JP2018510329A5 - - Google Patents

Download PDF

Info

Publication number
JP2018510329A5
JP2018510329A5 JP2017540674A JP2017540674A JP2018510329A5 JP 2018510329 A5 JP2018510329 A5 JP 2018510329A5 JP 2017540674 A JP2017540674 A JP 2017540674A JP 2017540674 A JP2017540674 A JP 2017540674A JP 2018510329 A5 JP2018510329 A5 JP 2018510329A5
Authority
JP
Japan
Prior art keywords
nanopore
fluid
conversion element
nanopore sensor
sensor according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2017540674A
Other languages
English (en)
Japanese (ja)
Other versions
JP2018510329A (ja
JP6800862B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2016/016664 external-priority patent/WO2016127007A2/en
Publication of JP2018510329A publication Critical patent/JP2018510329A/ja
Publication of JP2018510329A5 publication Critical patent/JP2018510329A5/ja
Application granted granted Critical
Publication of JP6800862B2 publication Critical patent/JP6800862B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2017540674A 2015-02-05 2016-02-04 流体通路を含むナノポアセンサ Active JP6800862B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562112630P 2015-02-05 2015-02-05
US62/112,630 2015-02-05
PCT/US2016/016664 WO2016127007A2 (en) 2015-02-05 2016-02-04 Nanopore sensor including fluidic passage

Related Child Applications (2)

Application Number Title Priority Date Filing Date
JP2020195190A Division JP7229219B2 (ja) 2015-02-05 2020-11-25 流体通路を含むナノポアセンサ
JP2020195192A Division JP7026757B2 (ja) 2015-02-05 2020-11-25 流体通路を含むナノポアセンサ

Publications (3)

Publication Number Publication Date
JP2018510329A JP2018510329A (ja) 2018-04-12
JP2018510329A5 true JP2018510329A5 (https=) 2019-03-14
JP6800862B2 JP6800862B2 (ja) 2020-12-16

Family

ID=55410256

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2017540674A Active JP6800862B2 (ja) 2015-02-05 2016-02-04 流体通路を含むナノポアセンサ
JP2020195190A Active JP7229219B2 (ja) 2015-02-05 2020-11-25 流体通路を含むナノポアセンサ
JP2020195192A Active JP7026757B2 (ja) 2015-02-05 2020-11-25 流体通路を含むナノポアセンサ
JP2022020919A Active JP7279219B2 (ja) 2015-02-05 2022-02-15 流体通路を含むナノポアセンサ

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2020195190A Active JP7229219B2 (ja) 2015-02-05 2020-11-25 流体通路を含むナノポアセンサ
JP2020195192A Active JP7026757B2 (ja) 2015-02-05 2020-11-25 流体通路を含むナノポアセンサ
JP2022020919A Active JP7279219B2 (ja) 2015-02-05 2022-02-15 流体通路を含むナノポアセンサ

Country Status (5)

Country Link
US (5) US10794895B2 (https=)
EP (2) EP4293349A3 (https=)
JP (4) JP6800862B2 (https=)
CN (2) CN112816679B (https=)
WO (1) WO2016127007A2 (https=)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0724736D0 (en) 2007-12-19 2008-01-30 Oxford Nanolabs Ltd Formation of layers of amphiphilic molecules
CN108051578B (zh) 2011-04-04 2020-07-24 哈佛大学校长及研究员协会 通过局部电位测量进行的纳米孔感测
GB201202519D0 (en) 2012-02-13 2012-03-28 Oxford Nanopore Tech Ltd Apparatus for supporting an array of layers of amphiphilic molecules and method of forming an array of layers of amphiphilic molecules
US11135546B2 (en) 2012-03-15 2021-10-05 Massachusetts Institute Of Technology Graphene based filter
GB201313121D0 (en) 2013-07-23 2013-09-04 Oxford Nanopore Tech Ltd Array of volumes of polar medium
US9901879B2 (en) * 2013-11-01 2018-02-27 Massachusetts Institute Of Technology Mitigating leaks in membranes
US9658190B2 (en) * 2014-12-18 2017-05-23 Genia Technologies, Inc. Printed electrode
CN112816679B (zh) 2015-02-05 2024-05-28 哈佛大学校长及研究员协会 一种用于感测分子穿过纳米孔的移位的方法
GB201510322D0 (en) * 2015-06-12 2015-07-29 Imp Innovations Ltd Apparatus and method
GB201611770D0 (en) 2016-07-06 2016-08-17 Oxford Nanopore Tech Microfluidic device
GB201619930D0 (en) * 2016-11-24 2017-01-11 Oxford Nanopore Tech Apparatus and methods for controlling insertion of a membrane channel into a membrane
EP3615684A4 (en) * 2017-04-28 2021-02-24 The University of Ottawa CONTROL OF TRANSLOCATING MOLECULES THROUGH A NANOPORE
AU2018290975B2 (en) 2017-06-29 2024-10-03 President And Fellows Of Harvard College Deterministic stepping of polymers through a nanopore
US10752496B2 (en) 2017-09-22 2020-08-25 Applied Materials, Inc. Pore formation in a substrate
GB2568895B (en) 2017-11-29 2021-10-27 Oxford Nanopore Tech Ltd Microfluidic device
EP3502688B1 (en) * 2017-12-22 2019-11-13 IMEC vzw Nanopore fet sensor with non-linear potential profile
NZ759671A (en) * 2018-02-16 2022-07-01 Illumina Inc Device for sequencing
GB2574048B (en) 2018-05-24 2021-06-16 Oxford Nanopore Tech Ltd Nanopore sensor component with electrostatic discharge protection
US12083483B2 (en) 2018-06-28 2024-09-10 Massachusetts Institute Of Technology Coatings to improve the selectivity of atomically thin membranes
US11307161B2 (en) 2018-07-11 2022-04-19 Aipore Inc. Flow passage
WO2020010589A1 (en) * 2018-07-12 2020-01-16 Shenzhen Genorivision Technology Co., Ltd. An apparatus for biopolymer sequencing
WO2020068400A2 (en) * 2018-09-07 2020-04-02 Ontera Inc. Sensing compositions, methods, and devices for the detection of molecules using a nanopore device
US11249067B2 (en) 2018-10-29 2022-02-15 Applied Materials, Inc. Nanopore flow cells and methods of fabrication
JP7492200B2 (ja) * 2019-03-12 2024-05-29 オックスフォード ナノポール テクノロジーズ ピーエルシー ナノ細孔センシングデバイスと操作方法およびその成形方法
JP7590000B2 (ja) * 2019-05-28 2024-11-26 国立大学法人 東京大学 ポアデバイスを用いた分析装置および分析法
CN112147185B (zh) * 2019-06-29 2022-07-01 清华大学 一种控制多肽穿过纳米孔速度的方法及其应用
US11536708B2 (en) * 2020-01-09 2022-12-27 Applied Materials, Inc. Methods to fabricate dual pore devices
WO2021188521A1 (en) 2020-03-18 2021-09-23 Nanodx, Inc. Measurement systems and associated techniques for sensing electrical characteristics of a sensor
AU2021299182A1 (en) * 2020-07-02 2023-01-05 Illumina, Inc. Devices with field effect transistors
EP4675256A3 (en) 2020-07-17 2026-01-28 Oxford Nanopore Technologies PLC Nanopore sensing device
US11738226B1 (en) 2021-03-11 2023-08-29 Darsh Shah Trampoline monitoring and alert system
US11994484B2 (en) * 2021-03-25 2024-05-28 The Regents Of The University Of California Apparatus and method for single cell discrimination
KR102514030B1 (ko) * 2021-03-31 2023-03-24 고려대학교 산학협력단 마이크로 포어를 이용한 단일 세포 분석 장치
US12493024B2 (en) 2021-03-31 2025-12-09 Illumina, Inc. Scalable circuit for molecular detection
GB2610380A (en) 2021-08-23 2023-03-08 Cambridge Entpr Ltd Nucleic acid detection
CN113690475B (zh) * 2021-08-30 2024-01-05 北京工业大学 一种柔性浓差电池及其制备方法
CN113552332B (zh) 2021-09-22 2022-04-22 成都齐碳科技有限公司 用于感测包含在液体中的分析物的装置和设备
GB202113935D0 (en) 2021-09-29 2021-11-10 Cambridge Entpr Ltd Nucleic acid characterisation
CN115876866B (zh) * 2021-09-30 2024-12-24 成都今是科技有限公司 纳米孔测序电路单元及基因测序装置
CN115901907B (zh) * 2021-09-30 2024-11-22 成都今是科技有限公司 一种超小面积的微电流检测电路单元和系统
CN114113280A (zh) * 2021-11-24 2022-03-01 中国科学院重庆绿色智能技术研究院 用于高分子聚合物自组装结构检测的检测体系及检测方法
US12487229B2 (en) 2021-12-08 2025-12-02 Western Digital Technologies, Inc. Devices, systems, and methods of using smart fluids to control molecule speeds
US11892445B2 (en) * 2021-12-08 2024-02-06 Western Digital Technologies, Inc. Devices, systems, and methods of using smart fluids to control translocation speed through a nanopore
US12259353B2 (en) 2022-04-19 2025-03-25 Western Digital Technologies, Inc. Amplifiers for biological sensing applications
KR102818274B1 (ko) * 2022-04-22 2025-06-10 울산과학기술원 멤브레인이 형성된 미세유체 채널 제작방법 및 그 미세유체 채널 내부에 멤브레인을 형성하는 장치
TWI825704B (zh) * 2022-05-06 2023-12-11 國立清華大學 微米孔微流體晶片系統及其量測細菌電性的用途
US20240027395A1 (en) * 2022-07-21 2024-01-25 Acorn Genetics Inc. Graphene nanoribbon with nanopore-based signal detection and genetic sequencing technology
KR20250116014A (ko) 2022-10-28 2025-07-31 리엑스유니버시테이트 그로닝겐 나노기공-기반 단백질 분석
WO2024141401A1 (en) * 2022-12-28 2024-07-04 Imec Vzw Fet-based nanopore sensing device
US12461064B2 (en) 2023-06-23 2025-11-04 Western Digital Technologies, Inc. Magnetic control of molecule translocation speed through a nanopore

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795782A (en) * 1995-03-17 1998-08-18 President & Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
US6362002B1 (en) 1995-03-17 2002-03-26 President And Fellows Of Harvard College Characterization of individual polymer molecules based on monomer-interface interactions
WO2000034527A2 (en) * 1998-12-11 2000-06-15 The Regents Of The University Of California Targeted molecular bar codes
US6783643B2 (en) 1999-06-22 2004-08-31 President And Fellows Of Harvard College Control of solid state dimensional features
EP2383776B1 (en) 1999-06-22 2015-02-25 President and Fellows of Harvard College Solid state nanopore device for evaluating biopolymers
US8206568B2 (en) 1999-06-22 2012-06-26 President And Fellows Of Harvard College Material deposition techniques for control of solid state aperture surface properties
US20060292041A1 (en) * 2000-03-23 2006-12-28 Dugas Matthew P Solid state membrane channel device for the measurement and characterization of atomic and molecular sized samples
US6723814B2 (en) 2000-05-16 2004-04-20 Biocure, Inc. Amphiphilic copolymer planar membranes
US6919002B2 (en) 2002-05-17 2005-07-19 Agilent Technologies, Inc. Nanopore system using nanotubes and C60 molecules
US6870361B2 (en) 2002-12-21 2005-03-22 Agilent Technologies, Inc. System with nano-scale conductor and nano-opening
US7910064B2 (en) * 2003-06-03 2011-03-22 Nanosys, Inc. Nanowire-based sensor configurations
WO2005017025A2 (en) 2003-08-15 2005-02-24 The President And Fellows Of Harvard College Study of polymer molecules and conformations with a nanopore
US7238485B2 (en) * 2004-03-23 2007-07-03 President And Fellows Of Harvard College Methods and apparatus for characterizing polynucleotides
US20060068401A1 (en) 2004-09-30 2006-03-30 Flory Curt A Biopolymer resonant tunneling with a gate voltage source
US20060210995A1 (en) 2005-03-15 2006-09-21 Joyce Timothy H Nanopore analysis systems and methods of using nanopore devices
ATE529734T1 (de) * 2005-04-06 2011-11-15 Harvard College Molekulare charakterisierung mit kohlenstoff- nanoröhrchen-steuerung
US7947485B2 (en) * 2005-06-03 2011-05-24 Hewlett-Packard Development Company, L.P. Method and apparatus for molecular analysis using nanoelectronic circuits
US20060275779A1 (en) * 2005-06-03 2006-12-07 Zhiyong Li Method and apparatus for molecular analysis using nanowires
US20070178507A1 (en) * 2006-01-31 2007-08-02 Wei Wu Method and apparatus for detection of molecules using nanopores
US9034637B2 (en) * 2007-04-25 2015-05-19 Nxp, B.V. Apparatus and method for molecule detection using nanopores
WO2009020682A2 (en) 2007-05-08 2009-02-12 The Trustees Of Boston University Chemical functionalization of solid-state nanopores and nanopore arrays and applications thereof
WO2009035647A1 (en) * 2007-09-12 2009-03-19 President And Fellows Of Harvard College High-resolution molecular graphene sensor comprising an aperture in the graphene layer
US8273532B2 (en) * 2007-10-02 2012-09-25 President And Fellows Of Harvard College Capture, recapture, and trapping of molecules with a nanopore
AU2008307486B2 (en) 2007-10-02 2014-08-14 President And Fellows Of Harvard College Carbon nanotube synthesis for nanopore devices
KR20110125226A (ko) 2009-01-30 2011-11-18 옥스포드 나노포어 테크놀로지즈 리미티드 혼성화 링커
GB0905140D0 (en) 2009-03-25 2009-05-06 Isis Innovation Method
WO2010111605A2 (en) * 2009-03-27 2010-09-30 Nabsys, Inc. Devices and methods for analyzing biomolecules and probes bound thereto
US9017937B1 (en) 2009-04-10 2015-04-28 Pacific Biosciences Of California, Inc. Nanopore sequencing using ratiometric impedance
US8986928B2 (en) * 2009-04-10 2015-03-24 Pacific Biosciences Of California, Inc. Nanopore sequencing devices and methods
BR112012005888B1 (pt) 2009-09-18 2019-10-22 President And Fellows Of Harvard College sensores de nanoporo de grafeno e método para avaliar uma molécula de polímero
US8748091B2 (en) 2009-12-18 2014-06-10 The Board Of Trustees Of The University Of Illinois Characterizing stretched polynucleotides in a synthetic nanopassage
EP2521796B1 (en) 2010-01-04 2015-07-29 Life Technologies Corporation Dna sequencing methods and detectors and systems for carrying out the same
US8652779B2 (en) * 2010-04-09 2014-02-18 Pacific Biosciences Of California, Inc. Nanopore sequencing using charge blockade labels
US8828211B2 (en) 2010-06-08 2014-09-09 President And Fellows Of Harvard College Nanopore device with graphene supported artificial lipid membrane
US8940148B2 (en) 2010-06-22 2015-01-27 International Business Machines Corporation Nano-fluidic field effective device to control DNA transport through the same
US8986524B2 (en) * 2011-01-28 2015-03-24 International Business Machines Corporation DNA sequence using multiple metal layer structure with different organic coatings forming different transient bondings to DNA
US8901914B2 (en) 2011-01-31 2014-12-02 The Regents Of The University Of California High throughput label free nanoparticle detection and size assay
KR101939420B1 (ko) 2011-02-11 2019-01-16 옥스포드 나노포어 테크놀로지즈 리미티드 돌연변이체 세공
CN108051578B (zh) * 2011-04-04 2020-07-24 哈佛大学校长及研究员协会 通过局部电位测量进行的纳米孔感测
US8518829B2 (en) * 2011-04-22 2013-08-27 International Business Machines Corporation Self-sealed fluidic channels for nanopore array
GB201111237D0 (en) * 2011-06-30 2011-08-17 Isis Innovation Nanochip
US10761043B2 (en) 2011-07-22 2020-09-01 The Trustees Of The University Of Pennsylvania Graphene-based nanopore and nanostructure devices and methods for macromolecular analysis
KR102023754B1 (ko) * 2011-07-27 2019-09-20 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 생체분자 특성규명용 나노포어 센서
JP6457811B2 (ja) * 2011-09-23 2019-01-23 オックスフォード ナノポール テクノロジーズ リミテッド ポリマー単位を含むポリマーの解析
CN104039979B (zh) 2011-10-21 2016-08-24 牛津纳米孔技术公司 使用孔和Hel308解旋酶表征目标多核苷酸的酶方法
KR101933619B1 (ko) 2011-12-26 2018-12-31 삼성전자주식회사 나노포어 소자 및 그 제조 방법, 나노포어 소자를 포함하는 핵산 검출 장치
WO2013123379A2 (en) * 2012-02-16 2013-08-22 The Regents Of The University Of California Nanopore sensor for enzyme-mediated protein translocation
CN104321441B (zh) 2012-02-16 2016-10-19 牛津楠路珀尔科技有限公司 聚合物的测量的分析
CA2833368A1 (en) * 2012-03-29 2013-10-03 Osaka University Polynucleotide base sequence determination method and polynucleotide base sequence determination device
KR101906967B1 (ko) * 2012-04-05 2018-10-11 삼성전자주식회사 나노갭 센서 및 이의 제조 방법
KR102083695B1 (ko) 2012-04-10 2020-03-02 옥스포드 나노포어 테크놀로지즈 리미티드 돌연변이체 리세닌 기공
EP3674412A1 (en) 2012-06-20 2020-07-01 The Trustees of Columbia University in the City of New York Nucleic acid sequencing by nanopore detection of tag molecules
CA2879261C (en) 2012-07-19 2022-12-06 Oxford Nanopore Technologies Limited Modified helicases
KR20150041146A (ko) * 2012-08-17 2015-04-15 오사카 유니버시티 시료의 분석 방법
US9021864B2 (en) 2012-08-21 2015-05-05 International Business Machines Corporation Sensing biomolecules using scanning probe with twin-nanopore to detect a change in the magnitude of the current through the second nanopore
CN102901763B (zh) 2012-09-25 2014-06-11 清华大学 基于石墨烯纳米孔-微腔-固态纳米孔的dna测序装置及制作方法
JP6282036B2 (ja) 2012-12-27 2018-02-21 クオンタムバイオシステムズ株式会社 物質の移動速度の制御方法および制御装置
US20160025702A1 (en) 2013-03-13 2016-01-28 Arizona Board Of Regents On Behalf Of Arizona State University Systems, devices and methods for translocation control
CA3116407C (en) 2013-03-15 2023-02-07 President And Fellows Of Harvard College Surface wetting method
JP2014190891A (ja) * 2013-03-28 2014-10-06 Hitachi High-Technologies Corp ナノポア式分析装置の電圧印加システム
US8890121B1 (en) * 2013-05-06 2014-11-18 International Business Machines Corporation Integrated nanowire/nanosheet nanogap and nanopore for DNA and RNA sequencing
US9377431B2 (en) * 2013-07-24 2016-06-28 Globalfoundries Inc. Heterojunction nanopore for sequencing
US10344324B2 (en) 2014-03-26 2019-07-09 International Business Machines Corporation Electrical trapping and stretching of charged biomolecules by single electrode gating structure
CN112816679B (zh) 2015-02-05 2024-05-28 哈佛大学校长及研究员协会 一种用于感测分子穿过纳米孔的移位的方法
GB201508669D0 (en) 2015-05-20 2015-07-01 Oxford Nanopore Tech Ltd Methods and apparatus for forming apertures in a solid state membrane using dielectric breakdown
NZ759671A (en) 2018-02-16 2022-07-01 Illumina Inc Device for sequencing
JP7492200B2 (ja) 2019-03-12 2024-05-29 オックスフォード ナノポール テクノロジーズ ピーエルシー ナノ細孔センシングデバイスと操作方法およびその成形方法
GB202016874D0 (en) 2020-10-23 2020-12-09 Oxford Nanopore Tech Ltd Nanopore support structure and manufacture thereof
EP4675256A3 (en) 2020-07-17 2026-01-28 Oxford Nanopore Technologies PLC Nanopore sensing device

Similar Documents

Publication Publication Date Title
JP2018510329A5 (https=)
US12392767B2 (en) Nanopore arrays
CN107850627B (zh) 用于测量电流的设备和方法
US9470651B2 (en) Electro-diffusion enhanced bio-molecule charge detection using electrostatic interaction
US20070048745A1 (en) Systems and methods for partitioned nanopore analysis of polymers
US20060210995A1 (en) Nanopore analysis systems and methods of using nanopore devices
CN110023753B (zh) 用于控制膜通道插入膜中的设备和方法
CN103492868B (zh) 物质的移动速度的控制方法及控制装置、以及它们的应用
US20080032290A1 (en) Nanopore flow cells
KR20160097639A (ko) 생체분자 농축 기능 일체형 센서 및 그 제조방법
US20230296582A1 (en) Calibration and profiling of a nanopore array device
JP5781256B2 (ja) リーダー装置および信号増幅方法
JP2019117050A (ja) 粒子検出装置
KR20170062696A (ko) 미세유체칩 기반의 병원균 검출에서 계면동전기 흐름전위에 의한 비표지 센싱 방법 및 장치
JP2007271619A (ja) イオン物質のサイズ及び濃度を同時に検出する方法及び装置
CN119096143A (zh) 纳米孔阵列装置的校准
CN120457341A (zh) 纳米孔阵列装置的校准
JP2019022522A (ja) 物質の移動速度の制御方法および制御装置、並びに、これらの利用