JP2018514204A5 - - Google Patents
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- JP2018514204A5 JP2018514204A5 JP2017554350A JP2017554350A JP2018514204A5 JP 2018514204 A5 JP2018514204 A5 JP 2018514204A5 JP 2017554350 A JP2017554350 A JP 2017554350A JP 2017554350 A JP2017554350 A JP 2017554350A JP 2018514204 A5 JP2018514204 A5 JP 2018514204A5
- Authority
- JP
- Japan
- Prior art keywords
- domain
- cell
- car
- signaling domain
- intracellular signaling
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1507368.7 | 2015-04-30 | ||
| GBGB1507368.7A GB201507368D0 (en) | 2015-04-30 | 2015-04-30 | Cell |
| PCT/GB2016/051235 WO2016174461A1 (en) | 2015-04-30 | 2016-04-29 | T cell which expresses a gamma-delta t cell receptor (tcr) and a chimeric antigen receptor (car) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018514204A JP2018514204A (ja) | 2018-06-07 |
| JP2018514204A5 true JP2018514204A5 (OSRAM) | 2019-06-06 |
| JP6986449B2 JP6986449B2 (ja) | 2021-12-22 |
Family
ID=53488907
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554350A Expired - Fee Related JP6986449B2 (ja) | 2015-04-30 | 2016-04-29 | ガンマデルタt細胞受容体(tcr)とキメラ抗原受容体(car)とを発現するt細胞 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US20180125890A1 (OSRAM) |
| EP (1) | EP3288567B1 (OSRAM) |
| JP (1) | JP6986449B2 (OSRAM) |
| KR (1) | KR20180020140A (OSRAM) |
| CN (1) | CN107771215A (OSRAM) |
| AU (1) | AU2016255611B2 (OSRAM) |
| BR (1) | BR112017023409A2 (OSRAM) |
| CA (1) | CA2982532C (OSRAM) |
| EA (1) | EA201792042A1 (OSRAM) |
| ES (1) | ES3018558T3 (OSRAM) |
| GB (1) | GB201507368D0 (OSRAM) |
| HK (1) | HK1252235A1 (OSRAM) |
| IL (1) | IL255186B (OSRAM) |
| SG (1) | SG11201708402UA (OSRAM) |
| WO (1) | WO2016174461A1 (OSRAM) |
| ZA (1) | ZA201706923B (OSRAM) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9511092B2 (en) | 2013-01-28 | 2016-12-06 | St. Jude Children's Research Hospital, Inc. | Chimeric receptor with NKG2D specificity for use in cell therapy against cancer and infectious disease |
| AU2015259877B2 (en) | 2014-05-15 | 2021-02-25 | National University Of Singapore | Modified natural killer cells and uses thereof |
| GB201506423D0 (en) * | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| GB201507368D0 (en) | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| CN110997719B (zh) | 2017-03-24 | 2020-12-11 | 莱蒂恩技术公司 | 用于用抗cd33免疫疗法治疗癌症的组合物和方法 |
| WO2018182511A1 (en) | 2017-03-27 | 2018-10-04 | National University Of Singapore | Stimulatory cell lines for ex vivo expansion and activation of natural killer cells |
| BR112019019917A2 (pt) | 2017-03-27 | 2020-04-22 | Nat Univ Singapore | receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais |
| EP3662055A1 (en) * | 2017-08-02 | 2020-06-10 | Autolus Limited | Cells expressing a chimeric antigen receptor or engineered tcr and comprising a nucleotide sequence which is selectively expressed |
| JP2020537640A (ja) * | 2017-09-27 | 2020-12-24 | オハイオ・ステイト・イノベーション・ファウンデーション | 組織因子標的化car−nk及びcar−t細胞療法 |
| GB201715918D0 (en) * | 2017-09-29 | 2017-11-15 | Tc Biopharm Ltd | Modified CAR-T |
| GB201720949D0 (en) | 2017-12-15 | 2018-01-31 | Autolus Ltd | Cell |
| AU2019219454A1 (en) | 2018-02-09 | 2020-08-27 | National University Of Singapore | Activating chimeric receptors and uses thereof in natural killer cell immunotherapy |
| GB201804701D0 (en) * | 2018-03-23 | 2018-05-09 | Gammadelta Therapeutics Ltd | Lymphocytes expressing heterologous targeting constructs |
| SG11202008976YA (en) | 2018-04-02 | 2020-10-29 | Nat Univ Singapore | Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells |
| US20210309713A1 (en) * | 2018-04-04 | 2021-10-07 | Daren Biotech Limited | Chimeric Antigen Receptor and Method for Treating Cancers |
| KR20210003810A (ko) * | 2018-04-18 | 2021-01-12 | 유씨엘 비즈니스 리미티드 | Treg 세포의 억제 특성을 향상시키기 위한 방법 |
| CN108588023B (zh) * | 2018-05-09 | 2020-02-14 | 河北森朗生物科技有限公司 | 一种生产嵌合抗原受体修饰的γδT细胞的方法 |
| CN110577932A (zh) * | 2018-06-07 | 2019-12-17 | 亘喜生物科技(上海)有限公司 | 一种脐带血来源的嵌合抗原受体t细胞 |
| AU2019291627A1 (en) * | 2018-06-19 | 2020-10-08 | Nanjing Legend Biotech Co., Ltd. | Engineered cells and uses thereof |
| JPWO2020027094A1 (ja) | 2018-07-31 | 2021-09-16 | サイアス株式会社 | iPS細胞を介して再生T細胞集団を製造する方法 |
| WO2020033464A1 (en) * | 2018-08-07 | 2020-02-13 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Car t-cells for the treatment of bone metastatic cancer |
| AU2019318021B2 (en) * | 2018-08-10 | 2025-01-30 | Kyoto University | Method for producing CD3-positive cell |
| JP7560882B2 (ja) | 2018-08-29 | 2024-10-03 | ナショナル ユニヴァーシティー オブ シンガポール | 遺伝子修飾免疫細胞の生存及び増加を特異的に刺激するための方法 |
| US20220111043A1 (en) * | 2018-09-19 | 2022-04-14 | Lava Therapeutics B.V. | Dual acting cd1d immunoglobulin |
| CN109234236A (zh) * | 2018-09-29 | 2019-01-18 | 吉林大学第医院 | 一种嵌合抗原受体γδT细胞的制备方法 |
| AU2019354395A1 (en) * | 2018-10-01 | 2021-05-06 | Adicet Therapeutics, Inc. | Compositions and methods regarding engineered and non-engineered γδ -T cells for treatment of solid tumors |
| SG11202103235PA (en) * | 2018-10-01 | 2021-04-29 | Adicet Bio Inc | COMPOSITIONS AND METHODS REGARDING ENGINEERED AND NON- ENGINEERED γδ-Τ CELLS FOR TREATMENT OF HEMATOLOGICAL TUMORS |
| JP2022523502A (ja) | 2019-01-29 | 2022-04-25 | シャンハイ ジャオ トン ユニバーシティ | キメラ抗原受容体およびその使用 |
| WO2020172555A1 (en) * | 2019-02-21 | 2020-08-27 | Regents Of The University Of Minnesota | Genetically modified gamma delta t cells and methods of making and using |
| CN118546959A (zh) | 2019-03-05 | 2024-08-27 | 恩卡尔塔公司 | Cd19定向性嵌合抗原受体及其在免疫疗法中的用途 |
| EP3953392A1 (en) * | 2019-04-12 | 2022-02-16 | Phanes Therapeutics, Inc. | Humanized anti-folate receptor 1 chimeric antigen receptors and uses thereof |
| US20230144237A1 (en) * | 2019-04-22 | 2023-05-11 | Nanjing Legend Biotech Co., Ltd. | Engineered cells and uses thereof |
| WO2020251046A1 (ja) | 2019-06-14 | 2020-12-17 | サイアス株式会社 | 医薬組成物 |
| EP3986442A4 (en) * | 2019-06-21 | 2023-10-25 | Shattuck Labs, Inc. | Chimeric protein expressing t-cells |
| GB201909283D0 (en) * | 2019-06-27 | 2019-08-14 | Cancer Research Tech Ltd | Fusion proteins with enzyme activity |
| CN110981972B (zh) * | 2019-12-25 | 2022-09-30 | 华夏源(上海)细胞基因工程股份有限公司 | 一种分泌双特异性抗体的嵌合抗原受体及其表达载体和应用 |
| BR112022017419A2 (pt) * | 2020-03-03 | 2022-10-18 | Janssen Biotech Inc | Células t gama-delta e usos das mesmas |
| EP4151660A4 (en) | 2020-05-22 | 2024-01-17 | Chongqing Precision Biotech Company Limited | Fusion protein for reversing tumor microenvironment and use thereof |
| KR20230088333A (ko) | 2020-07-17 | 2023-06-19 | 인스틸 바이오 유케이 리미티드 | 입양 세포 요법을 위한 표적화된 공동자극을 제공하는 수용체 |
| US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
| EP4355340A4 (en) | 2021-06-16 | 2025-05-21 | Instil Bio, Inc. | RECEPTORS FOR TARGETED COSTIMULATION FOR ADOPTIVE CELL THERAPY |
| EP4370213A4 (en) | 2021-07-16 | 2025-06-04 | Instil Bio (Uk) Limited | Chimeric molecules for targeted costimulation for adoptive cell therapy |
| CN113528455A (zh) * | 2021-07-19 | 2021-10-22 | 广州百暨基因科技有限公司 | 表达嵌合抗原受体的γδT细胞 |
| WO2023060126A1 (en) * | 2021-10-06 | 2023-04-13 | Dana-Farber Cancer Institute, Inc. | Engineered cytokine receptors for tunable adoptive cell therapy |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2360046A1 (en) | 1999-01-28 | 2000-08-03 | Lawrence S. Lamb, Jr. | In vitro activated gamma delta lymphocytes |
| DE60140526D1 (de) | 2000-04-03 | 2009-12-31 | Therapure Biopharma Inc | Herstellung von tcr gamma delta t-zellen |
| KR100732206B1 (ko) | 2000-09-11 | 2007-06-27 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | 티로신 키나제 억제제로서의 퀴놀리논 유도체 |
| WO2006006720A1 (ja) | 2004-07-13 | 2006-01-19 | Medinet., Co.Ltd | γδT細胞の培養方法、γδT細胞及び治療・予防剤 |
| DE602005022728D1 (de) | 2004-08-19 | 2010-09-16 | Univ Cardiff | Präparation antigenpräsentierender menschlicher gamma delta t-zellen und verwendung in der immuntherapie |
| JPWO2008152822A1 (ja) | 2007-06-15 | 2010-08-26 | 株式会社メディネット | 医薬 |
| PH12013501201A1 (en) | 2010-12-09 | 2013-07-29 | Univ Pennsylvania | Use of chimeric antigen receptor-modified t cells to treat cancer |
| US9833476B2 (en) * | 2011-08-31 | 2017-12-05 | The Trustees Of Dartmouth College | NKP30 receptor targeted therapeutics |
| EP3594245A1 (en) * | 2012-02-13 | 2020-01-15 | Seattle Children's Hospital d/b/a Seattle Children's Research Institute | Bispecific chimeric antigen receptors and therapeutic uses thereof |
| WO2013174404A1 (en) * | 2012-05-23 | 2013-11-28 | Ganymed Pharmaceuticals Ag | Combination therapy involving antibodies against claudin 18.2 for treatment of cancer |
| US10117896B2 (en) * | 2012-10-05 | 2018-11-06 | The Trustees Of The University Of Pennsylvania | Use of a trans-signaling approach in chimeric antigen receptors |
| NZ711807A (en) | 2013-02-06 | 2020-06-26 | Celgene Corp | Modified t lymphocytes having improved specificity |
| CN111139256A (zh) * | 2013-02-20 | 2020-05-12 | 诺华股份有限公司 | 使用人源化抗EGFRvIII嵌合抗原受体治疗癌症 |
| UY35468A (es) * | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| ES2828982T3 (es) * | 2013-05-14 | 2021-05-28 | Univ Texas | Aplicación humana de células t de receptor de antígeno quimérico (car) diseñadas |
| US10196444B2 (en) * | 2013-07-29 | 2019-02-05 | Bluebird Bio, Inc. | Multipartite signaling proteins and uses thereof |
| CA2926859A1 (en) | 2013-10-25 | 2015-04-30 | Board Of Regents, The University Of Texas System | Polyclonal gamma delta t cells for immunotherapy |
| WO2015066262A1 (en) * | 2013-11-04 | 2015-05-07 | Trustees Of Dartmouth College | Methods for preventing toxicity of adoptive cell therapy |
| DK3071222T3 (da) * | 2013-11-21 | 2020-11-16 | Ucl Business Ltd | Celle |
| CA3190002A1 (en) | 2014-02-14 | 2015-08-20 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors and methods of making |
| GB201403972D0 (en) * | 2014-03-06 | 2014-04-23 | Ucl Business Plc | Chimeric antigen receptor |
| WO2015142675A2 (en) | 2014-03-15 | 2015-09-24 | Novartis Ag | Treatment of cancer using chimeric antigen receptor |
| US20170158749A1 (en) * | 2014-04-23 | 2017-06-08 | Board Of Regents, The University Of Texas System | Chimeric antigen receptors (car) and methods for making and using the same |
| KR20170045205A (ko) | 2014-07-09 | 2017-04-26 | 티씨 바이오팜 리미티드 | 감마 델타 t 세포 및 이의 용도 |
| GB201506423D0 (en) | 2015-04-15 | 2015-05-27 | Tc Biopharm Ltd | Gamma delta T cells and uses thereof |
| DK3220926T3 (da) | 2014-11-17 | 2025-03-24 | Adicet Therapeutics Inc | Konstruerede gamma-delta-t-celler |
| GB201507368D0 (en) | 2015-04-30 | 2015-06-17 | Ucl Business Plc | Cell |
| CN105158466B (zh) | 2015-05-05 | 2017-12-22 | 中国科学院广州生物医药与健康研究院 | 一种检测抗cd19的嵌合抗原受体t细胞对白血病细胞抑制作用的方法 |
-
2015
- 2015-04-30 GB GBGB1507368.7A patent/GB201507368D0/en not_active Ceased
-
2016
- 2016-04-29 WO PCT/GB2016/051235 patent/WO2016174461A1/en not_active Ceased
- 2016-04-29 BR BR112017023409A patent/BR112017023409A2/pt not_active Application Discontinuation
- 2016-04-29 KR KR1020177034648A patent/KR20180020140A/ko not_active Ceased
- 2016-04-29 HK HK18111473.3A patent/HK1252235A1/zh unknown
- 2016-04-29 EP EP16720532.7A patent/EP3288567B1/en active Active
- 2016-04-29 ES ES16720532T patent/ES3018558T3/es active Active
- 2016-04-29 AU AU2016255611A patent/AU2016255611B2/en active Active
- 2016-04-29 EA EA201792042A patent/EA201792042A1/ru unknown
- 2016-04-29 US US15/567,165 patent/US20180125890A1/en not_active Abandoned
- 2016-04-29 CN CN201680024237.0A patent/CN107771215A/zh active Pending
- 2016-04-29 JP JP2017554350A patent/JP6986449B2/ja not_active Expired - Fee Related
- 2016-04-29 CA CA2982532A patent/CA2982532C/en active Active
- 2016-04-29 SG SG11201708402UA patent/SG11201708402UA/en unknown
-
2017
- 2017-10-12 ZA ZA2017/06923A patent/ZA201706923B/en unknown
- 2017-10-22 IL IL255186A patent/IL255186B/en unknown
-
2021
- 2021-11-17 US US17/528,836 patent/US12331316B2/en active Active
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