AU2016253429B2 - Derivatives of korormicin useful as antibiotics - Google Patents

Derivatives of korormicin useful as antibiotics Download PDF

Info

Publication number
AU2016253429B2
AU2016253429B2 AU2016253429A AU2016253429A AU2016253429B2 AU 2016253429 B2 AU2016253429 B2 AU 2016253429B2 AU 2016253429 A AU2016253429 A AU 2016253429A AU 2016253429 A AU2016253429 A AU 2016253429A AU 2016253429 B2 AU2016253429 B2 AU 2016253429B2
Authority
AU
Australia
Prior art keywords
compound
vibrio
peg
infection
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2016253429A
Other languages
English (en)
Other versions
AU2016253429A1 (en
Inventor
Elena DIBROV
Pavel DIBROV
Grant Pierce
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viotika Life Sciences Inc
Original Assignee
Viotika Life Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viotika Life Sciences Inc filed Critical Viotika Life Sciences Inc
Publication of AU2016253429A1 publication Critical patent/AU2016253429A1/en
Application granted granted Critical
Publication of AU2016253429B2 publication Critical patent/AU2016253429B2/en
Priority to AU2019202254A priority Critical patent/AU2019202254B2/en
Priority to AU2020267205A priority patent/AU2020267205B2/en
Priority to AU2022204906A priority patent/AU2022204906B2/en
Assigned to Viotika Life Sciences Inc. reassignment Viotika Life Sciences Inc. Request for Assignment Assignors: DIBROV, Elena, DIBROV, Pavel, PIERCE, GRANT
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
AU2016253429A 2015-04-23 2016-04-22 Derivatives of korormicin useful as antibiotics Ceased AU2016253429B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2019202254A AU2019202254B2 (en) 2015-04-23 2019-04-02 Derivatives of Korormicin Useful as Antibiotics
AU2020267205A AU2020267205B2 (en) 2015-04-23 2020-11-11 Derivatives of Korormicin Useful as Antibiotics
AU2022204906A AU2022204906B2 (en) 2015-04-23 2022-07-08 Derivatives of Korormicin Useful as Antibiotics

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562151902P 2015-04-23 2015-04-23
US62/151,902 2015-04-23
PCT/CA2016/050470 WO2016168938A1 (en) 2015-04-23 2016-04-22 Derivatives of korormicin useful as antibiotics

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2019202254A Division AU2019202254B2 (en) 2015-04-23 2019-04-02 Derivatives of Korormicin Useful as Antibiotics

Publications (2)

Publication Number Publication Date
AU2016253429A1 AU2016253429A1 (en) 2017-12-07
AU2016253429B2 true AU2016253429B2 (en) 2019-01-03

Family

ID=57142747

Family Applications (4)

Application Number Title Priority Date Filing Date
AU2016253429A Ceased AU2016253429B2 (en) 2015-04-23 2016-04-22 Derivatives of korormicin useful as antibiotics
AU2019202254A Ceased AU2019202254B2 (en) 2015-04-23 2019-04-02 Derivatives of Korormicin Useful as Antibiotics
AU2020267205A Ceased AU2020267205B2 (en) 2015-04-23 2020-11-11 Derivatives of Korormicin Useful as Antibiotics
AU2022204906A Ceased AU2022204906B2 (en) 2015-04-23 2022-07-08 Derivatives of Korormicin Useful as Antibiotics

Family Applications After (3)

Application Number Title Priority Date Filing Date
AU2019202254A Ceased AU2019202254B2 (en) 2015-04-23 2019-04-02 Derivatives of Korormicin Useful as Antibiotics
AU2020267205A Ceased AU2020267205B2 (en) 2015-04-23 2020-11-11 Derivatives of Korormicin Useful as Antibiotics
AU2022204906A Ceased AU2022204906B2 (en) 2015-04-23 2022-07-08 Derivatives of Korormicin Useful as Antibiotics

Country Status (8)

Country Link
US (5) US10166213B2 (enExample)
EP (1) EP3285762A4 (enExample)
JP (3) JP6842089B2 (enExample)
CN (2) CN107708689A (enExample)
AU (4) AU2016253429B2 (enExample)
CA (1) CA2983460A1 (enExample)
IL (2) IL310102A (enExample)
WO (1) WO2016168938A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3285762A4 (en) * 2015-04-23 2019-02-06 Dibrov, Pavel DERIVATIVES OF KORORMICIN AS ANTIBIOTICS
CN116617231B (zh) * 2023-06-12 2024-11-15 沈阳药科大学 2-氨基萘嵌间二氮杂苯氢溴化物增强对革兰氏阴性菌杀菌作用的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2315489A (en) * 1996-07-17 1998-02-04 Merck & Co Inc Antifungal agent
JP3905604B2 (ja) * 1997-03-04 2007-04-18 株式会社海洋バイオテクノロジー研究所 新規化学物質コロールミシン
JP2000281670A (ja) 1999-03-26 2000-10-10 Marine Biotechnol Inst Co Ltd 新規コロールミシン合成中間体及び製造法
JP2000336088A (ja) * 1999-05-27 2000-12-05 Marine Biotechnol Inst Co Ltd 新規化学物質Ｆ４２０ｍ類縁体
JP2001010908A (ja) * 1999-06-28 2001-01-16 Marine Biotechnol Inst Co Ltd 防汚剤
JP2003061645A (ja) 2001-08-23 2003-03-04 Marine Biotechnol Inst Co Ltd 海洋細菌の選択培地
WO2008116029A1 (en) * 2007-03-19 2008-09-25 Wisconsin Alumni Research Foundation Modulation of bacterial quorum sensing with synthetic ligands
WO2011001419A1 (en) * 2009-07-03 2011-01-06 National Institute For Biotechnology In The Negev Covalent inhibition of bacterial quorum sensing
EP3285762A4 (en) * 2015-04-23 2019-02-06 Dibrov, Pavel DERIVATIVES OF KORORMICIN AS ANTIBIOTICS

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
KOBAYASHI et al., "Total Synthesis of Korormicin", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (2001-05), vol. 2001, no. 10, pages 1873 - 1881 *
TEBBEN et al., "A Coralline Algal-Associated Bacterium, Pseudoalteromonas Strain J010, Yields Five New Korormicins and a Bromopyrrole", MARINE DRUGS, (2014-05-13), vol. 12, no. 5, pages 2802 - 2815 *
YOSHIKAWA et al., "Korormicin, a novel antibiotic specifically active against marine gram-negative bacteria, produced by a marine bacterium.", JOURNAL OF ANTIBIOTICS, (1997-11), vol. 50, no. 11, pages 949 - 953 *
YOSHIKAWA et al., "Planar structure and antibacterial activity of koromicin derivatives isolated from Pseudoalteromonas sp.", JOURNAL OF ANTIBIOTICS, (2003-10), vol. 56, pages 866 - 870 *

Also Published As

Publication number Publication date
US20200345682A1 (en) 2020-11-05
IL255182B2 (en) 2024-06-01
AU2022204906B2 (en) 2024-03-28
AU2022204906A1 (en) 2022-07-28
AU2019202254A1 (en) 2019-05-02
JP2018513194A (ja) 2018-05-24
JP7121225B2 (ja) 2022-08-18
US20190083450A1 (en) 2019-03-21
IL255182A0 (en) 2017-12-31
AU2020267205B2 (en) 2022-04-14
US10166213B2 (en) 2019-01-01
AU2016253429A1 (en) 2017-12-07
US10744111B2 (en) 2020-08-18
US12029716B2 (en) 2024-07-09
IL310102A (en) 2024-03-01
CA2983460A1 (en) 2016-10-27
IL255182B1 (en) 2024-02-01
EP3285762A4 (en) 2019-02-06
AU2019202254B2 (en) 2020-08-13
CN107708689A (zh) 2018-02-16
CN116574132A (zh) 2023-08-11
US20220257555A1 (en) 2022-08-18
US20180064680A1 (en) 2018-03-08
WO2016168938A1 (en) 2016-10-27
JP2022122857A (ja) 2022-08-23
EP3285762A1 (en) 2018-02-28
JP6842089B2 (ja) 2021-03-17
AU2020267205A1 (en) 2020-12-10
US20240358670A1 (en) 2024-10-31
US11324716B2 (en) 2022-05-10
JP2021073278A (ja) 2021-05-13

Similar Documents

Publication Publication Date Title
US20240358670A1 (en) Derivatives of korormicin useful as antibiotics
JP2010508280A (ja) 抗微生物性および抗ウイルス性化合物ならびにそれらの使用のための方法
AU2003267079B2 (en) Factors that bind intestinal toxins
US8748661B2 (en) Polyamino polyketide antibiotics and uses thereof
US20030147930A1 (en) Antibiotic, functional cosmetic and functional food containing levulinic acid and their derivatives
CA2413284A1 (fr) Utilisation d'acides en c4-c10 pour la prevention des infections a bacteries a gram negatif
JP6590924B2 (ja) 微生物感染を治療するための相乗的組成物
HK40087860A (en) Application of capsaicyns in the treatment of leaky gut
CN119837893A (zh) 5-氟-2′-脱氧胞苷在制备抗菌药物中的用途
Zhu et al. The Novel Antimicrobial Activities of Carrimycin Against Multidrug Resistant Acinetobacter baumannii and Pseudomonas aeruginosa Systemic Infection
KR20260052332A (ko) 디프라글루런트를 포함하는 항균용 조성물 및 세균 감염증의 예방 또는 치료용 약학적 조성물
KR20260047779A (ko) 트리페닐포스포늄 유도체를 유효성분으로 함유하는 여드름균에 대한 생물막 형성 억제 및 항균용 조성물
Dibrov Searching for New Antimicrobial Targets: Na+ Cycle in Energetics of Bacterial Pathogens
KR20220151426A (ko) 병원성 비브리오균의 병원성인자 발현 억제용 약학적 조성물
Durantia et al. Unsaturated fatty acids lactose esters: cytotoxicity, permeability enhancement and antimicrobial activity 2

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: VIOTIKA LIFE SCIENCES INC.

Free format text: FORMER OWNER(S): PIERCE, GRANT; DIBROV, ELENA; DIBROV, PAVEL

MK14 Patent ceased section 143(a) (annual fees not paid) or expired