JP6842089B2 - 抗生物質として有用なコロルマイシン誘導体 - Google Patents

抗生物質として有用なコロルマイシン誘導体 Download PDF

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JP6842089B2
JP6842089B2 JP2017555587A JP2017555587A JP6842089B2 JP 6842089 B2 JP6842089 B2 JP 6842089B2 JP 2017555587 A JP2017555587 A JP 2017555587A JP 2017555587 A JP2017555587 A JP 2017555587A JP 6842089 B2 JP6842089 B2 JP 6842089B2
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vibrio
infection
peg
bacteria
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JP2018513194A (ja
JP2018513194A5 (enExample
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ディブロフ，パベル
ディブロフ，エレナ
ピアース，グラント
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/54—Quaternary phosphonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
JP2017555587A 2015-04-23 2016-04-22 抗生物質として有用なコロルマイシン誘導体 Active JP6842089B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562151902P 2015-04-23 2015-04-23
US62/151,902 2015-04-23
PCT/CA2016/050470 WO2016168938A1 (en) 2015-04-23 2016-04-22 Derivatives of korormicin useful as antibiotics

Related Child Applications (1)

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JP2021015712A Division JP7121225B2 (ja) 2015-04-23 2021-02-03 抗生物質として有用なコロルマイシン誘導体

Publications (3)

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JP2018513194A JP2018513194A (ja) 2018-05-24
JP2018513194A5 JP2018513194A5 (enExample) 2019-05-23
JP6842089B2 true JP6842089B2 (ja) 2021-03-17

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JP2017555587A Active JP6842089B2 (ja) 2015-04-23 2016-04-22 抗生物質として有用なコロルマイシン誘導体
JP2021015712A Active JP7121225B2 (ja) 2015-04-23 2021-02-03 抗生物質として有用なコロルマイシン誘導体
JP2022032136A Pending JP2022122857A (ja) 2015-04-23 2022-03-02 抗生物質として有用なコロルマイシン誘導体

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JP2022032136A Pending JP2022122857A (ja) 2015-04-23 2022-03-02 抗生物質として有用なコロルマイシン誘導体

Country Status (8)

Country Link
US (5) US10166213B2 (enExample)
EP (1) EP3285762A4 (enExample)
JP (3) JP6842089B2 (enExample)
CN (2) CN107708689A (enExample)
AU (4) AU2016253429B2 (enExample)
CA (1) CA2983460A1 (enExample)
IL (2) IL310102A (enExample)
WO (1) WO2016168938A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3285762A4 (en) * 2015-04-23 2019-02-06 Dibrov, Pavel DERIVATIVES OF KORORMICIN AS ANTIBIOTICS
CN116617231B (zh) * 2023-06-12 2024-11-15 沈阳药科大学 2-氨基萘嵌间二氮杂苯氢溴化物增强对革兰氏阴性菌杀菌作用的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2315489A (en) * 1996-07-17 1998-02-04 Merck & Co Inc Antifungal agent
JP3905604B2 (ja) * 1997-03-04 2007-04-18 株式会社海洋バイオテクノロジー研究所 新規化学物質コロールミシン
JP2000281670A (ja) 1999-03-26 2000-10-10 Marine Biotechnol Inst Co Ltd 新規コロールミシン合成中間体及び製造法
JP2000336088A (ja) * 1999-05-27 2000-12-05 Marine Biotechnol Inst Co Ltd 新規化学物質Ｆ４２０ｍ類縁体
JP2001010908A (ja) * 1999-06-28 2001-01-16 Marine Biotechnol Inst Co Ltd 防汚剤
JP2003061645A (ja) 2001-08-23 2003-03-04 Marine Biotechnol Inst Co Ltd 海洋細菌の選択培地
WO2008116029A1 (en) * 2007-03-19 2008-09-25 Wisconsin Alumni Research Foundation Modulation of bacterial quorum sensing with synthetic ligands
WO2011001419A1 (en) * 2009-07-03 2011-01-06 National Institute For Biotechnology In The Negev Covalent inhibition of bacterial quorum sensing
EP3285762A4 (en) * 2015-04-23 2019-02-06 Dibrov, Pavel DERIVATIVES OF KORORMICIN AS ANTIBIOTICS

Also Published As

Publication number Publication date
US20200345682A1 (en) 2020-11-05
IL255182B2 (en) 2024-06-01
AU2022204906B2 (en) 2024-03-28
AU2022204906A1 (en) 2022-07-28
AU2019202254A1 (en) 2019-05-02
JP2018513194A (ja) 2018-05-24
JP7121225B2 (ja) 2022-08-18
US20190083450A1 (en) 2019-03-21
IL255182A0 (en) 2017-12-31
AU2020267205B2 (en) 2022-04-14
US10166213B2 (en) 2019-01-01
AU2016253429A1 (en) 2017-12-07
US10744111B2 (en) 2020-08-18
US12029716B2 (en) 2024-07-09
IL310102A (en) 2024-03-01
CA2983460A1 (en) 2016-10-27
IL255182B1 (en) 2024-02-01
EP3285762A4 (en) 2019-02-06
AU2019202254B2 (en) 2020-08-13
CN107708689A (zh) 2018-02-16
CN116574132A (zh) 2023-08-11
US20220257555A1 (en) 2022-08-18
US20180064680A1 (en) 2018-03-08
AU2016253429B2 (en) 2019-01-03
WO2016168938A1 (en) 2016-10-27
JP2022122857A (ja) 2022-08-23
EP3285762A1 (en) 2018-02-28
AU2020267205A1 (en) 2020-12-10
US20240358670A1 (en) 2024-10-31
US11324716B2 (en) 2022-05-10
JP2021073278A (ja) 2021-05-13

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