JP2018508580A5 - - Google Patents
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- Publication number
- JP2018508580A5 JP2018508580A5 JP2017565038A JP2017565038A JP2018508580A5 JP 2018508580 A5 JP2018508580 A5 JP 2018508580A5 JP 2017565038 A JP2017565038 A JP 2017565038A JP 2017565038 A JP2017565038 A JP 2017565038A JP 2018508580 A5 JP2018508580 A5 JP 2018508580A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide chain
- compound
- modified
- branched peg
- peg component
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003815 Interleukin-11 Human genes 0.000 claims 36
- 108090000177 Interleukin-11 Proteins 0.000 claims 36
- 229940074383 interleukin-11 Drugs 0.000 claims 20
- 150000001875 compounds Chemical class 0.000 claims 16
- 238000000034 method Methods 0.000 claims 10
- 239000008194 pharmaceutical composition Substances 0.000 claims 10
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 208000020084 Bone disease Diseases 0.000 claims 2
- 101001010568 Homo sapiens Interleukin-11 Proteins 0.000 claims 2
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 claims 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 2
- 210000000988 bone and bone Anatomy 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 102000049885 human IL11 Human genes 0.000 claims 2
- 238000002347 injection Methods 0.000 claims 2
- 239000007924 injection Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000004852 Lung Injury Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010069363 Traumatic lung injury Diseases 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000000202 analgesic effect Effects 0.000 claims 1
- 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
- 239000002260 anti-inflammatory agent Substances 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 208000010643 digestive system disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 208000018685 gastrointestinal system disease Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 231100000515 lung injury Toxicity 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 150000003254 radicals Chemical class 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 206010043554 thrombocytopenia Diseases 0.000 claims 1
- 230000000472 traumatic effect Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021120139A JP7801104B2 (ja) | 2015-03-03 | 2021-07-21 | ポリエチレングリコール（ｐｅｇ）－インターロイキン１１（ｉｌ－１１）コンジュゲートを生成するための反応中間体、および、ｐｅｇ－ｉｌ－１１コンジュゲートを精製する方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562127748P | 2015-03-03 | 2015-03-03 | |
| US62/127,748 | 2015-03-03 | ||
| PCT/US2016/020294 WO2016140983A1 (en) | 2015-03-03 | 2016-03-01 | Compositions and methods for pegylated il-11 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021120139A Division JP7801104B2 (ja) | 2015-03-03 | 2021-07-21 | ポリエチレングリコール（ｐｅｇ）－インターロイキン１１（ｉｌ－１１）コンジュゲートを生成するための反応中間体、および、ｐｅｇ－ｉｌ－１１コンジュゲートを精製する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018508580A JP2018508580A (ja) | 2018-03-29 |
| JP2018508580A5 true JP2018508580A5 (enExample) | 2019-04-11 |
| JP6937984B2 JP6937984B2 (ja) | 2021-09-22 |
Family
ID=56848663
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017565038A Active JP6937984B2 (ja) | 2015-03-03 | 2016-03-01 | ペグ化ｉｌ−１１の組成物および方法 |
| JP2021120139A Active JP7801104B2 (ja) | 2015-03-03 | 2021-07-21 | ポリエチレングリコール（ｐｅｇ）－インターロイキン１１（ｉｌ－１１）コンジュゲートを生成するための反応中間体、および、ｐｅｇ－ｉｌ－１１コンジュゲートを精製する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021120139A Active JP7801104B2 (ja) | 2015-03-03 | 2021-07-21 | ポリエチレングリコール（ｐｅｇ）－インターロイキン１１（ｉｌ－１１）コンジュゲートを生成するための反応中間体、および、ｐｅｇ－ｉｌ－１１コンジュゲートを精製する方法 |
Country Status (7)
| Country | Link |
|---|---|
| US (4) | US10335492B2 (enExample) |
| EP (1) | EP3265479A4 (enExample) |
| JP (2) | JP6937984B2 (enExample) |
| CN (1) | CN107849108A (enExample) |
| HK (1) | HK1246306A1 (enExample) |
| TW (2) | TWI708611B (enExample) |
| WO (1) | WO2016140983A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI708611B (zh) * | 2015-03-03 | 2020-11-01 | 香港商南沙生物科技（香港）有限公司 | 聚乙二醇化介白素-１１之組合物及方法 |
| KR102958185B1 (ko) * | 2021-09-28 | 2026-04-30 | 한양대학교 산학협력단 | 암 치료용 글리시리진-분지형 폴리에틸렌글리콜 컨쥬게이트 |
| CN118388578B (zh) * | 2024-04-01 | 2025-01-24 | 北京大学口腔医学院 | 一种用于聚乙二醇化蛋白质的方法、非共价聚乙二醇化蛋白及含有其的蛋白质药物和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824784A (en) * | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US7495087B2 (en) * | 1997-07-14 | 2009-02-24 | Bolder Biotechnology, Inc. | Cysteine muteins in the C-D loop of human interleukin-11 |
| CN1316436A (zh) * | 2000-04-06 | 2001-10-10 | 赵剑 | 水溶性缓释重组蛋白质的制备方法 |
| AU2003303636B2 (en) * | 2002-12-26 | 2010-08-05 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof with preserved receptor-binding activity |
| JP2005281302A (ja) * | 2004-03-03 | 2005-10-13 | Astellas Pharma Inc | 修飾インターロイキン−１１及びそれを含有する医薬組成物 |
| WO2005085283A1 (ja) * | 2004-03-03 | 2005-09-15 | Yamanouchi Pharmaceutical Co., Ltd. | 修飾インターロイキン−１１及びそれを含有する医薬組成物 |
| MX2011002055A (es) * | 2008-08-25 | 2011-03-30 | Viromed Co Ltd | Conjugados de biopolimeros que contienen un analogo de interleucina-11. |
| EP2438169B1 (en) * | 2009-06-03 | 2017-08-09 | Tobira Therapeutics, Inc. | Nucleic acid modulators of glycoprotein vi |
| DK2478066T3 (en) * | 2009-09-18 | 2017-06-19 | Protherics Medicines Dev Ltd | BAB TRIBLOCK POLYMERS WITH IMPROVED DELIVERY CHARACTERISTICS |
| NZ603399A (en) * | 2010-05-17 | 2014-09-26 | Cebix Inc | Pegylated c-peptide |
| US9023791B2 (en) | 2010-11-19 | 2015-05-05 | Novartis Ag | Fibroblast growth factor 21 mutations |
| WO2013020079A2 (en) * | 2011-08-04 | 2013-02-07 | Nektar Therapeutics | Conjugates of an il-11 moiety and a polymer |
| WO2014008242A1 (en) * | 2012-07-03 | 2014-01-09 | The Trustees Of Columbia University In The City Of New York | The use of interleukin-11 to protect against ischemia and reperfusion injury |
| US8963121B2 (en) * | 2012-12-07 | 2015-02-24 | Micron Technology, Inc. | Vertical solid-state transducers and high voltage solid-state transducers having buried contacts and associated systems and methods |
| WO2014138086A1 (en) | 2013-03-05 | 2014-09-12 | Shifa Biomedical | Compositions and methods for the production of virus-like particles |
| CN104073482A (zh) * | 2013-12-30 | 2014-10-01 | 江苏众红生物工程创药研究院有限公司 | 聚乙二醇化的组织激肽释放酶及其制备方法和应用 |
| TWI708611B (zh) * | 2015-03-03 | 2020-11-01 | 香港商南沙生物科技（香港）有限公司 | 聚乙二醇化介白素-１１之組合物及方法 |
-
2016
- 2016-03-01 TW TW105106142A patent/TWI708611B/zh active
- 2016-03-01 CN CN201680024112.8A patent/CN107849108A/zh active Pending
- 2016-03-01 HK HK18105366.5A patent/HK1246306A1/zh unknown
- 2016-03-01 WO PCT/US2016/020294 patent/WO2016140983A1/en not_active Ceased
- 2016-03-01 US US15/554,415 patent/US10335492B2/en active Active
- 2016-03-01 JP JP2017565038A patent/JP6937984B2/ja active Active
- 2016-03-01 TW TW109132750A patent/TWI849231B/zh active
- 2016-03-01 EP EP16759370.6A patent/EP3265479A4/en active Pending
-
2019
- 2019-05-21 US US16/418,850 patent/US10946103B2/en active Active
- 2019-05-21 US US16/418,841 patent/US10881739B2/en active Active
-
2021
- 2021-02-11 US US17/173,783 patent/US11931417B2/en active Active
- 2021-07-21 JP JP2021120139A patent/JP7801104B2/ja active Active
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