JP2018512431A5 - - Google Patents
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- JP2018512431A5 JP2018512431A5 JP2017553132A JP2017553132A JP2018512431A5 JP 2018512431 A5 JP2018512431 A5 JP 2018512431A5 JP 2017553132 A JP2017553132 A JP 2017553132A JP 2017553132 A JP2017553132 A JP 2017553132A JP 2018512431 A5 JP2018512431 A5 JP 2018512431A5
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562146116P | 2015-04-10 | 2015-04-10 | |
| US62/146,116 | 2015-04-10 | ||
| US201562249180P | 2015-10-30 | 2015-10-30 | |
| US62/249,180 | 2015-10-30 | ||
| PCT/US2016/026620 WO2016164708A1 (en) | 2015-04-10 | 2016-04-08 | Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080220A Division JP7111767B2 (ja) | 2015-04-10 | 2020-04-30 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512431A JP2018512431A (ja) | 2018-05-17 |
| JP2018512431A5 true JP2018512431A5 (enExample) | 2019-05-09 |
| JP6962819B2 JP6962819B2 (ja) | 2021-11-05 |
Family
ID=57072068
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553132A Active JP6962819B2 (ja) | 2015-04-10 | 2016-04-08 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
| JP2020080220A Active JP7111767B2 (ja) | 2015-04-10 | 2020-04-30 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
| JP2021085111A Pending JP2021119207A (ja) | 2015-04-10 | 2021-05-20 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080220A Active JP7111767B2 (ja) | 2015-04-10 | 2020-04-30 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
| JP2021085111A Pending JP2021119207A (ja) | 2015-04-10 | 2021-05-20 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10787500B2 (enExample) |
| EP (1) | EP3280444B1 (enExample) |
| JP (3) | JP6962819B2 (enExample) |
| CN (1) | CN108472360B (enExample) |
| AU (2) | AU2016245887B2 (enExample) |
| WO (1) | WO2016164708A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4793360A2 (en) | 2006-03-31 | 2026-08-19 | Chugai Seiyaku Kabushiki Kaisha | Methods for controlling blood pharmacokinetics of antibodies |
| EP3127921A1 (en) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
| EP4050026A1 (en) * | 2014-04-01 | 2022-08-31 | Adimab, LLC | Method of obtaining or identifying one or more common light chains for use in preparing a multispecific antibody |
| TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第viii凝血因子(fviii)機能替代活性的物質之抗體 |
| JP7082484B2 (ja) | 2015-04-01 | 2022-06-08 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| EP3280444B1 (en) | 2015-04-10 | 2024-05-08 | Adimab, LLC | Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species |
| US20200270363A1 (en) | 2015-12-25 | 2020-08-27 | Chugai Seiyaku Kabushiki Kaisha | Antibody having enhanced activity, and method for modifying same |
| SG11201803989WA (en) | 2015-12-28 | 2018-06-28 | Chugai Pharmaceutical Co Ltd | Method for promoting efficiency of purification of fc region-containing polypeptide |
| AU2017255077B2 (en) | 2016-04-28 | 2024-05-16 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing preparation |
| CA3027018A1 (en) | 2016-07-29 | 2018-02-01 | Chugai Seiyaku Kabushiki Kaisha | Bispecific antibody exhibiting increased alternative fviii-cofactor-function activity |
| US11352438B2 (en) | 2016-09-06 | 2022-06-07 | Chugai Seiyaku Kabushiki Kaisha | Methods of using a bispecific antibody that recognizes coagulation factor IX and/or activated coagulation factor IX and coagulation factor X and/or activated coagulation factor X |
| JP7209298B2 (ja) | 2017-03-31 | 2023-01-20 | 公立大学法人奈良県立医科大学 | 血液凝固第viii因子の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第ix因子異常症の予防および/または治療に用いられる医薬組成物 |
| CA3071236A1 (en) | 2017-09-29 | 2019-04-04 | Chugai Seiyaku Kabushiki Kaisha | Multispecific antigen-binding molecule having blood coagulation factor viii (fviii) cofactor function-substituting activity, and pharmaceutical formulation containing said moleculeas active ingredient |
| KR20260090008A (ko) * | 2017-11-01 | 2026-06-16 | 추가이 세이야쿠 가부시키가이샤 | 생물 활성이 저하된 항체 배리언트 및 아이소폼 |
| SG11202101369XA (en) * | 2018-08-17 | 2021-03-30 | Regeneron Pharma | Method and chromatography system for determining amount and purity of a multimeric protein |
| SG11202102713TA (en) * | 2018-09-21 | 2021-04-29 | Teneobio Inc | Methods for purifying heterodimeric, multispecific antibodies |
| US11022585B2 (en) | 2019-06-09 | 2021-06-01 | Dionex Corporation | Methods and systems for optimizing buffer conditions with liquid chromatography |
| CN114539416B (zh) * | 2020-11-26 | 2024-11-08 | 盛禾(中国)生物制药有限公司 | 一种双特异性抗体的层析纯化工艺 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US231A (en) | 1837-06-10 | Stove for heating irons for the use of tailors | ||
| US459004A (en) | 1891-09-08 | Box for steaming cops | ||
| US8188A (en) | 1851-07-01 | Htkstaht | ||
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| US6291159B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for producing polymers having a preselected activity |
| CA2079802C (en) | 1990-04-05 | 2001-09-18 | Roberto Crea | Walk-through mutagenesis |
| US5665563A (en) | 1991-10-11 | 1997-09-09 | Promega Corporation | Coupled transcription and translation in eukaryotic cell-free extract |
| EP0566714B1 (en) | 1991-10-11 | 1997-01-02 | Promega Corporation | Coupled transcription and translation in eukaryotic cell-free extract |
| US5492817A (en) | 1993-11-09 | 1996-02-20 | Promega Corporation | Coupled transcription and translation in eukaryotic cell-free extract |
| US20030036092A1 (en) | 1991-11-15 | 2003-02-20 | Board Of Regents, The University Of Texas System | Directed evolution of enzymes and antibodies |
| US5866344A (en) | 1991-11-15 | 1999-02-02 | Board Of Regents, The University Of Texas System | Antibody selection methods using cell surface expressed libraries |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6828422B1 (en) | 1995-08-18 | 2004-12-07 | Morphosys Ag | Protein/(poly)peptide libraries |
| EP0859841B1 (en) | 1995-08-18 | 2002-06-19 | MorphoSys AG | Protein/(poly)peptide libraries |
| US6165718A (en) | 1996-01-10 | 2000-12-26 | Novo Nordisk A/S Novo Alle | Method for in vivo production of a mutant library in cells |
| IL131016A (en) | 1997-01-21 | 2004-12-15 | Gen Hospital Corp | Selection of proteins using RNA-protein blends |
| US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| JP4093507B2 (ja) * | 1997-03-10 | 2008-06-04 | 旭化成ファーマ株式会社 | 緩衝液組成 |
| US6159688A (en) | 1997-03-18 | 2000-12-12 | Novo Nordisk A/S | Methods of producing polynucleotide variants |
| DE69834032T2 (de) | 1997-04-23 | 2006-12-07 | Universität Zürich | Verfahren zur erkennung von nucleinsäuremolekülen codierend für (poly)peptide, welche mit zielmolekülen interagieren |
| US7951917B1 (en) | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| JP4860098B2 (ja) | 2000-12-18 | 2012-01-25 | ダイアックス、コープ | 遺伝的パッケージの焦点を合わせたライブラリー |
| US20060235208A1 (en) | 2002-09-27 | 2006-10-19 | Xencor, Inc. | Fc variants with optimized properties |
| US20060134105A1 (en) | 2004-10-21 | 2006-06-22 | Xencor, Inc. | IgG immunoglobulin variants with optimized effector function |
| EP1786918A4 (en) | 2004-07-17 | 2009-02-11 | Imclone Systems Inc | NEW BISPECIFIC ANTIBODY TETRAVALENT |
| EP2824183B1 (en) * | 2005-04-08 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | Methods for producing bispecific antibodies |
| CN101460622A (zh) * | 2006-03-31 | 2009-06-17 | 中外制药株式会社 | 用于纯化双特异性抗体的抗体修饰方法 |
| JP5144499B2 (ja) * | 2006-03-31 | 2013-02-13 | 中外製薬株式会社 | 二重特異性抗体を精製するための抗体改変方法 |
| WO2008075455A1 (ja) | 2006-12-21 | 2008-06-26 | Sekisui Medical Co., Ltd. | トロンビン含有溶液中のα-トロンビンの安定化方法 |
| CA2693053C (en) | 2007-05-30 | 2021-01-05 | Xencor, Inc. | Methods and compositions for inhibiting cd32b expressing cells |
| CA2697922A1 (en) | 2007-08-28 | 2009-03-12 | Biogen Idec Ma Inc. | Compositions that bind multiple epitopes of igf-1r |
| WO2009036379A2 (en) | 2007-09-14 | 2009-03-19 | Adimab, Inc. | Rationally designed, synthetic antibody libraries and uses therefor |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| EP3127921A1 (en) * | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substition in cdr |
| EP3663318A1 (en) | 2008-01-07 | 2020-06-10 | Amgen Inc. | Method for making antibody fc-heterodimeric molecules using electrostatic steering effects |
| KR101181106B1 (ko) | 2008-03-06 | 2012-09-07 | 샤프 가부시키가이샤 | 액티브?매트릭스형 표시장치 |
| EP2297209A4 (en) | 2008-06-03 | 2012-08-01 | Abbott Lab | IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF |
| JP5540095B2 (ja) * | 2009-07-24 | 2014-07-02 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | 抗体製造の最適化 |
| US9493578B2 (en) | 2009-09-02 | 2016-11-15 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| CA2781682A1 (en) | 2009-12-04 | 2011-06-09 | Genentech, Inc. | Multispecific antibodies, antibody analogs, compositions, and methods |
| WO2011133886A2 (en) * | 2010-04-23 | 2011-10-27 | Genentech, Inc. | Production of heteromultimeric proteins |
| MX381912B (es) | 2010-07-16 | 2025-03-13 | Adimab Llc | Colecciones de anticuerpos. |
| BR112013002334A2 (pt) | 2010-07-30 | 2016-05-24 | Medimmune Llc | método para purificar polipeptídeos ou imunoconjugados ativos. |
| IN2014CN03887A (enExample) * | 2011-10-27 | 2015-10-16 | Genmab As | |
| EP3517548A1 (en) | 2012-03-13 | 2019-07-31 | NovImmune S.A. | Readily isolated bispecific antibodies with native immunoglobulin format |
| JP2015537212A (ja) * | 2012-11-15 | 2015-12-24 | ジェネンテック, インコーポレイテッド | イオン強度媒介のph勾配イオン交換クロマトグラフィー |
| EP3280444B1 (en) | 2015-04-10 | 2024-05-08 | Adimab, LLC | Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species |
-
2016
- 2016-04-08 EP EP16777345.6A patent/EP3280444B1/en active Active
- 2016-04-08 US US15/565,494 patent/US10787500B2/en active Active
- 2016-04-08 WO PCT/US2016/026620 patent/WO2016164708A1/en not_active Ceased
- 2016-04-08 JP JP2017553132A patent/JP6962819B2/ja active Active
- 2016-04-08 AU AU2016245887A patent/AU2016245887B2/en active Active
- 2016-04-08 CN CN201680033398.6A patent/CN108472360B/zh active Active
-
2020
- 2020-04-30 JP JP2020080220A patent/JP7111767B2/ja active Active
- 2020-08-21 US US16/999,123 patent/US20210047387A1/en not_active Abandoned
-
2021
- 2021-05-20 JP JP2021085111A patent/JP2021119207A/ja active Pending
- 2021-09-01 AU AU2021225195A patent/AU2021225195A1/en not_active Abandoned
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