JP2018512863A5 - - Google Patents
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- JP2018512863A5 JP2018512863A5 JP2017554329A JP2017554329A JP2018512863A5 JP 2018512863 A5 JP2018512863 A5 JP 2018512863A5 JP 2017554329 A JP2017554329 A JP 2017554329A JP 2017554329 A JP2017554329 A JP 2017554329A JP 2018512863 A5 JP2018512863 A5 JP 2018512863A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- fragment
- binding
- hiv
- binding molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562149460P | 2015-04-17 | 2015-04-17 | |
| US62/149,460 | 2015-04-17 | ||
| PCT/US2016/027979 WO2016168758A1 (en) | 2015-04-17 | 2016-04-15 | Multi-valent human immunodeficiency virus antigen binding molecules and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512863A JP2018512863A (ja) | 2018-05-24 |
| JP2018512863A5 true JP2018512863A5 (https=) | 2019-05-23 |
| JP6811723B2 JP6811723B2 (ja) | 2021-01-13 |
Family
ID=57126939
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017554329A Expired - Fee Related JP6811723B2 (ja) | 2015-04-17 | 2016-04-15 | 多価ヒト免疫不全ウイルス抗原結合分子およびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US10570191B2 (https=) |
| EP (1) | EP3283112A4 (https=) |
| JP (1) | JP6811723B2 (https=) |
| CN (1) | CN107847591B (https=) |
| AU (1) | AU2016249404B2 (https=) |
| CA (1) | CA2983034A1 (https=) |
| HK (1) | HK1245675A1 (https=) |
| WO (1) | WO2016168758A1 (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2922830A1 (en) | 2013-09-05 | 2015-04-16 | Igm Biosciences, Inc. | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
| EP3105250B1 (en) | 2014-02-10 | 2020-08-05 | IGM Biosciences, Inc. | Iga multi-specific binding molecules |
| PL3560954T3 (pl) | 2014-04-03 | 2021-12-13 | Igm Biosciences, Inc. | Zmodyfikowany łańcuch J |
| IL308212A (en) | 2015-01-20 | 2024-01-01 | Igm Biosciences Inc | Tumor necrosis factor-α receptor binding molecules and their uses |
| EP3957738A1 (en) | 2015-03-04 | 2022-02-23 | IGM Biosciences, Inc. | Cd20 binding molecules and uses thereof |
| WO2016154593A1 (en) * | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| CN107847591B (zh) * | 2015-04-17 | 2023-07-28 | Igm生物科学股份有限公司 | 多价人免疫缺陷病毒抗原结合分子及其应用 |
| EP3356401B1 (en) | 2015-09-30 | 2020-06-24 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| EP3355913B1 (en) | 2015-09-30 | 2024-10-30 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| SG11201809336QA (en) | 2016-05-09 | 2018-11-29 | Igm Biosciences Inc | Anti-pd-l1 antibodies |
| MX2019011986A (es) | 2017-04-07 | 2019-11-07 | Igm Biosciences Inc | Regiones constantes de igm humana modificadas para la modulacion de la funcion efectora de la citolisis dependiente de complemento referencia cruzada a solicitudes relacionadas. |
| AR112257A1 (es) | 2017-06-21 | 2019-10-09 | Gilead Sciences Inc | Anticuerpos multiespecíficos dirigidos al vih-1 gp120 y cd3 humana, composiciones que los comprende, ácido nucleico, vector y célula huésped relacionados, método para producirlos, método para detectar células que expresan gp120 y cd3, kit de anticuerpos, fragmentos de anticuerpo que se une a gp120 y método para producirlos |
| US20240239877A1 (en) * | 2017-12-18 | 2024-07-18 | Viiv Healthcare Uk (No. 5) Limited | Antigen binding polypeptides |
| MX2020009069A (es) | 2018-03-01 | 2020-10-08 | Igm Biosciences Inc | Mutaciones de fc de igm y de la cadena j que afectan la semivida de igm en suero. |
| EP3794027A4 (en) * | 2018-05-18 | 2022-02-09 | MacroGenics, Inc. | OPTIMIZED GP41 BINDING MOLECULES AND THEIR USES |
| DK4257600T3 (da) | 2018-07-03 | 2025-05-26 | Gilead Sciences Inc | Antistoffer rettet mod hiv gp120 og fremgangsmåder til at bruge dem |
| US20210292396A1 (en) * | 2018-07-27 | 2021-09-23 | International Aids Vaccine Initiative | Enginerred antibodies to hiv env |
| WO2020056383A1 (en) * | 2018-09-13 | 2020-03-19 | Children's National Medical Center | Cells comprising antibodies against human immunodeficiency virus and methods of preparing and using the same |
| US12365722B2 (en) | 2018-10-19 | 2025-07-22 | University Of Maryland, College Park | Multispecific antibodies targeting multiple epitopes on the HIV-1 envelope |
| WO2020105700A1 (ja) * | 2018-11-22 | 2020-05-28 | 富士レビオ株式会社 | 抗体コンジュゲート |
| CN109776683B (zh) * | 2019-03-19 | 2020-04-07 | 益科思特(北京)医药科技发展有限公司 | 一种双特异性抗体及其制备方法与应用 |
| JP7700093B2 (ja) * | 2019-07-08 | 2025-06-30 | カルフォルニア インスティテュート オブ テクノロジー | 多反応性が低下した抗ｈｉｖワクチン抗体 |
| JP2022544405A (ja) | 2019-08-15 | 2022-10-18 | アイジーエム バイオサイエンシズ インコーポレイテッド | 免疫刺激性多量体型結合分子 |
| EP4041757A4 (en) * | 2019-09-26 | 2024-04-17 | Regents of the University of Minnesota | VIRAL ANTIGEN BINDING NK ENGAGERS COMPOUNDS AND METHODS OF USE |
| EP4139362A2 (en) | 2020-04-22 | 2023-03-01 | IGM Biosciences Inc. | Pd-1 agonist multimeric binding molecules |
| JP7518286B2 (ja) * | 2020-08-25 | 2024-07-17 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖを標的とする多重特異性抗原結合分子及び使用方法 |
| US20230293670A1 (en) * | 2020-08-27 | 2023-09-21 | Cellid Co., Ltd. | Novel coronavirus recombinant spike protein, polynucleotide encoding same, vector comprising polynucleotide, and vaccine for preventing or treating coronavirus infection, comprising vector |
| CN113461811A (zh) * | 2021-06-30 | 2021-10-01 | 复旦大学 | 一种双特异性抗hiv-1抗体 |
| US12600801B2 (en) | 2022-07-11 | 2026-04-14 | Fred Hutchinson Cancer Center | Single-domain antibodies that bind ROR1 |
| CN116589566A (zh) * | 2022-11-18 | 2023-08-15 | 昆明医科大学第一附属医院 | 一种HIV-1中和抗体的改造重组单克隆IgM抗体及其应用 |
| WO2025178915A1 (en) * | 2024-02-23 | 2025-08-28 | Icahn School Of Medicine At Mount Sinai | Multivalent protein complexes und uses thereof |
| CN121537523B (zh) * | 2026-01-19 | 2026-04-21 | 武汉睿欣和生物科技有限公司 | 一种用于胃蛋白酶原i检测的pgi单克隆抗体组合及其应用 |
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| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US5892019A (en) | 1987-07-15 | 1999-04-06 | The United States Of America, As Represented By The Department Of Health And Human Services | Production of a single-gene-encoded immunoglobulin |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| DE69120146T2 (de) | 1990-01-12 | 1996-12-12 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| TW505656B (en) | 1995-12-18 | 2002-10-11 | Otsuka Pharma Co Ltd | Sugar-chain-recognizing antibodies and pharmaceutical composition for HIV infectious diseases |
| JP3463143B2 (ja) * | 1995-12-18 | 2003-11-05 | 秀親 岡田 | 糖鎖認識抗体及びｈｉｖ感染症治療剤 |
| US5834597A (en) | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| DE19622088A1 (de) * | 1996-05-31 | 1997-12-04 | Boehringer Mannheim Gmbh | Anti-HIV-Antikörper als Kontrollproben |
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| WO2004003021A1 (ja) * | 2002-07-01 | 2004-01-08 | Hidechika Okada | HIV感染細胞にアポトーシスを誘導するヒトIgM抗体及びHIV感染症治療剤 |
| JP4939929B2 (ja) * | 2003-03-26 | 2012-05-30 | ポール，サッドヒル | タンパク質分解抗体および共有結合抗体 |
| US20050014932A1 (en) | 2003-05-15 | 2005-01-20 | Iogenetics, Llc | Targeted biocides |
| US7513893B2 (en) * | 2004-03-12 | 2009-04-07 | Abraham Ebbie Soroudi | Device and method for treatment of eyelid diseases |
| AU2005334481A1 (en) * | 2004-08-11 | 2007-01-25 | Trubion Pharmaceuticals, Inc. | Binding domain fusion proteins |
| US20080038280A1 (en) | 2004-10-14 | 2008-02-14 | Government Of The United States Of America | A32 Monoclonal Antibody Fusion Proteins For Use As Hiv Inhibitors And Vaccines |
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| WO2006120230A2 (en) | 2005-05-12 | 2006-11-16 | Crucell Holland B.V. | Host cell specific binding molecules capable of neutralizing viruses and uses thereof |
| ATE529436T1 (de) | 2007-04-20 | 2011-11-15 | Hoffmann La Roche | Erkennung von primären infektionen mit krankheitserregern |
| EP2335069A4 (en) * | 2008-09-25 | 2012-08-01 | Univ Duke | METHOD FOR DETECTING ANTIBODIES AND ANTIBODY HIV VIRON COMPLEXES |
| EA022788B1 (ru) * | 2009-07-03 | 2016-03-31 | Бионор Иммуно Ас | Новые терапевтические и диагностические средства |
| WO2011035205A2 (en) | 2009-09-18 | 2011-03-24 | Calmune Corporation | Antibodies against candida, collections thereof and methods of use |
| CA2774636C (en) * | 2009-09-25 | 2019-05-21 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to hiv-1 and their use |
| EP2533811A4 (en) | 2010-02-12 | 2013-12-25 | Res Corp Technologies Inc | MULTIMETER PROTEINS WITH IMMUNE LOBULIN CONSTANTS DOMAINS |
| WO2012106578A1 (en) * | 2011-02-04 | 2012-08-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | HIV NEUTRALIZING ANTIBODIES HAVING MUTATIONS IN CONSTANT DOMAIN (Fc) |
| EP2760891B1 (en) * | 2011-09-26 | 2018-11-07 | JN Biosciences LLC | Hybrid constant regions |
| BR112014010823B1 (pt) | 2011-11-07 | 2021-02-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | anticorpos que se ligam a gp41 e neutralizam o vírus da imunodeficiência humana tipo 1 (hiv-1), seus usos, molécula de ácido nucleico, vetor de expressão, composição, kit, bem como métodos de detecção de infecção pelo hiv-1 e de teste de imunógeno potencial |
| EP2788376B1 (en) | 2011-12-08 | 2018-10-03 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Neutralizing antibodies to hiv-1 and their use |
| US20150004190A1 (en) * | 2012-01-26 | 2015-01-01 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vaccine compositions for hiv prevention and treatment |
| WO2013120012A2 (en) | 2012-02-08 | 2013-08-15 | Igm Biosciences Inc. | Cdim binding proteins and uses thereof |
| US20150044137A1 (en) | 2012-03-23 | 2015-02-12 | The United States of America, as represented by the Secretary, Dep. of Health Care Human Services | Neutralizing antibodies to hiv-1 and their use |
| JP2015524821A (ja) * | 2012-08-02 | 2015-08-27 | ジェイエヌ バイオサイエンシーズ エルエルシー | システイン変異及びμ尾部を介して多量体化した抗体又は融合タンパク質 |
| US20150216973A1 (en) * | 2012-08-08 | 2015-08-06 | Network Immunology Inc.. | Method for the induction of an immune response |
| JP2014124186A (ja) * | 2012-12-26 | 2014-07-07 | Industrial Technology Research Institute | 多価抗体フラグメントおよびその三量体化複合体 |
| CA2922830A1 (en) | 2013-09-05 | 2015-04-16 | Igm Biosciences, Inc. | Constant chain modified bispecific, penta- and hexavalent ig-m antibodies |
| US10167333B2 (en) | 2014-01-16 | 2019-01-01 | Mario Umberto Francesco Mondelli | Neutralizing human monoclonal antibodies against hepatitis B virus surface antigen |
| EP3105250B1 (en) | 2014-02-10 | 2020-08-05 | IGM Biosciences, Inc. | Iga multi-specific binding molecules |
| PL3560954T3 (pl) | 2014-04-03 | 2021-12-13 | Igm Biosciences, Inc. | Zmodyfikowany łańcuch J |
| IL308212A (en) | 2015-01-20 | 2024-01-01 | Igm Biosciences Inc | Tumor necrosis factor-α receptor binding molecules and their uses |
| EP3957738A1 (en) | 2015-03-04 | 2022-02-23 | IGM Biosciences, Inc. | Cd20 binding molecules and uses thereof |
| WO2016154593A1 (en) | 2015-03-25 | 2016-09-29 | Igm Biosciences, Inc. | Multi-valent hepatitis b virus antigen binding molecules and uses thereof |
| CN107847591B (zh) * | 2015-04-17 | 2023-07-28 | Igm生物科学股份有限公司 | 多价人免疫缺陷病毒抗原结合分子及其应用 |
| EP3355913B1 (en) | 2015-09-30 | 2024-10-30 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| EP3356401B1 (en) | 2015-09-30 | 2020-06-24 | IGM Biosciences, Inc. | Binding molecules with modified j-chain |
| SG11201809336QA (en) | 2016-05-09 | 2018-11-29 | Igm Biosciences Inc | Anti-pd-l1 antibodies |
| MX2019000799A (es) | 2016-07-20 | 2019-06-03 | Igm Biosciences Inc | Moleculas de union a gitr multimericas y usos de las mismas. |
| AU2017299608A1 (en) | 2016-07-20 | 2019-02-07 | Igm Biosciences, Inc. | Multimeric CD137/4-1BB binding molecules and uses thereof |
| JP2019530640A (ja) | 2016-07-20 | 2019-10-24 | アイジーエム バイオサイエンシズ インコーポレイテッド | 多量体ｏｘ４０結合分子及びその使用 |
| EP3496536A4 (en) | 2016-07-20 | 2020-02-12 | IGM Biosciences, Inc. | MULTIMERE CD40-BINDING MOLECULES AND USES THEREOF |
| MX2019011986A (es) | 2017-04-07 | 2019-11-07 | Igm Biosciences Inc | Regiones constantes de igm humana modificadas para la modulacion de la funcion efectora de la citolisis dependiente de complemento referencia cruzada a solicitudes relacionadas. |
| EP3759229A4 (en) | 2018-02-26 | 2021-12-29 | IGM Biosciences Inc. | Use of a multimeric anti-dr5 binding molecule in combination with a chemotherapeutic agent for treating cancer |
| MX2020009069A (es) | 2018-03-01 | 2020-10-08 | Igm Biosciences Inc | Mutaciones de fc de igm y de la cadena j que afectan la semivida de igm en suero. |
| US20210380701A1 (en) | 2018-10-23 | 2021-12-09 | Igm Biosciences, Inc. | MULTIVALENT IgM- AND IgA-Fc-BASED BINDING MOLECULES |
| US20220106398A1 (en) | 2019-02-08 | 2022-04-07 | Igm Biosciences, Inc. | Anti-gitr antigen-binding domains and uses thereof |
-
2016
- 2016-04-15 CN CN201680035419.8A patent/CN107847591B/zh not_active Expired - Fee Related
- 2016-04-15 EP EP16780944.1A patent/EP3283112A4/en not_active Withdrawn
- 2016-04-15 AU AU2016249404A patent/AU2016249404B2/en not_active Ceased
- 2016-04-15 JP JP2017554329A patent/JP6811723B2/ja not_active Expired - Fee Related
- 2016-04-15 WO PCT/US2016/027979 patent/WO2016168758A1/en not_active Ceased
- 2016-04-15 HK HK18105481.5A patent/HK1245675A1/zh unknown
- 2016-04-15 CA CA2983034A patent/CA2983034A1/en active Pending
- 2016-04-15 US US15/566,485 patent/US10570191B2/en active Active
-
2020
- 2020-01-07 US US16/736,327 patent/US11192941B2/en not_active Expired - Fee Related
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