JP2018512431A5 - - Google Patents
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- JP2018512431A5 JP2018512431A5 JP2017553132A JP2017553132A JP2018512431A5 JP 2018512431 A5 JP2018512431 A5 JP 2018512431A5 JP 2017553132 A JP2017553132 A JP 2017553132A JP 2017553132 A JP2017553132 A JP 2017553132A JP 2018512431 A5 JP2018512431 A5 JP 2018512431A5
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562146116P | 2015-04-10 | 2015-04-10 | |
| US62/146,116 | 2015-04-10 | ||
| US201562249180P | 2015-10-30 | 2015-10-30 | |
| US62/249,180 | 2015-10-30 | ||
| PCT/US2016/026620 WO2016164708A1 (en) | 2015-04-10 | 2016-04-08 | Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080220A Division JP7111767B2 (ja) | 2015-04-10 | 2020-04-30 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512431A JP2018512431A (ja) | 2018-05-17 |
| JP2018512431A5 true JP2018512431A5 (enExample) | 2019-05-09 |
| JP6962819B2 JP6962819B2 (ja) | 2021-11-05 |
Family
ID=57072068
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553132A Active JP6962819B2 (ja) | 2015-04-10 | 2016-04-08 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
| JP2020080220A Active JP7111767B2 (ja) | 2015-04-10 | 2020-04-30 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
| JP2021085111A Pending JP2021119207A (ja) | 2015-04-10 | 2021-05-20 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080220A Active JP7111767B2 (ja) | 2015-04-10 | 2020-04-30 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
| JP2021085111A Pending JP2021119207A (ja) | 2015-04-10 | 2021-05-20 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10787500B2 (enExample) |
| EP (1) | EP3280444B1 (enExample) |
| JP (3) | JP6962819B2 (enExample) |
| CN (1) | CN108472360B (enExample) |
| AU (2) | AU2016245887B2 (enExample) |
| WO (1) | WO2016164708A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| DK3126384T3 (da) * | 2014-04-01 | 2021-01-18 | Adimab Llc | Multispecifikke antistofanaloger omfattende en fælles letkæde, og fremgangsmåder til deres fremstilling og anvendelse |
| TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體 |
| US11142587B2 (en) | 2015-04-01 | 2021-10-12 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
| CN108472360B (zh) | 2015-04-10 | 2023-01-17 | 阿迪马布有限责任公司 | 从亲代同源二聚抗体种类中纯化异源二聚多特异性抗体的方法 |
| WO2017110980A1 (ja) | 2015-12-25 | 2017-06-29 | 中外製薬株式会社 | 増強された活性を有する抗体及びその改変方法 |
| SG11201803989WA (en) | 2015-12-28 | 2018-06-28 | Chugai Pharmaceutical Co Ltd | Method for promoting efficiency of purification of fc region-containing polypeptide |
| ES3055961T3 (en) | 2016-04-28 | 2026-02-17 | Chugai Pharmaceutical Co Ltd | Antibody-containing preparation |
| CN109415444B (zh) | 2016-07-29 | 2024-03-01 | 中外制药株式会社 | 显示增加的备选fviii辅因子功能活性的双特异性抗体 |
| EP3509637B1 (en) | 2016-09-06 | 2024-11-27 | Chugai Seiyaku Kabushiki Kaisha | Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x |
| EP3603670A4 (en) | 2017-03-31 | 2021-03-10 | Public University Corporation Nara Medical University | MEDICAL COMPOSITION FOR THE PREVENTION AND / OR TREATMENT OF BLOOD CLOG FACTOR IX ANOMALY WITH A MULTI-SPECIFIC ANTIGIBINDING MOLECULAR FUNCTION OF BLOOD CLOTHING FACTOR VIII |
| JP6496095B1 (ja) | 2017-09-29 | 2019-04-03 | 中外製薬株式会社 | 血液凝固第ｖｉｉｉ因子（ｆｖｉｉｉ）補因子機能代替活性を有する多重特異性抗原結合分子および当該分子を有効成分として含有する薬学的製剤 |
| TW202600611A (zh) * | 2017-11-01 | 2026-01-01 | 日商中外製藥股份有限公司 | 生物活性降低之抗體變異體與同功型 |
| US12152056B2 (en) * | 2018-08-17 | 2024-11-26 | Regeneron Pharmaceuticals, Inc. | Method and chromatography system for determining amount and purity of a multimeric protein |
| AU2019343053B2 (en) * | 2018-09-21 | 2026-04-30 | Teneobio, Inc. | Methods for purifying heterodimeric, multispecific antibodies |
| US11022585B2 (en) | 2019-06-09 | 2021-06-01 | Dionex Corporation | Methods and systems for optimizing buffer conditions with liquid chromatography |
| CN114539416B (zh) * | 2020-11-26 | 2024-11-08 | 盛禾(中国)生物制药有限公司 | 一种双特异性抗体的层析纯化工艺 |
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| US459004A (en) | 1891-09-08 | Box for steaming cops | ||
| US231A (en) | 1837-06-10 | Stove for heating irons for the use of tailors | ||
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| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
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| EP0527809B1 (en) | 1990-04-05 | 1995-08-16 | CREA, Roberto | Walk-through mutagenesis |
| US5492817A (en) | 1993-11-09 | 1996-02-20 | Promega Corporation | Coupled transcription and translation in eukaryotic cell-free extract |
| US5665563A (en) | 1991-10-11 | 1997-09-09 | Promega Corporation | Coupled transcription and translation in eukaryotic cell-free extract |
| DE69216385T2 (de) | 1991-10-11 | 1997-06-12 | Promega Corp | Gekoppelte transkription und translation in zellfreien eukaryoten-extrakten |
| US5866344A (en) | 1991-11-15 | 1999-02-02 | Board Of Regents, The University Of Texas System | Antibody selection methods using cell surface expressed libraries |
| US20030036092A1 (en) | 1991-11-15 | 2003-02-20 | Board Of Regents, The University Of Texas System | Directed evolution of enzymes and antibodies |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| ATE219517T1 (de) | 1995-08-18 | 2002-07-15 | Morphosys Ag | Protein-/(poly)peptidbibliotheken |
| US6696248B1 (en) | 1995-08-18 | 2004-02-24 | Morphosys Ag | Protein/(poly)peptide libraries |
| US6165718A (en) | 1996-01-10 | 2000-12-26 | Novo Nordisk A/S Novo Alle | Method for in vivo production of a mutant library in cells |
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| JP4093507B2 (ja) * | 1997-03-10 | 2008-06-04 | 旭化成ファーマ株式会社 | 緩衝液組成 |
| US6159688A (en) | 1997-03-18 | 2000-12-12 | Novo Nordisk A/S | Methods of producing polynucleotide variants |
| JP4086325B2 (ja) | 1997-04-23 | 2008-05-14 | プリュックテュン，アンドレアス | 標的分子と相互作用する（ポリ）ペプチドをコードする核酸分子の同定方法 |
| US7951917B1 (en) | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
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| WO2006020258A2 (en) | 2004-07-17 | 2006-02-23 | Imclone Systems Incorporated | Novel tetravalent bispecific antibody |
| CA2603264C (en) | 2005-04-08 | 2017-03-21 | Chugai Seiyaku Kabushiki Kaisha | Antibody substituting for function of blood coagulation factor viii |
| CN101460622A (zh) * | 2006-03-31 | 2009-06-17 | 中外制药株式会社 | 用于纯化双特异性抗体的抗体修饰方法 |
| EP2009101B1 (en) * | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| US8580532B2 (en) | 2006-12-21 | 2013-11-12 | Sekisui Medical Co., Ltd. | Method for stabilizing α-thrombin in thrombin-containing solution |
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| JP2010538012A (ja) | 2007-08-28 | 2010-12-09 | バイオジェン アイデック マサチューセッツ インコーポレイテッド | Ｉｇｆ−１ｒの複数のエピトープに結合する組成物 |
| EP3124497B1 (en) | 2007-09-14 | 2020-04-15 | Adimab, LLC | Rationally designed, synthetic antibody libraries and uses therefor |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| CN101874042B9 (zh) * | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| EP3663318A1 (en) | 2008-01-07 | 2020-06-10 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
| CN101939776A (zh) | 2008-03-06 | 2011-01-05 | 富士电机控股株式会社 | 有源矩阵型显示设备 |
| EP3002299A1 (en) | 2008-06-03 | 2016-04-06 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
| CN102471377B (zh) * | 2009-07-24 | 2015-04-22 | 霍夫曼-拉罗奇有限公司 | 优化抗体的生产 |
| WO2011028952A1 (en) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| RU2016105962A (ru) | 2009-12-04 | 2018-11-23 | Дженентек, Инк. | Мультиспецифические антитела, аналоги антител, композиции и способы |
| CA2796633C (en) * | 2010-04-23 | 2020-10-27 | Genentech, Inc. | Production of heteromultimeric proteins |
| KR102024922B1 (ko) | 2010-07-16 | 2019-09-25 | 아디맵 엘엘씨 | 항체 라이브러리 |
| ES2678204T3 (es) * | 2010-07-30 | 2018-08-09 | Medimmune, Llc | Método para purificar inmunoconjugados |
| DK2771364T3 (da) * | 2011-10-27 | 2019-08-19 | Genmab As | Fremstilling af heterodimere proteiner |
| WO2013136186A2 (en) | 2012-03-13 | 2013-09-19 | Novimmune S.A. | Readily isolated bispecific antibodies with native immunoglobulin format |
| WO2014078729A1 (en) * | 2012-11-15 | 2014-05-22 | Genentech, Inc. | IONIC STRENGTH-MEDIATED pH GRADIENT ION EXCHANGE CHROMATOGRAPHY |
| CN108472360B (zh) | 2015-04-10 | 2023-01-17 | 阿迪马布有限责任公司 | 从亲代同源二聚抗体种类中纯化异源二聚多特异性抗体的方法 |
-
2016
- 2016-04-08 CN CN201680033398.6A patent/CN108472360B/zh active Active
- 2016-04-08 WO PCT/US2016/026620 patent/WO2016164708A1/en not_active Ceased
- 2016-04-08 US US15/565,494 patent/US10787500B2/en active Active
- 2016-04-08 JP JP2017553132A patent/JP6962819B2/ja active Active
- 2016-04-08 EP EP16777345.6A patent/EP3280444B1/en active Active
- 2016-04-08 AU AU2016245887A patent/AU2016245887B2/en active Active
-
2020
- 2020-04-30 JP JP2020080220A patent/JP7111767B2/ja active Active
- 2020-08-21 US US16/999,123 patent/US20210047387A1/en not_active Abandoned
-
2021
- 2021-05-20 JP JP2021085111A patent/JP2021119207A/ja active Pending
- 2021-09-01 AU AU2021225195A patent/AU2021225195A1/en not_active Abandoned
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