25 深圳市清华源兴生物医药科技有限公司 Silver-contg. type antibiotic agent, prepn. method and application thereof
CN1935268A (en) * 2006-10-18 2007-03-28 上海川本卫生材料有限公司 Nano silver calcium alginate antibacterial dressing
WO2009141633A2 (en) * 2008-05-23 2009-11-26 Convatec Technologies Inc. Polysaccharide nanofibres having antimicrobial properties
CN101721733A (en) * 2008-10-22 2010-06-09 威海威高创新有限公司 Medical chitosan antiseptic dressing and preparation method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101096424A (en) * 2007-06-27 2008-01-02 东华大学 Glutin nano fabric film containing nano silver and preparation and application thereof

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1723778A (en) * 2004-07-20 2006-01-25 深圳市清华源兴生物医药科技有限公司 Silver-contg. type antibiotic agent, prepn. method and application thereof
CN1935268A (en) * 2006-10-18 2007-03-28 上海川本卫生材料有限公司 Nano silver calcium alginate antibacterial dressing
WO2009141633A2 (en) * 2008-05-23 2009-11-26 Convatec Technologies Inc. Polysaccharide nanofibres having antimicrobial properties
CN101721733A (en) * 2008-10-22 2010-06-09 威海威高创新有限公司 Medical chitosan antiseptic dressing and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9440001B2 (en) 2013-03-06 2016-09-13 Specialty Fibres and Materials Limited Absorbent materials

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