JP2018510908A5 - - Google Patents
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- Publication number
- JP2018510908A5 JP2018510908A5 JP2018500857A JP2018500857A JP2018510908A5 JP 2018510908 A5 JP2018510908 A5 JP 2018510908A5 JP 2018500857 A JP2018500857 A JP 2018500857A JP 2018500857 A JP2018500857 A JP 2018500857A JP 2018510908 A5 JP2018510908 A5 JP 2018510908A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl group
- alkyl
- coor
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 110
- 125000001424 substituent group Chemical group 0.000 claims 99
- 125000003118 aryl group Chemical group 0.000 claims 74
- -1 methylenedioxy group Chemical group 0.000 claims 68
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 40
- 125000001072 heteroaryl group Chemical group 0.000 claims 38
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 36
- 125000005843 halogen group Chemical group 0.000 claims 35
- 229910052736 halogen Inorganic materials 0.000 claims 32
- 150000002367 halogens Chemical class 0.000 claims 32
- 125000004432 carbon atom Chemical group C* 0.000 claims 20
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 15
- 239000000651 prodrug Substances 0.000 claims 15
- 229940002612 prodrug Drugs 0.000 claims 15
- 150000003839 salts Chemical class 0.000 claims 15
- 239000012453 solvate Substances 0.000 claims 15
- 125000000217 alkyl group Chemical group 0.000 claims 14
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 229910052760 oxygen Inorganic materials 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000002950 monocyclic group Chemical group 0.000 claims 4
- 125000001624 naphthyl group Chemical group 0.000 claims 4
- 125000006413 ring segment Chemical group 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 125000002178 anthracenyl group Chemical group C1(=CC=CC2=CC3=CC=CC=C3C=C12)* 0.000 claims 2
- 229940126573 antibacterial therapeutic Drugs 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 201000003883 Cystic fibrosis Diseases 0.000 claims 1
- 241000790917 Dioxys <bee> Species 0.000 claims 1
- 208000032536 Pseudomonas Infections Diseases 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 206010057190 Respiratory tract infections Diseases 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 150000001721 carbon Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 239000004615 ingredient Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15160612.6 | 2015-03-24 | ||
| EP15160612 | 2015-03-24 | ||
| PCT/EP2016/056486 WO2016151066A1 (en) | 2015-03-24 | 2016-03-24 | Inhibitors of pseudomonas aeruginosa lecb |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020192508A Division JP2021046411A (ja) | 2015-03-24 | 2020-11-19 | 緑膿菌（Ｐｓｅｕｄｏｍｏｎａｓ ａｅｒｕｇｉｎｏｓａ）ＬｅｃＢの阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018510908A JP2018510908A (ja) | 2018-04-19 |
| JP2018510908A5 true JP2018510908A5 (enExample) | 2019-04-11 |
| JP6862410B2 JP6862410B2 (ja) | 2021-04-21 |
Family
ID=52706073
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018500857A Active JP6862410B2 (ja) | 2015-03-24 | 2016-03-24 | 緑膿菌（Ｐｓｅｕｄｏｍｏｎａｓ ａｅｒｕｇｉｎｏｓａ）ＬｅｃＢの阻害剤 |
| JP2020192508A Withdrawn JP2021046411A (ja) | 2015-03-24 | 2020-11-19 | 緑膿菌（Ｐｓｅｕｄｏｍｏｎａｓ ａｅｒｕｇｉｎｏｓａ）ＬｅｃＢの阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020192508A Withdrawn JP2021046411A (ja) | 2015-03-24 | 2020-11-19 | 緑膿菌（Ｐｓｅｕｄｏｍｏｎａｓ ａｅｒｕｇｉｎｏｓａ）ＬｅｃＢの阻害剤 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US10407398B2 (enExample) |
| EP (1) | EP3274341B1 (enExample) |
| JP (2) | JP6862410B2 (enExample) |
| CN (1) | CN107531686B (enExample) |
| AU (1) | AU2016236187B2 (enExample) |
| IL (1) | IL254580B (enExample) |
| WO (1) | WO2016151066A1 (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7430381B2 (ja) * | 2020-02-04 | 2024-02-13 | 水谷ペイント株式会社 | バイオフィルム破壊能の評価方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT72878B (en) | 1980-04-24 | 1983-03-29 | Merck & Co Inc | Process for preparing mannich-base hydroxamic acid pro-drugs for the improved delivery of non-steroidal anti-inflammatory agents |
| US5789385A (en) * | 1993-06-16 | 1998-08-04 | Glycomed Incorporated | Sialyl Lewisx mimetics containing phenyl backbones |
| EP2650289B1 (en) | 2012-04-10 | 2016-07-27 | Universität Konstanz | Glycomimetics as pseudomonas Aeruginosa lectin inhibitors |
-
2016
- 2016-03-24 WO PCT/EP2016/056486 patent/WO2016151066A1/en not_active Ceased
- 2016-03-24 US US15/560,784 patent/US10407398B2/en active Active
- 2016-03-24 JP JP2018500857A patent/JP6862410B2/ja active Active
- 2016-03-24 CN CN201680024047.9A patent/CN107531686B/zh active Active
- 2016-03-24 EP EP16713807.2A patent/EP3274341B1/en active Active
- 2016-03-24 AU AU2016236187A patent/AU2016236187B2/en active Active
-
2017
- 2017-09-18 IL IL254580A patent/IL254580B/en active IP Right Grant
-
2020
- 2020-11-19 JP JP2020192508A patent/JP2021046411A/ja not_active Withdrawn
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