JP2018509452A - 修飾デソサミン糖をもつマクロライドおよびその使用 - Google Patents

修飾デソサミン糖をもつマクロライドおよびその使用 Download PDF

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Publication number
JP2018509452A
JP2018509452A JP2017550153A JP2017550153A JP2018509452A JP 2018509452 A JP2018509452 A JP 2018509452A JP 2017550153 A JP2017550153 A JP 2017550153A JP 2017550153 A JP2017550153 A JP 2017550153A JP 2018509452 A JP2018509452 A JP 2018509452A
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optionally substituted
formula
alkyl
compound
represented
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Japanese (ja)
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JP2018509452A5 (enExample
Inventor
マイヤーズ，アンドリュー，ジー．
セイプル，イアン，バス
ツァン，ジヤン
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Harvard University
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Harvard University
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
JP2017550153A 2015-03-25 2016-03-25 修飾デソサミン糖をもつマクロライドおよびその使用 Pending JP2018509452A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562138198P 2015-03-25 2015-03-25
US201562138168P 2015-03-25 2015-03-25
US62/138,198 2015-03-25
US62/138,168 2015-03-25
PCT/US2016/024333 WO2016154591A1 (en) 2015-03-25 2016-03-25 Macrolides with modified desosamine sugars and uses thereof

Publications (2)

Publication Number Publication Date
JP2018509452A true JP2018509452A (ja) 2018-04-05
JP2018509452A5 JP2018509452A5 (enExample) 2019-05-09

Family

ID=56977809

Family Applications (1)

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JP2017550153A Pending JP2018509452A (ja) 2015-03-25 2016-03-25 修飾デソサミン糖をもつマクロライドおよびその使用

Country Status (7)

Country Link
US (2) US10640528B2 (enExample)
EP (1) EP3273969A4 (enExample)
JP (1) JP2018509452A (enExample)
CN (1) CN107530365A (enExample)
CA (1) CA2980315A1 (enExample)
HK (1) HK1250371A1 (enExample)
WO (1) WO2016154591A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014248014B2 (en) 2013-04-04 2018-11-08 President And Fellows Of Harvard College Macrolides and methods of their preparation and use
EP3211997A4 (en) 2014-10-08 2018-10-24 President and Fellows of Harvard College 14-membered ketolides and methods of their preparation and use
EP3273969A4 (en) 2015-03-25 2018-11-21 President and Fellows of Harvard College Macrolides with modified desosamine sugars and uses thereof
US11673910B2 (en) 2017-04-28 2023-06-13 Zikani Therapeutics, Inc. Macrolides with modified desosamine sugars and uses thereof
SG11202105227QA (en) * 2018-11-19 2021-06-29 Zikani Therapeutics Inc C10-alkylene substituted 13-membered macrolides and uses thereof
IL283185B2 (en) * 2018-11-19 2024-06-01 Zikani Therapeutics Inc Macrolides with 13 members converted to C10-cyclic and their uses

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Also Published As

Publication number Publication date
HK1250371A1 (zh) 2018-12-14
US20200377542A1 (en) 2020-12-03
US10640528B2 (en) 2020-05-05
US20180066008A1 (en) 2018-03-08
WO2016154591A1 (en) 2016-09-29
CA2980315A1 (en) 2016-09-29
US11535643B2 (en) 2022-12-27
CN107530365A (zh) 2018-01-02
EP3273969A4 (en) 2018-11-21
EP3273969A1 (en) 2018-01-31

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