CN104069533A - Medical dressing and preparing method thereof - Google Patents
Medical dressing and preparing method thereof Download PDFInfo
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- CN104069533A CN104069533A CN201310102152.8A CN201310102152A CN104069533A CN 104069533 A CN104069533 A CN 104069533A CN 201310102152 A CN201310102152 A CN 201310102152A CN 104069533 A CN104069533 A CN 104069533A
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Abstract
A medical dressing and a preparing method thereof are provided. The method includes steps of: preparing a liquid antibacterial agent comprising a silicon-silver mixture; spraying the liquid antibacterial agent on a substrate; and drying and dehydrating the substrate sprayed with the liquid antibacterial agent to form a silicon-silver composition in a manner that the silicon-silver composition is dispersed on the substrate, wherein the silicon-silver mixture comprises elemental silver particles, an organosilicone crosslinking agent and water. The medical dressing adopts the silicon-silver composition as the antibacterial agent. The antibacterial effects are good and the silver particles are stable in property and not liable to oxidize. Wound infection can be effectively prevented. The preparing method is simple in step and low in cost.
Description
Technical field
The present invention relates to medical dressing field, particularly relate to a kind of medical dressing and preparation method thereof.
Background technology
Skin is the organ of human body maximum; skin covers whole body; and contact with external environment; play the barrier action of protection body, it makes the interior various tissues of body and organ avoid the invasion and attack of physical property, mechanicalness, chemical and pathogenic microorganism, for example, prevent the loss of moisture, electrolyte and plasma protein; resist antibacterial intrusion; prevent that poisonous substance from entering, keep out mechanical injuries, prevent the injury of ultraviolet radiation to human body etc.In addition, skin also has the physiologic functions such as sensation, secretion, excretion and thermoregulation.Therefore, skin is that ulcer wound or various burn, scratch etc. all should be nursed as early as possible, makes skin recovery organization and function, and dressing plays an important role in this respect.
Desirable medical dressing should possess following characteristics: cover and protect wound 1.; 2. good absorbent, can absorb transudate; Not with Incision adhesion, do not cause secondary damage; 4. soft comfortable, can alleviate wound pain; 5. can kill the antibacterial on wound, prevent wound infection.
Antimicrobial component in the argentiferous medical dressing of prior art is mainly silver ion, as sodium zirconium phosphate silver, silver sulfadiazine, Disilver carbonate and silver sulfate etc.The preparation technology of these argentiferous medical dressing is: before spray webbing, silver iron compound is added in dressing solution, after spray webbing calcification, silver iron compound is dispersed in dressing.In use, the silver ion in these dressing is discharged in transudate, thereby plays antibacterial effect.
But the argentiferous medical dressing of prior art has following defect: easily blackening under illumination or moist environment, affects the anti-microbial property of dressing; Secondly, from spinning to acupuncture, in this section of course of processing, need the dressing to containing silver ion to be protected, prevent fiber blackening; In the silver ion dressing of prior art, the consumption of silver compound is about 1-5%, and dressing is because larger silver-colored consumption causes the increase of cost; In addition, the release that silver ion is too much, can be deposited on skin, causes using rear skin darkening.
Summary of the invention
The technical problem that the present invention mainly solves is to provide a kind of medical dressing and preparation method thereof, medical dressing of the present invention is using silicon silver composite as antibacterial, good and the silver-colored particle properties of antibacterial effect is stable be difficult for oxidized, can effectively prevent that wound is infected, and its preparation methods steps is simple, with low cost.
For solving the problems of the technologies described above, the technical scheme that the present invention adopts is: the preparation method that a kind of medical dressing is provided, the preparation method of this medical dressing comprises step: prepare liquid antibacterial agent, liquid antibacterial agent comprises silicon silver mixture, and silicon silver mixture comprises simple substance silver granule, organosilicon cross-linking agent and water; Liquid antibacterial agent is sprayed on base material; The base material that is coated with liquid antibacterial agent is carried out to drying and dewatering, and to form silicon silver composite, silicon silver composite is dispersed on base material.
According to a preferred embodiment of the invention, organosilicon cross-linking agent comprises 3-aminopropyl trimethyl silane and MTES.
According to a preferred embodiment of the invention, base material comprises alginate fiber, polyurethane foam, PVA foam, flaky polymer hydrogel or hydrocolloid.
According to a preferred embodiment of the invention, alginate fiber comprises calcium alginate fibre or sodium alginate fiber.
According to a preferred embodiment of the invention, simple substance silver granule is micron order or nano level simple substance silver granule.
According to a preferred embodiment of the invention, the silver content of medical dressing is micro-gram/cm of 0.1-20.
For solving the problems of the technologies described above, another technical solution used in the present invention is: a kind of medical dressing is provided, and this medical dressing comprises: base material; Antibacterial, antibacterial comprises silicon silver composite, and silicon silver composite is dispersed on base material, and silicon silver composite is the complex of simple substance silver granule and organosilicon cross-linking agent.
According to a preferred embodiment of the invention, organosilicon cross-linking agent comprises 3-aminopropyl trimethyl silane and MTES.
According to a preferred embodiment of the invention, base material comprises alginate fiber, polyurethane foam, PVA foam, flaky polymer hydrogel or hydrocolloid.
According to a preferred embodiment of the invention, the silver content of medical dressing is micro-gram/cm of 0.1-20.
Medical dressing of the present invention is using silicon silver composite as antibacterial, can effectively prevent that wound is infected, the silver-colored grain diameter that this dressing uses is little, promote the anti-microbial property of dressing, make less silver-colored granule consumption just can obtain preferably antibacterial effect, and because simple substance silver granule is wrapped in the stereochemical structure of organosilicon formation, medical dressing of the present invention is being produced, storage and use procedure are all difficult for making the simple substance silver oxidized blackening of granule and then causing losing efficacy because of environmental effect, medical dressing absorption speed of the present invention is fast simultaneously, the biocompatibility that tool is good, can keep the humidity that wound is suitable, form a kind of microenvironment that is conducive to wound healing, for organizing the newborn good environment of creating, in addition, the preparation method of medical dressing of the present invention has advantages of that step is simple and with low cost.
Detailed description of the invention
To the technical scheme in embodiment of the present invention be clearly and completely described below, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtaining under creative work prerequisite, all belong to the scope of protection of the invention.
The invention provides a kind of preparation method of medical dressing, the preparation method of this medical dressing comprises following step S1, S2 and S3.Wherein,
Step S1: prepare liquid antibacterial agent, liquid antibacterial agent comprises silicon silver mixture, and silicon silver mixture comprises simple substance silver granule, organosilicon cross-linking agent and water.
In step S1, the preparation method of liquid silicon silver mixture comprises mixes simple substance silver granule, organosilicon cross-linking agent and water stir.Liquid silicon silver mixture can use or mix other antimicrobial components as liquid antibacterial agent separately and jointly form liquid antibacterial agent.
In addition, because micron or nano level simple substance silver granule has strong inhibition and killing action to tens of kinds of pathogenic microorganism such as escherichia coli, gonococcus, chlamydia trachomatiss, and can not produce drug resistance, impaired epithelial cell is also had to promotion repair, simple substance silver granule in the present embodiment is preferably micron or nano level simple substance silver granule, and the medical dressing obtaining to make the inventive method preparation has more excellent antibacterial effect.
Step S2: liquid antibacterial agent is sprayed on base material.
In step S2, base material can comprise alginate fiber, polyurethane foam, PVA foam, flaky polymer hydrogel or hydrocolloid.The alginate fiber using can be calcium alginate fibre or sodium alginate fiber.Spraying coating process can adopt automation spray painting apparatus to carry out, and can make liquid antibacterial agent be evenly dispersed in the surface of base material by the technique of spraying.
Step S3: the base material that is coated with liquid antibacterial agent is carried out to drying and dewatering, and to form silicon silver composite, this silicon silver composite is dispersed on base material.
Below the alginate medical dressing of preparing argentiferous taking alginate fiber as base material is illustrated as example, in the present embodiment, the organosilicon cross-linking agent of use comprises as shown in the formula the 3-aminopropyl trimethyl silane of (I) and the MTES of formula (II).
In step S1, each constituent of silicon silver mixture can adopt following proportioning: simple substance silver, 1-8% mass percent MTES, the 3-aminopropyl trimethyl silane of 1-40% mass percent and the water of 50-97% mass percent of 0.001-2% mass percent.
After the 3-aminopropyl trimethyl silane of formula (I) mixes with water, there is hydrolysis, generate the silicon alcohol compound as shown in the formula (III):
After the MTES of formula (II) mixes with water, there is hydrolysis, generate the silicon alcohol compound as shown in the formula (IV):
In step 2S, be sprayed on alginate fiber containing simple substance silver granule, the 3-aminopropyl trimethyl silane of formula (I), the MTES of formula (II) and the liquid antibacterial agent of water.The quantity for spray of liquid antibacterial agent is 1-1000g/m
2, be preferably 10-100g/m
2.
In step S3, the alginate fiber that is coated with liquid antibacterial agent is carried out to drying and dewatering, baking temperature is 70-105 DEG C.The silicon silver composite forming is the complex of simple substance silver granule and organosilicon cross-linking agent, organosilicon cross-linking agent forms silica stereochemical structure and simple substance silver granule is wrapped in and in silica stereochemical structure, forms silicon silver composite, and silica stereochemical structure forms covalent bond with base material and is connected with realization.
The reaction principle that this step is concrete is: when oven dry, the silanol key partial dehydration of the silicon alcohol compound of formula (III) and formula (IV), is combined into siliconoxygen bond.MTES (being the silicon alcohol compound of formula (IV)) after hydrolysis is cross-linked to each other and forms the first silica stereochemical structure and simple substance silver granule is wrapped in and wherein forms MSQ oligomer (polysiloxanes oligomer) through dehydration.
Simultaneously, 3-aminopropyl trimethyl silane (being the silicon alcohol compound of formula (III)) after hydrolysis forms the second silica stereochemical structure through dehydration and the hydroxy combining on alginate fiber, thereby the first silica stereochemical structure is cross-linked on alginate fiber, this the first silica stereochemical structure and the second silica stereochemical structure have formed silica stereochemical structure jointly, and remaining part simple substance silver granule are wrapped in to the alginate medical dressing that has formed the argentiferous of the present embodiment in this silica stereochemical structure simultaneously.
The silver content of the alginate medical dressing of the argentiferous of preparing and obtain can reach 0.1-20 μ g/cm
2, and be preferably 0.1-5 μ g/cm
2the steps such as process is cut, pack, sterilizing can be for patient, this dressing is taking alginate fiber as base material, using the complex of simple substance silver granule and organosilicon cross-linking agent as antibacterial, be attached on Sorbsan by spraying and drying process, be applicable to the dressing of moderate to height transudate wound.And the method step of preparing this dressing is simple, with low cost, be therefore applicable to large-scale industrial production.
Embodiment 1:
Simple substance silver granule 1g, 3-TSL 8330 200g, MTES 20g and water 779g are mixed to form to silicon silver mixture as liquid antibacterial agent, by preparation and 20 times of liquid antibacterial agent dilute with waters, with the liquid antibacterial agent after dilution with 100g/m
2consumption is sprayed on the one side of sodium alginate fiber, 90 DEG C of oven dry, and then the liquid antibacterial agent after use dilution is with 100g/m
2consumption is sprayed on the another side of sodium alginate fiber, and 90 DEG C of oven dry, obtain medical dressing.
Embodiment 2:
Simple substance silver granule 0.5g, 3-TSL 8330 200g, MTES 10g and water 789.5g are mixed to form to silicon silver mixture as liquid antibacterial agent, by preparation and 25 times of liquid antibacterial agent dilute with waters, with the liquid antibacterial agent after dilution with 50g/m
2consumption is sprayed on the one side of sodium alginate fiber, 90 DEG C of oven dry, and then the liquid antibacterial agent after use dilution is with 50g/m
2consumption is sprayed on the another side of sodium alginate fiber, and 90 DEG C of oven dry, obtain medical dressing.
Embodiment 1 and 2 is obtained to medical dressing and carry out respectively the result test of silver content and antibiotic rate, concrete grammar is as follows:
Silver content test:
Embodiment 1 and 2 is obtained to medical dressing and use respectively perchloric acid, Fluohydric acid. and nitric acid dissolve processing, then measure the silver content in treatment fluid with atomic absorption spectrophotometer respectively.
Antibiotic rate test:
Embodiment 1 and 2 is obtained to medical dressing and cut into respectively disk, inoculate 1mL on disk, 1-2*10^6CFU/mL bacterium liquid (enterococcus faecalis ATCC29212 or Pseudomonas aeruginosa ATCC9027), cultivates after 24 hours or 72 hours, bed board counting.
Above-described embodiment 1 and the silver content of embodiment 2 and the experimental result of antibiotic rate test (log reduction is the order of magnitude reducing) as shown in the table:
Can find out from experimental result, the silver content of dressing is higher, and antibacterial effect is better.Wherein, the silver content of the medical dressing of embodiment 2 is 0.105 μ g/cm
2, it can have more than 90% antibiotic rate to enterococcus faecalis ATCC29212, and the silver content of the medical dressing in embodiment 1 is increased to 0.989 μ g/cm
2, it can arrive 99.99% antibacterial effect to the antibiotic rate of enterococcus faecalis ATCC29212.
The embodiment of the present invention also provides a kind of medical dressing, and it comprises base material and antibacterial, and this medical dressing can obtain by the preparation method preparation of medical dressing of the present invention.
Wherein, base material can comprise alginate fiber, polyurethane foam, PVA foam, flaky polymer hydrogel or hydrocolloid.Alginate fiber in the present embodiment is preferably calcium alginate fibre or sodium alginate fiber, is certainly not limited in other embodiments this.
Antibacterial comprises silicon silver composite, and this silicon silver composite is dispersed on base material.Silicon silver composite in the present embodiment is the complex of simple substance silver granule and organosilicon cross-linking agent.
The alginate medical dressing of preparing by the preparation method of medical dressing of the present invention the argentiferous obtaining taking alginate fiber as base material is illustrated as example, organosilicon cross-linking agent forms silica stereochemical structure and simple substance silver granule is wrapped in and in silica stereochemical structure, forms silicon silver composite, and silica stereochemical structure forms covalent bond with alginate fiber and is connected to realize, so that silicon silver composite can be firmly attached on alginate fiber.The organosilicon cross-linking agent using comprises 3-aminopropyl trimethyl silane and MTES.Silica stereochemical structure comprises the first silica stereochemical structure and the second silica stereochemical structure, wherein the MTES after hydrolysis is cross-linked to each other and forms the first silica stereochemical structure through dehydration, 3-aminopropyl trimethyl silane after hydrolysis is cross-linked to the first silica stereochemical structure on alginate fiber through dehydration, and forms the second silica stereochemical structure with alginate fiber.The silver content of the alginate medical dressing of this argentiferous can reach 0.1-20 μ g/cm
2, and be preferably 0.1-5 μ g/cm
2.
The alginate medical dressing of argentiferous is a kind of dressing of moderate to height transudate wound that is applicable to, when use, alginate fiber absorbing wound exudate, pick up can reach 1000%, also can provide moisture content to drier wounds, for wound provides wet union environment, the healing of accelerated in wounds, in absorbing transudate, silver-colored granule slowly releases from silica stereochemical structure, kill the antibacterial in transudate and on wound, thereby effectively prevent the infection of wound.
Medical dressing of the present invention is owing to having used the silver-colored granule that particle diameter is little to replace silver iron compound, promote the anti-microbial property of dressing, make less consumption just can obtain the equal antibacterial effect of silver ion medical dressing on market, reduced silver-colored consumption, saved production cost.
Medical dressing of the present invention is using silicon silver composite as antibacterial, can effectively prevent that wound is infected, the silver-colored grain diameter that this dressing uses is little, promote the anti-microbial property of dressing, make less silver-colored granule consumption just can obtain preferably antibacterial effect, and because simple substance silver granule is wrapped in the stereochemical structure of organosilicon formation, medical dressing of the present invention is being produced, storage and use procedure are all difficult for making the simple substance silver oxidized blackening of granule and then causing losing efficacy because of environmental effect, medical dressing absorption speed of the present invention is fast simultaneously, the biocompatibility that tool is good, can keep the humidity that wound is suitable, form a kind of microenvironment that is conducive to wound healing, for organizing the newborn good environment of creating, in addition, the preparation method of medical dressing of the present invention possesses step advantage simple and with low cost.
The foregoing is only embodiments of the present invention; not thereby limit the scope of the claims of the present invention; every equivalent structure or conversion of equivalent flow process that utilizes description of the present invention to do; or be directly or indirectly used in other relevant technical fields, be all in like manner included in scope of patent protection of the present invention.
Claims (10)
1. a preparation method for medical dressing, is characterized in that, the preparation method of described medical dressing comprises step:
Prepare liquid antibacterial agent, described liquid antibacterial agent comprises silicon silver mixture, and described silicon silver mixture comprises simple substance silver granule, organosilicon cross-linking agent and water;
Liquid antibacterial agent is sprayed on base material;
The base material that is coated with described liquid antibacterial agent is carried out to drying and dewatering, and to form silicon silver composite, described silicon silver composite is dispersed on described base material.
2. the preparation method of medical dressing according to claim 1, is characterized in that, described organosilicon cross-linking agent comprises 3-aminopropyl trimethyl silane and MTES.
3. the preparation method of medical dressing according to claim 1, described base material comprises alginate fiber, polyurethane foam, PVA foam, flaky polymer hydrogel or hydrocolloid.
4. the preparation method of medical dressing according to claim 3, described alginate fiber comprises calcium alginate fibre or sodium alginate fiber.
5. the preparation method of medical dressing according to claim 1, described simple substance silver granule is micron order or nano level simple substance silver granule.
6. the preparation method of medical dressing according to claim 1, is characterized in that, the silver content of described medical dressing is micro-gram/cm of 0.1-20.
7. a medical dressing, is characterized in that, described medical dressing comprises:
Base material;
Antibacterial, described antibacterial comprises silicon silver composite, and described silicon silver composite is dispersed on described base material, and described silicon silver composite is the complex of simple substance silver granule and organosilicon cross-linking agent.
8. medical dressing according to claim 7, is characterized in that, described organosilicon cross-linking agent comprises 3-aminopropyl trimethyl silane and MTES.
9. medical dressing according to claim 7, is characterized in that, described base material comprises alginate fiber, polyurethane foam, PVA foam, flaky polymer hydrogel or hydrocolloid.
10. medical dressing according to claim 7, is characterized in that, the silver content of described medical dressing is micro-gram/cm of 0.1-20.
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| CN104645404A (en) * | 2015-02-12 | 2015-05-27 | 江西亚丰医材有限公司 | Treatment method of medical cotton fabric |
| CN107602806A (en) * | 2017-09-29 | 2018-01-19 | 鹤山市杰之星五金实业有限公司 | A kind of polyurethane foam based on sodium zirconium phosphate silver and preparation method thereof |
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| CN104069533B (en) | 2016-09-28 |
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