JP2018512431A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018512431A5 JP2018512431A5 JP2017553132A JP2017553132A JP2018512431A5 JP 2018512431 A5 JP2018512431 A5 JP 2018512431A5 JP 2017553132 A JP2017553132 A JP 2017553132A JP 2017553132 A JP2017553132 A JP 2017553132A JP 2018512431 A5 JP2018512431 A5 JP 2018512431A5
- Authority
- JP
- Japan
- Prior art keywords
- less
- units
- unit
- parent
- antibody species
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562146116P | 2015-04-10 | 2015-04-10 | |
| US62/146,116 | 2015-04-10 | ||
| US201562249180P | 2015-10-30 | 2015-10-30 | |
| US62/249,180 | 2015-10-30 | ||
| PCT/US2016/026620 WO2016164708A1 (en) | 2015-04-10 | 2016-04-08 | Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080220A Division JP7111767B2 (ja) | 2015-04-10 | 2020-04-30 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018512431A JP2018512431A (ja) | 2018-05-17 |
| JP2018512431A5 true JP2018512431A5 (cg-RX-API-DMAC7.html) | 2019-05-09 |
| JP6962819B2 JP6962819B2 (ja) | 2021-11-05 |
Family
ID=57072068
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017553132A Active JP6962819B2 (ja) | 2015-04-10 | 2016-04-08 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
| JP2020080220A Active JP7111767B2 (ja) | 2015-04-10 | 2020-04-30 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
| JP2021085111A Pending JP2021119207A (ja) | 2015-04-10 | 2021-05-20 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020080220A Active JP7111767B2 (ja) | 2015-04-10 | 2020-04-30 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
| JP2021085111A Pending JP2021119207A (ja) | 2015-04-10 | 2021-05-20 | 親ホモ二量体抗体種からのヘテロ二量体多重特異性抗体の精製方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10787500B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3280444B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6962819B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN108472360B (cg-RX-API-DMAC7.html) |
| AU (2) | AU2016245887B2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016164708A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101463631B1 (ko) | 2006-03-31 | 2014-11-19 | 추가이 세이야쿠 가부시키가이샤 | 항체의 혈중 동태를 제어하는 방법 |
| RU2510400C9 (ru) | 2007-09-26 | 2014-07-20 | Чугаи Сейяку Кабусики Кайся | Способ модификации изоэлектрической точки антитела с помощью аминокислотных замен в cdr |
| EP3825326A1 (en) * | 2014-04-01 | 2021-05-26 | Adimab, LLC | Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use |
| TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第viii凝血因子(fviii)機能替代活性的物質之抗體 |
| WO2016159213A1 (ja) | 2015-04-01 | 2016-10-06 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
| CN108472360B (zh) | 2015-04-10 | 2023-01-17 | 阿迪马布有限责任公司 | 从亲代同源二聚抗体种类中纯化异源二聚多特异性抗体的方法 |
| JP6954842B2 (ja) | 2015-12-25 | 2021-10-27 | 中外製薬株式会社 | 増強された活性を有する抗体及びその改変方法 |
| BR112018009312A8 (pt) | 2015-12-28 | 2019-02-26 | Chugai Pharmaceutical Co Ltd | método para promover eficiência de purificação de polipeptídeo contendo região de fc |
| CA3016301A1 (en) | 2016-04-28 | 2017-11-02 | Chugai Seiyaku Kabushiki Kaisha | Antibody-containing preparation |
| MY209831A (en) | 2016-09-06 | 2025-08-07 | Chugai Pharmaceutical Co Ltd | Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x |
| SG11202003833TA (en) * | 2017-11-01 | 2020-05-28 | Chugai Pharmaceutical Co Ltd | Antibody variant and isoform with lowered biological activity |
| MY207066A (en) * | 2018-08-17 | 2025-01-28 | Regeneron Pharma | Method and chromatography system for determining amount and purity of a multimeric protein |
| JP2022501357A (ja) * | 2018-09-21 | 2022-01-06 | テネオバイオ, インコーポレイテッド | ヘテロ二量体多重特異性抗体を精製するための方法 |
| US11022585B2 (en) | 2019-06-09 | 2021-06-01 | Dionex Corporation | Methods and systems for optimizing buffer conditions with liquid chromatography |
| CN114539416B (zh) * | 2020-11-26 | 2024-11-08 | 盛禾(中国)生物制药有限公司 | 一种双特异性抗体的层析纯化工艺 |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US459004A (en) | 1891-09-08 | Box for steaming cops | ||
| US231A (en) | 1837-06-10 | Stove for heating irons for the use of tailors | ||
| US8188A (en) | 1851-07-01 | Htkstaht | ||
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6291159B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for producing polymers having a preselected activity |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| WO1991015581A1 (en) | 1990-04-05 | 1991-10-17 | Roberto Crea | Walk-through mutagenesis |
| US5492817A (en) | 1993-11-09 | 1996-02-20 | Promega Corporation | Coupled transcription and translation in eukaryotic cell-free extract |
| US5665563A (en) | 1991-10-11 | 1997-09-09 | Promega Corporation | Coupled transcription and translation in eukaryotic cell-free extract |
| ES2097363T3 (es) | 1991-10-11 | 1997-04-01 | Promega Corp | Transcripcion y traduccion acopladas en un extracto exento de celulas eucariotas. |
| US20030036092A1 (en) | 1991-11-15 | 2003-02-20 | Board Of Regents, The University Of Texas System | Directed evolution of enzymes and antibodies |
| US5866344A (en) | 1991-11-15 | 1999-02-02 | Board Of Regents, The University Of Texas System | Antibody selection methods using cell surface expressed libraries |
| US5667988A (en) | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US6828422B1 (en) | 1995-08-18 | 2004-12-07 | Morphosys Ag | Protein/(poly)peptide libraries |
| EP0859841B1 (en) | 1995-08-18 | 2002-06-19 | MorphoSys AG | Protein/(poly)peptide libraries |
| US6165718A (en) | 1996-01-10 | 2000-12-26 | Novo Nordisk A/S Novo Alle | Method for in vivo production of a mutant library in cells |
| WO1998031700A1 (en) | 1997-01-21 | 1998-07-23 | The General Hospital Corporation | Selection of proteins using rna-protein fusions |
| US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| JP4093507B2 (ja) * | 1997-03-10 | 2008-06-04 | 旭化成ファーマ株式会社 | 緩衝液組成 |
| US6159688A (en) | 1997-03-18 | 2000-12-12 | Novo Nordisk A/S | Methods of producing polynucleotide variants |
| JP4086325B2 (ja) | 1997-04-23 | 2008-05-14 | プリュックテュン,アンドレアス | 標的分子と相互作用する(ポリ)ペプチドをコードする核酸分子の同定方法 |
| US7951917B1 (en) | 1997-05-02 | 2011-05-31 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
| JP4860098B2 (ja) | 2000-12-18 | 2012-01-25 | ダイアックス、コープ | 遺伝的パッケージの焦点を合わせたライブラリー |
| US20060235208A1 (en) | 2002-09-27 | 2006-10-19 | Xencor, Inc. | Fc variants with optimized properties |
| US20060134105A1 (en) | 2004-10-21 | 2006-06-22 | Xencor, Inc. | IgG immunoglobulin variants with optimized effector function |
| WO2006020258A2 (en) | 2004-07-17 | 2006-02-23 | Imclone Systems Incorporated | Novel tetravalent bispecific antibody |
| TW200714313A (en) * | 2005-04-08 | 2007-04-16 | Chugai Pharmaceutical Co Ltd | Antibodies that substitute for coagulation factor VIII |
| EP2009101B1 (en) * | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| CN101460622A (zh) * | 2006-03-31 | 2009-06-17 | 中外制药株式会社 | 用于纯化双特异性抗体的抗体修饰方法 |
| CN101558310B (zh) * | 2006-12-21 | 2013-05-08 | 积水医疗株式会社 | 含凝血酶的溶液中的α-凝血酶的稳定化方法 |
| EP3392273A1 (en) | 2007-05-30 | 2018-10-24 | Xencor, Inc. | Methods and compositions for inhibiting cd32b expressing cells |
| EP2197490A2 (en) | 2007-08-28 | 2010-06-23 | Biogen Idec MA, Inc. | Compositions that bind multiple epitopes of igf-1r |
| EP2193146B1 (en) | 2007-09-14 | 2016-05-25 | Adimab, LLC | Rationally designed, synthetic antibody libraries and uses therefor |
| US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
| RU2510400C9 (ru) * | 2007-09-26 | 2014-07-20 | Чугаи Сейяку Кабусики Кайся | Способ модификации изоэлектрической точки антитела с помощью аминокислотных замен в cdr |
| DK2235064T3 (en) | 2008-01-07 | 2016-01-11 | Amgen Inc | A process for the preparation of heterodimeric Fc molecules using electrostatic control effects |
| WO2009110132A1 (ja) | 2008-03-06 | 2009-09-11 | 富士電機ホールディングス株式会社 | アクティブ・マトリクス型表示装置 |
| EP2297209A4 (en) | 2008-06-03 | 2012-08-01 | Abbott Lab | IMMUNOGLOBULINS WITH TWO VARIABLE DOMAINS AND USES THEREOF |
| SG178078A1 (en) * | 2009-07-24 | 2012-03-29 | Hoffmann La Roche | Optimizing the production of antibodies |
| WO2011028952A1 (en) | 2009-09-02 | 2011-03-10 | Xencor, Inc. | Compositions and methods for simultaneous bivalent and monovalent co-engagement of antigens |
| CN107337734A (zh) * | 2009-12-04 | 2017-11-10 | 弗·哈夫曼-拉罗切有限公司 | 多特异性抗体、抗体类似物、组合物和方法 |
| CA2796633C (en) * | 2010-04-23 | 2020-10-27 | Genentech, Inc. | Production of heteromultimeric proteins |
| AU2011279073B2 (en) | 2010-07-16 | 2016-06-09 | Adimab, Llc | Antibody libraries |
| EP3797847A1 (en) * | 2010-07-30 | 2021-03-31 | Medlmmune, LLC | Purified active polypeptides or immunoconjugates |
| US10344050B2 (en) * | 2011-10-27 | 2019-07-09 | Genmab A/S | Production of heterodimeric proteins |
| PT2825559T (pt) | 2012-03-13 | 2019-06-07 | Novimmune Sa | Anticorpos biespecíficos prontamente isolados com formato de imunoglobulina nativo |
| JP2015537212A (ja) * | 2012-11-15 | 2015-12-24 | ジェネンテック, インコーポレイテッド | イオン強度媒介のph勾配イオン交換クロマトグラフィー |
| CN108472360B (zh) | 2015-04-10 | 2023-01-17 | 阿迪马布有限责任公司 | 从亲代同源二聚抗体种类中纯化异源二聚多特异性抗体的方法 |
-
2016
- 2016-04-08 CN CN201680033398.6A patent/CN108472360B/zh active Active
- 2016-04-08 EP EP16777345.6A patent/EP3280444B1/en active Active
- 2016-04-08 AU AU2016245887A patent/AU2016245887B2/en active Active
- 2016-04-08 JP JP2017553132A patent/JP6962819B2/ja active Active
- 2016-04-08 US US15/565,494 patent/US10787500B2/en active Active
- 2016-04-08 WO PCT/US2016/026620 patent/WO2016164708A1/en not_active Ceased
-
2020
- 2020-04-30 JP JP2020080220A patent/JP7111767B2/ja active Active
- 2020-08-21 US US16/999,123 patent/US20210047387A1/en not_active Abandoned
-
2021
- 2021-05-20 JP JP2021085111A patent/JP2021119207A/ja active Pending
- 2021-09-01 AU AU2021225195A patent/AU2021225195A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018512431A5 (cg-RX-API-DMAC7.html) | ||
| Gomis‐Fons et al. | Model‐based design and control of a small‐scale integrated continuous end‐to‐end mAb platform | |
| Westermeier | Reiner Westermeier, Tom Naven, and Hans-Rudolf Hçpker Proteomics in Practice | |
| Stein et al. | Cation exchange chromatography in antibody purification: pH screening for optimised binding and HCP removal | |
| RU2015122726A (ru) | ОПОСРЕДОВАННАЯ ИОННОЙ СИЛОЙ рН-ГРАДИЕНТНАЯ ИОНООБМЕННАЯ ХРОМАТОГРАФИЯ | |
| JP2015537212A5 (cg-RX-API-DMAC7.html) | ||
| Rathore et al. | Scale-up and optimization in preparative chromatography | |
| ES2988082T3 (es) | Elución de biomoléculas a partir de resinas multimodales utilizando MES y MOPS como modificadores de fase móvil | |
| JP2018516229A5 (cg-RX-API-DMAC7.html) | ||
| Trnovec et al. | Characterization of membrane adsorbers used for impurity removal during the continuous purification of monoclonal antibodies | |
| IL297116A (en) | A method for purifying single-stranded RNA | |
| RU2016104542A (ru) | Осуществление оптимизации входных условий ионообменной хроматографии | |
| Zhou et al. | Large‐scale identification of human biliary proteins from a cholesterol stone patient using a proteomic approach | |
| EP2814608B1 (en) | REDUCING pH EXCURSIONS IN ION EXCHANGE CHROMATOGRAPHY | |
| CN108350027A (zh) | 用于改进的蛋白质分离的相反的pH-盐梯度 | |
| Connell‐Crowley et al. | Cation exchange chromatography provides effective retrovirus clearance for antibody purification processes | |
| JP2016529489A5 (cg-RX-API-DMAC7.html) | ||
| Morrow Jr | Advances in antibody manufacturing using mammalian cells | |
| Che Hussian et al. | Factors affecting therapeutic protein purity and yield during chromatographic purification | |
| CN106480014B (zh) | 选择性分离核酸的方法及其套组 | |
| Chen et al. | Partition coefficient screening–An effective approach for finding the best conditions for byproduct removal as demonstrated by a bispecific antibody purification case | |
| Kostelec et al. | Production and Purification of mRNA | |
| CN116829569A (zh) | 蛋白质纯化缓冲液和方法 | |
| Ng et al. | pH‐based cation exchange chromatography in the capture and elution of monoclonal antibodies | |
| KR102140531B1 (ko) | Gly-Tβ4의 제조방법 |