JP2018513194A5 - - Google Patents
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- Publication number
- JP2018513194A5 JP2018513194A5 JP2017555587A JP2017555587A JP2018513194A5 JP 2018513194 A5 JP2018513194 A5 JP 2018513194A5 JP 2017555587 A JP2017555587 A JP 2017555587A JP 2017555587 A JP2017555587 A JP 2017555587A JP 2018513194 A5 JP2018513194 A5 JP 2018513194A5
- Authority
- JP
- Japan
- Prior art keywords
- vibrio
- group
- infections
- compound according
- neisseria
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 13
- 241000894006 Bacteria Species 0.000 claims 7
- 208000035143 Bacterial infection Diseases 0.000 claims 6
- 241000588653 Neisseria Species 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 241001138501 Salmonella enterica Species 0.000 claims 5
- 241000607598 Vibrio Species 0.000 claims 5
- 241000607516 Aeromonas caviae Species 0.000 claims 4
- 241000607574 Aeromonas veronii Species 0.000 claims 4
- 206010006448 Bronchiolitis Diseases 0.000 claims 4
- 206010012735 Diarrhoea Diseases 0.000 claims 4
- 208000005577 Gastroenteritis Diseases 0.000 claims 4
- 201000009906 Meningitis Diseases 0.000 claims 4
- 206010035664 Pneumonia Diseases 0.000 claims 4
- 241000589892 Treponema denticola Species 0.000 claims 4
- 241000607479 Yersinia pestis Species 0.000 claims 4
- 208000021240 acute bronchiolitis Diseases 0.000 claims 4
- 230000003115 biocidal effect Effects 0.000 claims 4
- 201000001371 inclusion conjunctivitis Diseases 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 206010034674 peritonitis Diseases 0.000 claims 4
- 206010044325 trachoma Diseases 0.000 claims 4
- 241000589242 Legionella pneumophila Species 0.000 claims 3
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 claims 3
- 241000607253 Vibrio mimicus Species 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 229940115932 legionella pneumophila Drugs 0.000 claims 3
- 125000000962 organic group Chemical group 0.000 claims 3
- 241000607534 Aeromonas Species 0.000 claims 2
- 241000606749 Aggregatibacter actinomycetemcomitans Species 0.000 claims 2
- 208000010266 Aggressive Periodontitis Diseases 0.000 claims 2
- 241000606124 Bacteroides fragilis Species 0.000 claims 2
- 208000014912 Central Nervous System Infections Diseases 0.000 claims 2
- 241001647372 Chlamydia pneumoniae Species 0.000 claims 2
- 241000606153 Chlamydia trachomatis Species 0.000 claims 2
- 206010008631 Cholera Diseases 0.000 claims 2
- 208000001860 Eye Infections Diseases 0.000 claims 2
- 208000001951 Fetal Death Diseases 0.000 claims 2
- 206010055690 Foetal death Diseases 0.000 claims 2
- 206010017917 Gastroenteritis vibrio Diseases 0.000 claims 2
- 206010017964 Gastrointestinal infection Diseases 0.000 claims 2
- 206010018296 Gingivitis ulcerative Diseases 0.000 claims 2
- 206010018612 Gonorrhoea Diseases 0.000 claims 2
- 241000606768 Haemophilus influenzae Species 0.000 claims 2
- 241000588747 Klebsiella pneumoniae Species 0.000 claims 2
- 208000032376 Lung infection Diseases 0.000 claims 2
- 241000588655 Moraxella catarrhalis Species 0.000 claims 2
- 241000588645 Neisseria sicca Species 0.000 claims 2
- 208000005141 Otitis Diseases 0.000 claims 2
- 206010033078 Otitis media Diseases 0.000 claims 2
- 206010033971 Paratyphoid fever Diseases 0.000 claims 2
- 241000606856 Pasteurella multocida Species 0.000 claims 2
- 241001672678 Photobacterium damselae subsp. damselae Species 0.000 claims 2
- 206010035148 Plague Diseases 0.000 claims 2
- 241000192142 Proteobacteria Species 0.000 claims 2
- 241000589516 Pseudomonas Species 0.000 claims 2
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 2
- 241000589630 Pseudomonas pseudoalcaligenes Species 0.000 claims 2
- 206010037660 Pyrexia Diseases 0.000 claims 2
- 206010057190 Respiratory tract infections Diseases 0.000 claims 2
- 241000499381 Salinivibrio costicola Species 0.000 claims 2
- 241000531795 Salmonella enterica subsp. enterica serovar Paratyphi A Species 0.000 claims 2
- 206010040047 Sepsis Diseases 0.000 claims 2
- 241001135258 Serratia proteamaculans Species 0.000 claims 2
- 241000312057 Simkania negevensis Z Species 0.000 claims 2
- 241001135235 Tannerella forsythia Species 0.000 claims 2
- 208000037386 Typhoid Diseases 0.000 claims 2
- 208000025865 Ulcer Diseases 0.000 claims 2
- 206010046914 Vaginal infection Diseases 0.000 claims 2
- 201000008100 Vaginitis Diseases 0.000 claims 2
- 241000607626 Vibrio cholerae Species 0.000 claims 2
- 241000607296 Vibrio cincinnatiensis Species 0.000 claims 2
- 241000607291 Vibrio fluvialis Species 0.000 claims 2
- 241001148070 Vibrio furnissii Species 0.000 claims 2
- 241000607618 Vibrio harveyi Species 0.000 claims 2
- 241000607272 Vibrio parahaemolyticus Species 0.000 claims 2
- 241000607265 Vibrio vulnificus Species 0.000 claims 2
- 206010048038 Wound infection Diseases 0.000 claims 2
- 241000607477 Yersinia pseudotuberculosis Species 0.000 claims 2
- 241000606834 [Haemophilus] ducreyi Species 0.000 claims 2
- 208000012873 acute gastroenteritis Diseases 0.000 claims 2
- 208000033608 aggressive 1 periodontitis Diseases 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 206010006451 bronchitis Diseases 0.000 claims 2
- 229940038705 chlamydia trachomatis Drugs 0.000 claims 2
- 208000034391 chronic adult periodontitis Diseases 0.000 claims 2
- 208000001277 chronic periodontitis Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000019258 ear infection Diseases 0.000 claims 2
- 206010014665 endocarditis Diseases 0.000 claims 2
- 208000011323 eye infectious disease Diseases 0.000 claims 2
- 210000000744 eyelid Anatomy 0.000 claims 2
- 231100000479 fetal death Toxicity 0.000 claims 2
- 208000001786 gonorrhea Diseases 0.000 claims 2
- 229940047650 haemophilus influenzae Drugs 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 230000000366 juvenile effect Effects 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 231100000252 nontoxic Toxicity 0.000 claims 2
- 230000003000 nontoxic effect Effects 0.000 claims 2
- 229940051027 pasteurella multocida Drugs 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 201000001245 periodontitis Diseases 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 206010040872 skin infection Diseases 0.000 claims 2
- 125000000547 substituted alkyl group Chemical group 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 201000008297 typhoid fever Diseases 0.000 claims 2
- 231100000397 ulcer Toxicity 0.000 claims 2
- 229940118696 vibrio cholerae Drugs 0.000 claims 2
- UNDUSVBXIVZGOQ-UHFFFAOYSA-N 1h-perimidin-2-amine Chemical group C1=CC(NC(N)=N2)=C3C2=CC=CC3=C1 UNDUSVBXIVZGOQ-UHFFFAOYSA-N 0.000 claims 1
- 241000606125 Bacteroides Species 0.000 claims 1
- 208000032841 Bulimia Diseases 0.000 claims 1
- 206010006550 Bulimia nervosa Diseases 0.000 claims 1
- 241000606161 Chlamydia Species 0.000 claims 1
- 241000555712 Forsythia Species 0.000 claims 1
- 201000008225 Klebsiella pneumonia Diseases 0.000 claims 1
- 241000589248 Legionella Species 0.000 claims 1
- 208000007764 Legionnaires' Disease Diseases 0.000 claims 1
- 241000606860 Pasteurella Species 0.000 claims 1
- 206010035717 Pneumonia klebsiella Diseases 0.000 claims 1
- 241001236193 Waddlia chondrophila Species 0.000 claims 1
- XSDQTOBWRPYKKA-UHFFFAOYSA-N amiloride Chemical group NC(=N)NC(=O)C1=NC(Cl)=C(N)N=C1N XSDQTOBWRPYKKA-UHFFFAOYSA-N 0.000 claims 1
- 229960002576 amiloride Drugs 0.000 claims 1
- 244000052616 bacterial pathogen Species 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 208000025222 central nervous system infectious disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-N guanidine group Chemical group NC(=N)N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000004437 phosphorous atom Chemical group 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 claims 1
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical group C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 claims 1
- 0 *C(/*(/*)=C(\*)/C(/*)=C(\*)/N)S(*)C(*)N(*)C1=C(*)C(*)(*)OC1=O Chemical compound *C(/*(/*)=C(\*)/C(/*)=C(\*)/N)S(*)C(*)N(*)C1=C(*)C(*)(*)OC1=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562151902P | 2015-04-23 | 2015-04-23 | |
| US62/151,902 | 2015-04-23 | ||
| PCT/CA2016/050470 WO2016168938A1 (en) | 2015-04-23 | 2016-04-22 | Derivatives of korormicin useful as antibiotics |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021015712A Division JP7121225B2 (ja) | 2015-04-23 | 2021-02-03 | 抗生物質として有用なコロルマイシン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513194A JP2018513194A (ja) | 2018-05-24 |
| JP2018513194A5 true JP2018513194A5 (enExample) | 2019-05-23 |
| JP6842089B2 JP6842089B2 (ja) | 2021-03-17 |
Family
ID=57142747
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017555587A Active JP6842089B2 (ja) | 2015-04-23 | 2016-04-22 | 抗生物質として有用なコロルマイシン誘導体 |
| JP2021015712A Active JP7121225B2 (ja) | 2015-04-23 | 2021-02-03 | 抗生物質として有用なコロルマイシン誘導体 |
| JP2022032136A Pending JP2022122857A (ja) | 2015-04-23 | 2022-03-02 | 抗生物質として有用なコロルマイシン誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021015712A Active JP7121225B2 (ja) | 2015-04-23 | 2021-02-03 | 抗生物質として有用なコロルマイシン誘導体 |
| JP2022032136A Pending JP2022122857A (ja) | 2015-04-23 | 2022-03-02 | 抗生物質として有用なコロルマイシン誘導体 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US10166213B2 (enExample) |
| EP (1) | EP3285762A4 (enExample) |
| JP (3) | JP6842089B2 (enExample) |
| CN (2) | CN107708689A (enExample) |
| AU (4) | AU2016253429B2 (enExample) |
| CA (1) | CA2983460A1 (enExample) |
| IL (2) | IL310102A (enExample) |
| WO (1) | WO2016168938A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3285762A4 (en) * | 2015-04-23 | 2019-02-06 | Dibrov, Pavel | DERIVATIVES OF KORORMICIN AS ANTIBIOTICS |
| CN116617231B (zh) * | 2023-06-12 | 2024-11-15 | 沈阳药科大学 | 2-氨基萘嵌间二氮杂苯氢溴化物增强对革兰氏阴性菌杀菌作用的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2315489A (en) * | 1996-07-17 | 1998-02-04 | Merck & Co Inc | Antifungal agent |
| JP3905604B2 (ja) * | 1997-03-04 | 2007-04-18 | 株式会社海洋バイオテクノロジー研究所 | 新規化学物質コロールミシン |
| JP2000281670A (ja) | 1999-03-26 | 2000-10-10 | Marine Biotechnol Inst Co Ltd | 新規コロールミシン合成中間体及び製造法 |
| JP2000336088A (ja) * | 1999-05-27 | 2000-12-05 | Marine Biotechnol Inst Co Ltd | 新規化学物質Ｆ４２０ｍ類縁体 |
| JP2001010908A (ja) * | 1999-06-28 | 2001-01-16 | Marine Biotechnol Inst Co Ltd | 防汚剤 |
| JP2003061645A (ja) | 2001-08-23 | 2003-03-04 | Marine Biotechnol Inst Co Ltd | 海洋細菌の選択培地 |
| WO2008116029A1 (en) * | 2007-03-19 | 2008-09-25 | Wisconsin Alumni Research Foundation | Modulation of bacterial quorum sensing with synthetic ligands |
| WO2011001419A1 (en) * | 2009-07-03 | 2011-01-06 | National Institute For Biotechnology In The Negev | Covalent inhibition of bacterial quorum sensing |
| EP3285762A4 (en) * | 2015-04-23 | 2019-02-06 | Dibrov, Pavel | DERIVATIVES OF KORORMICIN AS ANTIBIOTICS |
-
2016
- 2016-04-22 EP EP16782435.8A patent/EP3285762A4/en not_active Ceased
- 2016-04-22 US US15/500,006 patent/US10166213B2/en active Active
- 2016-04-22 WO PCT/CA2016/050470 patent/WO2016168938A1/en not_active Ceased
- 2016-04-22 IL IL310102A patent/IL310102A/en unknown
- 2016-04-22 AU AU2016253429A patent/AU2016253429B2/en not_active Ceased
- 2016-04-22 JP JP2017555587A patent/JP6842089B2/ja active Active
- 2016-04-22 IL IL255182A patent/IL255182B2/en unknown
- 2016-04-22 CA CA2983460A patent/CA2983460A1/en active Pending
- 2016-04-22 CN CN201680033925.3A patent/CN107708689A/zh active Pending
- 2016-04-22 CN CN202310483500.4A patent/CN116574132A/zh active Pending
-
2018
- 2018-11-15 US US16/192,117 patent/US10744111B2/en active Active
-
2019
- 2019-04-02 AU AU2019202254A patent/AU2019202254B2/en not_active Ceased
-
2020
- 2020-07-15 US US16/930,178 patent/US11324716B2/en active Active
- 2020-11-11 AU AU2020267205A patent/AU2020267205B2/en not_active Ceased
-
2021
- 2021-02-03 JP JP2021015712A patent/JP7121225B2/ja active Active
-
2022
- 2022-03-02 JP JP2022032136A patent/JP2022122857A/ja active Pending
- 2022-04-27 US US17/660,886 patent/US12029716B2/en active Active
- 2022-07-08 AU AU2022204906A patent/AU2022204906B2/en not_active Ceased
-
2024
- 2024-07-08 US US18/766,386 patent/US20240358670A1/en not_active Abandoned
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