JP2018509907A5 - - Google Patents
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- JP2018509907A5 JP2018509907A5 JP2017548919A JP2017548919A JP2018509907A5 JP 2018509907 A5 JP2018509907 A5 JP 2018509907A5 JP 2017548919 A JP2017548919 A JP 2017548919A JP 2017548919 A JP2017548919 A JP 2017548919A JP 2018509907 A5 JP2018509907 A5 JP 2018509907A5
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 982
- 230000027455 binding Effects 0.000 claims description 377
- 239000000427 antigen Substances 0.000 claims description 321
- 102000036639 antigens Human genes 0.000 claims description 321
- 108091007433 antigens Proteins 0.000 claims description 321
- 239000012634 fragment Substances 0.000 claims description 246
- 210000004027 cell Anatomy 0.000 claims description 197
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims description 83
- 102100023123 Mucin-16 Human genes 0.000 claims description 83
- 238000000338 in vitro Methods 0.000 claims description 52
- 108010082117 matrigel Proteins 0.000 claims description 52
- 230000009545 invasion Effects 0.000 claims description 51
- 238000000034 method Methods 0.000 claims description 49
- 229910052757 nitrogen Inorganic materials 0.000 claims description 32
- 230000013595 glycosylation Effects 0.000 claims description 31
- 238000006206 glycosylation reaction Methods 0.000 claims description 31
- 108091033319 polynucleotide Proteins 0.000 claims description 24
- 102000040430 polynucleotide Human genes 0.000 claims description 24
- 239000002157 polynucleotide Substances 0.000 claims description 24
- 125000000539 amino acid group Chemical group 0.000 claims description 22
- QLTSDROPCWIKKY-PMCTYKHCSA-N beta-D-glucosaminyl-(1->4)-beta-D-glucosamine Chemical compound O[C@@H]1[C@@H](N)[C@H](O)O[C@H](CO)[C@H]1O[C@H]1[C@H](N)[C@@H](O)[C@H](O)[C@@H](CO)O1 QLTSDROPCWIKKY-PMCTYKHCSA-N 0.000 claims description 19
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 14
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 14
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 11
- 239000003814 drug Substances 0.000 claims description 11
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 10
- 150000007523 nucleic acids Chemical group 0.000 claims description 10
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 229910052698 phosphorus Inorganic materials 0.000 claims description 10
- 206010028980 Neoplasm Diseases 0.000 claims description 7
- 229940127089 cytotoxic agent Drugs 0.000 claims description 7
- 239000002254 cytotoxic agent Substances 0.000 claims description 7
- 231100000599 cytotoxic agent Toxicity 0.000 claims description 7
- 229940079593 drug Drugs 0.000 claims description 7
- 239000012216 imaging agent Substances 0.000 claims description 7
- 108060003951 Immunoglobulin Proteins 0.000 claims description 6
- 102000018358 immunoglobulin Human genes 0.000 claims description 6
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims description 5
- 201000011510 cancer Diseases 0.000 claims description 5
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 238000012258 culturing Methods 0.000 claims description 4
- 229940124597 therapeutic agent Drugs 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 2
- 210000000481 breast Anatomy 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 201000005202 lung cancer Diseases 0.000 claims description 2
- 208000020816 lung neoplasm Diseases 0.000 claims description 2
- 210000003101 oviduct Anatomy 0.000 claims description 2
- 210000000496 pancreas Anatomy 0.000 claims description 2
- 210000004291 uterus Anatomy 0.000 claims description 2
- 201000005296 lung carcinoma Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000004303 peritoneum Anatomy 0.000 claims 1
- 230000002163 immunogen Effects 0.000 description 54
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 description 53
- 108010015899 Glycopeptides Proteins 0.000 description 53
- 102000002068 Glycopeptides Human genes 0.000 description 53
- 150000001720 carbohydrates Chemical class 0.000 description 14
- 108020001507 fusion proteins Proteins 0.000 description 7
- 102000037865 fusion proteins Human genes 0.000 description 7
- 150000002016 disaccharides Chemical class 0.000 description 6
- 229940127121 immunoconjugate Drugs 0.000 description 6
- 239000003795 chemical substances by application Substances 0.000 description 5
- 102000014914 Carrier Proteins Human genes 0.000 description 4
- 108010078791 Carrier Proteins Proteins 0.000 description 4
- 108090000288 Glycoproteins Proteins 0.000 description 4
- 102000003886 Glycoproteins Human genes 0.000 description 4
- 241000283984 Rodentia Species 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 2
- OVRNDRQMDRJTHS-RTRLPJTCSA-N N-acetyl-D-glucosamine Chemical compound CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-RTRLPJTCSA-N 0.000 description 2
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 2
- ATHHXGZTWNVVOU-UHFFFAOYSA-N N-methylformamide Chemical class CNC=O ATHHXGZTWNVVOU-UHFFFAOYSA-N 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 description 2
- 150000002772 monosaccharides Chemical class 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- 150000004044 tetrasaccharides Chemical class 0.000 description 2
- 150000004043 trisaccharides Chemical class 0.000 description 2
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 241000283074 Equus asinus Species 0.000 description 1
- 201000001342 Fallopian tube cancer Diseases 0.000 description 1
- 208000013452 Fallopian tube neoplasm Diseases 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 206010033128 Ovarian cancer Diseases 0.000 description 1
- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 208000026149 Primary peritoneal carcinoma Diseases 0.000 description 1
- 208000002495 Uterine Neoplasms Diseases 0.000 description 1
- 230000000890 antigenic effect Effects 0.000 description 1
- 150000001508 asparagines Chemical class 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
- 208000008443 pancreatic carcinoma Diseases 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 206010046766 uterine cancer Diseases 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562134402P | 2015-03-17 | 2015-03-17 | |
| US62/134,402 | 2015-03-17 | ||
| PCT/US2016/022643 WO2016149368A1 (en) | 2015-03-17 | 2016-03-16 | Anti-muc16 antibodies and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020162274A Division JP2021000132A (ja) | 2015-03-17 | 2020-09-28 | 抗ｍｕｃ１６抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018509907A JP2018509907A (ja) | 2018-04-12 |
| JP2018509907A5 true JP2018509907A5 (OSRAM) | 2019-04-25 |
| JP6968698B2 JP6968698B2 (ja) | 2021-11-24 |
Family
ID=55755670
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017548919A Active JP6968698B2 (ja) | 2015-03-17 | 2016-03-16 | 抗ｍｕｃ１６抗体及びその使用 |
| JP2020162274A Withdrawn JP2021000132A (ja) | 2015-03-17 | 2020-09-28 | 抗ｍｕｃ１６抗体及びその使用 |
| JP2022091593A Withdrawn JP2022116314A (ja) | 2015-03-17 | 2022-06-06 | 抗ｍｕｃ１６抗体及びその使用 |
| JP2024232825A Pending JP2025061682A (ja) | 2015-03-17 | 2024-12-27 | 抗ｍｕｃ１６抗体及びその使用 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020162274A Withdrawn JP2021000132A (ja) | 2015-03-17 | 2020-09-28 | 抗ｍｕｃ１６抗体及びその使用 |
| JP2022091593A Withdrawn JP2022116314A (ja) | 2015-03-17 | 2022-06-06 | 抗ｍｕｃ１６抗体及びその使用 |
| JP2024232825A Pending JP2025061682A (ja) | 2015-03-17 | 2024-12-27 | 抗ｍｕｃ１６抗体及びその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US11066480B2 (OSRAM) |
| EP (2) | EP4190817A1 (OSRAM) |
| JP (4) | JP6968698B2 (OSRAM) |
| KR (1) | KR102618312B1 (OSRAM) |
| CN (2) | CN115368460A (OSRAM) |
| AU (3) | AU2016233309B2 (OSRAM) |
| CA (1) | CA2979976A1 (OSRAM) |
| ES (1) | ES2929614T3 (OSRAM) |
| IL (3) | IL296062A (OSRAM) |
| MX (2) | MX391249B (OSRAM) |
| RU (1) | RU2758113C2 (OSRAM) |
| SG (1) | SG11201707538XA (OSRAM) |
| WO (1) | WO2016149368A1 (OSRAM) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9169328B2 (en) | 2010-03-26 | 2015-10-27 | Memorial Sloan Kettering Cancer Center | Antibodies to MUC16 and methods of use thereof |
| SI3218005T1 (sl) | 2014-11-12 | 2023-06-30 | Seagen Inc. | Z glikanom delujoče spojine, in postopki uporabe |
| ES2929614T3 (es) | 2015-03-17 | 2022-11-30 | Memorial Sloan Kettering Cancer Center | Anticuerpos anti-MUC16 y usos de los mismos |
| IL295398B2 (en) | 2015-10-23 | 2025-01-01 | Eureka Therapeutics Inc | Antibody/T-cell receptor chimeric constructs and their uses |
| CA3002097A1 (en) | 2015-11-12 | 2017-05-18 | Siamab Therapeutics, Inc. | Glycan-interacting compounds and methods of use |
| RS63660B1 (sr) * | 2016-09-23 | 2022-11-30 | Regeneron Pharma | Anti-muc16 (mucin 16) antitela |
| EP3541847A4 (en) * | 2016-11-17 | 2020-07-08 | Seattle Genetics, Inc. | COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE |
| EP3544612A4 (en) | 2016-11-23 | 2020-05-13 | Acetylon Pharmaceuticals, Inc. | PHARMACEUTICAL COMBINATIONS COMPRISING A HISTONE DEACETYLASE INHIBITOR AND A CD38 INHIBITOR AND METHODS OF USING THE SAME |
| EP3589319A4 (en) | 2017-03-03 | 2021-07-14 | Seagen Inc. | COMPOUNDS INTERACTING WITH GLYCAN AND METHODS OF USE |
| CN110741016A (zh) | 2017-04-26 | 2020-01-31 | 优瑞科生物技术公司 | 嵌合抗体/t-细胞受体构筑体及其用途 |
| EA201990784A1 (ru) * | 2017-09-14 | 2019-09-30 | Ридженерон Фармасьютикалз, Инк. | Анти-muc16 (mucin16) антитела |
| WO2019152895A1 (en) * | 2018-02-01 | 2019-08-08 | Memorial Sloan Kettering Cancer Center | Antibodies to galectin-3 and methods of use thereof |
| CN112119095B (zh) * | 2018-05-09 | 2025-08-15 | 奎斯特制药科技公司 | Muc16单克隆抗体及其用途 |
| CN110527667A (zh) * | 2018-05-25 | 2019-12-03 | 深圳宾德生物技术有限公司 | 一种靶向muc16的嵌合抗原受体和嵌合抗原受体t细胞及其制备方法和应用 |
| CN110526974A (zh) * | 2018-05-25 | 2019-12-03 | 深圳宾德生物技术有限公司 | 一种靶向muc16的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
| CN110526988A (zh) * | 2018-05-25 | 2019-12-03 | 深圳宾德生物技术有限公司 | 一种靶向muc1的嵌合抗原受体和嵌合抗原受体t细胞及其制备方法和应用 |
| CN110526977A (zh) * | 2018-05-25 | 2019-12-03 | 深圳宾德生物技术有限公司 | 一种靶向muc1的单链抗体、嵌合抗原受体t细胞及其制备方法和应用 |
| US12168696B2 (en) * | 2018-11-16 | 2024-12-17 | Memorial Sloan Kettering Cancer Center | Antibodies to mucin-16 (MUC16), encoding polynucleotides and methods of treating MUC16-positive cancer |
| CN114127116A (zh) * | 2019-05-08 | 2022-03-01 | 纪念斯隆凯特琳癌症中心 | 针对黏蛋白-16的人源化抗体及其使用方法 |
| CN118453851A (zh) | 2019-06-21 | 2024-08-09 | 瑞泽恩制药公司 | 结合muc16和cd3的双特异性抗原结合分子与4-1bb共刺激组合的用途 |
| US20210040174A1 (en) * | 2019-08-08 | 2021-02-11 | Navrogen, Inc. | Composition and Use of Humoral Immune Suppressor Antagonists for the Treatment of Humoral Immune Suppressed Diseases |
| US20230340623A1 (en) * | 2020-06-30 | 2023-10-26 | Universiteit Antwerpen | Mucins and isoforms thereof in diseases characterized by barrier dysfunction |
| US11883432B2 (en) | 2020-12-18 | 2024-01-30 | Century Therapeutics, Inc. | Chimeric antigen receptor system with adaptable receptor specificity |
| US12404315B2 (en) | 2020-12-21 | 2025-09-02 | Allogene Therapeutics, Inc. | Protease-activating CD45-gate CAR |
| EP4284918A1 (en) | 2021-01-29 | 2023-12-06 | Allogene Therapeutics, Inc. | Knockdown or knockout of one or more of tap2, nlrc5, beta2m, trac, rfx5, rfxap and rfxank to mitigate t cell recognition of allogeneic cell products |
| WO2022204249A1 (en) * | 2021-03-24 | 2022-09-29 | Memorial Sloan-Kettering Cancer Center | Variants of humanized anti-muc16 ectodomain antibodies for treatment of muc16 overexpressing tumors |
| CN113061186B (zh) * | 2021-04-09 | 2022-05-13 | 福州迈新生物技术开发有限公司 | 抗ca125蛋白的单克隆抗体及其细胞株、制备方法和应用 |
| CN115260305B (zh) * | 2021-04-29 | 2025-02-28 | 郑州大学 | 抗SARS-CoV-2 RBD单克隆抗体和应用 |
| CN114835805B (zh) * | 2022-06-10 | 2023-06-06 | 郑州大学 | 抗SARS-CoV-2 spike蛋白的单克隆抗体及应用 |
| WO2024026445A1 (en) | 2022-07-29 | 2024-02-01 | Allogene Therapeutics Inc. | Engineered cells with reduced gene expression to mitigate immune cell recognition |
| US20240262929A1 (en) * | 2023-02-06 | 2024-08-08 | Ibio, Inc. | Anti-muc16 antibodies |
| WO2025096560A1 (en) | 2023-10-30 | 2025-05-08 | Allogene Therapeutics, Inc. | Engineered cells |
| CN118684782A (zh) * | 2024-07-17 | 2024-09-24 | 武汉科技大学 | 一种muc16和folr1双靶点嵌合抗原受体dcar-16-r1及应用 |
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-
2016
- 2016-03-16 ES ES16716959T patent/ES2929614T3/es active Active
- 2016-03-16 EP EP22192814.6A patent/EP4190817A1/en active Pending
- 2016-03-16 CN CN202210174122.7A patent/CN115368460A/zh active Pending
- 2016-03-16 CN CN201680028517.9A patent/CN107667120B/zh active Active
- 2016-03-16 KR KR1020177029700A patent/KR102618312B1/ko active Active
- 2016-03-16 EP EP16716959.8A patent/EP3271398B1/en active Active
- 2016-03-16 SG SG11201707538XA patent/SG11201707538XA/en unknown
- 2016-03-16 WO PCT/US2016/022643 patent/WO2016149368A1/en not_active Ceased
- 2016-03-16 RU RU2017134592A patent/RU2758113C2/ru active
- 2016-03-16 JP JP2017548919A patent/JP6968698B2/ja active Active
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2020
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